2OG-Fe(II) oxygenase superfamily, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGV6_LEIDO

TriTrypDb:

LdBPK_260390.1 , LdCL_260009400 , LDHU3_26.0500

Length:

563

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IGV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGV6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	373	375	PF00675	0.417
CLV_NRD_NRD_1	380	382	PF00675	0.430
CLV_NRD_NRD_1	542	544	PF00675	0.513
CLV_PCSK_KEX2_1	372	374	PF00082	0.444
CLV_PCSK_KEX2_1	380	382	PF00082	0.427
CLV_PCSK_KEX2_1	519	521	PF00082	0.317
CLV_PCSK_KEX2_1	542	544	PF00082	0.478
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.299
CLV_PCSK_SKI1_1	20	24	PF00082	0.540
CLV_PCSK_SKI1_1	380	384	PF00082	0.577
DEG_APCC_DBOX_1	379	387	PF00400	0.578
DEG_COP1_1	327	336	PF00400	0.509
DEG_SPOP_SBC_1	242	246	PF00917	0.680
DEG_SPOP_SBC_1	288	292	PF00917	0.499
DOC_ANK_TNKS_1	145	152	PF00023	0.627
DOC_CYCLIN_yCln2_LP_2	61	64	PF00134	0.569
DOC_MAPK_gen_1	252	260	PF00069	0.532
DOC_MAPK_MEF2A_6	221	230	PF00069	0.500
DOC_PP2B_LxvP_1	142	145	PF13499	0.522
DOC_PP2B_LxvP_1	15	18	PF13499	0.566
DOC_PP2B_LxvP_1	230	233	PF13499	0.509
DOC_PP2B_LxvP_1	61	64	PF13499	0.569
DOC_USP7_MATH_1	120	124	PF00917	0.639
DOC_USP7_MATH_1	234	238	PF00917	0.567
DOC_USP7_MATH_1	242	246	PF00917	0.658
DOC_USP7_MATH_1	267	271	PF00917	0.569
DOC_USP7_MATH_1	313	317	PF00917	0.793
DOC_USP7_MATH_1	398	402	PF00917	0.457
DOC_WW_Pin1_4	101	106	PF00397	0.685
DOC_WW_Pin1_4	109	114	PF00397	0.657
DOC_WW_Pin1_4	116	121	PF00397	0.593
DOC_WW_Pin1_4	204	209	PF00397	0.808
DOC_WW_Pin1_4	80	85	PF00397	0.511
LIG_14-3-3_CanoR_1	157	166	PF00244	0.527
LIG_14-3-3_CanoR_1	312	318	PF00244	0.794
LIG_14-3-3_CanoR_1	326	336	PF00244	0.371
LIG_14-3-3_CanoR_1	536	542	PF00244	0.502
LIG_14-3-3_CanoR_1	88	92	PF00244	0.499
LIG_Actin_WH2_2	84	100	PF00022	0.517
LIG_BIR_II_1	1	5	PF00653	0.639
LIG_BIR_III_4	52	56	PF00653	0.488
LIG_Clathr_ClatBox_1	339	343	PF01394	0.481
LIG_FHA_1	198	204	PF00498	0.728
LIG_FHA_1	312	318	PF00498	0.798
LIG_FHA_1	511	517	PF00498	0.517
LIG_FHA_1	519	525	PF00498	0.517
LIG_FHA_1	67	73	PF00498	0.578
LIG_FHA_2	345	351	PF00498	0.417
LIG_FHA_2	473	479	PF00498	0.517
LIG_FHA_2	521	527	PF00498	0.555
LIG_FHA_2	548	554	PF00498	0.622
LIG_FHA_2	81	87	PF00498	0.476
LIG_Integrin_RGD_1	533	535	PF01839	0.355
LIG_LIR_Apic_2	480	485	PF02991	0.521
LIG_LIR_Gen_1	353	363	PF02991	0.476
LIG_LIR_Gen_1	401	410	PF02991	0.482
LIG_LIR_Gen_1	443	452	PF02991	0.538
LIG_LIR_Gen_1	473	479	PF02991	0.555
LIG_LIR_LC3C_4	500	503	PF02991	0.518
LIG_LIR_Nem_3	353	358	PF02991	0.412
LIG_LIR_Nem_3	438	444	PF02991	0.542
LIG_LIR_Nem_3	52	57	PF02991	0.584
LIG_LIR_Nem_3	553	559	PF02991	0.536
LIG_LIR_Nem_3	69	74	PF02991	0.333
LIG_LYPXL_yS_3	556	559	PF13949	0.600
LIG_PDZ_Class_3	558	563	PF00595	0.500
LIG_Pex14_1	32	36	PF04695	0.468
LIG_Pex14_2	378	382	PF04695	0.416
LIG_REV1ctd_RIR_1	34	41	PF16727	0.467
LIG_SH2_NCK_1	444	448	PF00017	0.459
LIG_SH2_SRC	442	445	PF00017	0.555
LIG_SH2_STAT5	259	262	PF00017	0.451
LIG_SH2_STAT5	369	372	PF00017	0.506
LIG_SH2_STAT5	403	406	PF00017	0.480
LIG_SH2_STAT5	474	477	PF00017	0.555
LIG_SH2_STAT5	495	498	PF00017	0.555
LIG_SH3_3	331	337	PF00018	0.523
LIG_SH3_3	423	429	PF00018	0.555
LIG_SH3_3	485	491	PF00018	0.555
LIG_SUMO_SIM_anti_2	162	167	PF11976	0.567
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.470
LIG_SUMO_SIM_anti_2	500	505	PF11976	0.517
LIG_SUMO_SIM_par_1	467	473	PF11976	0.498
LIG_TRAF2_1	297	300	PF00917	0.740
LIG_TRAF2_1	348	351	PF00917	0.510
LIG_UBA3_1	11	16	PF00899	0.501
LIG_WRC_WIRS_1	528	533	PF05994	0.606
LIG_WW_3	17	21	PF00397	0.549
MOD_CDK_SPxK_1	101	107	PF00069	0.586
MOD_CK1_1	109	115	PF00069	0.774
MOD_CK1_1	185	191	PF00069	0.671
MOD_CK1_1	207	213	PF00069	0.718
MOD_CK1_1	243	249	PF00069	0.654
MOD_CK1_1	289	295	PF00069	0.572
MOD_CK1_1	470	476	PF00069	0.555
MOD_CK2_1	344	350	PF00069	0.482
MOD_CK2_1	472	478	PF00069	0.532
MOD_CK2_1	520	526	PF00069	0.555
MOD_CK2_1	547	553	PF00069	0.627
MOD_GlcNHglycan	116	119	PF01048	0.779
MOD_GlcNHglycan	178	181	PF01048	0.629
MOD_GlcNHglycan	187	190	PF01048	0.669
MOD_GlcNHglycan	249	252	PF01048	0.681
MOD_GSK3_1	116	123	PF00069	0.697
MOD_GSK3_1	157	164	PF00069	0.666
MOD_GSK3_1	181	188	PF00069	0.692
MOD_GSK3_1	203	210	PF00069	0.803
MOD_GSK3_1	240	247	PF00069	0.648
MOD_GSK3_1	287	294	PF00069	0.610
MOD_GSK3_1	301	308	PF00069	0.714
MOD_GSK3_1	311	318	PF00069	0.795
MOD_GSK3_1	510	517	PF00069	0.566
MOD_GSK3_1	518	525	PF00069	0.547
MOD_GSK3_1	543	550	PF00069	0.613
MOD_N-GLC_1	234	239	PF02516	0.630
MOD_NEK2_1	127	132	PF00069	0.501
MOD_NEK2_1	159	164	PF00069	0.558
MOD_NEK2_1	203	208	PF00069	0.726
MOD_NEK2_1	22	27	PF00069	0.560
MOD_NEK2_1	467	472	PF00069	0.513
MOD_NEK2_1	477	482	PF00069	0.509
MOD_NEK2_1	537	542	PF00069	0.555
MOD_PIKK_1	195	201	PF00454	0.602
MOD_PIKK_1	301	307	PF00454	0.661
MOD_PIKK_1	311	317	PF00454	0.655
MOD_PIKK_1	327	333	PF00454	0.530
MOD_PIKK_1	543	549	PF00454	0.546
MOD_PKA_2	301	307	PF00069	0.661
MOD_PKA_2	311	317	PF00069	0.675
MOD_PKA_2	398	404	PF00069	0.509
MOD_PKA_2	535	541	PF00069	0.502
MOD_PKA_2	547	553	PF00069	0.502
MOD_PKA_2	87	93	PF00069	0.506
MOD_Plk_1	234	240	PF00069	0.637
MOD_Plk_1	350	356	PF00069	0.469
MOD_Plk_1	477	483	PF00069	0.545
MOD_Plk_4	161	167	PF00069	0.573
MOD_Plk_4	220	226	PF00069	0.532
MOD_Plk_4	234	240	PF00069	0.539
MOD_Plk_4	350	356	PF00069	0.506
MOD_Plk_4	398	404	PF00069	0.509
MOD_Plk_4	472	478	PF00069	0.493
MOD_ProDKin_1	101	107	PF00069	0.689
MOD_ProDKin_1	109	115	PF00069	0.658
MOD_ProDKin_1	116	122	PF00069	0.591
MOD_ProDKin_1	204	210	PF00069	0.806
MOD_ProDKin_1	80	86	PF00069	0.516
MOD_SUMO_rev_2	344	354	PF00179	0.528
TRG_DiLeu_BaEn_1	92	97	PF01217	0.503
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.504
TRG_DiLeu_BaLyEn_6	282	287	PF01217	0.504
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.502
TRG_ENDOCYTIC_2	403	406	PF00928	0.492
TRG_ENDOCYTIC_2	444	447	PF00928	0.553
TRG_ENDOCYTIC_2	474	477	PF00928	0.555
TRG_ENDOCYTIC_2	556	559	PF00928	0.600
TRG_ER_diArg_1	268	271	PF00400	0.592
TRG_ER_diArg_1	310	313	PF00400	0.689
TRG_ER_diArg_1	362	365	PF00400	0.530
TRG_ER_diArg_1	372	374	PF00400	0.407
TRG_ER_diArg_1	380	382	PF00400	0.354
TRG_ER_diArg_1	406	409	PF00400	0.413
TRG_ER_diArg_1	541	543	PF00400	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB74	Leptomonas seymouri	52%	100%
A0A1X0NTZ1	Trypanosomatidae	41%	100%
A4HEP6	Leishmania braziliensis	73%	100%
A4I1X6	Leishmania infantum	100%	100%
E9AY22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q9F1	Leishmania major	91%	100%