Protein phosphatase methylesterase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGV5_LEIDO

TriTrypDb:

LdBPK_320960.1 , LdCL_320015200 , LDHU3_32.1250

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGV5

Function

Biological processes
Term	Name	Level	Count
GO:0006482	protein demethylation	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008214	protein dealkylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0070988	demethylation	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0051723	protein methylesterase activity	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.441
CLV_NRD_NRD_1	172	174	PF00675	0.358
CLV_NRD_NRD_1	246	248	PF00675	0.419
CLV_PCSK_KEX2_1	246	248	PF00082	0.405
CLV_PCSK_KEX2_1	250	252	PF00082	0.367
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.409
CLV_PCSK_PC7_1	246	252	PF00082	0.428
CLV_PCSK_SKI1_1	117	121	PF00082	0.461
CLV_PCSK_SKI1_1	209	213	PF00082	0.404
CLV_PCSK_SKI1_1	247	251	PF00082	0.390
CLV_PCSK_SKI1_1	51	55	PF00082	0.318
CLV_PCSK_SKI1_1	90	94	PF00082	0.441
DEG_APCC_DBOX_1	50	58	PF00400	0.426
DOC_MAPK_MEF2A_6	95	104	PF00069	0.441
DOC_USP7_MATH_1	149	153	PF00917	0.420
DOC_USP7_UBL2_3	117	121	PF12436	0.435
LIG_14-3-3_CanoR_1	123	128	PF00244	0.404
LIG_14-3-3_CanoR_1	34	38	PF00244	0.444
LIG_CaM_IQ_9	256	272	PF13499	0.490
LIG_deltaCOP1_diTrp_1	176	183	PF00928	0.384
LIG_FHA_1	106	112	PF00498	0.384
LIG_FHA_1	208	214	PF00498	0.363
LIG_FHA_1	236	242	PF00498	0.417
LIG_FHA_1	254	260	PF00498	0.446
LIG_FHA_1	65	71	PF00498	0.325
LIG_FHA_2	124	130	PF00498	0.441
LIG_FHA_2	9	15	PF00498	0.523
LIG_LIR_Gen_1	134	143	PF02991	0.377
LIG_LIR_Gen_1	187	198	PF02991	0.333
LIG_LIR_Gen_1	52	60	PF02991	0.361
LIG_LIR_Nem_3	126	130	PF02991	0.387
LIG_LIR_Nem_3	180	186	PF02991	0.316
LIG_LIR_Nem_3	187	193	PF02991	0.276
LIG_LIR_Nem_3	52	56	PF02991	0.319
LIG_LYPXL_L_2	64	73	PF13949	0.316
LIG_PALB2_WD40_1	178	186	PF16756	0.298
LIG_Pex14_1	179	183	PF04695	0.298
LIG_SH2_STAT5	232	235	PF00017	0.290
LIG_SH2_STAT5	71	74	PF00017	0.333
LIG_SH3_3	148	154	PF00018	0.333
LIG_SUMO_SIM_anti_2	45	50	PF11976	0.420
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.420
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.441
LIG_SUMO_SIM_par_1	97	103	PF11976	0.304
LIG_WRC_WIRS_1	116	121	PF05994	0.441
MOD_CK2_1	123	129	PF00069	0.426
MOD_CK2_1	8	14	PF00069	0.610
MOD_CK2_1	88	94	PF00069	0.366
MOD_CMANNOS	179	182	PF00535	0.298
MOD_GlcNHglycan	266	269	PF01048	0.622
MOD_GlcNHglycan	3	6	PF01048	0.667
MOD_GlcNHglycan	86	89	PF01048	0.441
MOD_GlcNHglycan	90	93	PF01048	0.425
MOD_GlcNHglycan	96	99	PF01048	0.384
MOD_GSK3_1	105	112	PF00069	0.312
MOD_GSK3_1	84	91	PF00069	0.360
MOD_N-GLC_1	264	269	PF02516	0.621
MOD_N-GLC_1	270	275	PF02516	0.674
MOD_N-GLC_1	88	93	PF02516	0.441
MOD_N-GLC_2	227	229	PF02516	0.356
MOD_NEK2_1	198	203	PF00069	0.420
MOD_NEK2_1	207	212	PF00069	0.413
MOD_NEK2_1	73	78	PF00069	0.327
MOD_PIKK_1	253	259	PF00454	0.540
MOD_PKA_2	33	39	PF00069	0.441
MOD_PKA_2	94	100	PF00069	0.401
MOD_Plk_1	149	155	PF00069	0.411
MOD_Plk_1	207	213	PF00069	0.366
MOD_Plk_1	270	276	PF00069	0.706
MOD_Plk_1	88	94	PF00069	0.441
MOD_Plk_2-3	42	48	PF00069	0.441
MOD_Plk_4	115	121	PF00069	0.414
MOD_Plk_4	237	243	PF00069	0.416
MOD_SUMO_for_1	60	63	PF00179	0.441
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.333
TRG_ER_diArg_1	245	247	PF00400	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9A5	Leptomonas seymouri	69%	74%
A0A0S4KPE9	Bodo saltans	41%	85%
A0A1X0NUM3	Trypanosomatidae	52%	83%
A0A3R7K8V0	Trypanosoma rangeli	53%	85%
A4HK72	Leishmania braziliensis	88%	100%
A4I7Q7	Leishmania infantum	100%	100%
D0A9W2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	85%
E9B2L5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P0CO62	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	35%	66%
P0CO63	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	35%	66%
P38796	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	70%
Q4FZT2	Rattus norvegicus	32%	73%
Q4IQC1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	36%	70%
Q4Q5J1	Leishmania major	94%	100%
Q4WKB2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	33%	67%
Q54TN3	Dictyostelium discoideum	33%	87%
Q58DN4	Bos taurus	32%	74%
Q5ALW7	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	78%
Q5BGN7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	69%
Q5R4F9	Pongo abelii	32%	73%
Q6BZG3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	33%	72%
Q6CGE1	Yarrowia lipolytica (strain CLIB 122 / E 150)	38%	67%
Q6CQZ5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	71%
Q6FNL6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	73%
Q74Z47	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	30%	73%
Q8BVQ5	Mus musculus	32%	73%
Q9BIB3	Caenorhabditis elegans	35%	77%
Q9P7D2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	82%
Q9Y570	Homo sapiens	32%	73%
V5BL54	Trypanosoma cruzi	54%	73%