SAC3/GANP/Nin1/mts3/eIF-3 p25 family/COP9 signalosome, subunit CSN8, putative

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 3 subunit k

Species:

Leishmania donovani

UniProt:

A0A3Q8IGV2_LEIDO

TriTrypDb:

LdBPK_322330.1 , LdCL_320028600 , LDHU3_32.2890

Length:

233

Annotations

Annotations by Jardim et al.

Translation, eukaryotic translation initiation factor 3 subunit k

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	yes	yes: 2
Forrest at al. (metacyclic)	yes	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005852	eukaryotic translation initiation factor 3 complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote: 213

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IGV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGV2

Function

Biological processes
Term	Name	Level	Count
GO:0006417	regulation of translation	6	12
GO:0006446	regulation of translational initiation	7	12
GO:0009889	regulation of biosynthetic process	4	12
GO:0010468	regulation of gene expression	5	12
GO:0010556	regulation of macromolecule biosynthetic process	5	12
GO:0010608	post-transcriptional regulation of gene expression	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031326	regulation of cellular biosynthetic process	5	12
GO:0034248	regulation of amide metabolic process	5	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0080090	regulation of primary metabolic process	4	12
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0044877	protein-containing complex binding	2	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.768
CLV_PCSK_KEX2_1	209	211	PF00082	0.754
CLV_PCSK_SKI1_1	137	141	PF00082	0.308
CLV_PCSK_SKI1_1	163	167	PF00082	0.522
CLV_PCSK_SKI1_1	25	29	PF00082	0.416
CLV_PCSK_SKI1_1	39	43	PF00082	0.341
DEG_MDM2_SWIB_1	97	104	PF02201	0.526
DOC_CYCLIN_yClb5_NLxxxL_5	17	24	PF00134	0.495
DOC_MAPK_FxFP_2	182	185	PF00069	0.517
DOC_MAPK_MEF2A_6	39	47	PF00069	0.374
DOC_PP4_FxxP_1	182	185	PF00568	0.418
DOC_USP7_MATH_1	169	173	PF00917	0.595
DOC_USP7_MATH_1	37	41	PF00917	0.514
DOC_WW_Pin1_4	142	147	PF00397	0.526
DOC_WW_Pin1_4	69	74	PF00397	0.570
LIG_14-3-3_CanoR_1	117	126	PF00244	0.538
LIG_14-3-3_CanoR_1	195	203	PF00244	0.477
LIG_14-3-3_CanoR_1	209	219	PF00244	0.628
LIG_14-3-3_CanoR_1	223	228	PF00244	0.752
LIG_14-3-3_CanoR_1	52	62	PF00244	0.490
LIG_14-3-3_CanoR_1	96	104	PF00244	0.541
LIG_BRCT_BRCA1_1	110	114	PF00533	0.495
LIG_BRCT_BRCA1_1	173	177	PF00533	0.500
LIG_eIF4E_1	83	89	PF01652	0.551
LIG_FHA_1	118	124	PF00498	0.538
LIG_FHA_1	133	139	PF00498	0.429
LIG_LIR_Apic_2	15	21	PF02991	0.478
LIG_LIR_Gen_1	140	149	PF02991	0.541
LIG_LIR_Gen_1	226	231	PF02991	0.707
LIG_LIR_Gen_1	99	109	PF02991	0.570
LIG_LIR_Nem_3	140	144	PF02991	0.500
LIG_LIR_Nem_3	99	104	PF02991	0.531
LIG_NRBOX	42	48	PF00104	0.334
LIG_NRBOX	84	90	PF00104	0.551
LIG_Pex14_2	94	98	PF04695	0.465
LIG_SH2_CRK	18	22	PF00017	0.459
LIG_SH2_SRC	81	84	PF00017	0.570
LIG_SH2_STAT5	141	144	PF00017	0.477
LIG_SH2_STAT5	26	29	PF00017	0.419
LIG_SH2_STAT5	81	84	PF00017	0.501
MOD_CK1_1	132	138	PF00069	0.567
MOD_CK1_1	56	62	PF00069	0.490
MOD_CK2_1	100	106	PF00069	0.536
MOD_CK2_1	118	124	PF00069	0.504
MOD_CK2_1	27	33	PF00069	0.502
MOD_CMANNOS	98	101	PF00535	0.265
MOD_GlcNHglycan	171	174	PF01048	0.554
MOD_GlcNHglycan	212	215	PF01048	0.551
MOD_GSK3_1	118	125	PF00069	0.519
MOD_GSK3_1	194	201	PF00069	0.487
MOD_GSK3_1	52	59	PF00069	0.488
MOD_GSK3_1	96	103	PF00069	0.550
MOD_NEK2_1	27	32	PF00069	0.439
MOD_NEK2_1	46	51	PF00069	0.369
MOD_PIKK_1	4	10	PF00454	0.543
MOD_PIKK_1	96	102	PF00454	0.557
MOD_PKA_2	118	124	PF00069	0.510
MOD_PKA_2	194	200	PF00069	0.474
MOD_Plk_1	197	203	PF00069	0.542
MOD_Plk_1	37	43	PF00069	0.497
MOD_Plk_2-3	71	77	PF00069	0.524
MOD_Plk_4	118	124	PF00069	0.498
MOD_Plk_4	137	143	PF00069	0.374
MOD_Plk_4	171	177	PF00069	0.463
MOD_Plk_4	198	204	PF00069	0.483
MOD_Plk_4	37	43	PF00069	0.440
MOD_ProDKin_1	142	148	PF00069	0.526
MOD_ProDKin_1	69	75	PF00069	0.570
MOD_SUMO_rev_2	159	168	PF00179	0.564
TRG_ENDOCYTIC_2	141	144	PF00928	0.477
TRG_ER_diArg_1	179	182	PF00400	0.558
TRG_ER_diArg_1	208	210	PF00400	0.762
TRG_ER_diArg_1	222	225	PF00400	0.743

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAH2	Leptomonas seymouri	80%	100%
A0A0S4JSL7	Bodo saltans	29%	100%
A0A1X0NU56	Trypanosomatidae	45%	100%
A0A422N8G6	Trypanosoma rangeli	45%	100%
A4HKK8	Leishmania braziliensis	93%	100%
A4I841	Leishmania infantum	100%	100%
D0AAA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B2Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q557	Leishmania major	99%	100%
Q567V6	Danio rerio	26%	100%
Q6C830	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	100%
Q94HF1	Oryza sativa subsp. japonica	24%	100%
Q9SZA3	Arabidopsis thaliana	22%	100%
V5AW96	Trypanosoma cruzi	44%	100%