LeishMANIAdb
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60S ribosome subunit biogenesis protein NIP7 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
60S ribosome subunit biogenesis protein NIP7 homolog
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IGU9_LEIDO
TriTrypDb:
LdBPK_331430.1 * , LdCL_330020700 , LDHU3_33.2130
Length:
181

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 11
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11
GO:0030684 preribosome 3 1
GO:0030687 preribosome, large subunit precursor 4 1
GO:0032991 protein-containing complex 1 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A0A3Q8IGU9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGU9

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0022607 cellular component assembly 4 11
GO:0042255 ribosome assembly 7 11
GO:0070925 organelle assembly 5 11
GO:0071840 cellular component organization or biogenesis 2 11
GO:0140694 non-membrane-bounded organelle assembly 6 11
GO:0022613 ribonucleoprotein complex biogenesis 4 1
GO:0042273 ribosomal large subunit biogenesis 5 1
GO:0044085 cellular component biogenesis 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 154 156 PF00675 0.292
CLV_NRD_NRD_1 29 31 PF00675 0.333
CLV_PCSK_SKI1_1 10 14 PF00082 0.290
CLV_PCSK_SKI1_1 2 6 PF00082 0.309
CLV_PCSK_SKI1_1 51 55 PF00082 0.301
DEG_APCC_DBOX_1 115 123 PF00400 0.290
DEG_Nend_UBRbox_1 1 4 PF02207 0.288
DOC_MAPK_gen_1 42 50 PF00069 0.308
DOC_MAPK_MEF2A_6 44 52 PF00069 0.306
DOC_MAPK_MEF2A_6 61 69 PF00069 0.225
DOC_USP7_MATH_1 147 151 PF00917 0.363
DOC_USP7_UBL2_3 11 15 PF12436 0.309
DOC_USP7_UBL2_3 97 101 PF12436 0.290
DOC_WW_Pin1_4 123 128 PF00397 0.290
LIG_14-3-3_CanoR_1 121 129 PF00244 0.290
LIG_14-3-3_CanoR_1 81 90 PF00244 0.533
LIG_14-3-3_CterR_2 179 181 PF00244 0.569
LIG_FHA_1 22 28 PF00498 0.290
LIG_FHA_1 7 13 PF00498 0.290
LIG_FHA_2 3 9 PF00498 0.309
LIG_FHA_2 83 89 PF00498 0.545
LIG_LIR_Gen_1 126 137 PF02991 0.333
LIG_LIR_Nem_3 126 132 PF02991 0.309
LIG_SH2_CRK 129 133 PF00017 0.309
LIG_SH2_CRK 47 51 PF00017 0.291
LIG_SH2_PTP2 19 22 PF00017 0.221
LIG_SH2_STAT3 89 92 PF00017 0.531
LIG_SH2_STAT5 173 176 PF00017 0.290
LIG_SH2_STAT5 19 22 PF00017 0.290
LIG_SH2_STAT5 89 92 PF00017 0.531
LIG_TRAF2_1 102 105 PF00917 0.290
LIG_TYR_ITIM 45 50 PF00017 0.309
LIG_UBA3_1 95 101 PF00899 0.350
MOD_CDK_SPK_2 123 128 PF00069 0.309
MOD_CK1_1 57 63 PF00069 0.363
MOD_CK2_1 147 153 PF00069 0.401
MOD_CK2_1 2 8 PF00069 0.309
MOD_CK2_1 82 88 PF00069 0.592
MOD_GSK3_1 2 9 PF00069 0.307
MOD_N-GLC_1 112 117 PF02516 0.399
MOD_N-GLC_1 22 27 PF02516 0.333
MOD_NEK2_2 91 96 PF00069 0.539
MOD_PIKK_1 158 164 PF00454 0.401
MOD_PKA_2 120 126 PF00069 0.290
MOD_Plk_1 22 28 PF00069 0.333
MOD_Plk_4 91 97 PF00069 0.517
MOD_ProDKin_1 123 129 PF00069 0.290
MOD_SUMO_rev_2 3 12 PF00179 0.309
TRG_ENDOCYTIC_2 129 132 PF00928 0.309
TRG_ENDOCYTIC_2 19 22 PF00928 0.221
TRG_ENDOCYTIC_2 47 50 PF00928 0.291
TRG_ENDOCYTIC_2 93 96 PF00928 0.531
TRG_Pf-PMV_PEXEL_1 2 6 PF00026 0.290

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4L7 Leptomonas seymouri 96% 100%
A0A0S4JB45 Bodo saltans 78% 100%
A0A1X0P123 Trypanosomatidae 79% 93%
A0A422NCH7 Trypanosoma rangeli 88% 99%
A4HLJ6 Leishmania braziliensis 98% 100%
A4I906 Leishmania infantum 99% 100%
A4QND5 Xenopus tropicalis 52% 100%
B0G104 Dictyostelium discoideum 46% 100%
D0A502 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 84%
E9B3X1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
Q08962 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 48% 100%
Q1MTQ9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 55% 100%
Q4Q453 Leishmania major 99% 100%
Q4T2X8 Tetraodon nigroviridis 50% 100%
Q503P2 Danio rerio 51% 100%
Q56P27 Sus scrofa 49% 100%
Q5R9J1 Pongo abelii 49% 100%
Q6DFH9 Xenopus laevis 50% 100%
Q9CXK8 Mus musculus 50% 100%
Q9WV50 Rattus norvegicus 48% 100%
Q9Y221 Homo sapiens 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS