Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGU6_LEIDO

TriTrypDb:

LdBPK_260250.1 , LdCL_260008000 , LDHU3_26.0360

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGU6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.513
CLV_C14_Caspase3-7	70	74	PF00656	0.573
CLV_NRD_NRD_1	143	145	PF00675	0.551
CLV_NRD_NRD_1	173	175	PF00675	0.528
CLV_NRD_NRD_1	346	348	PF00675	0.348
CLV_NRD_NRD_1	403	405	PF00675	0.490
CLV_NRD_NRD_1	414	416	PF00675	0.513
CLV_NRD_NRD_1	488	490	PF00675	0.394
CLV_NRD_NRD_1	529	531	PF00675	0.364
CLV_PCSK_FUR_1	401	405	PF00082	0.539
CLV_PCSK_KEX2_1	136	138	PF00082	0.620
CLV_PCSK_KEX2_1	145	147	PF00082	0.531
CLV_PCSK_KEX2_1	173	175	PF00082	0.555
CLV_PCSK_KEX2_1	38	40	PF00082	0.607
CLV_PCSK_KEX2_1	401	403	PF00082	0.498
CLV_PCSK_KEX2_1	488	490	PF00082	0.394
CLV_PCSK_KEX2_1	529	531	PF00082	0.364
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.707
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.675
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.555
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.407
CLV_PCSK_SKI1_1	175	179	PF00082	0.643
CLV_PCSK_SKI1_1	230	234	PF00082	0.415
CLV_PCSK_SKI1_1	265	269	PF00082	0.450
CLV_PCSK_SKI1_1	272	276	PF00082	0.390
CLV_PCSK_SKI1_1	326	330	PF00082	0.442
CLV_PCSK_SKI1_1	365	369	PF00082	0.435
CLV_PCSK_SKI1_1	39	43	PF00082	0.507
CLV_PCSK_SKI1_1	404	408	PF00082	0.535
CLV_PCSK_SKI1_1	469	473	PF00082	0.455
DEG_APCC_DBOX_1	229	237	PF00400	0.409
DEG_APCC_DBOX_1	257	265	PF00400	0.506
DEG_APCC_DBOX_1	402	410	PF00400	0.496
DOC_ANK_TNKS_1	68	75	PF00023	0.395
DOC_CDC14_PxL_1	376	384	PF14671	0.396
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.662
DOC_CYCLIN_yCln2_LP_2	370	376	PF00134	0.362
DOC_MAPK_gen_1	144	153	PF00069	0.560
DOC_MAPK_gen_1	263	270	PF00069	0.490
DOC_MAPK_MEF2A_6	146	155	PF00069	0.537
DOC_MAPK_MEF2A_6	365	374	PF00069	0.295
DOC_MAPK_NFAT4_5	365	373	PF00069	0.297
DOC_PP1_RVXF_1	228	235	PF00149	0.423
DOC_PP2B_LxvP_1	124	127	PF13499	0.654
DOC_PP2B_LxvP_1	370	373	PF13499	0.443
DOC_PP4_FxxP_1	184	187	PF00568	0.538
DOC_SPAK_OSR1_1	52	56	PF12202	0.402
DOC_USP7_MATH_1	218	222	PF00917	0.531
DOC_USP7_MATH_1	492	496	PF00917	0.507
DOC_USP7_MATH_1	536	540	PF00917	0.590
DOC_USP7_MATH_1	99	103	PF00917	0.542
DOC_WW_Pin1_4	223	228	PF00397	0.427
DOC_WW_Pin1_4	393	398	PF00397	0.501
DOC_WW_Pin1_4	457	462	PF00397	0.381
LIG_14-3-3_CanoR_1	121	125	PF00244	0.557
LIG_14-3-3_CanoR_1	182	187	PF00244	0.541
LIG_14-3-3_CanoR_1	283	289	PF00244	0.585
LIG_14-3-3_CanoR_1	404	410	PF00244	0.477
LIG_14-3-3_CanoR_1	415	420	PF00244	0.539
LIG_14-3-3_CanoR_1	46	55	PF00244	0.511
LIG_14-3-3_CanoR_1	537	541	PF00244	0.531
LIG_14-3-3_CanoR_1	577	586	PF00244	0.402
LIG_APCC_ABBA_1	156	161	PF00400	0.536
LIG_APCC_ABBA_1	53	58	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	52	58	PF00400	0.435
LIG_BIR_III_4	217	221	PF00653	0.537
LIG_BRCT_BRCA1_1	438	442	PF00533	0.367
LIG_CtBP_PxDLS_1	583	589	PF00389	0.349
LIG_CtBP_PxDLS_1	592	596	PF00389	0.409
LIG_eIF4E_1	103	109	PF01652	0.453
LIG_eIF4E_1	435	441	PF01652	0.451
LIG_FHA_1	283	289	PF00498	0.581
LIG_FHA_1	74	80	PF00498	0.559
LIG_FHA_2	212	218	PF00498	0.512
LIG_FHA_2	40	46	PF00498	0.478
LIG_FHA_2	406	412	PF00498	0.579
LIG_FHA_2	472	478	PF00498	0.476
LIG_FHA_2	551	557	PF00498	0.456
LIG_FHA_2	569	575	PF00498	0.463
LIG_LIR_Gen_1	102	109	PF02991	0.333
LIG_LIR_Gen_1	226	236	PF02991	0.439
LIG_LIR_Gen_1	241	252	PF02991	0.392
LIG_LIR_Gen_1	558	569	PF02991	0.478
LIG_LIR_Gen_1	58	68	PF02991	0.417
LIG_LIR_Nem_3	102	107	PF02991	0.520
LIG_LIR_Nem_3	179	184	PF02991	0.648
LIG_LIR_Nem_3	217	222	PF02991	0.475
LIG_LIR_Nem_3	226	231	PF02991	0.443
LIG_LIR_Nem_3	241	247	PF02991	0.434
LIG_LIR_Nem_3	311	317	PF02991	0.472
LIG_LIR_Nem_3	51	56	PF02991	0.416
LIG_LIR_Nem_3	558	564	PF02991	0.493
LIG_LIR_Nem_3	58	63	PF02991	0.334
LIG_LIR_Nem_3	94	100	PF02991	0.542
LIG_MAD2	365	373	PF02301	0.262
LIG_MYND_1	494	498	PF01753	0.522
LIG_NRBOX	232	238	PF00104	0.497
LIG_NRBOX	446	452	PF00104	0.368
LIG_NRBOX	482	488	PF00104	0.387
LIG_NRBOX	82	88	PF00104	0.414
LIG_PCNA_PIPBox_1	429	438	PF02747	0.350
LIG_PCNA_yPIPBox_3	423	436	PF02747	0.426
LIG_Pex14_2	467	471	PF04695	0.314
LIG_Rb_pABgroove_1	549	557	PF01858	0.267
LIG_SH2_CRK	219	223	PF00017	0.497
LIG_SH2_CRK	228	232	PF00017	0.556
LIG_SH2_NCK_1	56	60	PF00017	0.357
LIG_SH2_NCK_1	579	583	PF00017	0.520
LIG_SH2_PTP2	209	212	PF00017	0.490
LIG_SH2_SRC	56	59	PF00017	0.324
LIG_SH2_STAP1	118	122	PF00017	0.596
LIG_SH2_STAP1	228	232	PF00017	0.544
LIG_SH2_STAP1	248	252	PF00017	0.317
LIG_SH2_STAP1	292	296	PF00017	0.578
LIG_SH2_STAP1	56	60	PF00017	0.454
LIG_SH2_STAT5	103	106	PF00017	0.582
LIG_SH2_STAT5	209	212	PF00017	0.487
LIG_SH2_STAT5	315	318	PF00017	0.523
LIG_SH2_STAT5	435	438	PF00017	0.450
LIG_SH2_STAT5	485	488	PF00017	0.450
LIG_SH2_STAT5	524	527	PF00017	0.349
LIG_SH2_STAT5	579	582	PF00017	0.527
LIG_SH3_1	488	494	PF00018	0.540
LIG_SH3_3	148	154	PF00018	0.538
LIG_SH3_3	488	494	PF00018	0.454
LIG_SH3_3	497	503	PF00018	0.306
LIG_SUMO_SIM_anti_2	28	35	PF11976	0.415
LIG_SUMO_SIM_par_1	449	455	PF11976	0.374
LIG_TRAF2_1	138	141	PF00917	0.615
LIG_TRAF2_1	274	277	PF00917	0.530
LIG_TRAF2_1	42	45	PF00917	0.487
LIG_UBA3_1	183	189	PF00899	0.645
LIG_WRC_WIRS_1	23	28	PF05994	0.427
LIG_WRC_WIRS_1	456	461	PF05994	0.471
MOD_CDK_SPxxK_3	223	230	PF00069	0.403
MOD_CK1_1	25	31	PF00069	0.547
MOD_CK1_1	425	431	PF00069	0.654
MOD_CK1_1	455	461	PF00069	0.296
MOD_CK2_1	114	120	PF00069	0.564
MOD_CK2_1	135	141	PF00069	0.600
MOD_CK2_1	39	45	PF00069	0.426
MOD_CK2_1	471	477	PF00069	0.375
MOD_CK2_1	567	573	PF00069	0.445
MOD_GlcNHglycan	244	247	PF01048	0.391
MOD_GlcNHglycan	294	297	PF01048	0.456
MOD_GlcNHglycan	322	325	PF01048	0.490
MOD_GlcNHglycan	419	422	PF01048	0.673
MOD_GlcNHglycan	424	427	PF01048	0.682
MOD_GlcNHglycan	48	51	PF01048	0.522
MOD_GSK3_1	116	123	PF00069	0.536
MOD_GSK3_1	22	29	PF00069	0.423
MOD_GSK3_1	415	422	PF00069	0.623
MOD_GSK3_1	424	431	PF00069	0.681
MOD_GSK3_1	467	474	PF00069	0.376
MOD_GSK3_1	573	580	PF00069	0.544
MOD_N-GLC_1	239	244	PF02516	0.566
MOD_NEK2_1	275	280	PF00069	0.410
MOD_NEK2_1	419	424	PF00069	0.588
MOD_NEK2_1	436	441	PF00069	0.454
MOD_NEK2_1	467	472	PF00069	0.369
MOD_NEK2_1	509	514	PF00069	0.425
MOD_NEK2_1	567	572	PF00069	0.379
MOD_NEK2_1	79	84	PF00069	0.515
MOD_NEK2_2	218	223	PF00069	0.530
MOD_NEK2_2	536	541	PF00069	0.484
MOD_NEK2_2	550	555	PF00069	0.223
MOD_PIKK_1	425	431	PF00454	0.610
MOD_PKA_1	415	421	PF00069	0.615
MOD_PKA_2	120	126	PF00069	0.533
MOD_PKA_2	282	288	PF00069	0.431
MOD_PKA_2	414	420	PF00069	0.571
MOD_PKA_2	536	542	PF00069	0.542
MOD_Plk_1	239	245	PF00069	0.570
MOD_Plk_1	275	281	PF00069	0.525
MOD_Plk_2-3	135	141	PF00069	0.562
MOD_Plk_4	120	126	PF00069	0.571
MOD_Plk_4	161	167	PF00069	0.680
MOD_Plk_4	239	245	PF00069	0.557
MOD_Plk_4	284	290	PF00069	0.486
MOD_Plk_4	405	411	PF00069	0.470
MOD_Plk_4	431	437	PF00069	0.350
MOD_Plk_4	452	458	PF00069	0.379
MOD_Plk_4	492	498	PF00069	0.517
MOD_Plk_4	550	556	PF00069	0.337
MOD_Plk_4	99	105	PF00069	0.474
MOD_ProDKin_1	223	229	PF00069	0.420
MOD_ProDKin_1	393	399	PF00069	0.492
MOD_ProDKin_1	457	463	PF00069	0.381
TRG_DiLeu_BaEn_1	120	125	PF01217	0.554
TRG_DiLeu_BaEn_1	452	457	PF01217	0.468
TRG_DiLeu_BaEn_3	477	483	PF01217	0.504
TRG_DiLeu_BaEn_4	478	484	PF01217	0.509
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.439
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.329
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.407
TRG_ENDOCYTIC_2	181	184	PF00928	0.566
TRG_ENDOCYTIC_2	209	212	PF00928	0.388
TRG_ENDOCYTIC_2	219	222	PF00928	0.434
TRG_ENDOCYTIC_2	228	231	PF00928	0.449
TRG_ENDOCYTIC_2	506	509	PF00928	0.481
TRG_ER_diArg_1	401	404	PF00400	0.462
TRG_ER_diArg_1	487	489	PF00400	0.398
TRG_ER_diArg_1	529	531	PF00400	0.476
TRG_ER_diArg_1	540	543	PF00400	0.550
TRG_NLS_MonoCore_2	171	176	PF00514	0.516
TRG_NLS_MonoExtC_3	171	176	PF00514	0.532
TRG_NLS_MonoExtN_4	171	177	PF00514	0.517
TRG_NLS_MonoExtN_4	401	408	PF00514	0.533
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	529	534	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P504	Leptomonas seymouri	66%	88%
A0A0S4IN30	Bodo saltans	26%	68%
A0A1X0NT69	Trypanosomatidae	33%	80%
A0A3S5IS00	Trypanosoma rangeli	34%	86%
A4HEN5	Leishmania braziliensis	86%	100%
A4I1W3	Leishmania infantum	100%	100%
C9ZS57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	82%
E9AY08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9G5	Leishmania major	93%	100%
V5BZE7	Trypanosoma cruzi	34%	86%