Transcription factor S-II (TFIIS) family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transcription elongation factor-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IGU5_LEIDO

TriTrypDb:

LdBPK_332950.1 , LdCL_330036600 , LDHU3_33.4100

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A0A3Q8IGU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGU5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006351	DNA-templated transcription	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0032774	RNA biosynthetic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0097659	nucleic acid-templated transcription	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003746	translation elongation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.600
CLV_C14_Caspase3-7	58	62	PF00656	0.620
CLV_NRD_NRD_1	319	321	PF00675	0.622
CLV_NRD_NRD_1	349	351	PF00675	0.527
CLV_PCSK_KEX2_1	132	134	PF00082	0.641
CLV_PCSK_KEX2_1	273	275	PF00082	0.592
CLV_PCSK_KEX2_1	440	442	PF00082	0.418
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.613
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.592
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.418
CLV_PCSK_PC7_1	128	134	PF00082	0.644
CLV_PCSK_SKI1_1	186	190	PF00082	0.468
CLV_PCSK_SKI1_1	351	355	PF00082	0.547
CLV_PCSK_SKI1_1	362	366	PF00082	0.463
CLV_PCSK_SKI1_1	459	463	PF00082	0.352
CLV_PCSK_SKI1_1	74	78	PF00082	0.506
DEG_APCC_DBOX_1	185	193	PF00400	0.421
DEG_SCF_SKP2-CKS1_1	383	390	PF00560	0.565
DEG_SPOP_SBC_1	334	338	PF00917	0.579
DOC_MAPK_gen_1	359	369	PF00069	0.538
DOC_MAPK_MEF2A_6	362	369	PF00069	0.551
DOC_MAPK_NFAT4_5	362	370	PF00069	0.577
DOC_PP2B_LxvP_1	254	257	PF13499	0.734
DOC_USP7_MATH_1	112	116	PF00917	0.543
DOC_USP7_MATH_1	117	121	PF00917	0.726
DOC_USP7_MATH_1	149	153	PF00917	0.705
DOC_USP7_MATH_1	210	214	PF00917	0.444
DOC_USP7_MATH_1	245	249	PF00917	0.634
DOC_USP7_MATH_1	265	269	PF00917	0.718
DOC_USP7_MATH_1	280	284	PF00917	0.714
DOC_USP7_MATH_1	286	290	PF00917	0.661
DOC_USP7_MATH_1	97	101	PF00917	0.589
DOC_WW_Pin1_4	266	271	PF00397	0.686
DOC_WW_Pin1_4	282	287	PF00397	0.707
DOC_WW_Pin1_4	289	294	PF00397	0.719
DOC_WW_Pin1_4	31	36	PF00397	0.639
DOC_WW_Pin1_4	330	335	PF00397	0.543
DOC_WW_Pin1_4	384	389	PF00397	0.530
LIG_14-3-3_CanoR_1	228	234	PF00244	0.434
LIG_14-3-3_CanoR_1	23	30	PF00244	0.466
LIG_14-3-3_CanoR_1	320	324	PF00244	0.538
LIG_14-3-3_CanoR_1	441	446	PF00244	0.394
LIG_APCC_ABBA_1	10	15	PF00400	0.531
LIG_APCC_ABBAyCdc20_2	9	15	PF00400	0.530
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_FHA_1	456	462	PF00498	0.336
LIG_FHA_2	198	204	PF00498	0.565
LIG_FHA_2	320	326	PF00498	0.597
LIG_FHA_2	336	342	PF00498	0.448
LIG_FHA_2	355	361	PF00498	0.529
LIG_FHA_2	399	405	PF00498	0.517
LIG_FHA_2	442	448	PF00498	0.438
LIG_FHA_2	460	466	PF00498	0.141
LIG_FHA_2	50	56	PF00498	0.580
LIG_FHA_2	68	74	PF00498	0.345
LIG_LIR_Gen_1	156	166	PF02991	0.592
LIG_LIR_Gen_1	322	331	PF02991	0.570
LIG_LIR_Gen_1	8	17	PF02991	0.452
LIG_LIR_Nem_3	156	161	PF02991	0.625
LIG_LIR_Nem_3	322	327	PF02991	0.571
LIG_LIR_Nem_3	8	14	PF02991	0.431
LIG_MYND_1	218	222	PF01753	0.552
LIG_PCNA_PIPBox_1	426	435	PF02747	0.493
LIG_SH2_CRK	324	328	PF00017	0.567
LIG_SH2_GRB2like	324	327	PF00017	0.566
LIG_SH2_NCK_1	324	328	PF00017	0.567
LIG_SH2_SRC	13	16	PF00017	0.582
LIG_SH2_SRC	324	327	PF00017	0.577
LIG_SH2_SRC	4	7	PF00017	0.547
LIG_SH2_STAP1	324	328	PF00017	0.577
LIG_SH2_STAP1	340	344	PF00017	0.495
LIG_SH2_STAT3	391	394	PF00017	0.563
LIG_SH2_STAT3	446	449	PF00017	0.355
LIG_SH2_STAT5	13	16	PF00017	0.584
LIG_SH2_STAT5	198	201	PF00017	0.565
LIG_SH2_STAT5	391	394	PF00017	0.563
LIG_SH2_STAT5	4	7	PF00017	0.546
LIG_SH2_STAT5	460	463	PF00017	0.412
LIG_SH3_2	279	284	PF14604	0.603
LIG_SH3_3	219	225	PF00018	0.547
LIG_SH3_3	264	270	PF00018	0.751
LIG_SH3_3	276	282	PF00018	0.775
LIG_SH3_3	44	50	PF00018	0.613
LIG_TRAF2_1	26	29	PF00917	0.572
LIG_TRAF2_1	406	409	PF00917	0.574
LIG_TYR_ITSM	320	327	PF00017	0.597
LIG_UBA3_1	426	434	PF00899	0.501
LIG_WRC_WIRS_1	230	235	PF05994	0.533
MOD_CDK_SPK_2	384	389	PF00069	0.563
MOD_CDK_SPxK_1	384	390	PF00069	0.564
MOD_CDK_SPxxK_3	266	273	PF00069	0.774
MOD_CK1_1	171	177	PF00069	0.448
MOD_CK1_1	213	219	PF00069	0.579
MOD_CK1_1	289	295	PF00069	0.678
MOD_CK1_1	333	339	PF00069	0.588
MOD_CK2_1	197	203	PF00069	0.557
MOD_CK2_1	23	29	PF00069	0.475
MOD_CK2_1	398	404	PF00069	0.532
MOD_CK2_1	441	447	PF00069	0.340
MOD_CK2_1	449	455	PF00069	0.315
MOD_CK2_1	49	55	PF00069	0.521
MOD_CK2_1	67	73	PF00069	0.350
MOD_GlcNHglycan	114	117	PF01048	0.517
MOD_GlcNHglycan	119	122	PF01048	0.661
MOD_GlcNHglycan	153	156	PF01048	0.714
MOD_GlcNHglycan	174	177	PF01048	0.492
MOD_GlcNHglycan	259	262	PF01048	0.687
MOD_GlcNHglycan	293	296	PF01048	0.666
MOD_GlcNHglycan	311	314	PF01048	0.747
MOD_GlcNHglycan	382	385	PF01048	0.487
MOD_GlcNHglycan	451	454	PF01048	0.347
MOD_GlcNHglycan	99	102	PF01048	0.626
MOD_GSK3_1	149	156	PF00069	0.696
MOD_GSK3_1	167	174	PF00069	0.552
MOD_GSK3_1	282	289	PF00069	0.673
MOD_GSK3_1	315	322	PF00069	0.685
MOD_GSK3_1	330	337	PF00069	0.427
MOD_GSK3_1	380	387	PF00069	0.447
MOD_GSK3_1	455	462	PF00069	0.369
MOD_N-GLC_1	427	432	PF02516	0.496
MOD_N-GLC_2	64	66	PF02516	0.571
MOD_NEK2_1	202	207	PF00069	0.430
MOD_NEK2_1	287	292	PF00069	0.746
MOD_NEK2_1	335	340	PF00069	0.655
MOD_NEK2_1	427	432	PF00069	0.528
MOD_NEK2_1	67	72	PF00069	0.492
MOD_NEK2_1	82	87	PF00069	0.452
MOD_PIKK_1	213	219	PF00454	0.588
MOD_PIKK_1	315	321	PF00454	0.630
MOD_PKA_2	319	325	PF00069	0.548
MOD_PKA_2	436	442	PF00069	0.228
MOD_Plk_1	180	186	PF00069	0.485
MOD_Plk_1	340	346	PF00069	0.525
MOD_Plk_1	372	378	PF00069	0.567
MOD_Plk_1	427	433	PF00069	0.481
MOD_Plk_1	82	88	PF00069	0.540
MOD_Plk_4	210	216	PF00069	0.458
MOD_Plk_4	319	325	PF00069	0.583
MOD_Plk_4	340	346	PF00069	0.582
MOD_Plk_4	372	378	PF00069	0.560
MOD_Plk_4	428	434	PF00069	0.430
MOD_Plk_4	441	447	PF00069	0.344
MOD_Plk_4	49	55	PF00069	0.575
MOD_ProDKin_1	266	272	PF00069	0.688
MOD_ProDKin_1	282	288	PF00069	0.706
MOD_ProDKin_1	289	295	PF00069	0.720
MOD_ProDKin_1	31	37	PF00069	0.634
MOD_ProDKin_1	330	336	PF00069	0.544
MOD_ProDKin_1	384	390	PF00069	0.531
MOD_SUMO_rev_2	201	207	PF00179	0.542
TRG_DiLeu_BaEn_1	361	366	PF01217	0.581
TRG_DiLeu_BaEn_3	371	377	PF01217	0.574
TRG_ENDOCYTIC_2	158	161	PF00928	0.621
TRG_ENDOCYTIC_2	324	327	PF00928	0.566
TRG_ENDOCYTIC_2	328	331	PF00928	0.501
TRG_ENDOCYTIC_2	44	47	PF00928	0.526
TRG_ER_diArg_1	367	370	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZC4	Leptomonas seymouri	61%	98%
A0A0S4JM53	Bodo saltans	24%	91%
A0A0S4JM77	Bodo saltans	29%	100%
A0A1X0NRX7	Trypanosomatidae	38%	99%
A0A3R7KDK8	Trypanosoma rangeli	38%	100%
A4HLZ2	Leishmania braziliensis	82%	100%
A4I9C2	Leishmania infantum	100%	100%
C9ZJ99	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B4C1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q3Q4	Leishmania major	93%	100%
V5BJM3	Trypanosoma cruzi	36%	99%