Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGU1_LEIDO

TriTrypDb:

LdBPK_331290.1 , LdCL_330019100 , LDHU3_33.1940

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0035869	ciliary transition zone	2	2

Expansion

Sequence features

A0A3Q8IGU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.530
CLV_NRD_NRD_1	116	118	PF00675	0.514
CLV_NRD_NRD_1	253	255	PF00675	0.382
CLV_NRD_NRD_1	420	422	PF00675	0.574
CLV_NRD_NRD_1	430	432	PF00675	0.475
CLV_NRD_NRD_1	617	619	PF00675	0.744
CLV_NRD_NRD_1	77	79	PF00675	0.508
CLV_PCSK_FUR_1	75	79	PF00082	0.511
CLV_PCSK_KEX2_1	116	118	PF00082	0.385
CLV_PCSK_KEX2_1	403	405	PF00082	0.608
CLV_PCSK_KEX2_1	430	432	PF00082	0.631
CLV_PCSK_KEX2_1	617	619	PF00082	0.740
CLV_PCSK_KEX2_1	77	79	PF00082	0.528
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.599
CLV_PCSK_SKI1_1	17	21	PF00082	0.542
CLV_PCSK_SKI1_1	238	242	PF00082	0.489
CLV_PCSK_SKI1_1	374	378	PF00082	0.534
CLV_Separin_Metazoa	427	431	PF03568	0.484
DEG_APCC_DBOX_1	373	381	PF00400	0.477
DEG_APCC_DBOX_1	429	437	PF00400	0.531
DEG_SPOP_SBC_1	449	453	PF00917	0.494
DEG_SPOP_SBC_1	497	501	PF00917	0.708
DOC_MAPK_gen_1	233	242	PF00069	0.498
DOC_MAPK_gen_1	421	428	PF00069	0.499
DOC_MAPK_gen_1	77	87	PF00069	0.517
DOC_PP2B_LxvP_1	537	540	PF13499	0.638
DOC_PP2B_LxvP_1	575	578	PF13499	0.613
DOC_USP7_MATH_1	139	143	PF00917	0.451
DOC_USP7_MATH_1	161	165	PF00917	0.478
DOC_USP7_MATH_1	176	180	PF00917	0.569
DOC_USP7_MATH_1	366	370	PF00917	0.436
DOC_USP7_MATH_1	372	376	PF00917	0.418
DOC_USP7_MATH_1	448	452	PF00917	0.562
DOC_USP7_MATH_1	455	459	PF00917	0.497
DOC_USP7_MATH_1	507	511	PF00917	0.643
DOC_USP7_MATH_1	531	535	PF00917	0.804
DOC_USP7_MATH_1	608	612	PF00917	0.581
DOC_USP7_UBL2_3	399	403	PF12436	0.585
DOC_WW_Pin1_4	466	471	PF00397	0.620
DOC_WW_Pin1_4	487	492	PF00397	0.639
DOC_WW_Pin1_4	499	504	PF00397	0.720
DOC_WW_Pin1_4	521	526	PF00397	0.650
DOC_WW_Pin1_4	8	13	PF00397	0.688
LIG_14-3-3_CanoR_1	249	254	PF00244	0.426
LIG_14-3-3_CanoR_1	336	346	PF00244	0.497
LIG_14-3-3_CanoR_1	421	427	PF00244	0.525
LIG_14-3-3_CanoR_1	511	516	PF00244	0.646
LIG_14-3-3_CanoR_1	549	554	PF00244	0.694
LIG_14-3-3_CterR_2	617	621	PF00244	0.725
LIG_Actin_WH2_2	239	256	PF00022	0.508
LIG_APCC_ABBA_1	106	111	PF00400	0.479
LIG_BRCT_BRCA1_1	140	144	PF00533	0.388
LIG_CtBP_PxDLS_1	492	496	PF00389	0.523
LIG_EVH1_1	575	579	PF00568	0.638
LIG_FHA_1	183	189	PF00498	0.495
LIG_FHA_1	338	344	PF00498	0.552
LIG_FHA_1	410	416	PF00498	0.510
LIG_FHA_1	421	427	PF00498	0.537
LIG_FHA_1	43	49	PF00498	0.462
LIG_FHA_1	435	441	PF00498	0.504
LIG_FHA_1	60	66	PF00498	0.604
LIG_FHA_2	405	411	PF00498	0.456
LIG_FHA_2	469	475	PF00498	0.625
LIG_Integrin_RGD_1	133	135	PF01839	0.415
LIG_LIR_Gen_1	211	220	PF02991	0.286
LIG_LIR_Gen_1	44	55	PF02991	0.542
LIG_LIR_Gen_1	86	95	PF02991	0.459
LIG_LIR_Nem_3	211	216	PF02991	0.277
LIG_LIR_Nem_3	565	571	PF02991	0.722
LIG_LIR_Nem_3	86	91	PF02991	0.458
LIG_LYPXL_SIV_4	344	352	PF13949	0.593
LIG_NRBOX	602	608	PF00104	0.505
LIG_PCNA_yPIPBox_3	225	238	PF02747	0.369
LIG_SH2_CRK	88	92	PF00017	0.520
LIG_SH2_SRC	171	174	PF00017	0.509
LIG_SH2_SRC	568	571	PF00017	0.648
LIG_SH2_STAP1	109	113	PF00017	0.516
LIG_SH2_STAP1	339	343	PF00017	0.546
LIG_SH2_STAT3	339	342	PF00017	0.629
LIG_SH2_STAT5	109	112	PF00017	0.516
LIG_SH2_STAT5	127	130	PF00017	0.398
LIG_SH2_STAT5	166	169	PF00017	0.465
LIG_SH2_STAT5	270	273	PF00017	0.407
LIG_SH2_STAT5	303	306	PF00017	0.479
LIG_SH2_STAT5	339	342	PF00017	0.629
LIG_SH2_STAT5	345	348	PF00017	0.602
LIG_SH3_1	444	450	PF00018	0.621
LIG_SH3_2	536	541	PF14604	0.599
LIG_SH3_2	593	598	PF14604	0.578
LIG_SH3_3	444	450	PF00018	0.665
LIG_SH3_3	464	470	PF00018	0.636
LIG_SH3_3	479	485	PF00018	0.594
LIG_SH3_3	486	492	PF00018	0.720
LIG_SH3_3	506	512	PF00018	0.781
LIG_SH3_3	517	523	PF00018	0.642
LIG_SH3_3	533	539	PF00018	0.691
LIG_SH3_3	541	547	PF00018	0.771
LIG_SH3_3	573	579	PF00018	0.641
LIG_SH3_3	580	586	PF00018	0.648
LIG_SH3_3	588	594	PF00018	0.651
LIG_SH3_CIN85_PxpxPR_1	536	541	PF14604	0.527
LIG_SUMO_SIM_anti_2	361	367	PF11976	0.609
LIG_SUMO_SIM_anti_2	425	430	PF11976	0.447
LIG_SUMO_SIM_par_1	485	490	PF11976	0.634
LIG_SUMO_SIM_par_1	83	89	PF11976	0.503
LIG_TRAF2_1	407	410	PF00917	0.568
LIG_WRC_WIRS_1	373	378	PF05994	0.542
LIG_WRC_WIRS_1	66	71	PF05994	0.410
LIG_WW_3	538	542	PF00397	0.527
MOD_CDK_SPxxK_3	8	15	PF00069	0.555
MOD_CK1_1	142	148	PF00069	0.382
MOD_CK1_1	181	187	PF00069	0.476
MOD_CK1_1	193	199	PF00069	0.378
MOD_CK1_1	289	295	PF00069	0.524
MOD_CK1_1	41	47	PF00069	0.531
MOD_CK1_1	496	502	PF00069	0.762
MOD_CK1_1	510	516	PF00069	0.514
MOD_CK2_1	404	410	PF00069	0.562
MOD_CK2_1	468	474	PF00069	0.742
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.562
MOD_GlcNHglycan	102	105	PF01048	0.503
MOD_GlcNHglycan	123	126	PF01048	0.456
MOD_GlcNHglycan	178	181	PF01048	0.305
MOD_GlcNHglycan	192	195	PF01048	0.519
MOD_GlcNHglycan	206	209	PF01048	0.486
MOD_GlcNHglycan	210	213	PF01048	0.380
MOD_GlcNHglycan	221	224	PF01048	0.350
MOD_GlcNHglycan	225	228	PF01048	0.372
MOD_GlcNHglycan	263	266	PF01048	0.399
MOD_GlcNHglycan	291	294	PF01048	0.488
MOD_GlcNHglycan	306	309	PF01048	0.468
MOD_GlcNHglycan	366	369	PF01048	0.565
MOD_GlcNHglycan	441	444	PF01048	0.649
MOD_GlcNHglycan	457	460	PF01048	0.672
MOD_GlcNHglycan	494	498	PF01048	0.683
MOD_GlcNHglycan	516	519	PF01048	0.732
MOD_GlcNHglycan	533	536	PF01048	0.572
MOD_GlcNHglycan	551	554	PF01048	0.613
MOD_GlcNHglycan	609	613	PF01048	0.651
MOD_GSK3_1	117	124	PF00069	0.560
MOD_GSK3_1	138	145	PF00069	0.445
MOD_GSK3_1	17	24	PF00069	0.618
MOD_GSK3_1	178	185	PF00069	0.571
MOD_GSK3_1	204	211	PF00069	0.534
MOD_GSK3_1	215	222	PF00069	0.536
MOD_GSK3_1	306	313	PF00069	0.443
MOD_GSK3_1	37	44	PF00069	0.517
MOD_GSK3_1	372	379	PF00069	0.562
MOD_GSK3_1	405	412	PF00069	0.588
MOD_GSK3_1	434	441	PF00069	0.537
MOD_GSK3_1	462	469	PF00069	0.648
MOD_GSK3_1	493	500	PF00069	0.712
MOD_GSK3_1	503	510	PF00069	0.706
MOD_GSK3_1	527	534	PF00069	0.638
MOD_GSK3_1	560	567	PF00069	0.748
MOD_GSK3_1	613	620	PF00069	0.707
MOD_N-GLC_1	42	47	PF02516	0.522
MOD_NEK2_1	144	149	PF00069	0.469
MOD_NEK2_1	304	309	PF00069	0.473
MOD_NEK2_1	376	381	PF00069	0.509
MOD_NEK2_1	38	43	PF00069	0.461
MOD_NEK2_1	436	441	PF00069	0.585
MOD_NEK2_1	498	503	PF00069	0.775
MOD_NEK2_1	607	612	PF00069	0.564
MOD_NEK2_1	99	104	PF00069	0.478
MOD_NEK2_2	83	88	PF00069	0.406
MOD_PIKK_1	144	150	PF00454	0.450
MOD_PIKK_1	338	344	PF00454	0.629
MOD_PKA_2	204	210	PF00069	0.540
MOD_PKA_2	383	389	PF00069	0.612
MOD_PKA_2	420	426	PF00069	0.617
MOD_PKA_2	434	440	PF00069	0.565
MOD_PKA_2	510	516	PF00069	0.646
MOD_PKA_2	548	554	PF00069	0.739
MOD_Plk_1	142	148	PF00069	0.473
MOD_Plk_1	17	23	PF00069	0.677
MOD_Plk_1	181	187	PF00069	0.497
MOD_Plk_1	275	281	PF00069	0.445
MOD_Plk_1	310	316	PF00069	0.489
MOD_Plk_1	42	48	PF00069	0.516
MOD_Plk_1	493	499	PF00069	0.800
MOD_Plk_4	275	281	PF00069	0.478
MOD_Plk_4	42	48	PF00069	0.516
MOD_Plk_4	511	517	PF00069	0.730
MOD_Plk_4	83	89	PF00069	0.456
MOD_ProDKin_1	466	472	PF00069	0.620
MOD_ProDKin_1	487	493	PF00069	0.640
MOD_ProDKin_1	499	505	PF00069	0.719
MOD_ProDKin_1	521	527	PF00069	0.651
MOD_ProDKin_1	8	14	PF00069	0.686
MOD_SUMO_rev_2	24	29	PF00179	0.484
MOD_SUMO_rev_2	416	423	PF00179	0.490
TRG_DiLeu_BaEn_1	173	178	PF01217	0.574
TRG_DiLeu_BaEn_1	358	363	PF01217	0.531
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.324
TRG_ENDOCYTIC_2	200	203	PF00928	0.541
TRG_ENDOCYTIC_2	391	394	PF00928	0.528
TRG_ENDOCYTIC_2	568	571	PF00928	0.648
TRG_ENDOCYTIC_2	88	91	PF00928	0.517
TRG_ER_diArg_1	115	117	PF00400	0.385
TRG_ER_diArg_1	429	431	PF00400	0.494
TRG_ER_diArg_1	617	619	PF00400	0.751
TRG_ER_diArg_1	74	77	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I367	Leptomonas seymouri	68%	91%
A0A1X0P0X2	Trypanosomatidae	39%	94%
A0A1X0P178	Trypanosomatidae	36%	100%
A0A3R7M637	Trypanosoma rangeli	34%	100%
A0A422N1N7	Trypanosoma rangeli	22%	72%
A4HLH8	Leishmania braziliensis	74%	98%
A4HLH9	Leishmania braziliensis	31%	100%
A4I8Y8	Leishmania infantum	99%	100%
E9B3V7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
E9B3V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	71%
Q4Q466	Leishmania major	29%	73%
Q4Q467	Leishmania major	92%	100%