TMF_TATA_bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGT3_LEIDO

TriTrypDb:

LdBPK_332810.1 , LdCL_330035200 , LDHU3_33.3950

Length:

1228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGT3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1170	1174	PF00656	0.721
CLV_C14_Caspase3-7	333	337	PF00656	0.629
CLV_C14_Caspase3-7	35	39	PF00656	0.713
CLV_C14_Caspase3-7	893	897	PF00656	0.502
CLV_MEL_PAP_1	367	373	PF00089	0.539
CLV_NRD_NRD_1	1012	1014	PF00675	0.542
CLV_NRD_NRD_1	1044	1046	PF00675	0.534
CLV_NRD_NRD_1	1050	1052	PF00675	0.547
CLV_NRD_NRD_1	1088	1090	PF00675	0.601
CLV_NRD_NRD_1	1136	1138	PF00675	0.691
CLV_NRD_NRD_1	1225	1227	PF00675	0.707
CLV_NRD_NRD_1	206	208	PF00675	0.792
CLV_NRD_NRD_1	25	27	PF00675	0.586
CLV_NRD_NRD_1	456	458	PF00675	0.539
CLV_NRD_NRD_1	524	526	PF00675	0.504
CLV_NRD_NRD_1	551	553	PF00675	0.637
CLV_NRD_NRD_1	785	787	PF00675	0.661
CLV_NRD_NRD_1	857	859	PF00675	0.487
CLV_NRD_NRD_1	92	94	PF00675	0.684
CLV_PCSK_KEX2_1	1012	1014	PF00082	0.542
CLV_PCSK_KEX2_1	1071	1073	PF00082	0.561
CLV_PCSK_KEX2_1	1136	1138	PF00082	0.691
CLV_PCSK_KEX2_1	1225	1227	PF00082	0.707
CLV_PCSK_KEX2_1	206	208	PF00082	0.785
CLV_PCSK_KEX2_1	25	27	PF00082	0.586
CLV_PCSK_KEX2_1	456	458	PF00082	0.495
CLV_PCSK_KEX2_1	631	633	PF00082	0.465
CLV_PCSK_KEX2_1	662	664	PF00082	0.526
CLV_PCSK_KEX2_1	707	709	PF00082	0.520
CLV_PCSK_KEX2_1	785	787	PF00082	0.661
CLV_PCSK_KEX2_1	857	859	PF00082	0.487
CLV_PCSK_KEX2_1	92	94	PF00082	0.684
CLV_PCSK_KEX2_1	986	988	PF00082	0.482
CLV_PCSK_PC1ET2_1	1071	1073	PF00082	0.597
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.465
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.511
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.520
CLV_PCSK_PC1ET2_1	986	988	PF00082	0.482
CLV_PCSK_PC7_1	1132	1138	PF00082	0.707
CLV_PCSK_SKI1_1	1051	1055	PF00082	0.602
CLV_PCSK_SKI1_1	1137	1141	PF00082	0.701
CLV_PCSK_SKI1_1	347	351	PF00082	0.581
CLV_PCSK_SKI1_1	361	365	PF00082	0.442
CLV_PCSK_SKI1_1	586	590	PF00082	0.555
CLV_PCSK_SKI1_1	594	598	PF00082	0.462
CLV_PCSK_SKI1_1	626	630	PF00082	0.529
CLV_PCSK_SKI1_1	632	636	PF00082	0.474
CLV_PCSK_SKI1_1	889	893	PF00082	0.510
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DEG_SCF_FBW7_1	405	412	PF00400	0.681
DEG_SPOP_SBC_1	1189	1193	PF00917	0.648
DEG_SPOP_SBC_1	212	216	PF00917	0.637
DEG_SPOP_SBC_1	539	543	PF00917	0.527
DOC_CKS1_1	127	132	PF01111	0.566
DOC_CKS1_1	264	269	PF01111	0.672
DOC_CKS1_1	87	92	PF01111	0.576
DOC_CYCLIN_RxL_1	623	633	PF00134	0.485
DOC_MAPK_DCC_7	816	824	PF00069	0.528
DOC_MAPK_gen_1	56	63	PF00069	0.656
DOC_MAPK_gen_1	876	883	PF00069	0.532
DOC_MAPK_MEF2A_6	751	759	PF00069	0.554
DOC_MAPK_MEF2A_6	816	824	PF00069	0.528
DOC_PP1_RVXF_1	1156	1163	PF00149	0.559
DOC_PP2B_LxvP_1	230	233	PF13499	0.647
DOC_PP2B_LxvP_1	255	258	PF13499	0.667
DOC_PP4_FxxP_1	1207	1210	PF00568	0.713
DOC_PP4_FxxP_1	244	247	PF00568	0.573
DOC_USP7_MATH_1	109	113	PF00917	0.656
DOC_USP7_MATH_1	1176	1180	PF00917	0.777
DOC_USP7_MATH_1	1183	1187	PF00917	0.677
DOC_USP7_MATH_1	119	123	PF00917	0.588
DOC_USP7_MATH_1	1201	1205	PF00917	0.846
DOC_USP7_MATH_1	128	132	PF00917	0.549
DOC_USP7_MATH_1	199	203	PF00917	0.638
DOC_USP7_MATH_1	220	224	PF00917	0.668
DOC_USP7_MATH_1	247	251	PF00917	0.673
DOC_USP7_MATH_1	330	334	PF00917	0.566
DOC_USP7_MATH_1	555	559	PF00917	0.644
DOC_USP7_MATH_1	562	566	PF00917	0.511
DOC_USP7_MATH_1	729	733	PF00917	0.643
DOC_USP7_UBL2_3	1052	1056	PF12436	0.605
DOC_WW_Pin1_4	1206	1211	PF00397	0.723
DOC_WW_Pin1_4	126	131	PF00397	0.644
DOC_WW_Pin1_4	133	138	PF00397	0.657
DOC_WW_Pin1_4	15	20	PF00397	0.648
DOC_WW_Pin1_4	171	176	PF00397	0.751
DOC_WW_Pin1_4	214	219	PF00397	0.761
DOC_WW_Pin1_4	233	238	PF00397	0.538
DOC_WW_Pin1_4	263	268	PF00397	0.565
DOC_WW_Pin1_4	405	410	PF00397	0.731
DOC_WW_Pin1_4	86	91	PF00397	0.568
LIG_14-3-3_CanoR_1	1072	1081	PF00244	0.550
LIG_14-3-3_CanoR_1	120	125	PF00244	0.670
LIG_14-3-3_CanoR_1	213	218	PF00244	0.713
LIG_14-3-3_CanoR_1	361	371	PF00244	0.461
LIG_14-3-3_CanoR_1	382	386	PF00244	0.547
LIG_14-3-3_CanoR_1	423	431	PF00244	0.536
LIG_14-3-3_CanoR_1	456	460	PF00244	0.494
LIG_14-3-3_CanoR_1	510	519	PF00244	0.501
LIG_14-3-3_CanoR_1	594	603	PF00244	0.498
LIG_14-3-3_CanoR_1	764	768	PF00244	0.628
LIG_14-3-3_CanoR_1	92	101	PF00244	0.619
LIG_14-3-3_CterR_2	1225	1228	PF00244	0.676
LIG_Actin_WH2_2	367	384	PF00022	0.535
LIG_BRCT_BRCA1_1	1203	1207	PF00533	0.846
LIG_deltaCOP1_diTrp_1	4	12	PF00928	0.578
LIG_deltaCOP1_diTrp_1	417	422	PF00928	0.540
LIG_FAT_LD_1	755	763	PF03623	0.562
LIG_FHA_1	1185	1191	PF00498	0.728
LIG_FHA_1	276	282	PF00498	0.490
LIG_FHA_1	4	10	PF00498	0.624
LIG_FHA_1	409	415	PF00498	0.580
LIG_FHA_1	42	48	PF00498	0.598
LIG_FHA_1	437	443	PF00498	0.527
LIG_FHA_1	444	450	PF00498	0.470
LIG_FHA_1	752	758	PF00498	0.494
LIG_FHA_1	828	834	PF00498	0.539
LIG_FHA_2	172	178	PF00498	0.695
LIG_FHA_2	363	369	PF00498	0.542
LIG_FHA_2	653	659	PF00498	0.464
LIG_FHA_2	723	729	PF00498	0.596
LIG_FHA_2	789	795	PF00498	0.596
LIG_FHA_2	933	939	PF00498	0.478
LIG_FHA_2	951	957	PF00498	0.360
LIG_HCF-1_HBM_1	611	614	PF13415	0.556
LIG_LIR_Apic_2	1204	1210	PF02991	0.723
LIG_LIR_Apic_2	243	247	PF02991	0.577
LIG_LIR_Gen_1	1157	1164	PF02991	0.603
LIG_LIR_Gen_1	129	140	PF02991	0.712
LIG_LIR_Gen_1	869	877	PF02991	0.439
LIG_LIR_Nem_3	1109	1115	PF02991	0.595
LIG_LIR_Nem_3	1157	1162	PF02991	0.604
LIG_LIR_Nem_3	129	135	PF02991	0.653
LIG_LIR_Nem_3	368	374	PF02991	0.451
LIG_LIR_Nem_3	869	874	PF02991	0.525
LIG_NRBOX	1098	1104	PF00104	0.514
LIG_NRBOX	823	829	PF00104	0.566
LIG_PCNA_yPIPBox_3	901	913	PF02747	0.481
LIG_Pex14_1	849	853	PF04695	0.555
LIG_RPA_C_Fungi	115	127	PF08784	0.616
LIG_SH2_NCK_1	118	122	PF00017	0.691
LIG_SH2_NCK_1	614	618	PF00017	0.504
LIG_SH2_PTP2	1112	1115	PF00017	0.565
LIG_SH2_STAP1	317	321	PF00017	0.564
LIG_SH2_STAT5	1112	1115	PF00017	0.565
LIG_SH3_3	1116	1122	PF00018	0.668
LIG_SH3_3	124	130	PF00018	0.733
LIG_SH3_3	134	140	PF00018	0.608
LIG_SH3_3	261	267	PF00018	0.684
LIG_SUMO_SIM_anti_2	737	742	PF11976	0.546
LIG_SUMO_SIM_anti_2	754	760	PF11976	0.422
LIG_SUMO_SIM_par_1	901	907	PF11976	0.491
LIG_TRAF2_1	1108	1111	PF00917	0.576
LIG_TRAF2_1	158	161	PF00917	0.574
LIG_TRAF2_1	485	488	PF00917	0.522
LIG_TRAF2_1	567	570	PF00917	0.543
LIG_TRAF2_1	645	648	PF00917	0.515
LIG_TRAF2_1	946	949	PF00917	0.546
LIG_TRAF2_1	960	963	PF00917	0.405
LIG_WRC_WIRS_1	9	14	PF05994	0.589
MOD_CDK_SPxK_1	86	92	PF00069	0.573
MOD_CDK_SPxxK_3	86	93	PF00069	0.576
MOD_CK1_1	1065	1071	PF00069	0.592
MOD_CK1_1	1167	1173	PF00069	0.722
MOD_CK1_1	1188	1194	PF00069	0.704
MOD_CK1_1	1206	1212	PF00069	0.690
MOD_CK1_1	122	128	PF00069	0.748
MOD_CK1_1	131	137	PF00069	0.736
MOD_CK1_1	188	194	PF00069	0.692
MOD_CK1_1	200	206	PF00069	0.616
MOD_CK1_1	235	241	PF00069	0.685
MOD_CK1_1	403	409	PF00069	0.715
MOD_CK1_1	558	564	PF00069	0.625
MOD_CK1_1	732	738	PF00069	0.561
MOD_CK1_1	942	948	PF00069	0.421
MOD_CK1_1	96	102	PF00069	0.589
MOD_CK1_1	968	974	PF00069	0.429
MOD_CK2_1	171	177	PF00069	0.700
MOD_CK2_1	362	368	PF00069	0.544
MOD_CK2_1	630	636	PF00069	0.507
MOD_CK2_1	652	658	PF00069	0.465
MOD_CK2_1	676	682	PF00069	0.524
MOD_CK2_1	722	728	PF00069	0.593
MOD_CK2_1	788	794	PF00069	0.597
MOD_CK2_1	8	14	PF00069	0.535
MOD_CK2_1	82	88	PF00069	0.606
MOD_CK2_1	932	938	PF00069	0.481
MOD_CK2_1	943	949	PF00069	0.438
MOD_CK2_1	994	1000	PF00069	0.543
MOD_CMANNOS	2	5	PF00535	0.548
MOD_Cter_Amidation	204	207	PF01082	0.588
MOD_GlcNHglycan	1099	1102	PF01048	0.553
MOD_GlcNHglycan	1144	1147	PF01048	0.646
MOD_GlcNHglycan	1168	1172	PF01048	0.752
MOD_GlcNHglycan	1187	1190	PF01048	0.664
MOD_GlcNHglycan	1192	1195	PF01048	0.604
MOD_GlcNHglycan	124	127	PF01048	0.687
MOD_GlcNHglycan	191	194	PF01048	0.643
MOD_GlcNHglycan	199	202	PF01048	0.670
MOD_GlcNHglycan	230	233	PF01048	0.712
MOD_GlcNHglycan	237	240	PF01048	0.694
MOD_GlcNHglycan	249	252	PF01048	0.624
MOD_GlcNHglycan	332	335	PF01048	0.653
MOD_GlcNHglycan	402	405	PF01048	0.703
MOD_GlcNHglycan	479	483	PF01048	0.612
MOD_GlcNHglycan	512	515	PF01048	0.490
MOD_GlcNHglycan	553	556	PF01048	0.676
MOD_GlcNHglycan	557	560	PF01048	0.634
MOD_GlcNHglycan	564	567	PF01048	0.504
MOD_GlcNHglycan	678	681	PF01048	0.463
MOD_GlcNHglycan	686	689	PF01048	0.494
MOD_GlcNHglycan	73	76	PF01048	0.761
MOD_GlcNHglycan	794	798	PF01048	0.658
MOD_GlcNHglycan	82	85	PF01048	0.666
MOD_GlcNHglycan	896	899	PF01048	0.502
MOD_GSK3_1	1181	1188	PF00069	0.751
MOD_GSK3_1	122	129	PF00069	0.643
MOD_GSK3_1	131	138	PF00069	0.660
MOD_GSK3_1	171	178	PF00069	0.761
MOD_GSK3_1	185	192	PF00069	0.601
MOD_GSK3_1	228	235	PF00069	0.708
MOD_GSK3_1	324	331	PF00069	0.564
MOD_GSK3_1	393	400	PF00069	0.569
MOD_GSK3_1	4	11	PF00069	0.527
MOD_GSK3_1	405	412	PF00069	0.579
MOD_GSK3_1	540	547	PF00069	0.653
MOD_GSK3_1	551	558	PF00069	0.605
MOD_GSK3_1	594	601	PF00069	0.410
MOD_GSK3_1	676	683	PF00069	0.439
MOD_GSK3_1	730	737	PF00069	0.516
MOD_GSK3_1	82	89	PF00069	0.608
MOD_GSK3_1	823	830	PF00069	0.547
MOD_GSK3_1	890	897	PF00069	0.506
MOD_GSK3_1	939	946	PF00069	0.463
MOD_GSK3_1	965	972	PF00069	0.434
MOD_N-GLC_1	1176	1181	PF02516	0.678
MOD_N-GLC_1	472	477	PF02516	0.509
MOD_N-GLC_1	859	864	PF02516	0.545
MOD_NEK2_1	1054	1059	PF00069	0.615
MOD_NEK2_1	1190	1195	PF00069	0.722
MOD_NEK2_1	189	194	PF00069	0.597
MOD_NEK2_1	381	386	PF00069	0.561
MOD_NEK2_1	965	970	PF00069	0.546
MOD_PIKK_1	1072	1078	PF00454	0.516
MOD_PIKK_1	1106	1112	PF00454	0.590
MOD_PIKK_1	1127	1133	PF00454	0.642
MOD_PIKK_1	1196	1202	PF00454	0.721
MOD_PIKK_1	156	162	PF00454	0.632
MOD_PIKK_1	220	226	PF00454	0.740
MOD_PIKK_1	266	272	PF00454	0.715
MOD_PIKK_1	275	281	PF00454	0.572
MOD_PIKK_1	437	443	PF00454	0.563
MOD_PIKK_1	598	604	PF00454	0.414
MOD_PIKK_1	652	658	PF00454	0.446
MOD_PIKK_1	680	686	PF00454	0.452
MOD_PIKK_1	739	745	PF00454	0.522
MOD_PIKK_1	93	99	PF00454	0.592
MOD_PIKK_1	994	1000	PF00454	0.543
MOD_PK_1	120	126	PF00069	0.614
MOD_PK_1	730	736	PF00069	0.514
MOD_PKA_1	25	31	PF00069	0.590
MOD_PKA_2	119	125	PF00069	0.622
MOD_PKA_2	212	218	PF00069	0.712
MOD_PKA_2	24	30	PF00069	0.609
MOD_PKA_2	381	387	PF00069	0.548
MOD_PKA_2	422	428	PF00069	0.509
MOD_PKA_2	455	461	PF00069	0.494
MOD_PKA_2	551	557	PF00069	0.630
MOD_PKA_2	64	70	PF00069	0.723
MOD_PKA_2	722	728	PF00069	0.581
MOD_PKA_2	763	769	PF00069	0.629
MOD_Plk_1	1038	1044	PF00069	0.565
MOD_Plk_1	1065	1071	PF00069	0.592
MOD_Plk_1	180	186	PF00069	0.798
MOD_Plk_1	275	281	PF00069	0.527
MOD_Plk_1	310	316	PF00069	0.468
MOD_Plk_1	730	736	PF00069	0.572
MOD_Plk_1	849	855	PF00069	0.555
MOD_Plk_1	859	865	PF00069	0.441
MOD_Plk_1	879	885	PF00069	0.330
MOD_Plk_2-3	630	636	PF00069	0.403
MOD_Plk_2-3	879	885	PF00069	0.535
MOD_Plk_2-3	950	956	PF00069	0.544
MOD_Plk_2-3	991	997	PF00069	0.547
MOD_Plk_4	128	134	PF00069	0.745
MOD_Plk_4	766	772	PF00069	0.642
MOD_Plk_4	834	840	PF00069	0.537
MOD_ProDKin_1	1206	1212	PF00069	0.719
MOD_ProDKin_1	126	132	PF00069	0.649
MOD_ProDKin_1	133	139	PF00069	0.651
MOD_ProDKin_1	15	21	PF00069	0.652
MOD_ProDKin_1	171	177	PF00069	0.754
MOD_ProDKin_1	214	220	PF00069	0.760
MOD_ProDKin_1	233	239	PF00069	0.540
MOD_ProDKin_1	263	269	PF00069	0.565
MOD_ProDKin_1	405	411	PF00069	0.728
MOD_ProDKin_1	86	92	PF00069	0.573
MOD_SUMO_for_1	357	360	PF00179	0.513
MOD_SUMO_for_1	502	505	PF00179	0.519
MOD_SUMO_for_1	744	747	PF00179	0.534
MOD_SUMO_for_1	883	886	PF00179	0.541
MOD_SUMO_for_1	960	963	PF00179	0.548
MOD_SUMO_rev_2	458	463	PF00179	0.522
MOD_SUMO_rev_2	726	732	PF00179	0.654
MOD_SUMO_rev_2	747	752	PF00179	0.528
TRG_DiLeu_BaEn_1	1111	1116	PF01217	0.610
TRG_DiLeu_BaEn_1	973	978	PF01217	0.486
TRG_DiLeu_BaEn_4	426	432	PF01217	0.522
TRG_DiLeu_BaEn_4	570	576	PF01217	0.545
TRG_DiLeu_BaEn_4	949	955	PF01217	0.542
TRG_DiLeu_BaLyEn_6	817	822	PF01217	0.612
TRG_ENDOCYTIC_2	1112	1115	PF00928	0.565
TRG_ER_diArg_1	1012	1015	PF00400	0.542
TRG_ER_diArg_1	455	457	PF00400	0.540
TRG_ER_diArg_1	572	575	PF00400	0.596
TRG_ER_diArg_1	721	724	PF00400	0.574
TRG_ER_diArg_1	785	787	PF00400	0.601
TRG_ER_diArg_1	857	859	PF00400	0.487
TRG_ER_diArg_1	92	94	PF00400	0.684
TRG_NES_CRM1_1	747	760	PF08389	0.574
TRG_Pf-PMV_PEXEL_1	1006	1010	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	1012	1016	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	1045	1049	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	626	630	PF00026	0.481
TRG_Pf-PMV_PEXEL_1	707	711	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	92	97	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLX8	Leishmania braziliensis	55%	96%
A4I9A7	Leishmania infantum	99%	100%
E9B4A7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q3R9	Leishmania major	85%	100%