Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGT2_LEIDO

TriTrypDb:

LdBPK_321950.1 , LdCL_320025000 , LDHU3_32.2450

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGT2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.623
CLV_C14_Caspase3-7	159	163	PF00656	0.604
CLV_C14_Caspase3-7	332	336	PF00656	0.753
CLV_C14_Caspase3-7	375	379	PF00656	0.720
CLV_NRD_NRD_1	115	117	PF00675	0.614
CLV_NRD_NRD_1	262	264	PF00675	0.600
CLV_NRD_NRD_1	376	378	PF00675	0.719
CLV_NRD_NRD_1	408	410	PF00675	0.623
CLV_PCSK_KEX2_1	115	117	PF00082	0.614
CLV_PCSK_KEX2_1	261	263	PF00082	0.572
CLV_PCSK_KEX2_1	376	378	PF00082	0.725
CLV_PCSK_KEX2_1	408	410	PF00082	0.623
CLV_PCSK_SKI1_1	358	362	PF00082	0.714
CLV_PCSK_SKI1_1	81	85	PF00082	0.577
DEG_APCC_DBOX_1	357	365	PF00400	0.711
DEG_APCC_DBOX_1	94	102	PF00400	0.609
DEG_SCF_TRCP1_1	311	316	PF00400	0.640
DOC_ANK_TNKS_1	37	44	PF00023	0.540
DOC_CYCLIN_RxL_1	355	365	PF00134	0.710
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	393	399	PF00134	0.689
DOC_CYCLIN_yCln2_LP_2	85	91	PF00134	0.607
DOC_MAPK_MEF2A_6	367	374	PF00069	0.706
DOC_PP2B_LxvP_1	154	157	PF13499	0.665
DOC_PP2B_LxvP_1	24	27	PF13499	0.504
DOC_PP2B_LxvP_1	386	389	PF13499	0.624
DOC_PP4_FxxP_1	201	204	PF00568	0.692
DOC_PP4_FxxP_1	29	32	PF00568	0.542
DOC_PP4_FxxP_1	51	54	PF00568	0.635
DOC_USP7_MATH_1	220	224	PF00917	0.755
DOC_USP7_MATH_1	231	235	PF00917	0.722
DOC_USP7_MATH_1	25	29	PF00917	0.584
DOC_USP7_MATH_1	289	293	PF00917	0.764
DOC_USP7_MATH_1	346	350	PF00917	0.695
DOC_USP7_MATH_1	389	393	PF00917	0.695
DOC_WW_Pin1_4	227	232	PF00397	0.830
DOC_WW_Pin1_4	261	266	PF00397	0.591
DOC_WW_Pin1_4	293	298	PF00397	0.674
LIG_14-3-3_CanoR_1	115	123	PF00244	0.338
LIG_14-3-3_CanoR_1	186	192	PF00244	0.664
LIG_14-3-3_CanoR_1	81	86	PF00244	0.581
LIG_14-3-3_CanoR_1	95	105	PF00244	0.540
LIG_Actin_WH2_2	121	139	PF00022	0.683
LIG_Actin_WH2_2	79	97	PF00022	0.603
LIG_ActinCP_TwfCPI_2	29	38	PF01115	0.550
LIG_APCC_ABBA_1	37	42	PF00400	0.663
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BRCT_BRCA1_1	391	395	PF00533	0.683
LIG_FHA_1	361	367	PF00498	0.728
LIG_FHA_1	43	49	PF00498	0.492
LIG_FHA_1	77	83	PF00498	0.622
LIG_FHA_2	188	194	PF00498	0.690
LIG_FHA_2	82	88	PF00498	0.500
LIG_FXI_DFP_1	172	176	PF00024	0.670
LIG_IRF3_LxIS_1	289	296	PF10401	0.740
LIG_LIR_Apic_2	199	204	PF02991	0.701
LIG_LIR_Apic_2	28	32	PF02991	0.583
LIG_LIR_Apic_2	50	54	PF02991	0.585
LIG_LIR_Gen_1	189	197	PF02991	0.644
LIG_LIR_Gen_1	267	274	PF02991	0.551
LIG_LIR_Nem_3	117	123	PF02991	0.564
LIG_LIR_Nem_3	173	178	PF02991	0.603
LIG_LIR_Nem_3	189	195	PF02991	0.563
LIG_LIR_Nem_3	267	271	PF02991	0.726
LIG_LIR_Nem_3	6	12	PF02991	0.631
LIG_Pex14_2	171	175	PF04695	0.663
LIG_SH2_CRK	10	14	PF00017	0.599
LIG_SH2_CRK	120	124	PF00017	0.551
LIG_SH2_NCK_1	347	351	PF00017	0.768
LIG_SH2_SRC	192	195	PF00017	0.635
LIG_SH2_STAP1	192	196	PF00017	0.643
LIG_SH2_STAP1	347	351	PF00017	0.718
LIG_SH2_STAP1	92	96	PF00017	0.543
LIG_SH2_STAT5	240	243	PF00017	0.673
LIG_SH2_STAT5	410	413	PF00017	0.641
LIG_SH3_1	179	185	PF00018	0.705
LIG_SH3_2	396	401	PF14604	0.625
LIG_SH3_3	179	185	PF00018	0.705
LIG_SH3_3	201	207	PF00018	0.703
LIG_SH3_3	393	399	PF00018	0.616
LIG_SH3_3	68	74	PF00018	0.572
LIG_SUMO_SIM_par_1	156	162	PF11976	0.640
LIG_SUMO_SIM_par_1	81	87	PF11976	0.458
LIG_TYR_ITSM	188	195	PF00017	0.690
LIG_WRC_WIRS_1	26	31	PF05994	0.577
LIG_WRC_WIRS_1	48	53	PF05994	0.526
MOD_CK1_1	187	193	PF00069	0.622
MOD_CK1_1	307	313	PF00069	0.732
MOD_CK1_1	345	351	PF00069	0.706
MOD_CK1_1	97	103	PF00069	0.561
MOD_CK2_1	261	267	PF00069	0.646
MOD_CK2_1	279	285	PF00069	0.754
MOD_GlcNHglycan	129	134	PF01048	0.589
MOD_GlcNHglycan	221	225	PF01048	0.789
MOD_GlcNHglycan	227	230	PF01048	0.755
MOD_GlcNHglycan	279	282	PF01048	0.686
MOD_GlcNHglycan	311	314	PF01048	0.719
MOD_GlcNHglycan	320	323	PF01048	0.737
MOD_GlcNHglycan	325	328	PF01048	0.760
MOD_GlcNHglycan	344	347	PF01048	0.506
MOD_GlcNHglycan	348	351	PF01048	0.734
MOD_GlcNHglycan	5	8	PF01048	0.701
MOD_GSK3_1	227	234	PF00069	0.714
MOD_GSK3_1	266	273	PF00069	0.615
MOD_GSK3_1	279	286	PF00069	0.705
MOD_GSK3_1	289	296	PF00069	0.609
MOD_GSK3_1	309	316	PF00069	0.674
MOD_GSK3_1	342	349	PF00069	0.734
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	164	169	PF00069	0.703
MOD_NEK2_1	283	288	PF00069	0.725
MOD_NEK2_1	33	38	PF00069	0.587
MOD_NEK2_1	360	365	PF00069	0.759
MOD_NEK2_1	47	52	PF00069	0.582
MOD_NEK2_1	94	99	PF00069	0.648
MOD_NEK2_2	389	394	PF00069	0.744
MOD_NEK2_2	76	81	PF00069	0.620
MOD_PIKK_1	11	17	PF00454	0.625
MOD_PIKK_1	114	120	PF00454	0.572
MOD_PIKK_1	266	272	PF00454	0.644
MOD_PKA_2	114	120	PF00069	0.556
MOD_PKA_2	225	231	PF00069	0.784
MOD_PKA_2	94	100	PF00069	0.583
MOD_Plk_1	238	244	PF00069	0.662
MOD_Plk_1	266	272	PF00069	0.733
MOD_Plk_4	187	193	PF00069	0.688
MOD_Plk_4	304	310	PF00069	0.772
MOD_Plk_4	313	319	PF00069	0.608
MOD_Plk_4	47	53	PF00069	0.496
MOD_Plk_4	81	87	PF00069	0.521
MOD_Plk_4	97	103	PF00069	0.541
MOD_ProDKin_1	227	233	PF00069	0.828
MOD_ProDKin_1	261	267	PF00069	0.592
MOD_ProDKin_1	293	299	PF00069	0.671
MOD_SUMO_rev_2	125	132	PF00179	0.509
MOD_SUMO_rev_2	36	45	PF00179	0.662
MOD_SUMO_rev_2	369	375	PF00179	0.755
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.710
TRG_ENDOCYTIC_2	120	123	PF00928	0.558
TRG_ENDOCYTIC_2	192	195	PF00928	0.619
TRG_ENDOCYTIC_2	9	12	PF00928	0.534
TRG_ER_diArg_1	260	263	PF00400	0.578
TRG_ER_diArg_1	408	410	PF00400	0.669
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I475	Leptomonas seymouri	56%	100%
A0A1X0NUD6	Trypanosomatidae	31%	100%
A4I801	Leishmania infantum	100%	100%
E9B2W3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q593	Leishmania major	89%	100%
V5BF21	Trypanosoma cruzi	29%	100%