DNA polymerase alpha subunit B

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGT0_LEIDO

TriTrypDb:

LdBPK_320700.1 , LdCL_320012500 , LDHU3_32.0860

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	235	237	PF00675	0.371
CLV_NRD_NRD_1	298	300	PF00675	0.457
CLV_NRD_NRD_1	55	57	PF00675	0.551
CLV_PCSK_KEX2_1	235	237	PF00082	0.447
CLV_PCSK_KEX2_1	298	300	PF00082	0.457
CLV_PCSK_SKI1_1	181	185	PF00082	0.405
CLV_PCSK_SKI1_1	217	221	PF00082	0.591
CLV_PCSK_SKI1_1	248	252	PF00082	0.537
DEG_SPOP_SBC_1	258	262	PF00917	0.547
DOC_MAPK_DCC_7	217	226	PF00069	0.527
DOC_MAPK_MEF2A_6	217	226	PF00069	0.529
DOC_PP2B_LxvP_1	77	80	PF13499	0.484
DOC_PP4_FxxP_1	28	31	PF00568	0.369
DOC_PP4_FxxP_1	293	296	PF00568	0.469
DOC_PP4_MxPP_1	120	123	PF00568	0.483
DOC_USP7_MATH_1	123	127	PF00917	0.614
DOC_USP7_MATH_1	204	208	PF00917	0.615
DOC_USP7_MATH_1	213	217	PF00917	0.558
DOC_WW_Pin1_4	129	134	PF00397	0.649
LIG_14-3-3_CanoR_1	175	185	PF00244	0.469
LIG_14-3-3_CanoR_1	217	222	PF00244	0.723
LIG_14-3-3_CanoR_1	235	242	PF00244	0.344
LIG_14-3-3_CanoR_1	71	80	PF00244	0.413
LIG_Actin_WH2_2	221	237	PF00022	0.494
LIG_BIR_II_1	1	5	PF00653	0.362
LIG_BRCT_BRCA1_1	6	10	PF00533	0.331
LIG_Clathr_ClatBox_1	184	188	PF01394	0.467
LIG_FHA_1	189	195	PF00498	0.351
LIG_FHA_1	48	54	PF00498	0.414
LIG_FHA_1	60	66	PF00498	0.468
LIG_FHA_1	73	79	PF00498	0.343
LIG_FHA_1	82	88	PF00498	0.415
LIG_FHA_2	155	161	PF00498	0.518
LIG_IRF3_LxIS_1	267	272	PF10401	0.460
LIG_LIR_Apic_2	26	31	PF02991	0.368
LIG_LIR_Apic_2	261	267	PF02991	0.566
LIG_LIR_Apic_2	292	296	PF02991	0.472
LIG_LIR_Gen_1	266	276	PF02991	0.425
LIG_LIR_Gen_1	40	49	PF02991	0.406
LIG_LIR_Nem_3	186	192	PF02991	0.396
LIG_LIR_Nem_3	266	271	PF02991	0.445
LIG_LIR_Nem_3	284	290	PF02991	0.343
LIG_LIR_Nem_3	292	297	PF02991	0.390
LIG_LIR_Nem_3	37	41	PF02991	0.431
LIG_MLH1_MIPbox_1	6	10	PF16413	0.331
LIG_Pex14_2	28	32	PF04695	0.346
LIG_Pex14_2	91	95	PF04695	0.445
LIG_SH2_CRK	189	193	PF00017	0.361
LIG_SH2_CRK	294	298	PF00017	0.403
LIG_SH2_SRC	264	267	PF00017	0.508
LIG_SH2_SRC	268	271	PF00017	0.422
LIG_SH2_STAP1	39	43	PF00017	0.484
LIG_SH2_STAT5	268	271	PF00017	0.507
LIG_SH2_STAT5	9	12	PF00017	0.388
LIG_SH3_3	133	139	PF00018	0.554
LIG_SH3_3	216	222	PF00018	0.672
LIG_SH3_3	252	258	PF00018	0.527
LIG_SH3_3	46	52	PF00018	0.349
LIG_SUMO_SIM_par_1	183	188	PF11976	0.444
LIG_SUMO_SIM_par_1	190	196	PF11976	0.358
LIG_TRAF2_1	157	160	PF00917	0.464
LIG_TRAF2_1	200	203	PF00917	0.600
LIG_TYR_ITIM	187	192	PF00017	0.407
LIG_WRC_WIRS_1	35	40	PF05994	0.515
LIG_WW_2	222	225	PF00397	0.541
LIG_WW_3	253	257	PF00397	0.532
MOD_CK1_1	211	217	PF00069	0.668
MOD_CK2_1	154	160	PF00069	0.464
MOD_CK2_1	86	92	PF00069	0.527
MOD_GlcNHglycan	125	128	PF01048	0.691
MOD_GlcNHglycan	206	209	PF01048	0.756
MOD_GlcNHglycan	210	213	PF01048	0.761
MOD_GlcNHglycan	237	240	PF01048	0.455
MOD_GlcNHglycan	25	28	PF01048	0.317
MOD_GlcNHglycan	44	47	PF01048	0.469
MOD_GSK3_1	100	107	PF00069	0.491
MOD_GSK3_1	125	132	PF00069	0.682
MOD_GSK3_1	204	211	PF00069	0.721
MOD_GSK3_1	213	220	PF00069	0.715
MOD_NEK2_1	10	15	PF00069	0.403
MOD_NEK2_1	176	181	PF00069	0.467
MOD_NEK2_1	234	239	PF00069	0.391
MOD_NEK2_1	4	9	PF00069	0.326
MOD_PIKK_1	10	16	PF00454	0.431
MOD_PIKK_1	154	160	PF00454	0.361
MOD_PKA_1	235	241	PF00069	0.450
MOD_PKA_2	204	210	PF00069	0.687
MOD_PKA_2	23	29	PF00069	0.324
MOD_PKA_2	234	240	PF00069	0.418
MOD_Plk_4	15	21	PF00069	0.434
MOD_Plk_4	188	194	PF00069	0.350
MOD_Plk_4	259	265	PF00069	0.643
MOD_Plk_4	34	40	PF00069	0.429
MOD_Plk_4	5	11	PF00069	0.336
MOD_ProDKin_1	129	135	PF00069	0.641
TRG_DiLeu_BaEn_1	146	151	PF01217	0.431
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.385
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.420
TRG_ENDOCYTIC_2	189	192	PF00928	0.367
TRG_ENDOCYTIC_2	268	271	PF00928	0.507
TRG_ENDOCYTIC_2	294	297	PF00928	0.395
TRG_ENDOCYTIC_2	41	44	PF00928	0.338
TRG_ER_diArg_1	234	236	PF00400	0.424
TRG_ER_diArg_1	297	299	PF00400	0.428
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I005	Leptomonas seymouri	70%	100%
A0A0S4KR83	Bodo saltans	39%	100%
A0A1X0NUS9	Trypanosomatidae	55%	100%
A4HK47	Leishmania braziliensis	86%	100%
A4I7L5	Leishmania infantum	100%	100%
D0A9T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B2J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q5L6	Leishmania major	95%	100%
V5AQU0	Trypanosoma cruzi	56%	100%