CHAP domain/Glutathionylspermidine synthase preATP-grasp, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glutathionylspermidine synthase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGS6_LEIDO

TriTrypDb:

LdBPK_252500.1 , LdCL_250030900 , LDHU3_25.3000

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGS6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008885	glutathionylspermidine synthase activity	5	2
GO:0016874	ligase activity	2	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016880	acid-ammonia (or amide) ligase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.408
CLV_C14_Caspase3-7	315	319	PF00656	0.459
CLV_C14_Caspase3-7	511	515	PF00656	0.372
CLV_C14_Caspase3-7	691	695	PF00656	0.572
CLV_NRD_NRD_1	338	340	PF00675	0.372
CLV_NRD_NRD_1	61	63	PF00675	0.591
CLV_NRD_NRD_1	84	86	PF00675	0.562
CLV_NRD_NRD_1	89	91	PF00675	0.565
CLV_PCSK_KEX2_1	260	262	PF00082	0.525
CLV_PCSK_KEX2_1	338	340	PF00082	0.372
CLV_PCSK_KEX2_1	654	656	PF00082	0.445
CLV_PCSK_KEX2_1	84	86	PF00082	0.508
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.525
CLV_PCSK_PC1ET2_1	654	656	PF00082	0.500
CLV_PCSK_SKI1_1	227	231	PF00082	0.492
CLV_PCSK_SKI1_1	538	542	PF00082	0.372
CLV_PCSK_SKI1_1	544	548	PF00082	0.372
CLV_PCSK_SKI1_1	654	658	PF00082	0.382
DEG_Nend_Nbox_1	1	3	PF02207	0.645
DOC_ANK_TNKS_1	260	267	PF00023	0.537
DOC_MAPK_gen_1	450	457	PF00069	0.348
DOC_MAPK_gen_1	62	68	PF00069	0.642
DOC_MAPK_gen_1	689	698	PF00069	0.463
DOC_MAPK_gen_1	701	709	PF00069	0.456
DOC_MAPK_MEF2A_6	106	114	PF00069	0.291
DOC_MAPK_MEF2A_6	450	457	PF00069	0.348
DOC_PP1_RVXF_1	419	426	PF00149	0.459
DOC_PP1_RVXF_1	454	461	PF00149	0.372
DOC_PP2B_LxvP_1	2	5	PF13499	0.641
DOC_PP4_FxxP_1	327	330	PF00568	0.372
DOC_PP4_MxPP_1	343	346	PF00568	0.372
DOC_USP7_MATH_1	126	130	PF00917	0.290
DOC_USP7_MATH_1	134	138	PF00917	0.258
DOC_USP7_MATH_1	298	302	PF00917	0.372
DOC_USP7_MATH_1	512	516	PF00917	0.459
DOC_USP7_MATH_1	56	60	PF00917	0.572
DOC_USP7_MATH_1	622	626	PF00917	0.631
DOC_USP7_MATH_1	628	632	PF00917	0.652
DOC_USP7_MATH_2	605	611	PF00917	0.521
DOC_USP7_UBL2_3	415	419	PF12436	0.459
DOC_USP7_UBL2_3	452	456	PF12436	0.372
DOC_USP7_UBL2_3	660	664	PF12436	0.448
DOC_USP7_UBL2_3	72	76	PF12436	0.339
DOC_WW_Pin1_4	106	111	PF00397	0.370
DOC_WW_Pin1_4	115	120	PF00397	0.297
DOC_WW_Pin1_4	145	150	PF00397	0.308
DOC_WW_Pin1_4	26	31	PF00397	0.436
DOC_WW_Pin1_4	48	53	PF00397	0.599
DOC_WW_Pin1_4	515	520	PF00397	0.348
LIG_14-3-3_CanoR_1	190	198	PF00244	0.567
LIG_14-3-3_CanoR_1	297	303	PF00244	0.372
LIG_14-3-3_CanoR_1	304	314	PF00244	0.372
LIG_14-3-3_CanoR_1	338	342	PF00244	0.372
LIG_14-3-3_CanoR_1	434	441	PF00244	0.372
LIG_14-3-3_CanoR_1	508	516	PF00244	0.380
LIG_BRCT_BRCA1_1	347	351	PF00533	0.381
LIG_BRCT_BRCA1_1	613	617	PF00533	0.655
LIG_Clathr_ClatBox_1	19	23	PF01394	0.563
LIG_DCNL_PONY_1	1	4	PF03556	0.647
LIG_deltaCOP1_diTrp_1	103	111	PF00928	0.311
LIG_FHA_1	107	113	PF00498	0.370
LIG_FHA_1	15	21	PF00498	0.508
LIG_FHA_1	155	161	PF00498	0.370
LIG_FHA_1	193	199	PF00498	0.472
LIG_FHA_1	308	314	PF00498	0.372
LIG_FHA_1	511	517	PF00498	0.380
LIG_FHA_1	566	572	PF00498	0.372
LIG_FHA_1	685	691	PF00498	0.450
LIG_FHA_2	116	122	PF00498	0.370
LIG_FHA_2	43	49	PF00498	0.485
LIG_FHA_2	518	524	PF00498	0.372
LIG_FHA_2	642	648	PF00498	0.556
LIG_FHA_2	689	695	PF00498	0.498
LIG_HCF-1_HBM_1	7	10	PF13415	0.660
LIG_Integrin_isoDGR_2	582	584	PF01839	0.372
LIG_LIR_Apic_2	245	251	PF02991	0.523
LIG_LIR_Apic_2	324	330	PF02991	0.372
LIG_LIR_Gen_1	108	119	PF02991	0.370
LIG_LIR_Gen_1	121	126	PF02991	0.291
LIG_LIR_Gen_1	340	347	PF02991	0.459
LIG_LIR_Gen_1	405	411	PF02991	0.372
LIG_LIR_Gen_1	41	52	PF02991	0.495
LIG_LIR_Gen_1	432	443	PF02991	0.459
LIG_LIR_Gen_1	496	506	PF02991	0.372
LIG_LIR_Nem_3	108	114	PF02991	0.370
LIG_LIR_Nem_3	121	125	PF02991	0.291
LIG_LIR_Nem_3	147	153	PF02991	0.308
LIG_LIR_Nem_3	224	229	PF02991	0.451
LIG_LIR_Nem_3	282	287	PF02991	0.426
LIG_LIR_Nem_3	324	329	PF02991	0.372
LIG_LIR_Nem_3	405	410	PF02991	0.372
LIG_LIR_Nem_3	41	47	PF02991	0.494
LIG_LIR_Nem_3	496	502	PF02991	0.372
LIG_LIR_Nem_3	51	57	PF02991	0.564
LIG_LIR_Nem_3	534	540	PF02991	0.372
LIG_LIR_Nem_3	662	668	PF02991	0.403
LIG_LIR_Nem_3	67	73	PF02991	0.336
LIG_LIR_Nem_3	675	681	PF02991	0.320
LIG_MYND_1	247	251	PF01753	0.524
LIG_PCNA_PIPBox_1	380	389	PF02747	0.348
LIG_Pex14_2	657	661	PF04695	0.381
LIG_REV1ctd_RIR_1	654	664	PF16727	0.522
LIG_SH2_CRK	54	58	PF00017	0.659
LIG_SH2_CRK	70	74	PF00017	0.210
LIG_SH2_STAP1	182	186	PF00017	0.522
LIG_SH2_STAT3	506	509	PF00017	0.372
LIG_SH2_STAT5	258	261	PF00017	0.506
LIG_SH2_STAT5	285	288	PF00017	0.391
LIG_SH2_STAT5	321	324	PF00017	0.394
LIG_SH2_STAT5	326	329	PF00017	0.348
LIG_SH2_STAT5	435	438	PF00017	0.372
LIG_SH2_STAT5	576	579	PF00017	0.372
LIG_SH2_STAT5	665	668	PF00017	0.397
LIG_SH2_STAT5	713	716	PF00017	0.584
LIG_SH2_STAT5	86	89	PF00017	0.308
LIG_SH3_3	226	232	PF00018	0.483
LIG_SH3_3	233	239	PF00018	0.377
LIG_SH3_3	241	247	PF00018	0.315
LIG_SH3_3	513	519	PF00018	0.353
LIG_SH3_3	529	535	PF00018	0.421
LIG_SH3_3	574	580	PF00018	0.473
LIG_SUMO_SIM_anti_2	195	202	PF11976	0.460
LIG_SUMO_SIM_anti_2	488	494	PF11976	0.381
LIG_SUMO_SIM_par_1	194	202	PF11976	0.466
LIG_SUMO_SIM_par_1	471	476	PF11976	0.432
LIG_SUMO_SIM_par_1	478	486	PF11976	0.377
LIG_SUMO_SIM_par_1	64	69	PF11976	0.396
LIG_TRAF2_1	604	607	PF00917	0.509
LIG_TRFH_1	327	331	PF08558	0.381
LIG_TYR_ITIM	68	73	PF00017	0.575
LIG_UBA3_1	616	620	PF00899	0.469
LIG_WRC_WIRS_1	57	62	PF05994	0.579
MOD_CDK_SPxxK_3	106	113	PF00069	0.314
MOD_CK1_1	145	151	PF00069	0.270
MOD_CK1_1	192	198	PF00069	0.563
MOD_CK1_1	394	400	PF00069	0.389
MOD_CK1_1	498	504	PF00069	0.372
MOD_CK1_1	515	521	PF00069	0.372
MOD_CK1_1	610	616	PF00069	0.657
MOD_CK1_1	641	647	PF00069	0.639
MOD_CK1_1	688	694	PF00069	0.436
MOD_CK2_1	115	121	PF00069	0.308
MOD_CK2_1	42	48	PF00069	0.468
MOD_CMANNOS	494	497	PF00535	0.372
MOD_DYRK1A_RPxSP_1	106	110	PF00069	0.314
MOD_GlcNHglycan	191	194	PF01048	0.602
MOD_GlcNHglycan	281	284	PF01048	0.484
MOD_GlcNHglycan	318	321	PF01048	0.372
MOD_GlcNHglycan	347	350	PF01048	0.381
MOD_GlcNHglycan	368	372	PF01048	0.312
MOD_GlcNHglycan	510	513	PF01048	0.459
MOD_GlcNHglycan	626	629	PF01048	0.702
MOD_GlcNHglycan	647	650	PF01048	0.549
MOD_GSK3_1	188	195	PF00069	0.579
MOD_GSK3_1	387	394	PF00069	0.340
MOD_GSK3_1	42	49	PF00069	0.485
MOD_GSK3_1	508	515	PF00069	0.404
MOD_GSK3_1	607	614	PF00069	0.547
MOD_GSK3_1	624	631	PF00069	0.486
MOD_GSK3_1	634	641	PF00069	0.454
MOD_GSK3_1	684	691	PF00069	0.416
MOD_N-GLC_1	126	131	PF02516	0.508
MOD_N-GLC_1	705	710	PF02516	0.585
MOD_N-GLC_2	529	531	PF02516	0.459
MOD_N-GLC_2	638	640	PF02516	0.543
MOD_NEK2_1	259	264	PF00069	0.428
MOD_NEK2_1	307	312	PF00069	0.459
MOD_NEK2_1	42	47	PF00069	0.581
MOD_NEK2_1	609	614	PF00069	0.642
MOD_NEK2_1	645	650	PF00069	0.509
MOD_NEK2_2	206	211	PF00069	0.492
MOD_NEK2_2	298	303	PF00069	0.372
MOD_PIKK_1	376	382	PF00454	0.372
MOD_PIKK_1	387	393	PF00454	0.372
MOD_PIKK_1	611	617	PF00454	0.570
MOD_PIKK_1	628	634	PF00454	0.619
MOD_PK_1	692	698	PF00069	0.553
MOD_PKA_2	14	20	PF00069	0.505
MOD_PKA_2	189	195	PF00069	0.589
MOD_PKA_2	337	343	PF00069	0.372
MOD_PKA_2	433	439	PF00069	0.372
MOD_Plk_1	120	126	PF00069	0.352
MOD_Plk_1	705	711	PF00069	0.594
MOD_Plk_4	394	400	PF00069	0.372
MOD_Plk_4	498	504	PF00069	0.372
MOD_Plk_4	641	647	PF00069	0.569
MOD_Plk_4	692	698	PF00069	0.466
MOD_ProDKin_1	106	112	PF00069	0.370
MOD_ProDKin_1	115	121	PF00069	0.297
MOD_ProDKin_1	145	151	PF00069	0.308
MOD_ProDKin_1	26	32	PF00069	0.439
MOD_ProDKin_1	48	54	PF00069	0.607
MOD_ProDKin_1	515	521	PF00069	0.348
MOD_SUMO_rev_2	59	65	PF00179	0.583
TRG_DiLeu_LyEn_5	332	337	PF01217	0.372
TRG_ENDOCYTIC_2	214	217	PF00928	0.527
TRG_ENDOCYTIC_2	326	329	PF00928	0.372
TRG_ENDOCYTIC_2	386	389	PF00928	0.459
TRG_ENDOCYTIC_2	435	438	PF00928	0.459
TRG_ENDOCYTIC_2	54	57	PF00928	0.667
TRG_ENDOCYTIC_2	665	668	PF00928	0.375
TRG_ENDOCYTIC_2	70	73	PF00928	0.337
TRG_ER_diArg_1	337	339	PF00400	0.372
TRG_ER_diArg_1	84	86	PF00400	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y6	Leptomonas seymouri	27%	100%
A0A0N1PC88	Leptomonas seymouri	71%	100%
A0A0S4J0Y2	Bodo saltans	38%	82%
A0A0S4JSQ6	Bodo saltans	29%	100%
A0A1X0ND08	Trypanosomatidae	52%	100%
A0A1X0NR71	Trypanosomatidae	30%	100%
A0A3Q8IGF4	Leishmania donovani	28%	92%
A0A3R7LYC7	Trypanosoma rangeli	30%	100%
A4HFW1	Leishmania braziliensis	26%	91%
A4I1T8	Leishmania infantum	99%	100%
A4I2Z3	Leishmania infantum	29%	92%
C9ZJE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AXX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AZ89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	92%
O60993	Crithidia fasciculata	28%	100%
P0AES0	Escherichia coli (strain K12)	27%	100%
P0AES1	Shigella flexneri	27%	100%
P90518	Crithidia fasciculata	70%	100%
Q711P7	Leishmania major	28%	92%
Q9GT49	Trypanosoma cruzi (strain CL Brener)	30%	100%
V5ASH7	Trypanosoma cruzi	49%	100%
V5AYP7	Trypanosoma cruzi	31%	100%