LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8IGS5_LEIDO
TriTrypDb:
LdBPK_330900.1 , LdCL_330015100 , LDHU3_33.1430
Length:
434

Annotations

LeishMANIAdb annotations

A small folded protein with a long C-terminal TM segment. Very unclear topology.. Expanded on multiple lineages, especially Strigomonas.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 5, no: 12
NetGPI no yes: 0, no: 17
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3Q8IGS5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGS5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016491 oxidoreductase activity 2 1
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 3 1
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 218 220 PF00675 0.313
CLV_NRD_NRD_1 26 28 PF00675 0.415
CLV_NRD_NRD_1 3 5 PF00675 0.577
CLV_NRD_NRD_1 73 75 PF00675 0.345
CLV_PCSK_KEX2_1 218 220 PF00082 0.308
CLV_PCSK_KEX2_1 3 5 PF00082 0.577
CLV_PCSK_KEX2_1 407 409 PF00082 0.618
CLV_PCSK_PC1ET2_1 407 409 PF00082 0.657
CLV_PCSK_SKI1_1 168 172 PF00082 0.269
CLV_PCSK_SKI1_1 218 222 PF00082 0.299
CLV_PCSK_SKI1_1 396 400 PF00082 0.543
CLV_PCSK_SKI1_1 77 81 PF00082 0.352
DEG_SPOP_SBC_1 112 116 PF00917 0.423
DOC_CYCLIN_RxL_1 39 47 PF00134 0.478
DOC_CYCLIN_yCln2_LP_2 294 300 PF00134 0.528
DOC_CYCLIN_yCln2_LP_2 5 11 PF00134 0.194
DOC_MAPK_FxFP_2 13 16 PF00069 0.194
DOC_MAPK_gen_1 3 9 PF00069 0.392
DOC_MAPK_gen_1 333 341 PF00069 0.449
DOC_MAPK_MEF2A_6 206 214 PF00069 0.528
DOC_MAPK_MEF2A_6 334 343 PF00069 0.446
DOC_PP1_RVXF_1 175 181 PF00149 0.528
DOC_PP2B_LxvP_1 100 103 PF13499 0.528
DOC_PP2B_LxvP_1 294 297 PF13499 0.486
DOC_PP2B_LxvP_1 36 39 PF13499 0.554
DOC_PP2B_LxvP_1 5 8 PF13499 0.194
DOC_PP4_FxxP_1 13 16 PF00568 0.194
DOC_USP7_MATH_1 111 115 PF00917 0.513
DOC_USP7_MATH_1 119 123 PF00917 0.580
DOC_USP7_MATH_1 128 132 PF00917 0.570
DOC_USP7_MATH_1 155 159 PF00917 0.528
DOC_USP7_MATH_1 234 238 PF00917 0.521
DOC_USP7_MATH_1 402 406 PF00917 0.385
DOC_USP7_MATH_1 419 423 PF00917 0.414
DOC_USP7_UBL2_3 403 407 PF12436 0.322
DOC_WW_Pin1_4 121 126 PF00397 0.453
DOC_WW_Pin1_4 134 139 PF00397 0.419
DOC_WW_Pin1_4 220 225 PF00397 0.444
DOC_WW_Pin1_4 30 35 PF00397 0.597
DOC_WW_Pin1_4 53 58 PF00397 0.482
LIG_14-3-3_CanoR_1 27 37 PF00244 0.714
LIG_14-3-3_CanoR_1 77 82 PF00244 0.493
LIG_Actin_WH2_2 203 220 PF00022 0.528
LIG_APCC_ABBA_1 376 381 PF00400 0.433
LIG_APCC_ABBAyCdc20_2 139 145 PF00400 0.423
LIG_APCC_ABBAyCdc20_2 369 375 PF00400 0.293
LIG_BRCT_BRCA1_1 405 409 PF00533 0.314
LIG_deltaCOP1_diTrp_1 285 293 PF00928 0.480
LIG_EVH1_1 36 40 PF00568 0.525
LIG_EVH1_2 10 14 PF00568 0.194
LIG_FHA_1 107 113 PF00498 0.590
LIG_FHA_1 165 171 PF00498 0.480
LIG_FHA_1 253 259 PF00498 0.528
LIG_FHA_1 31 37 PF00498 0.693
LIG_FHA_1 334 340 PF00498 0.421
LIG_FHA_2 318 324 PF00498 0.528
LIG_FHA_2 66 72 PF00498 0.500
LIG_GBD_Chelix_1 345 353 PF00786 0.258
LIG_LIR_Apic_2 185 190 PF02991 0.528
LIG_LIR_Gen_1 153 164 PF02991 0.482
LIG_LIR_Gen_1 237 247 PF02991 0.423
LIG_LIR_Gen_1 292 301 PF02991 0.528
LIG_LIR_Gen_1 358 368 PF02991 0.327
LIG_LIR_Gen_1 84 89 PF02991 0.461
LIG_LIR_Gen_1 96 103 PF02991 0.461
LIG_LIR_Nem_3 153 159 PF02991 0.482
LIG_LIR_Nem_3 285 290 PF02991 0.475
LIG_LIR_Nem_3 292 296 PF02991 0.564
LIG_LIR_Nem_3 358 364 PF02991 0.345
LIG_LIR_Nem_3 367 371 PF02991 0.337
LIG_LIR_Nem_3 84 88 PF02991 0.461
LIG_LIR_Nem_3 96 100 PF02991 0.461
LIG_MAD2 42 50 PF02301 0.446
LIG_MYND_1 34 38 PF01753 0.534
LIG_NRBOX 348 354 PF00104 0.394
LIG_Pex14_2 13 17 PF04695 0.194
LIG_SH2_STAP1 361 365 PF00017 0.279
LIG_SH2_STAT5 361 364 PF00017 0.378
LIG_SH2_STAT5 371 374 PF00017 0.391
LIG_SH2_STAT5 67 70 PF00017 0.468
LIG_SH3_2 37 42 PF14604 0.580
LIG_SH3_3 135 141 PF00018 0.499
LIG_SH3_3 145 151 PF00018 0.453
LIG_SH3_3 169 175 PF00018 0.486
LIG_SH3_3 293 299 PF00018 0.531
LIG_SH3_3 306 312 PF00018 0.528
LIG_SH3_3 31 37 PF00018 0.675
LIG_SH3_3 5 11 PF00018 0.220
LIG_SH3_CIN85_PxpxPR_1 134 139 PF14604 0.423
LIG_SH3_CIN85_PxpxPR_1 37 42 PF14604 0.496
LIG_SUMO_SIM_anti_2 166 174 PF11976 0.468
LIG_SUMO_SIM_par_1 166 174 PF11976 0.468
LIG_SUMO_SIM_par_1 350 356 PF11976 0.474
LIG_SUMO_SIM_par_1 42 47 PF11976 0.486
LIG_SxIP_EBH_1 42 55 PF03271 0.445
LIG_UBA3_1 426 434 PF00899 0.366
LIG_WRC_WIRS_1 354 359 PF05994 0.465
LIG_WW_2 34 37 PF00397 0.541
LIG_WW_3 39 43 PF00397 0.599
MOD_CDK_SPK_2 134 139 PF00069 0.433
MOD_CDK_SPxxK_3 53 60 PF00069 0.554
MOD_CK1_1 319 325 PF00069 0.528
MOD_CK1_1 355 361 PF00069 0.388
MOD_CK1_1 391 397 PF00069 0.456
MOD_CK2_1 353 359 PF00069 0.507
MOD_GlcNHglycan 115 118 PF01048 0.317
MOD_GlcNHglycan 134 137 PF01048 0.222
MOD_GlcNHglycan 197 200 PF01048 0.236
MOD_GlcNHglycan 258 261 PF01048 0.297
MOD_GlcNHglycan 30 33 PF01048 0.468
MOD_GlcNHglycan 389 393 PF01048 0.673
MOD_GlcNHglycan 423 426 PF01048 0.595
MOD_GSK3_1 128 135 PF00069 0.442
MOD_GSK3_1 247 254 PF00069 0.593
MOD_GSK3_1 355 362 PF00069 0.393
MOD_GSK3_1 65 72 PF00069 0.493
MOD_N-GLC_1 202 207 PF02516 0.248
MOD_N-GLC_1 317 322 PF02516 0.334
MOD_NEK2_1 143 148 PF00069 0.566
MOD_NEK2_1 256 261 PF00069 0.416
MOD_NEK2_1 332 337 PF00069 0.578
MOD_NEK2_1 352 357 PF00069 0.343
MOD_NEK2_1 44 49 PF00069 0.494
MOD_NEK2_1 69 74 PF00069 0.469
MOD_PIKK_1 359 365 PF00454 0.363
MOD_PKA_1 333 339 PF00069 0.407
MOD_PKA_1 403 409 PF00069 0.404
MOD_PKA_2 164 170 PF00069 0.552
MOD_PKA_2 256 262 PF00069 0.456
MOD_Plk_1 359 365 PF00069 0.277
MOD_Plk_1 388 394 PF00069 0.399
MOD_Plk_1 69 75 PF00069 0.505
MOD_Plk_4 143 149 PF00069 0.490
MOD_Plk_4 155 161 PF00069 0.497
MOD_Plk_4 44 50 PF00069 0.481
MOD_ProDKin_1 121 127 PF00069 0.453
MOD_ProDKin_1 134 140 PF00069 0.419
MOD_ProDKin_1 220 226 PF00069 0.444
MOD_ProDKin_1 30 36 PF00069 0.594
MOD_ProDKin_1 53 59 PF00069 0.482
TRG_DiLeu_BaEn_4 173 179 PF01217 0.528
TRG_DiLeu_BaLyEn_6 274 279 PF01217 0.438
TRG_DiLeu_BaLyEn_6 74 79 PF01217 0.454
TRG_ENDOCYTIC_2 361 364 PF00928 0.383
TRG_ER_diArg_1 2 4 PF00400 0.525
TRG_ER_diArg_1 217 219 PF00400 0.513
TRG_ER_diArg_1 231 234 PF00400 0.596
TRG_ER_diArg_1 281 284 PF00400 0.423

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P304 Leptomonas seymouri 56% 100%
A0A0N0P958 Leptomonas seymouri 26% 100%
A0A0S4JG88 Bodo saltans 32% 100%
A0A1X0P126 Trypanosomatidae 33% 100%
A0A3S7X466 Leishmania donovani 26% 100%
A4HJ26 Leishmania braziliensis 28% 100%
A4HLE0 Leishmania braziliensis 82% 100%
A4I6E8 Leishmania infantum 28% 100%
A4I8U9 Leishmania infantum 100% 100%
D0A4U6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E8NHM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B1J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B3R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q4A6 Leishmania major 93% 100%
Q4Q6L5 Leishmania major 25% 92%
V5BPD5 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS