Recombinase rad51, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

recombinase rad51, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGS3_LEIDO

TriTrypDb:

LdBPK_332620.1 , LdCL_330033300 , LDHU3_33.3730

Length:

687

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005657	replication fork	2	1
GO:0032991	protein-containing complex	1	1
GO:0033061	DNA recombinase mediator complex	2	1
GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex	3	1
GO:0033065	Rad51C-XRCC3 complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IGS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGS3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006259	DNA metabolic process	4	9
GO:0006281	DNA repair	5	8
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0000707	meiotic DNA recombinase assembly	4	1
GO:0000730	DNA recombinase assembly	7	1
GO:0006310	DNA recombination	5	1
GO:0007131	reciprocal meiotic recombination	3	1
GO:0016043	cellular component organization	3	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0022607	cellular component assembly	4	1
GO:0035825	homologous recombination	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090735	DNA repair complex assembly	6	1
GO:0140527	reciprocal homologous recombination	7	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003676	nucleic acid binding	3	9
GO:0003677	DNA binding	4	9
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0008094	ATP-dependent activity, acting on DNA	2	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140097	catalytic activity, acting on DNA	3	9
GO:0140299	small molecule sensor activity	1	9
GO:0140612	DNA damage sensor activity	2	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9
GO:0140657	ATP-dependent activity	1	9
GO:0140664	ATP-dependent DNA damage sensor activity	3	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.584
CLV_NRD_NRD_1	343	345	PF00675	0.628
CLV_NRD_NRD_1	501	503	PF00675	0.392
CLV_NRD_NRD_1	566	568	PF00675	0.500
CLV_NRD_NRD_1	652	654	PF00675	0.580
CLV_NRD_NRD_1	668	670	PF00675	0.464
CLV_NRD_NRD_1	72	74	PF00675	0.786
CLV_NRD_NRD_1	75	77	PF00675	0.792
CLV_PCSK_FUR_1	73	77	PF00082	0.641
CLV_PCSK_KEX2_1	334	336	PF00082	0.717
CLV_PCSK_KEX2_1	501	503	PF00082	0.392
CLV_PCSK_KEX2_1	566	568	PF00082	0.500
CLV_PCSK_KEX2_1	652	654	PF00082	0.428
CLV_PCSK_KEX2_1	668	670	PF00082	0.414
CLV_PCSK_KEX2_1	72	74	PF00082	0.793
CLV_PCSK_KEX2_1	75	77	PF00082	0.803
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.717
CLV_PCSK_SKI1_1	303	307	PF00082	0.515
CLV_PCSK_SKI1_1	436	440	PF00082	0.352
CLV_PCSK_SKI1_1	504	508	PF00082	0.413
CLV_PCSK_SKI1_1	586	590	PF00082	0.336
CLV_PCSK_SKI1_1	643	647	PF00082	0.403
CLV_PCSK_SKI1_1	675	679	PF00082	0.660
DOC_CYCLIN_RxL_1	109	123	PF00134	0.731
DOC_CYCLIN_RxL_1	501	511	PF00134	0.488
DOC_MAPK_gen_1	501	507	PF00069	0.384
DOC_MAPK_gen_1	566	572	PF00069	0.443
DOC_MAPK_MEF2A_6	253	262	PF00069	0.471
DOC_PP1_RVXF_1	502	508	PF00149	0.441
DOC_USP7_MATH_1	297	301	PF00917	0.452
DOC_USP7_MATH_1	417	421	PF00917	0.705
DOC_USP7_MATH_1	423	427	PF00917	0.682
DOC_USP7_MATH_1	446	450	PF00917	0.405
DOC_USP7_MATH_1	549	553	PF00917	0.642
DOC_USP7_MATH_1	597	601	PF00917	0.633
DOC_USP7_MATH_1	658	662	PF00917	0.426
DOC_USP7_MATH_1	682	686	PF00917	0.566
DOC_USP7_MATH_1	93	97	PF00917	0.650
DOC_WW_Pin1_4	328	333	PF00397	0.768
DOC_WW_Pin1_4	335	340	PF00397	0.708
DOC_WW_Pin1_4	413	418	PF00397	0.626
DOC_WW_Pin1_4	604	609	PF00397	0.619
DOC_WW_Pin1_4	61	66	PF00397	0.613
LIG_14-3-3_CanoR_1	133	137	PF00244	0.521
LIG_14-3-3_CanoR_1	344	348	PF00244	0.497
LIG_14-3-3_CanoR_1	379	387	PF00244	0.444
LIG_14-3-3_CanoR_1	515	521	PF00244	0.312
LIG_14-3-3_CanoR_1	53	59	PF00244	0.657
LIG_14-3-3_CanoR_1	566	571	PF00244	0.616
LIG_14-3-3_CanoR_1	586	592	PF00244	0.290
LIG_Actin_WH2_2	630	648	PF00022	0.517
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_4	577	581	PF00653	0.408
LIG_BIR_III_4	77	81	PF00653	0.607
LIG_BRCT_BRCA1_1	449	453	PF00533	0.445
LIG_FHA_1	252	258	PF00498	0.487
LIG_FHA_1	294	300	PF00498	0.558
LIG_FHA_1	379	385	PF00498	0.332
LIG_FHA_1	517	523	PF00498	0.524
LIG_FHA_1	529	535	PF00498	0.474
LIG_FHA_1	583	589	PF00498	0.351
LIG_FHA_1	613	619	PF00498	0.656
LIG_FHA_2	118	124	PF00498	0.540
LIG_FHA_2	200	206	PF00498	0.478
LIG_FHA_2	509	515	PF00498	0.424
LIG_FHA_2	611	617	PF00498	0.477
LIG_LIR_Gen_1	114	124	PF02991	0.686
LIG_LIR_Nem_3	114	119	PF02991	0.698
LIG_LIR_Nem_3	590	594	PF02991	0.488
LIG_MAD2	643	651	PF02301	0.502
LIG_MYND_1	339	343	PF01753	0.600
LIG_NRBOX	382	388	PF00104	0.350
LIG_PCNA_yPIPBox_3	634	645	PF02747	0.432
LIG_Rb_LxCxE_1	1	14	PF01857	0.602
LIG_SH2_CRK	594	598	PF00017	0.581
LIG_SH2_NCK_1	594	598	PF00017	0.587
LIG_SH2_PTP2	377	380	PF00017	0.384
LIG_SH2_STAT5	25	28	PF00017	0.546
LIG_SH2_STAT5	377	380	PF00017	0.421
LIG_SH2_STAT5	54	57	PF00017	0.498
LIG_SH3_1	337	343	PF00018	0.623
LIG_SH3_2	340	345	PF14604	0.580
LIG_SH3_2	68	73	PF14604	0.613
LIG_SH3_3	163	169	PF00018	0.702
LIG_SH3_3	307	313	PF00018	0.568
LIG_SH3_3	337	343	PF00018	0.686
LIG_SH3_3	567	573	PF00018	0.454
LIG_SH3_3	599	605	PF00018	0.599
LIG_SH3_3	62	68	PF00018	0.627
LIG_SUMO_SIM_anti_2	27	36	PF11976	0.551
LIG_SUMO_SIM_par_1	27	36	PF11976	0.551
LIG_SUMO_SIM_par_1	436	442	PF11976	0.316
LIG_TYR_ITIM	375	380	PF00017	0.440
LIG_WRC_WIRS_1	222	227	PF05994	0.516
LIG_WRC_WIRS_1	588	593	PF05994	0.439
LIG_WW_3	165	169	PF00397	0.655
LIG_WW_3	311	315	PF00397	0.518
MOD_CDC14_SPxK_1	331	334	PF00782	0.628
MOD_CDK_SPK_2	328	333	PF00069	0.626
MOD_CDK_SPxK_1	328	334	PF00069	0.629
MOD_CDK_SPxxK_3	328	335	PF00069	0.632
MOD_CK1_1	176	182	PF00069	0.760
MOD_CK1_1	328	334	PF00069	0.731
MOD_CK1_1	392	398	PF00069	0.553
MOD_CK1_1	407	413	PF00069	0.628
MOD_CK1_1	427	433	PF00069	0.529
MOD_CK1_1	461	467	PF00069	0.680
MOD_CK1_1	552	558	PF00069	0.669
MOD_CK1_1	606	612	PF00069	0.587
MOD_CK1_1	621	627	PF00069	0.573
MOD_CK1_1	632	638	PF00069	0.668
MOD_CK1_1	9	15	PF00069	0.514
MOD_CK1_1	98	104	PF00069	0.681
MOD_CK2_1	117	123	PF00069	0.531
MOD_CK2_1	176	182	PF00069	0.595
MOD_CK2_1	199	205	PF00069	0.456
MOD_CK2_1	392	398	PF00069	0.432
MOD_CK2_1	508	514	PF00069	0.424
MOD_CK2_1	544	550	PF00069	0.644
MOD_CK2_1	610	616	PF00069	0.493
MOD_DYRK1A_RPxSP_1	604	608	PF00069	0.576
MOD_GlcNHglycan	150	153	PF01048	0.776
MOD_GlcNHglycan	175	178	PF01048	0.749
MOD_GlcNHglycan	193	196	PF01048	0.547
MOD_GlcNHglycan	244	248	PF01048	0.299
MOD_GlcNHglycan	359	362	PF01048	0.569
MOD_GlcNHglycan	410	413	PF01048	0.698
MOD_GlcNHglycan	420	423	PF01048	0.663
MOD_GlcNHglycan	425	429	PF01048	0.637
MOD_GlcNHglycan	463	466	PF01048	0.628
MOD_GlcNHglycan	467	470	PF01048	0.618
MOD_GlcNHglycan	49	52	PF01048	0.593
MOD_GlcNHglycan	547	550	PF01048	0.671
MOD_GlcNHglycan	551	554	PF01048	0.698
MOD_GlcNHglycan	558	561	PF01048	0.785
MOD_GlcNHglycan	647	650	PF01048	0.489
MOD_GSK3_1	176	183	PF00069	0.650
MOD_GSK3_1	217	224	PF00069	0.405
MOD_GSK3_1	293	300	PF00069	0.568
MOD_GSK3_1	315	322	PF00069	0.699
MOD_GSK3_1	404	411	PF00069	0.582
MOD_GSK3_1	413	420	PF00069	0.673
MOD_GSK3_1	423	430	PF00069	0.595
MOD_GSK3_1	457	464	PF00069	0.640
MOD_GSK3_1	524	531	PF00069	0.385
MOD_GSK3_1	540	547	PF00069	0.605
MOD_GSK3_1	552	559	PF00069	0.715
MOD_GSK3_1	6	13	PF00069	0.593
MOD_GSK3_1	606	613	PF00069	0.561
MOD_GSK3_1	628	635	PF00069	0.667
MOD_GSK3_1	91	98	PF00069	0.715
MOD_N-GLC_1	117	122	PF02516	0.637
MOD_N-GLC_1	145	150	PF02516	0.613
MOD_N-GLC_1	314	319	PF02516	0.566
MOD_N-GLC_1	540	545	PF02516	0.626
MOD_N-GLC_2	106	108	PF02516	0.531
MOD_NEK2_1	10	15	PF00069	0.537
MOD_NEK2_1	260	265	PF00069	0.503
MOD_NEK2_1	32	37	PF00069	0.578
MOD_NEK2_1	389	394	PF00069	0.456
MOD_NEK2_1	439	444	PF00069	0.406
MOD_NEK2_1	458	463	PF00069	0.662
MOD_NEK2_1	507	512	PF00069	0.488
MOD_NEK2_1	516	521	PF00069	0.427
MOD_NEK2_1	535	540	PF00069	0.732
MOD_NEK2_1	587	592	PF00069	0.461
MOD_NEK2_1	645	650	PF00069	0.445
MOD_NEK2_1	657	662	PF00069	0.349
MOD_NEK2_2	154	159	PF00069	0.606
MOD_NEK2_2	199	204	PF00069	0.495
MOD_NEK2_2	343	348	PF00069	0.497
MOD_PIKK_1	251	257	PF00454	0.448
MOD_PIKK_1	305	311	PF00454	0.497
MOD_PIKK_1	484	490	PF00454	0.516
MOD_PIKK_1	621	627	PF00454	0.521
MOD_PIKK_1	670	676	PF00454	0.689
MOD_PK_1	566	572	PF00069	0.443
MOD_PKA_1	566	572	PF00069	0.443
MOD_PKA_1	652	658	PF00069	0.408
MOD_PKA_2	132	138	PF00069	0.550
MOD_PKA_2	154	160	PF00069	0.596
MOD_PKA_2	325	331	PF00069	0.762
MOD_PKA_2	343	349	PF00069	0.495
MOD_PKA_2	378	384	PF00069	0.466
MOD_PKA_2	447	453	PF00069	0.475
MOD_PKA_2	500	506	PF00069	0.387
MOD_PKA_2	566	572	PF00069	0.465
MOD_PKA_2	603	609	PF00069	0.576
MOD_PKA_2	652	658	PF00069	0.408
MOD_Plk_1	111	117	PF00069	0.557
MOD_Plk_1	145	151	PF00069	0.556
MOD_Plk_1	314	320	PF00069	0.621
MOD_Plk_1	364	370	PF00069	0.569
MOD_Plk_1	465	471	PF00069	0.523
MOD_Plk_1	99	105	PF00069	0.630
MOD_Plk_2-3	364	370	PF00069	0.384
MOD_Plk_4	282	288	PF00069	0.450
MOD_Plk_4	297	303	PF00069	0.365
MOD_Plk_4	367	373	PF00069	0.503
MOD_Plk_4	392	398	PF00069	0.494
MOD_Plk_4	508	514	PF00069	0.489
MOD_Plk_4	54	60	PF00069	0.539
MOD_Plk_4	566	572	PF00069	0.516
MOD_Plk_4	597	603	PF00069	0.543
MOD_ProDKin_1	328	334	PF00069	0.771
MOD_ProDKin_1	335	341	PF00069	0.709
MOD_ProDKin_1	413	419	PF00069	0.628
MOD_ProDKin_1	604	610	PF00069	0.618
MOD_ProDKin_1	61	67	PF00069	0.614
MOD_SUMO_rev_2	398	408	PF00179	0.517
MOD_SUMO_rev_2	42	49	PF00179	0.583
TRG_DiLeu_BaEn_1	28	33	PF01217	0.495
TRG_DiLeu_BaEn_2	111	117	PF01217	0.586
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.610
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.298
TRG_DiLeu_BaLyEn_6	583	588	PF01217	0.326
TRG_ENDOCYTIC_2	377	380	PF00928	0.398
TRG_ER_diArg_1	500	502	PF00400	0.389
TRG_ER_diArg_1	651	653	PF00400	0.487
TRG_ER_diArg_1	71	73	PF00400	0.763
TRG_ER_diArg_1	74	76	PF00400	0.789
TRG_NLS_MonoExtC_3	332	337	PF00514	0.708
TRG_NLS_MonoExtN_4	332	338	PF00514	0.710
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	504	508	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE01	Leptomonas seymouri	41%	100%
A4HLW0	Leishmania braziliensis	68%	100%
D0A661	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AHR7	Leishmania infantum	99%	100%
E9B488	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q3T8	Leishmania major	89%	100%
V5BTS0	Trypanosoma cruzi	36%	100%