LeishMANIAdb
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Protein phosphatase 2C, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein phosphatase 2C, putative
Gene product:
protein phosphatase 2C, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IGS1_LEIDO
TriTrypDb:
LdBPK_321770.1 , LdCL_320023200 , LDHU3_32.2230
Length:
563

Annotations

LeishMANIAdb annotations

This large family encompasses many diverse protein phosphatases. Some appear to have evolved transmembrane segments. Very tentatively they might regulate transmembrane receptor kinases.. The TM and non-TM groups diverged early in Eukaryota and appear to be distinct enough that they probably should not be part of the same cluster. This latter group has not expanded.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 1
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 1
Pissara et al. no yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 22
NetGPI no yes: 0, no: 22
Cellular components
Term Name Level Count
GO:0016020 membrane 2 6
GO:0110165 cellular anatomical entity 1 9
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0005737 cytoplasm 2 3
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0005654 nucleoplasm 2 1

Expansion

Sequence features

A0A3Q8IGS1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGS1

Function

Biological processes
Term Name Level Count
GO:0006470 protein dephosphorylation 5 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016311 dephosphorylation 5 16
GO:0019538 protein metabolic process 3 16
GO:0036211 protein modification process 4 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043412 macromolecule modification 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:0035970 peptidyl-threonine dephosphorylation 6 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 23
GO:0004721 phosphoprotein phosphatase activity 3 23
GO:0004722 protein serine/threonine phosphatase activity 4 23
GO:0016787 hydrolase activity 2 23
GO:0016788 hydrolase activity, acting on ester bonds 3 23
GO:0016791 phosphatase activity 5 23
GO:0017018 myosin phosphatase activity 5 10
GO:0042578 phosphoric ester hydrolase activity 4 23
GO:0140096 catalytic activity, acting on a protein 2 23
GO:0005488 binding 1 6
GO:0043167 ion binding 2 6
GO:0043169 cation binding 3 6
GO:0046872 metal ion binding 4 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 366 370 PF00656 0.273
CLV_C14_Caspase3-7 522 526 PF00656 0.732
CLV_NRD_NRD_1 10 12 PF00675 0.553
CLV_NRD_NRD_1 112 114 PF00675 0.365
CLV_NRD_NRD_1 145 147 PF00675 0.218
CLV_NRD_NRD_1 281 283 PF00675 0.212
CLV_NRD_NRD_1 45 47 PF00675 0.444
CLV_NRD_NRD_1 473 475 PF00675 0.519
CLV_PCSK_FUR_1 43 47 PF00082 0.407
CLV_PCSK_KEX2_1 10 12 PF00082 0.570
CLV_PCSK_KEX2_1 112 114 PF00082 0.368
CLV_PCSK_KEX2_1 145 147 PF00082 0.216
CLV_PCSK_KEX2_1 281 283 PF00082 0.212
CLV_PCSK_KEX2_1 392 394 PF00082 0.394
CLV_PCSK_KEX2_1 45 47 PF00082 0.405
CLV_PCSK_PC1ET2_1 392 394 PF00082 0.394
CLV_PCSK_SKI1_1 261 265 PF00082 0.396
CLV_PCSK_SKI1_1 504 508 PF00082 0.535
CLV_PCSK_SKI1_1 51 55 PF00082 0.390
CLV_Separin_Metazoa 109 113 PF03568 0.370
DEG_APCC_DBOX_1 356 364 PF00400 0.250
DEG_APCC_DBOX_1 50 58 PF00400 0.339
DOC_CKS1_1 451 456 PF01111 0.498
DOC_MAPK_gen_1 281 289 PF00069 0.212
DOC_MAPK_gen_1 351 360 PF00069 0.237
DOC_MAPK_MEF2A_6 51 59 PF00069 0.334
DOC_PP2B_LxvP_1 6 9 PF13499 0.435
DOC_PP4_FxxP_1 349 352 PF00568 0.250
DOC_PP4_MxPP_1 412 415 PF00568 0.453
DOC_USP7_MATH_1 17 21 PF00917 0.472
DOC_USP7_MATH_1 240 244 PF00917 0.212
DOC_USP7_MATH_1 302 306 PF00917 0.309
DOC_USP7_MATH_1 310 314 PF00917 0.311
DOC_USP7_MATH_1 418 422 PF00917 0.554
DOC_USP7_MATH_1 441 445 PF00917 0.571
DOC_USP7_MATH_1 468 472 PF00917 0.616
DOC_USP7_MATH_1 491 495 PF00917 0.758
DOC_USP7_MATH_1 502 506 PF00917 0.527
DOC_USP7_MATH_1 510 514 PF00917 0.563
DOC_USP7_MATH_1 523 527 PF00917 0.546
DOC_USP7_MATH_1 538 542 PF00917 0.521
DOC_USP7_MATH_1 549 553 PF00917 0.530
DOC_USP7_UBL2_3 190 194 PF12436 0.220
DOC_WW_Pin1_4 370 375 PF00397 0.245
DOC_WW_Pin1_4 406 411 PF00397 0.575
DOC_WW_Pin1_4 450 455 PF00397 0.556
DOC_WW_Pin1_4 483 488 PF00397 0.584
DOC_WW_Pin1_4 545 550 PF00397 0.548
LIG_14-3-3_CanoR_1 145 149 PF00244 0.295
LIG_14-3-3_CanoR_1 45 49 PF00244 0.408
LIG_APCC_ABBA_1 226 231 PF00400 0.250
LIG_Clathr_ClatBox_1 154 158 PF01394 0.250
LIG_DCNL_PONY_1 1 4 PF03556 0.472
LIG_EH1_1 47 55 PF00400 0.328
LIG_FHA_1 151 157 PF00498 0.250
LIG_FHA_1 45 51 PF00498 0.585
LIG_FHA_1 506 512 PF00498 0.663
LIG_FHA_1 56 62 PF00498 0.459
LIG_FHA_1 75 81 PF00498 0.369
LIG_LIR_Apic_2 348 352 PF02991 0.250
LIG_LIR_Gen_1 180 191 PF02991 0.260
LIG_LIR_Gen_1 203 212 PF02991 0.265
LIG_LIR_Gen_1 327 337 PF02991 0.315
LIG_LIR_Nem_3 130 136 PF02991 0.295
LIG_LIR_Nem_3 180 186 PF02991 0.254
LIG_LIR_Nem_3 203 208 PF02991 0.265
LIG_LIR_Nem_3 327 332 PF02991 0.315
LIG_LIR_Nem_3 63 68 PF02991 0.351
LIG_LIR_Nem_3 69 73 PF02991 0.353
LIG_PCNA_yPIPBox_3 273 287 PF02747 0.250
LIG_PCNA_yPIPBox_3 31 45 PF02747 0.416
LIG_SH2_CRK 70 74 PF00017 0.361
LIG_SH2_SRC 211 214 PF00017 0.244
LIG_SH2_SRC 229 232 PF00017 0.175
LIG_SH2_STAT3 181 184 PF00017 0.250
LIG_SH2_STAT3 26 29 PF00017 0.390
LIG_SH2_STAT5 177 180 PF00017 0.344
LIG_SH2_STAT5 211 214 PF00017 0.256
LIG_SH2_STAT5 229 232 PF00017 0.302
LIG_SH2_STAT5 236 239 PF00017 0.218
LIG_SH2_STAT5 26 29 PF00017 0.413
LIG_SH2_STAT5 277 280 PF00017 0.222
LIG_SH2_STAT5 48 51 PF00017 0.387
LIG_SH3_3 259 265 PF00018 0.255
LIG_SH3_3 412 418 PF00018 0.753
LIG_SH3_3 543 549 PF00018 0.519
LIG_SH3_3 6 12 PF00018 0.473
LIG_SUMO_SIM_anti_2 153 158 PF11976 0.242
LIG_SUMO_SIM_anti_2 385 390 PF11976 0.296
LIG_SUMO_SIM_anti_2 58 63 PF11976 0.301
LIG_SUMO_SIM_par_1 152 158 PF11976 0.250
LIG_SUMO_SIM_par_1 285 290 PF11976 0.250
LIG_SUMO_SIM_par_1 57 63 PF11976 0.472
LIG_SUMO_SIM_par_1 72 77 PF11976 0.292
LIG_UBA3_1 1 5 PF00899 0.473
LIG_UBA3_1 154 159 PF00899 0.250
LIG_WRC_WIRS_1 215 220 PF05994 0.237
LIG_WW_3 413 417 PF00397 0.442
LIG_WW_3 7 11 PF00397 0.464
MOD_CDK_SPK_2 487 492 PF00069 0.525
MOD_CK1_1 214 220 PF00069 0.280
MOD_CK1_1 429 435 PF00069 0.542
MOD_CK1_1 444 450 PF00069 0.485
MOD_CK1_1 500 506 PF00069 0.596
MOD_CK1_1 513 519 PF00069 0.507
MOD_CK1_1 533 539 PF00069 0.512
MOD_CK2_1 310 316 PF00069 0.294
MOD_GlcNHglycan 127 130 PF01048 0.373
MOD_GlcNHglycan 169 172 PF01048 0.258
MOD_GlcNHglycan 19 22 PF01048 0.415
MOD_GlcNHglycan 312 315 PF01048 0.315
MOD_GlcNHglycan 420 423 PF01048 0.529
MOD_GlcNHglycan 431 434 PF01048 0.518
MOD_GlcNHglycan 470 473 PF01048 0.754
MOD_GlcNHglycan 494 497 PF01048 0.597
MOD_GlcNHglycan 504 507 PF01048 0.689
MOD_GlcNHglycan 518 521 PF01048 0.523
MOD_GlcNHglycan 536 539 PF01048 0.533
MOD_GSK3_1 167 174 PF00069 0.315
MOD_GSK3_1 398 405 PF00069 0.533
MOD_GSK3_1 427 434 PF00069 0.546
MOD_GSK3_1 453 460 PF00069 0.616
MOD_GSK3_1 483 490 PF00069 0.696
MOD_GSK3_1 492 499 PF00069 0.540
MOD_GSK3_1 512 519 PF00069 0.555
MOD_GSK3_1 529 536 PF00069 0.625
MOD_GSK3_1 545 552 PF00069 0.753
MOD_N-GLC_1 249 254 PF02516 0.220
MOD_N-GLC_1 382 387 PF02516 0.355
MOD_N-GLC_1 434 439 PF02516 0.573
MOD_N-GLC_1 533 538 PF02516 0.534
MOD_NEK2_1 287 292 PF00069 0.318
MOD_NEK2_1 511 516 PF00069 0.786
MOD_NEK2_1 55 60 PF00069 0.353
MOD_NEK2_2 538 543 PF00069 0.519
MOD_PIKK_1 25 31 PF00454 0.376
MOD_PK_1 249 255 PF00069 0.220
MOD_PKA_2 144 150 PF00069 0.357
MOD_PKA_2 317 323 PF00069 0.253
MOD_PKA_2 44 50 PF00069 0.457
MOD_PKA_2 523 529 PF00069 0.570
MOD_Plk_1 382 388 PF00069 0.355
MOD_Plk_1 426 432 PF00069 0.651
MOD_Plk_4 150 156 PF00069 0.267
MOD_Plk_4 382 388 PF00069 0.289
MOD_Plk_4 57 63 PF00069 0.359
MOD_Plk_4 74 80 PF00069 0.534
MOD_ProDKin_1 370 376 PF00069 0.245
MOD_ProDKin_1 406 412 PF00069 0.573
MOD_ProDKin_1 450 456 PF00069 0.558
MOD_ProDKin_1 483 489 PF00069 0.585
MOD_ProDKin_1 545 551 PF00069 0.548
MOD_SUMO_for_1 193 196 PF00179 0.220
MOD_SUMO_rev_2 254 263 PF00179 0.299
MOD_SUMO_rev_2 476 486 PF00179 0.570
TRG_ENDOCYTIC_2 202 205 PF00928 0.215
TRG_ENDOCYTIC_2 70 73 PF00928 0.363
TRG_ER_diArg_1 111 113 PF00400 0.349
TRG_ER_diArg_1 144 146 PF00400 0.212
TRG_ER_diArg_1 281 283 PF00400 0.227
TRG_ER_diArg_1 350 353 PF00400 0.212
TRG_ER_diArg_1 9 11 PF00400 0.504
TRG_Pf-PMV_PEXEL_1 291 295 PF00026 0.212
TRG_Pf-PMV_PEXEL_1 36 40 PF00026 0.460

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PET0 Leptomonas seymouri 73% 97%
A0A3Q8IFG7 Leishmania donovani 30% 100%
A0A3Q8IL63 Leishmania donovani 29% 100%
A0A3S7WTA2 Leishmania donovani 36% 100%
A0A3S7WZ14 Leishmania donovani 32% 100%
A4H7Y6 Leishmania braziliensis 36% 100%
A4HAW5 Leishmania braziliensis 30% 100%
A4HE10 Leishmania braziliensis 31% 100%
A4HHY5 Leishmania braziliensis 28% 100%
A4HKF6 Leishmania braziliensis 78% 100%
A4HWB4 Leishmania infantum 36% 100%
A4I1B7 Leishmania infantum 32% 100%
A4I565 Leishmania infantum 31% 100%
A4I7Y4 Leishmania infantum 100% 100%
A4IA25 Leishmania infantum 29% 100%
D0AA51 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AQ14 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9AXF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B0G2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9B2U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B540 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q2U6 Leishmania major 29% 100%
Q4Q5B1 Leishmania major 92% 100%
Q4Q7S1 Leishmania major 31% 100%
Q4QA19 Leishmania major 32% 100%
Q4QFG7 Leishmania major 35% 100%
Q6K5I0 Oryza sativa subsp. japonica 30% 100%
Q9CAJ0 Arabidopsis thaliana 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS