Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGR9_LEIDO

TriTrypDb:

LdBPK_320560.1 , LdCL_320011100 , LDHU3_32.0710

Length:

145

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGR9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGR9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.580
CLV_NRD_NRD_1	141	143	PF00675	0.580
CLV_NRD_NRD_1	70	72	PF00675	0.587
CLV_NRD_NRD_1	78	80	PF00675	0.558
CLV_PCSK_FUR_1	139	143	PF00082	0.579
CLV_PCSK_FUR_1	68	72	PF00082	0.603
CLV_PCSK_KEX2_1	129	131	PF00082	0.583
CLV_PCSK_KEX2_1	138	140	PF00082	0.577
CLV_PCSK_KEX2_1	141	143	PF00082	0.580
CLV_PCSK_KEX2_1	70	72	PF00082	0.583
CLV_PCSK_KEX2_1	77	79	PF00082	0.534
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.577
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.559
CLV_PCSK_PC7_1	134	140	PF00082	0.578
CLV_PCSK_SKI1_1	4	8	PF00082	0.561
DEG_MDM2_SWIB_1	83	91	PF02201	0.568
DEG_Nend_Nbox_1	1	3	PF02207	0.581
DOC_CKS1_1	28	33	PF01111	0.663
DOC_CKS1_1	45	50	PF01111	0.614
DOC_CKS1_1	98	103	PF01111	0.549
DOC_CYCLIN_yClb1_LxF_4	31	36	PF00134	0.512
DOC_MAPK_gen_1	129	137	PF00069	0.580
DOC_MAPK_MEF2A_6	129	137	PF00069	0.580
DOC_MAPK_NFAT4_5	130	138	PF00069	0.578
DOC_PP1_RVXF_1	31	37	PF00149	0.514
DOC_PP1_RVXF_1	70	77	PF00149	0.573
DOC_PP4_FxxP_1	36	39	PF00568	0.678
DOC_USP7_MATH_1	119	123	PF00917	0.585
DOC_WW_Pin1_4	104	109	PF00397	0.518
DOC_WW_Pin1_4	27	32	PF00397	0.598
DOC_WW_Pin1_4	44	49	PF00397	0.663
DOC_WW_Pin1_4	97	102	PF00397	0.541
LIG_14-3-3_CanoR_1	113	119	PF00244	0.566
LIG_14-3-3_CanoR_1	134	138	PF00244	0.578
LIG_14-3-3_CanoR_1	33	37	PF00244	0.690
LIG_FHA_1	33	39	PF00498	0.652
LIG_FHA_1	45	51	PF00498	0.488
LIG_FHA_1	5	11	PF00498	0.586
LIG_LIR_Apic_2	35	39	PF02991	0.690
LIG_LIR_Gen_1	107	115	PF02991	0.620
LIG_LIR_Nem_3	107	112	PF02991	0.614
LIG_LIR_Nem_3	114	118	PF02991	0.615
LIG_MYND_1	48	52	PF01753	0.690
LIG_Pex14_2	83	87	PF04695	0.544
LIG_SH2_STAP1	19	23	PF00017	0.697
LIG_SH2_STAT5	19	22	PF00017	0.686
LIG_SH2_STAT5	23	26	PF00017	0.697
LIG_SH3_1	95	101	PF00018	0.579
LIG_SH3_2	28	33	PF14604	0.592
LIG_SH3_3	22	28	PF00018	0.673
LIG_SH3_3	95	101	PF00018	0.551
LIG_UBA3_1	37	43	PF00899	0.714
LIG_WRC_WIRS_1	112	117	PF05994	0.574
MOD_CDK_SPxK_1	27	33	PF00069	0.630
MOD_CK1_1	114	120	PF00069	0.619
MOD_CK1_1	18	24	PF00069	0.622
MOD_CK1_1	44	50	PF00069	0.672
MOD_CK1_1	59	65	PF00069	0.597
MOD_Cter_Amidation	127	130	PF01082	0.578
MOD_Cter_Amidation	139	142	PF01082	0.579
MOD_Cter_Amidation	68	71	PF01082	0.602
MOD_GSK3_1	107	114	PF00069	0.602
MOD_GSK3_1	14	21	PF00069	0.584
MOD_N-GLC_1	41	46	PF02516	0.678
MOD_NEK2_1	2	7	PF00069	0.682
MOD_PIKK_1	107	113	PF00454	0.568
MOD_PKA_2	133	139	PF00069	0.578
MOD_PKA_2	32	38	PF00069	0.652
MOD_Plk_1	41	47	PF00069	0.678
MOD_Plk_4	19	25	PF00069	0.716
MOD_Plk_4	32	38	PF00069	0.665
MOD_ProDKin_1	104	110	PF00069	0.518
MOD_ProDKin_1	27	33	PF00069	0.603
MOD_ProDKin_1	44	50	PF00069	0.652
MOD_ProDKin_1	97	103	PF00069	0.538
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.685
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.683
TRG_ER_diArg_1	129	131	PF00400	0.583
TRG_ER_diArg_1	139	142	PF00400	0.569
TRG_ER_diArg_1	68	71	PF00400	0.591
TRG_NLS_MonoCore_2	76	81	PF00514	0.669
TRG_NLS_MonoExtC_3	137	142	PF00514	0.579
TRG_NLS_MonoExtC_3	76	81	PF00514	0.576
TRG_NLS_MonoExtN_4	129	135	PF00514	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6S4	Leptomonas seymouri	79%	100%
A0A0S4J453	Bodo saltans	72%	80%
A0A1X0NUR5	Trypanosomatidae	70%	100%
A0A3R7L1E5	Trypanosoma rangeli	81%	100%
A4HK29	Leishmania braziliensis	92%	100%
A4I7M9	Leishmania infantum	100%	100%
D0A9S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9B2H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q5N0	Leishmania major	99%	100%