LeishMANIAdb
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Polyadenylate-binding protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Polyadenylate-binding protein
Gene product:
polyadenylate-binding protein 1, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IGR8_LEIDO
TriTrypDb:
LdBPK_355360.1 , LdCL_350055900 , LDHU3_35.6680
Length:
560

Annotations

Annotations by Jardim et al.

RNA Processing, Polyadenylate-binding PABP1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005634 nucleus 5 1
GO:0005829 cytosol 2 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0032991 protein-containing complex 1 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0099080 supramolecular complex 2 1
GO:1990904 ribonucleoprotein complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8IGR8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGR8

PDB structure(s): 6h7a_A , 6h7a_B , 6h7b_A , 6h7b_C

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006378 mRNA polyadenylation 7 1
GO:0006396 RNA processing 6 1
GO:0006397 mRNA processing 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0016071 mRNA metabolic process 6 1
GO:0031123 RNA 3'-end processing 7 1
GO:0031124 mRNA 3'-end processing 8 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043631 RNA polyadenylation 6 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003727 single-stranded RNA binding 5 1
GO:0003729 mRNA binding 5 1
GO:0003730 mRNA 3'-UTR binding 6 1
GO:0005515 protein binding 2 1
GO:0008143 poly(A) binding 7 1
GO:0008187 poly-pyrimidine tract binding 6 1
GO:0008190 eukaryotic initiation factor 4E binding 4 1
GO:0008266 poly(U) RNA binding 7 1
GO:0031369 translation initiation factor binding 3 1
GO:0031370 eukaryotic initiation factor 4G binding 4 1
GO:0070717 poly-purine tract binding 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 165 169 PF00656 0.534
CLV_NRD_NRD_1 194 196 PF00675 0.423
CLV_NRD_NRD_1 384 386 PF00675 0.459
CLV_PCSK_KEX2_1 194 196 PF00082 0.423
CLV_PCSK_KEX2_1 384 386 PF00082 0.459
CLV_PCSK_KEX2_1 541 543 PF00082 0.310
CLV_PCSK_KEX2_1 89 91 PF00082 0.244
CLV_PCSK_PC1ET2_1 541 543 PF00082 0.310
CLV_PCSK_PC1ET2_1 89 91 PF00082 0.228
CLV_PCSK_SKI1_1 184 188 PF00082 0.457
CLV_PCSK_SKI1_1 212 216 PF00082 0.250
CLV_PCSK_SKI1_1 499 503 PF00082 0.250
CLV_PCSK_SKI1_1 505 509 PF00082 0.310
DEG_ODPH_VHL_1 513 526 PF01847 0.450
DEG_SCF_FBW7_1 465 472 PF00400 0.654
DOC_CDC14_PxL_1 511 519 PF14671 0.510
DOC_CKS1_1 456 461 PF01111 0.634
DOC_CKS1_1 466 471 PF01111 0.581
DOC_CKS1_1 477 482 PF01111 0.587
DOC_CKS1_1 484 489 PF01111 0.541
DOC_MAPK_gen_1 151 160 PF00069 0.430
DOC_MAPK_gen_1 384 394 PF00069 0.497
DOC_MAPK_MEF2A_6 388 396 PF00069 0.511
DOC_MAPK_MEF2A_6 520 528 PF00069 0.444
DOC_PP1_RVXF_1 391 397 PF00149 0.527
DOC_PP1_RVXF_1 95 101 PF00149 0.485
DOC_PP4_FxxP_1 456 459 PF00568 0.619
DOC_USP7_MATH_1 457 461 PF00917 0.636
DOC_USP7_MATH_1 82 86 PF00917 0.492
DOC_USP7_MATH_2 487 493 PF00917 0.395
DOC_USP7_UBL2_3 118 122 PF12436 0.534
DOC_USP7_UBL2_3 225 229 PF12436 0.445
DOC_WW_Pin1_4 440 445 PF00397 0.724
DOC_WW_Pin1_4 455 460 PF00397 0.650
DOC_WW_Pin1_4 465 470 PF00397 0.580
DOC_WW_Pin1_4 476 481 PF00397 0.637
DOC_WW_Pin1_4 483 488 PF00397 0.547
DOC_WW_Pin1_4 491 496 PF00397 0.444
LIG_14-3-3_CanoR_1 388 392 PF00244 0.526
LIG_14-3-3_CanoR_1 546 554 PF00244 0.510
LIG_Actin_WH2_2 92 110 PF00022 0.516
LIG_APCC_ABBA_1 324 329 PF00400 0.510
LIG_BIR_II_1 1 5 PF00653 0.628
LIG_BIR_III_3 1 5 PF00653 0.567
LIG_BRCT_BRCA1_1 345 349 PF00533 0.430
LIG_BRCT_BRCA1_1 84 88 PF00533 0.510
LIG_CaM_IQ_9 391 407 PF13499 0.517
LIG_FHA_1 477 483 PF00498 0.620
LIG_FHA_1 546 552 PF00498 0.461
LIG_FHA_2 317 323 PF00498 0.463
LIG_FHA_2 484 490 PF00498 0.555
LIG_Integrin_isoDGR_2 368 370 PF01839 0.230
LIG_LIR_Gen_1 131 140 PF02991 0.510
LIG_LIR_Gen_1 224 233 PF02991 0.430
LIG_LIR_Gen_1 386 396 PF02991 0.488
LIG_LIR_Gen_1 504 515 PF02991 0.441
LIG_LIR_Gen_1 522 533 PF02991 0.444
LIG_LIR_Nem_3 131 136 PF02991 0.433
LIG_LIR_Nem_3 152 158 PF02991 0.430
LIG_LIR_Nem_3 224 230 PF02991 0.430
LIG_LIR_Nem_3 325 330 PF02991 0.424
LIG_LIR_Nem_3 346 352 PF02991 0.423
LIG_LIR_Nem_3 386 392 PF02991 0.486
LIG_LIR_Nem_3 43 48 PF02991 0.430
LIG_LIR_Nem_3 504 510 PF02991 0.441
LIG_LIR_Nem_3 532 537 PF02991 0.461
LIG_LIR_Nem_3 65 71 PF02991 0.430
LIG_LIR_Nem_3 85 91 PF02991 0.482
LIG_MYND_1 480 484 PF01753 0.596
LIG_MYND_1 515 519 PF01753 0.510
LIG_PCNA_TLS_4 220 227 PF02747 0.430
LIG_PCNA_yPIPBox_3 194 203 PF02747 0.416
LIG_Pex14_2 226 230 PF04695 0.430
LIG_Pex14_2 314 318 PF04695 0.430
LIG_PTB_Apo_2 304 311 PF02174 0.390
LIG_PTB_Phospho_1 304 310 PF10480 0.399
LIG_REV1ctd_RIR_1 224 233 PF16727 0.430
LIG_SH2_CRK 155 159 PF00017 0.430
LIG_SH2_CRK 389 393 PF00017 0.560
LIG_SH2_CRK 68 72 PF00017 0.430
LIG_SH2_GRB2like 70 73 PF00017 0.430
LIG_SH2_NCK_1 511 515 PF00017 0.487
LIG_SH2_SRC 511 514 PF00017 0.510
LIG_SH2_STAT3 210 213 PF00017 0.430
LIG_SH2_STAT5 188 191 PF00017 0.385
LIG_SH2_STAT5 210 213 PF00017 0.420
LIG_SH2_STAT5 28 31 PF00017 0.430
LIG_SH2_STAT5 281 284 PF00017 0.371
LIG_SH2_STAT5 310 313 PF00017 0.427
LIG_SH2_STAT5 389 392 PF00017 0.529
LIG_SH2_STAT5 70 73 PF00017 0.430
LIG_SH3_3 441 447 PF00018 0.611
LIG_SH3_3 474 480 PF00018 0.666
LIG_SH3_3 481 487 PF00018 0.558
LIG_TRAF2_1 4 7 PF00917 0.554
LIG_TRAF2_1 486 489 PF00917 0.636
LIG_TRAF2_1 494 497 PF00917 0.510
LIG_TYR_ITIM 66 71 PF00017 0.284
LIG_UBA3_1 292 298 PF00899 0.480
LIG_UBA3_1 323 328 PF00899 0.395
LIG_UBA3_1 524 531 PF00899 0.303
LIG_WRC_WIRS_1 351 356 PF05994 0.284
LIG_WRPW_2 45 48 PF00400 0.303
LIG_WW_2 480 483 PF00397 0.599
MOD_CDK_SPK_2 465 470 PF00069 0.721
MOD_CK1_1 138 144 PF00069 0.376
MOD_CK1_1 343 349 PF00069 0.428
MOD_CK2_1 483 489 PF00069 0.575
MOD_CK2_1 491 497 PF00069 0.267
MOD_GlcNHglycan 109 112 PF01048 0.429
MOD_GlcNHglycan 162 167 PF01048 0.417
MOD_GlcNHglycan 234 237 PF01048 0.286
MOD_GlcNHglycan 241 245 PF01048 0.280
MOD_GlcNHglycan 342 345 PF01048 0.428
MOD_GlcNHglycan 459 462 PF01048 0.681
MOD_GlcNHglycan 77 80 PF01048 0.301
MOD_GSK3_1 131 138 PF00069 0.337
MOD_GSK3_1 465 472 PF00069 0.698
MOD_LATS_1 159 165 PF00433 0.350
MOD_N-GLC_1 204 209 PF02516 0.359
MOD_NEK2_1 107 112 PF00069 0.433
MOD_PIKK_1 59 65 PF00454 0.284
MOD_PK_1 135 141 PF00069 0.370
MOD_PKA_2 107 113 PF00069 0.422
MOD_PKA_2 387 393 PF00069 0.527
MOD_PKA_2 545 551 PF00069 0.395
MOD_Plk_2-3 125 131 PF00069 0.395
MOD_Plk_2-3 178 184 PF00069 0.597
MOD_Plk_4 135 141 PF00069 0.316
MOD_Plk_4 23 29 PF00069 0.364
MOD_Plk_4 387 393 PF00069 0.513
MOD_Plk_4 47 53 PF00069 0.281
MOD_ProDKin_1 440 446 PF00069 0.725
MOD_ProDKin_1 455 461 PF00069 0.649
MOD_ProDKin_1 465 471 PF00069 0.582
MOD_ProDKin_1 476 482 PF00069 0.629
MOD_ProDKin_1 483 489 PF00069 0.546
MOD_ProDKin_1 491 497 PF00069 0.303
MOD_SUMO_for_1 160 163 PF00179 0.395
MOD_SUMO_rev_2 121 129 PF00179 0.395
MOD_SUMO_rev_2 147 152 PF00179 0.359
MOD_SUMO_rev_2 178 187 PF00179 0.463
MOD_SUMO_rev_2 329 335 PF00179 0.428
MOD_SUMO_rev_2 535 543 PF00179 0.391
TRG_DiLeu_BaEn_1 532 537 PF01217 0.326
TRG_DiLeu_BaLyEn_6 288 293 PF01217 0.449
TRG_DiLeu_BaLyEn_6 373 378 PF01217 0.303
TRG_ENDOCYTIC_2 155 158 PF00928 0.284
TRG_ENDOCYTIC_2 330 333 PF00928 0.276
TRG_ENDOCYTIC_2 389 392 PF00928 0.529
TRG_ENDOCYTIC_2 534 537 PF00928 0.395
TRG_ENDOCYTIC_2 68 71 PF00928 0.284
TRG_ER_diArg_1 193 195 PF00400 0.412
TRG_ER_diArg_1 421 424 PF00400 0.726
TRG_NES_CRM1_1 516 527 PF08389 0.395
TRG_Pf-PMV_PEXEL_1 541 545 PF00026 0.348

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3Y8 Leptomonas seymouri 87% 99%
A0A0N0P5A9 Leptomonas seymouri 38% 99%
A0A0N1I0F0 Leptomonas seymouri 35% 100%
A0A0R4IEW8 Danio rerio 23% 100%
A0A0S4IKZ4 Bodo saltans 33% 98%
A0A0S4JPT3 Bodo saltans 38% 99%
A0A1X0P4T3 Trypanosomatidae 73% 100%
A0A1X0P4V5 Trypanosomatidae 41% 98%
A0A1X0P525 Trypanosomatidae 35% 100%
A0A3Q8IF40 Leishmania donovani 35% 100%
A0A3Q8IMW2 Leishmania donovani 37% 96%
A0A3R7NAH9 Trypanosoma rangeli 75% 100%
A0A422NK82 Trypanosoma rangeli 34% 100%
A1CRM1 Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107) 35% 74%
A1D4K4 Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181) 42% 75%
A3LXL0 Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) 36% 89%
A4HDV5 Leishmania braziliensis 40% 100%
A4HNG6 Leishmania braziliensis 95% 100%
A4I150 Leishmania infantum 38% 100%
A4IBV3 Leishmania infantum 32% 99%
A4IC57 Leishmania infantum 100% 100%
A4QUF0 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 38% 73%
A5DM21 Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) 38% 89%
A5DW14 Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) 38% 85%
C9ZYE6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 69% 99%
C9ZYQ8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AFP0 Leishmania major 36% 94%
E9AFX7 Leishmania major 99% 100%
E9AX84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B6U3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 94%
E9B730 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
F1QB54 Danio rerio 44% 88%
F4HT49 Arabidopsis thaliana 37% 100%
O04319 Arabidopsis thaliana 36% 100%
O09032 Rattus norvegicus 23% 100%
O22173 Arabidopsis thaliana 39% 85%
O64380 Arabidopsis thaliana 43% 85%
P04147 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40% 97%
P09405 Mus musculus 23% 79%
P0CP46 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 39% 83%
P0CP47 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 39% 83%
P11940 Homo sapiens 46% 88%
P13383 Rattus norvegicus 23% 79%
P15771 Gallus gallus 22% 81%
P19338 Homo sapiens 22% 79%
P20397 Xenopus laevis 23% 86%
P20965 Xenopus laevis 45% 88%
P21187 Drosophila melanogaster 43% 88%
P26378 Homo sapiens 22% 100%
P29341 Mus musculus 46% 88%
P31209 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 86%
P39684 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 92%
P42731 Arabidopsis thaliana 38% 89%
P61286 Bos taurus 46% 88%
Q05196 Arabidopsis thaliana 42% 82%
Q13310 Homo sapiens 38% 87%
Q1DXH0 Coccidioides immitis (strain RS) 35% 73%
Q1ZXC2 Dictyostelium discoideum 34% 69%
Q2GSX8 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 38% 72%
Q4P8R9 Ustilago maydis (strain 521 / FGSC 9021) 39% 86%
Q4QA88 Leishmania major 36% 100%
Q4R2Z0 Macaca fascicularis 23% 100%
Q4R4J7 Macaca fascicularis 22% 79%
Q4VXU2 Homo sapiens 45% 91%
Q4WJT7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 22% 68%
Q4WK03 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 41% 74%
Q54BM2 Dictyostelium discoideum 36% 99%
Q5AI15 Candida albicans (strain SC5314 / ATCC MYA-2876) 38% 89%
Q5B630 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 36% 77%
Q5BGA9 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 23% 68%
Q5R8F7 Pongo abelii 46% 88%
Q5RF26 Pongo abelii 22% 79%
Q61701 Mus musculus 23% 100%
Q6BI95 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 38% 89%
Q6CDH3 Yarrowia lipolytica (strain CLIB 122 / E 150) 35% 89%
Q6CSV3 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 38% 95%
Q6DEY7 Xenopus tropicalis 44% 89%
Q6FKG4 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 39% 97%
Q6GR16 Xenopus laevis 44% 89%
Q6IP09 Xenopus laevis 45% 88%
Q74ZS6 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 39% 96%
Q7S6N6 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 35% 73%
Q8SR30 Encephalitozoon cuniculi (strain GB-M1) 29% 100%
Q98SP8 Xenopus laevis 44% 89%
Q9EPH8 Rattus norvegicus 46% 88%
Q9FXA2 Arabidopsis thaliana 42% 83%
Q9H361 Homo sapiens 43% 89%
Q9ZQA8 Arabidopsis thaliana 33% 92%
V5BYR2 Trypanosoma cruzi 71% 99%
V5DUJ1 Trypanosoma cruzi 35% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS