Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGR5_LEIDO

TriTrypDb:

LdBPK_330800.1 , LdCL_330013500 , LDHU3_33.1110

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGR5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.472
CLV_NRD_NRD_1	19	21	PF00675	0.356
CLV_NRD_NRD_1	197	199	PF00675	0.537
CLV_NRD_NRD_1	238	240	PF00675	0.665
CLV_NRD_NRD_1	679	681	PF00675	0.670
CLV_NRD_NRD_1	683	685	PF00675	0.701
CLV_NRD_NRD_1	705	707	PF00675	0.501
CLV_PCSK_FUR_1	234	238	PF00082	0.683
CLV_PCSK_FUR_1	680	684	PF00082	0.540
CLV_PCSK_KEX2_1	118	120	PF00082	0.472
CLV_PCSK_KEX2_1	19	21	PF00082	0.356
CLV_PCSK_KEX2_1	197	199	PF00082	0.617
CLV_PCSK_KEX2_1	234	236	PF00082	0.641
CLV_PCSK_KEX2_1	237	239	PF00082	0.653
CLV_PCSK_KEX2_1	675	677	PF00082	0.615
CLV_PCSK_KEX2_1	679	681	PF00082	0.676
CLV_PCSK_KEX2_1	682	684	PF00082	0.698
CLV_PCSK_KEX2_1	705	707	PF00082	0.501
CLV_PCSK_KEX2_1	757	759	PF00082	0.628
CLV_PCSK_PC1ET2_1	675	677	PF00082	0.570
CLV_PCSK_PC1ET2_1	757	759	PF00082	0.417
CLV_PCSK_PC7_1	193	199	PF00082	0.559
CLV_PCSK_PC7_1	234	240	PF00082	0.674
CLV_PCSK_PC7_1	679	685	PF00082	0.583
CLV_PCSK_SKI1_1	201	205	PF00082	0.627
CLV_PCSK_SKI1_1	376	380	PF00082	0.415
CLV_PCSK_SKI1_1	411	415	PF00082	0.471
CLV_PCSK_SKI1_1	457	461	PF00082	0.536
CLV_PCSK_SKI1_1	604	608	PF00082	0.512
CLV_PCSK_SKI1_1	758	762	PF00082	0.463
DEG_APCC_DBOX_1	375	383	PF00400	0.494
DEG_APCC_DBOX_1	410	418	PF00400	0.469
DEG_APCC_DBOX_1	603	611	PF00400	0.420
DEG_Nend_Nbox_1	1	3	PF02207	0.474
DEG_SCF_FBW7_1	64	71	PF00400	0.390
DEG_SPOP_SBC_1	562	566	PF00917	0.499
DOC_CKS1_1	713	718	PF01111	0.564
DOC_CYCLIN_RxL_1	373	381	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	416	419	PF00134	0.476
DOC_MAPK_DCC_7	308	316	PF00069	0.452
DOC_MAPK_gen_1	457	465	PF00069	0.384
DOC_MAPK_gen_1	705	713	PF00069	0.641
DOC_MAPK_gen_1	757	765	PF00069	0.418
DOC_MAPK_MEF2A_6	274	281	PF00069	0.768
DOC_MAPK_MEF2A_6	477	486	PF00069	0.435
DOC_MAPK_MEF2A_6	757	765	PF00069	0.461
DOC_MAPK_NFAT4_5	758	766	PF00069	0.409
DOC_PP1_RVXF_1	358	365	PF00149	0.377
DOC_PP1_RVXF_1	475	482	PF00149	0.456
DOC_PP1_RVXF_1	61	67	PF00149	0.552
DOC_PP2B_LxvP_1	416	419	PF13499	0.476
DOC_USP7_MATH_1	167	171	PF00917	0.620
DOC_USP7_MATH_1	196	200	PF00917	0.689
DOC_USP7_MATH_1	230	234	PF00917	0.593
DOC_USP7_MATH_1	241	245	PF00917	0.663
DOC_USP7_MATH_1	257	261	PF00917	0.720
DOC_USP7_MATH_1	45	49	PF00917	0.632
DOC_USP7_MATH_1	494	498	PF00917	0.700
DOC_USP7_MATH_1	504	508	PF00917	0.767
DOC_USP7_MATH_1	530	534	PF00917	0.660
DOC_USP7_MATH_1	555	559	PF00917	0.574
DOC_USP7_MATH_1	592	596	PF00917	0.492
DOC_USP7_MATH_1	731	735	PF00917	0.601
DOC_USP7_MATH_1	753	757	PF00917	0.510
DOC_USP7_UBL2_3	514	518	PF12436	0.649
DOC_WW_Pin1_4	226	231	PF00397	0.734
DOC_WW_Pin1_4	29	34	PF00397	0.574
DOC_WW_Pin1_4	307	312	PF00397	0.512
DOC_WW_Pin1_4	325	330	PF00397	0.677
DOC_WW_Pin1_4	41	46	PF00397	0.575
DOC_WW_Pin1_4	588	593	PF00397	0.418
DOC_WW_Pin1_4	595	600	PF00397	0.381
DOC_WW_Pin1_4	619	624	PF00397	0.432
DOC_WW_Pin1_4	64	69	PF00397	0.507
DOC_WW_Pin1_4	694	699	PF00397	0.649
DOC_WW_Pin1_4	712	717	PF00397	0.554
LIG_14-3-3_CanoR_1	10	15	PF00244	0.503
LIG_14-3-3_CanoR_1	19	25	PF00244	0.477
LIG_14-3-3_CanoR_1	198	204	PF00244	0.682
LIG_14-3-3_CanoR_1	51	57	PF00244	0.665
LIG_14-3-3_CanoR_1	567	575	PF00244	0.492
LIG_14-3-3_CanoR_1	582	590	PF00244	0.392
LIG_14-3-3_CanoR_1	668	677	PF00244	0.537
LIG_14-3-3_CanoR_1	705	713	PF00244	0.470
LIG_BIR_III_2	719	723	PF00653	0.578
LIG_BIR_III_4	472	476	PF00653	0.491
LIG_BIR_III_4	725	729	PF00653	0.570
LIG_BRCT_BRCA1_1	264	268	PF00533	0.697
LIG_BRCT_BRCA1_1	352	356	PF00533	0.420
LIG_CSL_BTD_1	316	319	PF09270	0.326
LIG_DLG_GKlike_1	10	17	PF00625	0.346
LIG_FHA_1	10	16	PF00498	0.386
LIG_FHA_1	179	185	PF00498	0.666
LIG_FHA_1	281	287	PF00498	0.650
LIG_FHA_1	410	416	PF00498	0.433
LIG_FHA_1	485	491	PF00498	0.554
LIG_FHA_1	567	573	PF00498	0.378
LIG_FHA_1	583	589	PF00498	0.374
LIG_FHA_1	662	668	PF00498	0.630
LIG_FHA_2	170	176	PF00498	0.673
LIG_FHA_2	333	339	PF00498	0.469
LIG_FHA_2	576	582	PF00498	0.521
LIG_Integrin_RGD_1	684	686	PF01839	0.592
LIG_LIR_Apic_2	551	555	PF02991	0.526
LIG_LIR_Apic_2	625	631	PF02991	0.372
LIG_LIR_Gen_1	312	322	PF02991	0.553
LIG_LIR_Gen_1	385	394	PF02991	0.378
LIG_LIR_Gen_1	621	631	PF02991	0.516
LIG_LIR_Gen_1	9	17	PF02991	0.423
LIG_LIR_Nem_3	312	318	PF02991	0.545
LIG_LIR_Nem_3	385	390	PF02991	0.383
LIG_LIR_Nem_3	621	627	PF02991	0.515
LIG_LIR_Nem_3	9	14	PF02991	0.424
LIG_MAD2	615	623	PF02301	0.425
LIG_NRBOX	90	96	PF00104	0.462
LIG_PDZ_Class_2	766	771	PF00595	0.418
LIG_REV1ctd_RIR_1	766	771	PF16727	0.551
LIG_SH2_NCK_1	123	127	PF00017	0.521
LIG_SH2_NCK_1	590	594	PF00017	0.423
LIG_SH2_STAP1	425	429	PF00017	0.491
LIG_SH2_STAP1	584	588	PF00017	0.405
LIG_SH2_STAP1	83	87	PF00017	0.480
LIG_SH2_STAT3	455	458	PF00017	0.529
LIG_SH2_STAT5	23	26	PF00017	0.526
LIG_SH2_STAT5	343	346	PF00017	0.422
LIG_SH2_STAT5	374	377	PF00017	0.359
LIG_SH2_STAT5	421	424	PF00017	0.551
LIG_SH2_STAT5	455	458	PF00017	0.485
LIG_SH2_STAT5	584	587	PF00017	0.461
LIG_SH2_STAT5	628	631	PF00017	0.397
LIG_SH2_STAT5	751	754	PF00017	0.423
LIG_SH3_3	107	113	PF00018	0.635
LIG_SH3_3	114	120	PF00018	0.557
LIG_SH3_3	400	406	PF00018	0.442
LIG_SH3_3	412	418	PF00018	0.341
LIG_SH3_3	483	489	PF00018	0.501
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.476
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.378
LIG_SUMO_SIM_par_1	277	284	PF11976	0.614
LIG_WRC_WIRS_1	534	539	PF05994	0.527
LIG_WRPW_2	401	404	PF00400	0.546
LIG_WW_1	418	421	PF00397	0.340
MOD_CDK_SPxK_1	595	601	PF00069	0.460
MOD_CK1_1	199	205	PF00069	0.749
MOD_CK1_1	252	258	PF00069	0.601
MOD_CK1_1	270	276	PF00069	0.663
MOD_CK1_1	280	286	PF00069	0.611
MOD_CK1_1	40	46	PF00069	0.569
MOD_CK1_1	497	503	PF00069	0.681
MOD_CK1_1	533	539	PF00069	0.674
MOD_CK1_1	542	548	PF00069	0.653
MOD_CK1_1	558	564	PF00069	0.592
MOD_CK1_1	566	572	PF00069	0.628
MOD_CK1_1	595	601	PF00069	0.462
MOD_CK1_1	661	667	PF00069	0.596
MOD_CK1_1	712	718	PF00069	0.715
MOD_CK1_1	756	762	PF00069	0.431
MOD_CK2_1	151	157	PF00069	0.530
MOD_CK2_1	332	338	PF00069	0.486
MOD_CK2_1	731	737	PF00069	0.656
MOD_Cter_Amidation	17	20	PF01082	0.359
MOD_GlcNHglycan	148	151	PF01048	0.518
MOD_GlcNHglycan	198	201	PF01048	0.664
MOD_GlcNHglycan	20	23	PF01048	0.469
MOD_GlcNHglycan	230	233	PF01048	0.613
MOD_GlcNHglycan	254	257	PF01048	0.659
MOD_GlcNHglycan	259	262	PF01048	0.687
MOD_GlcNHglycan	323	326	PF01048	0.610
MOD_GlcNHglycan	33	36	PF01048	0.610
MOD_GlcNHglycan	38	42	PF01048	0.609
MOD_GlcNHglycan	425	428	PF01048	0.569
MOD_GlcNHglycan	496	499	PF01048	0.664
MOD_GlcNHglycan	52	55	PF01048	0.582
MOD_GlcNHglycan	58	61	PF01048	0.531
MOD_GlcNHglycan	689	692	PF01048	0.596
MOD_GlcNHglycan	706	709	PF01048	0.553
MOD_GlcNHglycan	732	736	PF01048	0.689
MOD_GlcNHglycan	91	94	PF01048	0.400
MOD_GSK3_1	139	146	PF00069	0.462
MOD_GSK3_1	222	229	PF00069	0.623
MOD_GSK3_1	252	259	PF00069	0.652
MOD_GSK3_1	321	328	PF00069	0.460
MOD_GSK3_1	37	44	PF00069	0.665
MOD_GSK3_1	52	59	PF00069	0.491
MOD_GSK3_1	532	539	PF00069	0.684
MOD_GSK3_1	554	561	PF00069	0.580
MOD_GSK3_1	562	569	PF00069	0.486
MOD_GSK3_1	588	595	PF00069	0.454
MOD_GSK3_1	64	71	PF00069	0.524
MOD_N-GLC_1	152	157	PF02516	0.505
MOD_N-GLC_1	619	624	PF02516	0.504
MOD_N-GLC_1	737	742	PF02516	0.509
MOD_NEK2_1	224	229	PF00069	0.777
MOD_NEK2_1	704	709	PF00069	0.408
MOD_NEK2_1	89	94	PF00069	0.364
MOD_PIKK_1	634	640	PF00454	0.552
MOD_PIKK_1	669	675	PF00454	0.552
MOD_PKA_1	675	681	PF00069	0.612
MOD_PKA_2	18	24	PF00069	0.473
MOD_PKA_2	196	202	PF00069	0.606
MOD_PKA_2	222	228	PF00069	0.601
MOD_PKA_2	494	500	PF00069	0.758
MOD_PKA_2	50	56	PF00069	0.680
MOD_PKA_2	566	572	PF00069	0.402
MOD_PKA_2	575	581	PF00069	0.384
MOD_PKA_2	675	681	PF00069	0.638
MOD_PKA_2	704	710	PF00069	0.370
MOD_PKA_2	9	15	PF00069	0.525
MOD_PKB_1	237	245	PF00069	0.603
MOD_Plk_1	178	184	PF00069	0.633
MOD_Plk_1	539	545	PF00069	0.541
MOD_Plk_1	649	655	PF00069	0.498
MOD_Plk_1	745	751	PF00069	0.453
MOD_Plk_4	10	16	PF00069	0.360
MOD_Plk_4	199	205	PF00069	0.666
MOD_Plk_4	351	357	PF00069	0.346
MOD_Plk_4	388	394	PF00069	0.439
MOD_Plk_4	441	447	PF00069	0.383
MOD_Plk_4	52	58	PF00069	0.614
MOD_Plk_4	533	539	PF00069	0.529
MOD_ProDKin_1	226	232	PF00069	0.735
MOD_ProDKin_1	29	35	PF00069	0.576
MOD_ProDKin_1	307	313	PF00069	0.510
MOD_ProDKin_1	325	331	PF00069	0.672
MOD_ProDKin_1	41	47	PF00069	0.575
MOD_ProDKin_1	588	594	PF00069	0.418
MOD_ProDKin_1	595	601	PF00069	0.385
MOD_ProDKin_1	619	625	PF00069	0.431
MOD_ProDKin_1	64	70	PF00069	0.498
MOD_ProDKin_1	694	700	PF00069	0.647
MOD_ProDKin_1	712	718	PF00069	0.554
MOD_SUMO_for_1	459	462	PF00179	0.490
MOD_SUMO_rev_2	515	520	PF00179	0.597
MOD_SUMO_rev_2	55	64	PF00179	0.504
TRG_DiLeu_BaEn_1	336	341	PF01217	0.436
TRG_DiLeu_BaEn_1	461	466	PF01217	0.465
TRG_DiLeu_BaEn_4	461	467	PF01217	0.461
TRG_DiLeu_LyEn_5	461	466	PF01217	0.354
TRG_ENDOCYTIC_2	343	346	PF00928	0.463
TRG_ENDOCYTIC_2	646	649	PF00928	0.413
TRG_ER_diArg_1	109	112	PF00400	0.567
TRG_ER_diArg_1	117	119	PF00400	0.479
TRG_ER_diArg_1	234	237	PF00400	0.633
TRG_ER_diArg_1	238	240	PF00400	0.648
TRG_ER_diArg_1	679	681	PF00400	0.636
TRG_ER_diArg_1	682	684	PF00400	0.656
TRG_ER_diArg_1	704	706	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	376	380	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P467	Leptomonas seymouri	57%	89%
A0A0S4IVX1	Bodo saltans	28%	100%
A0A1X0P116	Trypanosomatidae	32%	100%
A4HLB5	Leishmania braziliensis	77%	100%
A4I8U1	Leishmania infantum	100%	100%
D0A4T7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B3Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4D0	Leishmania major	93%	100%
V5BFB4	Trypanosoma cruzi	39%	100%