TBC1 domain family member 23

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab-GTPase-TBC domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGR4_LEIDO

TriTrypDb:

LdCL_330031800 , LDHU3_33.3550

Length:

859

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0005829	cytosol	2	15
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	15
GO:0005802	trans-Golgi network	4	2
GO:0031984	organelle subcompartment	2	2
GO:0098791	Golgi apparatus subcompartment	3	2

Expansion

Sequence features

A0A3Q8IGR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGR4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	15
GO:0009987	cellular process	1	15
GO:0016192	vesicle-mediated transport	4	15
GO:0016197	endosomal transport	4	15
GO:0016482	cytosolic transport	4	15
GO:0042147	retrograde transport, endosome to Golgi	5	15
GO:0046907	intracellular transport	3	15
GO:0051179	localization	1	15
GO:0051234	establishment of localization	2	15
GO:0051641	cellular localization	2	15
GO:0051649	establishment of localization in cell	3	15
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0099022	vesicle tethering	4	2
GO:0099041	vesicle tethering to Golgi	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.538
CLV_C14_Caspase3-7	81	85	PF00656	0.458
CLV_NRD_NRD_1	283	285	PF00675	0.329
CLV_NRD_NRD_1	323	325	PF00675	0.400
CLV_NRD_NRD_1	490	492	PF00675	0.498
CLV_NRD_NRD_1	777	779	PF00675	0.661
CLV_NRD_NRD_1	91	93	PF00675	0.538
CLV_PCSK_KEX2_1	151	153	PF00082	0.408
CLV_PCSK_KEX2_1	283	285	PF00082	0.329
CLV_PCSK_KEX2_1	323	325	PF00082	0.400
CLV_PCSK_KEX2_1	435	437	PF00082	0.602
CLV_PCSK_KEX2_1	490	492	PF00082	0.502
CLV_PCSK_KEX2_1	634	636	PF00082	0.616
CLV_PCSK_KEX2_1	777	779	PF00082	0.663
CLV_PCSK_KEX2_1	91	93	PF00082	0.538
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.408
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.602
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.616
CLV_PCSK_SKI1_1	151	155	PF00082	0.595
CLV_PCSK_SKI1_1	217	221	PF00082	0.469
CLV_PCSK_SKI1_1	253	257	PF00082	0.364
CLV_PCSK_SKI1_1	283	287	PF00082	0.304
CLV_PCSK_SKI1_1	332	336	PF00082	0.502
CLV_PCSK_SKI1_1	373	377	PF00082	0.467
CLV_PCSK_SKI1_1	526	530	PF00082	0.437
CLV_PCSK_SKI1_1	778	782	PF00082	0.631
DEG_APCC_DBOX_1	118	126	PF00400	0.471
DEG_APCC_DBOX_1	322	330	PF00400	0.420
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DEG_SCF_FBW7_1	25	30	PF00400	0.546
DEG_SCF_FBW7_1	385	390	PF00400	0.389
DEG_SPOP_SBC_1	246	250	PF00917	0.433
DEG_SPOP_SBC_1	801	805	PF00917	0.727
DOC_CYCLIN_RxL_1	321	331	PF00134	0.333
DOC_CYCLIN_yCln2_LP_2	305	311	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	760	766	PF00134	0.563
DOC_MAPK_gen_1	323	329	PF00069	0.396
DOC_MAPK_gen_1	91	97	PF00069	0.436
DOC_MAPK_MEF2A_6	526	534	PF00069	0.459
DOC_MAPK_RevD_3	309	324	PF00069	0.329
DOC_PP1_RVXF_1	295	302	PF00149	0.439
DOC_PP1_RVXF_1	390	397	PF00149	0.473
DOC_PP1_RVXF_1	572	578	PF00149	0.452
DOC_PP2B_LxvP_1	760	763	PF13499	0.559
DOC_PP2B_LxvP_1	780	783	PF13499	0.669
DOC_PP4_FxxP_1	258	261	PF00568	0.420
DOC_PP4_FxxP_1	344	347	PF00568	0.361
DOC_USP7_MATH_1	247	251	PF00917	0.357
DOC_USP7_MATH_1	446	450	PF00917	0.555
DOC_USP7_MATH_1	50	54	PF00917	0.857
DOC_USP7_MATH_1	624	628	PF00917	0.571
DOC_USP7_MATH_1	650	654	PF00917	0.681
DOC_USP7_MATH_1	690	694	PF00917	0.764
DOC_USP7_MATH_1	764	768	PF00917	0.778
DOC_USP7_MATH_1	770	774	PF00917	0.605
DOC_USP7_MATH_1	78	82	PF00917	0.496
DOC_USP7_MATH_1	792	796	PF00917	0.738
DOC_USP7_MATH_1	802	806	PF00917	0.717
DOC_USP7_MATH_1	842	846	PF00917	0.685
DOC_WW_Pin1_4	23	28	PF00397	0.607
DOC_WW_Pin1_4	364	369	PF00397	0.598
DOC_WW_Pin1_4	383	388	PF00397	0.308
DOC_WW_Pin1_4	405	410	PF00397	0.424
DOC_WW_Pin1_4	416	421	PF00397	0.423
DOC_WW_Pin1_4	553	558	PF00397	0.510
DOC_WW_Pin1_4	57	62	PF00397	0.784
DOC_WW_Pin1_4	783	788	PF00397	0.742
DOC_WW_Pin1_4	837	842	PF00397	0.600
LIG_14-3-3_CanoR_1	213	221	PF00244	0.400
LIG_14-3-3_CanoR_1	323	327	PF00244	0.427
LIG_14-3-3_CanoR_1	362	366	PF00244	0.460
LIG_14-3-3_CanoR_1	777	783	PF00244	0.628
LIG_14-3-3_CanoR_1	815	820	PF00244	0.681
LIG_14-3-3_CanoR_1	92	98	PF00244	0.482
LIG_Actin_WH2_2	391	408	PF00022	0.412
LIG_Actin_WH2_2	728	746	PF00022	0.594
LIG_APCC_ABBA_1	396	401	PF00400	0.451
LIG_BIR_III_2	445	449	PF00653	0.513
LIG_Clathr_ClatBox_1	125	129	PF01394	0.475
LIG_FHA_1	174	180	PF00498	0.414
LIG_FHA_1	204	210	PF00498	0.454
LIG_FHA_1	24	30	PF00498	0.521
LIG_FHA_1	246	252	PF00498	0.400
LIG_FHA_1	334	340	PF00498	0.366
LIG_FHA_1	388	394	PF00498	0.233
LIG_FHA_1	417	423	PF00498	0.545
LIG_FHA_1	5	11	PF00498	0.598
LIG_FHA_1	511	517	PF00498	0.344
LIG_FHA_1	540	546	PF00498	0.414
LIG_FHA_1	663	669	PF00498	0.760
LIG_FHA_2	173	179	PF00498	0.483
LIG_FHA_2	263	269	PF00498	0.438
LIG_FHA_2	406	412	PF00498	0.500
LIG_FHA_2	54	60	PF00498	0.668
LIG_LIR_Apic_2	191	196	PF02991	0.452
LIG_LIR_Gen_1	300	309	PF02991	0.305
LIG_LIR_Gen_1	449	456	PF02991	0.393
LIG_LIR_Gen_1	461	471	PF02991	0.399
LIG_LIR_Gen_1	827	837	PF02991	0.546
LIG_LIR_Nem_3	144	149	PF02991	0.514
LIG_LIR_Nem_3	191	197	PF02991	0.442
LIG_LIR_Nem_3	223	228	PF02991	0.337
LIG_LIR_Nem_3	300	304	PF02991	0.306
LIG_LIR_Nem_3	449	455	PF02991	0.401
LIG_LIR_Nem_3	461	466	PF02991	0.399
LIG_LIR_Nem_3	827	833	PF02991	0.538
LIG_LYPXL_S_1	398	402	PF13949	0.406
LIG_LYPXL_yS_3	399	402	PF13949	0.418
LIG_MAD2	392	400	PF02301	0.233
LIG_NRBOX	121	127	PF00104	0.443
LIG_PCNA_PIPBox_1	271	280	PF02747	0.420
LIG_PCNA_yPIPBox_3	213	225	PF02747	0.473
LIG_PCNA_yPIPBox_3	271	284	PF02747	0.420
LIG_PCNA_yPIPBox_3	71	80	PF02747	0.533
LIG_Pex14_2	830	834	PF04695	0.544
LIG_SH2_CRK	123	127	PF00017	0.366
LIG_SH2_CRK	225	229	PF00017	0.396
LIG_SH2_GRB2like	193	196	PF00017	0.489
LIG_SH2_NCK_1	244	248	PF00017	0.460
LIG_SH2_PTP2	452	455	PF00017	0.309
LIG_SH2_PTP2	465	468	PF00017	0.454
LIG_SH2_SRC	244	247	PF00017	0.466
LIG_SH2_SRC	452	455	PF00017	0.462
LIG_SH2_STAP1	149	153	PF00017	0.488
LIG_SH2_STAP1	292	296	PF00017	0.413
LIG_SH2_STAT3	259	262	PF00017	0.388
LIG_SH2_STAT3	598	601	PF00017	0.635
LIG_SH2_STAT5	123	126	PF00017	0.384
LIG_SH2_STAT5	149	152	PF00017	0.520
LIG_SH2_STAT5	193	196	PF00017	0.542
LIG_SH2_STAT5	207	210	PF00017	0.355
LIG_SH2_STAT5	277	280	PF00017	0.364
LIG_SH2_STAT5	313	316	PF00017	0.313
LIG_SH2_STAT5	318	321	PF00017	0.302
LIG_SH2_STAT5	452	455	PF00017	0.347
LIG_SH2_STAT5	465	468	PF00017	0.454
LIG_SH2_STAT5	522	525	PF00017	0.413
LIG_SH2_STAT5	598	601	PF00017	0.635
LIG_SH3_2	739	744	PF14604	0.592
LIG_SH3_3	131	137	PF00018	0.518
LIG_SH3_3	22	28	PF00018	0.628
LIG_SH3_3	306	312	PF00018	0.346
LIG_SH3_3	417	423	PF00018	0.472
LIG_SH3_3	463	469	PF00018	0.423
LIG_SH3_3	58	64	PF00018	0.627
LIG_SH3_3	736	742	PF00018	0.654
LIG_SH3_3	745	751	PF00018	0.708
LIG_SH3_3	769	775	PF00018	0.760
LIG_SH3_3	795	801	PF00018	0.774
LIG_SUMO_SIM_anti_2	300	307	PF11976	0.267
LIG_SUMO_SIM_anti_2	325	331	PF11976	0.405
LIG_SUMO_SIM_anti_2	728	737	PF11976	0.635
LIG_SUMO_SIM_par_1	124	133	PF11976	0.554
LIG_SUMO_SIM_par_1	284	291	PF11976	0.376
LIG_SUMO_SIM_par_1	300	307	PF11976	0.273
LIG_SxIP_EBH_1	536	549	PF03271	0.437
LIG_TRAF2_1	141	144	PF00917	0.656
LIG_TRAF2_1	85	88	PF00917	0.615
LIG_TRFH_1	396	400	PF08558	0.436
LIG_UBA3_1	227	233	PF00899	0.381
LIG_UBA3_1	326	332	PF00899	0.471
MOD_CDK_SPK_2	405	410	PF00069	0.353
MOD_CK1_1	212	218	PF00069	0.471
MOD_CK1_1	238	244	PF00069	0.373
MOD_CK1_1	459	465	PF00069	0.473
MOD_CK1_1	53	59	PF00069	0.753
MOD_CK1_1	60	66	PF00069	0.693
MOD_CK1_1	641	647	PF00069	0.599
MOD_CK1_1	652	658	PF00069	0.646
MOD_CK1_1	671	677	PF00069	0.578
MOD_CK1_1	682	688	PF00069	0.707
MOD_CK1_1	691	697	PF00069	0.613
MOD_CK1_1	96	102	PF00069	0.534
MOD_CK2_1	172	178	PF00069	0.444
MOD_CK2_1	405	411	PF00069	0.504
MOD_CK2_1	53	59	PF00069	0.859
MOD_CK2_1	63	69	PF00069	0.678
MOD_CK2_1	636	642	PF00069	0.723
MOD_CK2_1	672	678	PF00069	0.588
MOD_CK2_1	719	725	PF00069	0.709
MOD_CK2_1	770	776	PF00069	0.658
MOD_CK2_1	82	88	PF00069	0.413
MOD_CK2_1	848	854	PF00069	0.731
MOD_GlcNHglycan	237	240	PF01048	0.351
MOD_GlcNHglycan	430	433	PF01048	0.603
MOD_GlcNHglycan	588	591	PF01048	0.710
MOD_GlcNHglycan	594	598	PF01048	0.688
MOD_GlcNHglycan	654	657	PF01048	0.647
MOD_GlcNHglycan	668	671	PF01048	0.623
MOD_GlcNHglycan	674	677	PF01048	0.637
MOD_GlcNHglycan	682	685	PF01048	0.747
MOD_GlcNHglycan	687	690	PF01048	0.694
MOD_GlcNHglycan	695	698	PF01048	0.630
MOD_GlcNHglycan	760	763	PF01048	0.676
MOD_GlcNHglycan	767	770	PF01048	0.612
MOD_GlcNHglycan	772	775	PF01048	0.523
MOD_GlcNHglycan	804	807	PF01048	0.692
MOD_GlcNHglycan	817	820	PF01048	0.530
MOD_GlcNHglycan	850	853	PF01048	0.701
MOD_GSK3_1	108	115	PF00069	0.365
MOD_GSK3_1	23	30	PF00069	0.628
MOD_GSK3_1	287	294	PF00069	0.403
MOD_GSK3_1	318	325	PF00069	0.445
MOD_GSK3_1	383	390	PF00069	0.343
MOD_GSK3_1	424	431	PF00069	0.461
MOD_GSK3_1	5	12	PF00069	0.769
MOD_GSK3_1	53	60	PF00069	0.752
MOD_GSK3_1	636	643	PF00069	0.575
MOD_GSK3_1	646	653	PF00069	0.547
MOD_GSK3_1	662	669	PF00069	0.604
MOD_GSK3_1	672	679	PF00069	0.593
MOD_GSK3_1	688	695	PF00069	0.739
MOD_GSK3_1	778	785	PF00069	0.782
MOD_GSK3_1	78	85	PF00069	0.449
MOD_N-GLC_1	405	410	PF02516	0.510
MOD_N-GLC_1	564	569	PF02516	0.465
MOD_NEK2_1	203	208	PF00069	0.438
MOD_NEK2_1	220	225	PF00069	0.514
MOD_NEK2_1	235	240	PF00069	0.442
MOD_NEK2_1	279	284	PF00069	0.420
MOD_NEK2_1	327	332	PF00069	0.566
MOD_NEK2_1	342	347	PF00069	0.321
MOD_NEK2_1	502	507	PF00069	0.479
MOD_NEK2_1	539	544	PF00069	0.463
MOD_NEK2_1	734	739	PF00069	0.567
MOD_NEK2_1	743	748	PF00069	0.605
MOD_NEK2_1	758	763	PF00069	0.637
MOD_NEK2_2	188	193	PF00069	0.404
MOD_NEK2_2	93	98	PF00069	0.561
MOD_PIKK_1	333	339	PF00454	0.460
MOD_PIKK_1	387	393	PF00454	0.405
MOD_PIKK_1	456	462	PF00454	0.294
MOD_PIKK_1	69	75	PF00454	0.527
MOD_PIKK_1	711	717	PF00454	0.667
MOD_PK_1	91	97	PF00069	0.436
MOD_PKA_1	91	97	PF00069	0.436
MOD_PKA_2	212	218	PF00069	0.413
MOD_PKA_2	322	328	PF00069	0.388
MOD_PKA_2	361	367	PF00069	0.554
MOD_PKA_2	636	642	PF00069	0.591
MOD_PKA_2	711	717	PF00069	0.721
MOD_PKA_2	743	749	PF00069	0.684
MOD_PKA_2	91	97	PF00069	0.436
MOD_Plk_1	144	150	PF00069	0.513
MOD_Plk_1	188	194	PF00069	0.522
MOD_Plk_1	835	841	PF00069	0.652
MOD_Plk_4	188	194	PF00069	0.525
MOD_Plk_4	203	209	PF00069	0.302
MOD_Plk_4	247	253	PF00069	0.347
MOD_Plk_4	273	279	PF00069	0.404
MOD_Plk_4	371	377	PF00069	0.437
MOD_Plk_4	743	749	PF00069	0.716
MOD_Plk_4	78	84	PF00069	0.382
MOD_ProDKin_1	23	29	PF00069	0.609
MOD_ProDKin_1	364	370	PF00069	0.597
MOD_ProDKin_1	383	389	PF00069	0.306
MOD_ProDKin_1	405	411	PF00069	0.425
MOD_ProDKin_1	416	422	PF00069	0.416
MOD_ProDKin_1	553	559	PF00069	0.505
MOD_ProDKin_1	57	63	PF00069	0.781
MOD_ProDKin_1	783	789	PF00069	0.743
MOD_ProDKin_1	837	843	PF00069	0.601
MOD_SUMO_rev_2	63	72	PF00179	0.606
TRG_DiLeu_BaEn_1	511	516	PF01217	0.369
TRG_DiLeu_BaEn_1	730	735	PF01217	0.672
TRG_DiLeu_BaEn_4	511	517	PF01217	0.369
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.420
TRG_DiLeu_BaLyEn_6	541	546	PF01217	0.386
TRG_ENDOCYTIC_2	123	126	PF00928	0.368
TRG_ENDOCYTIC_2	225	228	PF00928	0.356
TRG_ENDOCYTIC_2	399	402	PF00928	0.500
TRG_ENDOCYTIC_2	452	455	PF00928	0.291
TRG_ENDOCYTIC_2	465	468	PF00928	0.485
TRG_ER_diArg_1	283	285	PF00400	0.331
TRG_ER_diArg_1	489	491	PF00400	0.503
TRG_ER_diArg_1	546	549	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P357	Leptomonas seymouri	58%	100%
A0A1X0P274	Trypanosomatidae	31%	100%
A0A3S7X2Z8	Leishmania donovani	99%	98%
A4HHY0	Leishmania braziliensis	76%	100%
A4HLU8	Leishmania braziliensis	76%	100%
A4I560	Leishmania infantum	100%	100%
C9ZQI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AHQ3	Leishmania infantum	100%	100%
E9B0F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B474	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q3V2	Leishmania major	92%	99%
Q4Q7S6	Leishmania major	92%	99%
V5DD41	Trypanosoma cruzi	33%	100%