Haloacid dehalogenase-like hydrolase/Sucrose-6F-phosphate phosphohydrolase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

haloacid dehalogenase-like hydrolase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGR3_LEIDO

TriTrypDb:

LdBPK_281450.1 , LdCL_280019100 , LDHU3_28.1820

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGR3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.405
CLV_NRD_NRD_1	325	327	PF00675	0.218
CLV_NRD_NRD_1	39	41	PF00675	0.169
CLV_NRD_NRD_1	74	76	PF00675	0.216
CLV_PCSK_KEX2_1	39	41	PF00082	0.188
CLV_PCSK_KEX2_1	74	76	PF00082	0.218
CLV_PCSK_SKI1_1	201	205	PF00082	0.251
CLV_PCSK_SKI1_1	242	246	PF00082	0.263
CLV_PCSK_SKI1_1	329	333	PF00082	0.404
CLV_PCSK_SKI1_1	39	43	PF00082	0.171
DEG_APCC_DBOX_1	74	82	PF00400	0.380
DEG_Kelch_Keap1_1	103	108	PF01344	0.419
DOC_CYCLIN_yCln2_LP_2	256	262	PF00134	0.354
DOC_MAPK_gen_1	273	280	PF00069	0.419
DOC_MAPK_HePTP_8	219	231	PF00069	0.388
DOC_MAPK_MEF2A_6	222	231	PF00069	0.388
DOC_MAPK_MEF2A_6	307	315	PF00069	0.388
DOC_PP1_RVXF_1	199	205	PF00149	0.450
DOC_PP2B_LxvP_1	256	259	PF13499	0.356
DOC_PP4_FxxP_1	231	234	PF00568	0.354
DOC_USP7_MATH_1	5	9	PF00917	0.387
DOC_USP7_MATH_1	83	87	PF00917	0.511
DOC_USP7_MATH_2	261	267	PF00917	0.380
DOC_USP7_UBL2_3	242	246	PF12436	0.419
DOC_WW_Pin1_4	181	186	PF00397	0.486
DOC_WW_Pin1_4	22	27	PF00397	0.463
DOC_WW_Pin1_4	266	271	PF00397	0.434
DOC_WW_Pin1_4	300	305	PF00397	0.354
DOC_WW_Pin1_4	86	91	PF00397	0.500
LIG_14-3-3_CanoR_1	273	279	PF00244	0.370
LIG_14-3-3_CanoR_1	39	48	PF00244	0.369
LIG_deltaCOP1_diTrp_1	142	150	PF00928	0.460
LIG_EH1_1	163	171	PF00400	0.354
LIG_eIF4E_1	164	170	PF01652	0.354
LIG_EVH1_1	78	82	PF00568	0.354
LIG_FHA_1	104	110	PF00498	0.459
LIG_FHA_1	134	140	PF00498	0.394
LIG_FHA_1	174	180	PF00498	0.395
LIG_FHA_1	182	188	PF00498	0.366
LIG_FHA_1	51	57	PF00498	0.449
LIG_FHA_1	89	95	PF00498	0.486
LIG_FHA_2	208	214	PF00498	0.374
LIG_FHA_2	27	33	PF00498	0.444
LIG_FHA_2	316	322	PF00498	0.505
LIG_GBD_Chelix_1	119	127	PF00786	0.276
LIG_LIR_Apic_2	228	234	PF02991	0.354
LIG_LIR_Gen_1	122	128	PF02991	0.430
LIG_LIR_Gen_1	251	261	PF02991	0.380
LIG_LIR_Nem_3	122	127	PF02991	0.430
LIG_LIR_Nem_3	9	15	PF02991	0.388
LIG_PCNA_yPIPBox_3	64	75	PF02747	0.363
LIG_Pex14_2	203	207	PF04695	0.419
LIG_REV1ctd_RIR_1	68	78	PF16727	0.380
LIG_SH2_CRK	124	128	PF00017	0.388
LIG_SH2_NCK_1	57	61	PF00017	0.441
LIG_SH2_SRC	57	60	PF00017	0.511
LIG_SH2_STAP1	254	258	PF00017	0.380
LIG_SH2_STAP1	57	61	PF00017	0.388
LIG_SH2_STAT3	162	165	PF00017	0.380
LIG_SH2_STAT5	33	36	PF00017	0.392
LIG_SH2_STAT5	92	95	PF00017	0.463
LIG_SH3_3	20	26	PF00018	0.354
LIG_SH3_3	76	82	PF00018	0.524
LIG_SUMO_SIM_anti_2	312	318	PF11976	0.508
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.397
LIG_SxIP_EBH_1	3	13	PF03271	0.341
LIG_TRFH_1	124	128	PF08558	0.431
MOD_CDK_SPK_2	300	305	PF00069	0.354
MOD_CDK_SPxxK_3	266	273	PF00069	0.380
MOD_CDK_SPxxK_3	300	307	PF00069	0.354
MOD_CK1_1	183	189	PF00069	0.393
MOD_CK1_1	266	272	PF00069	0.380
MOD_CK1_1	31	37	PF00069	0.451
MOD_CK1_1	86	92	PF00069	0.373
MOD_CK2_1	207	213	PF00069	0.431
MOD_CK2_1	26	32	PF00069	0.388
MOD_CK2_1	315	321	PF00069	0.505
MOD_GlcNHglycan	159	162	PF01048	0.251
MOD_GlcNHglycan	189	192	PF01048	0.191
MOD_GlcNHglycan	231	234	PF01048	0.205
MOD_GlcNHglycan	85	88	PF01048	0.243
MOD_GSK3_1	129	136	PF00069	0.458
MOD_GSK3_1	179	186	PF00069	0.539
MOD_GSK3_1	203	210	PF00069	0.380
MOD_GSK3_1	22	29	PF00069	0.369
MOD_GSK3_1	225	232	PF00069	0.523
MOD_GSK3_1	88	95	PF00069	0.510
MOD_N-GLC_1	300	305	PF02516	0.248
MOD_NEK2_1	19	24	PF00069	0.444
MOD_NEK2_1	203	208	PF00069	0.394
MOD_NEK2_1	227	232	PF00069	0.446
MOD_NEK2_1	274	279	PF00069	0.437
MOD_NEK2_1	289	294	PF00069	0.535
MOD_NMyristoyl	1	7	PF02799	0.408
MOD_PIKK_1	39	45	PF00454	0.369
MOD_PKA_1	39	45	PF00069	0.388
MOD_PKA_2	274	280	PF00069	0.367
MOD_PKA_2	39	45	PF00069	0.435
MOD_Plk_1	225	231	PF00069	0.362
MOD_Plk_4	19	25	PF00069	0.444
MOD_Plk_4	207	213	PF00069	0.380
MOD_Plk_4	88	94	PF00069	0.354
MOD_ProDKin_1	181	187	PF00069	0.486
MOD_ProDKin_1	22	28	PF00069	0.463
MOD_ProDKin_1	266	272	PF00069	0.434
MOD_ProDKin_1	300	306	PF00069	0.354
MOD_ProDKin_1	86	92	PF00069	0.500
MOD_SUMO_rev_2	172	179	PF00179	0.393
TRG_DiLeu_BaEn_1	105	110	PF01217	0.529
TRG_DiLeu_BaEn_1	122	127	PF01217	0.360
TRG_ENDOCYTIC_2	124	127	PF00928	0.388
TRG_ENDOCYTIC_2	164	167	PF00928	0.394
TRG_ENDOCYTIC_2	254	257	PF00928	0.380
TRG_ENDOCYTIC_2	57	60	PF00928	0.449
TRG_ER_diArg_1	38	40	PF00400	0.388
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.188
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.169

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7I9	Leptomonas seymouri	64%	100%
A0A0N0P7W9	Leptomonas seymouri	31%	100%
A0A0N1I1D8	Leptomonas seymouri	41%	100%
A0A0N1I836	Leptomonas seymouri	29%	100%
A0A0N1I9R7	Leptomonas seymouri	24%	100%
A0A0N1ILU0	Leptomonas seymouri	28%	89%
A0A0N1IM34	Leptomonas seymouri	31%	100%
A0A0N1PEM6	Leptomonas seymouri	27%	86%
A0A1X0NRL0	Trypanosomatidae	30%	100%
A0A1X0NYN3	Trypanosomatidae	35%	100%
A0A1X0NYY3	Trypanosomatidae	33%	100%
A0A1X0P2Q4	Trypanosomatidae	28%	97%
A0A3Q8IAZ9	Leishmania donovani	28%	89%
A0A3Q8IDX0	Leishmania donovani	41%	100%
A0A3Q8IEU6	Leishmania donovani	28%	100%
A0A3R7M7Z1	Trypanosoma rangeli	31%	100%
A0A3S7X1G8	Leishmania donovani	29%	100%
A0A422MX56	Trypanosoma rangeli	32%	100%
A0A422N4F0	Trypanosoma rangeli	27%	88%
A1A8B5	Escherichia coli O1:K1 / APEC	32%	100%
A1JNL2	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	30%	100%
A4HGI1	Leishmania braziliensis	79%	100%
A4HGI6	Leishmania braziliensis	41%	100%
A4HGI8	Leishmania braziliensis	27%	94%
A4HGI9	Leishmania braziliensis	27%	84%
A4HGJ0	Leishmania braziliensis	29%	99%
A4I3L4	Leishmania infantum	41%	100%
A4I3L5	Leishmania infantum	28%	89%
A4I3L6	Leishmania infantum	28%	86%
A4I3L7	Leishmania infantum	28%	100%
A4TPD3	Yersinia pestis (strain Pestoides F)	30%	100%
A4W7B7	Enterobacter sp. (strain 638)	32%	100%
A6T5I9	Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)	30%	100%
A7FLB5	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	29%	100%
A7MFJ6	Cronobacter sakazakii (strain ATCC BAA-894)	31%	100%
A7ZIK4	Escherichia coli O139:H28 (strain E24377A / ETEC)	32%	100%
A7ZXA4	Escherichia coli O9:H4 (strain HS)	32%	100%
A8AK07	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	30%	100%
A8GAR8	Serratia proteamaculans (strain 568)	28%	100%
A9MM14	Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)	31%	100%
A9MWC0	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	31%	100%
A9QZP3	Yersinia pestis bv. Antiqua (strain Angola)	30%	100%
B1IZE7	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	33%	100%
B1JHR2	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	29%	100%
B1LJK3	Escherichia coli (strain SMS-3-5 / SECEC)	32%	100%
B1XFN4	Escherichia coli (strain K12 / DH10B)	32%	100%
B2K6W6	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	29%	100%
B2U4Q1	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	32%	100%
B4SWV0	Salmonella newport (strain SL254)	31%	100%
B4T9F2	Salmonella heidelberg (strain SL476)	31%	100%
B4TMD5	Salmonella schwarzengrund (strain CVM19633)	30%	100%
B5BD74	Salmonella paratyphi A (strain AKU_12601)	31%	100%
B5EXJ7	Salmonella agona (strain SL483)	31%	100%
B5FKW1	Salmonella dublin (strain CT_02021853)	31%	100%
B5QU47	Salmonella enteritidis PT4 (strain P125109)	31%	100%
B5R6V8	Salmonella gallinarum (strain 287/91 / NCTC 13346)	31%	100%
B5Y0T3	Klebsiella pneumoniae (strain 342)	30%	100%
B5Z3V4	Escherichia coli O157:H7 (strain EC4115 / EHEC)	33%	100%
B6HZQ3	Escherichia coli (strain SE11)	32%	100%
B7L683	Escherichia coli (strain 55989 / EAEC)	32%	100%
B7LMD3	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	33%	100%
B7M3T9	Escherichia coli O8 (strain IAI1)	32%	100%
B7MDA5	Escherichia coli O45:K1 (strain S88 / ExPEC)	32%	100%
B7MQG2	Escherichia coli O81 (strain ED1a)	32%	100%
B7N900	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	32%	100%
B7NJ48	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	32%	100%
B7UJR9	Escherichia coli O127:H6 (strain E2348/69 / EPEC)	32%	100%
C4ZTK3	Escherichia coli (strain K12 / MC4100 / BW2952)	32%	100%
D0A7S2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D0A841	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AZV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AZV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	88%
E9AZV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	86%
E9AZV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
P27848	Escherichia coli (strain K12)	34%	100%
P44771	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	33%	100%
P46891	Escherichia coli (strain K12)	32%	100%
P57140	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	26%	100%
P94592	Bacillus subtilis (strain 168)	26%	100%
Q0T7D7	Shigella flexneri serotype 5b (strain 8401)	33%	100%
Q0TKJ5	Escherichia coli O6:K15:H31 (strain 536 / UPEC)	32%	100%
Q1C4L7	Yersinia pestis bv. Antiqua (strain Antiqua)	30%	100%
Q1CL56	Yersinia pestis bv. Antiqua (strain Nepal516)	30%	100%
Q1RF89	Escherichia coli (strain UTI89 / UPEC)	32%	100%
Q325F5	Shigella boydii serotype 4 (strain Sb227)	32%	100%
Q3Z4V2	Shigella sonnei (strain Ss046)	32%	100%
Q4Q8C8	Leishmania major	28%	100%
Q4Q8C9	Leishmania major	29%	84%
Q4Q8D0	Leishmania major	28%	90%
Q4Q8D1	Leishmania major	42%	100%
Q57SA6	Salmonella choleraesuis (strain SC-B67)	31%	100%
Q5PFM4	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	31%	100%
Q66DS5	Yersinia pseudotuberculosis serotype I (strain IP32953)	29%	100%
Q7CK25	Yersinia pestis	30%	100%
Q83M49	Shigella flexneri	33%	100%
Q89B25	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	24%	100%
Q8FKA2	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	32%	100%
Q8KA73	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	25%	100%
Q8X8L6	Escherichia coli O157:H7	33%	100%
Q8XE50	Escherichia coli O157:H7	33%	100%
Q8Z8U7	Salmonella typhi	31%	100%
Q8ZRB6	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	31%	100%
V5BGL5	Trypanosoma cruzi	31%	100%
V5D8D2	Trypanosoma cruzi	34%	100%