Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGR0_LEIDO

TriTrypDb:

LdBPK_320370.1 , LdCL_320008600 , LDHU3_32.0460

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0030990	intraciliary transport particle	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A0A3Q8IGR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.788
CLV_NRD_NRD_1	18	20	PF00675	0.412
CLV_NRD_NRD_1	236	238	PF00675	0.572
CLV_NRD_NRD_1	249	251	PF00675	0.518
CLV_PCSK_FUR_1	149	153	PF00082	0.589
CLV_PCSK_KEX2_1	151	153	PF00082	0.643
CLV_PCSK_KEX2_1	18	20	PF00082	0.412
CLV_PCSK_KEX2_1	249	251	PF00082	0.617
CLV_PCSK_KEX2_1	340	342	PF00082	0.665
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.643
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.665
CLV_PCSK_SKI1_1	152	156	PF00082	0.667
CLV_PCSK_SKI1_1	237	241	PF00082	0.595
CLV_PCSK_SKI1_1	249	253	PF00082	0.522
DEG_APCC_DBOX_1	248	256	PF00400	0.602
DEG_Nend_UBRbox_3	1	3	PF02207	0.575
DOC_ANK_TNKS_1	94	101	PF00023	0.629
DOC_CYCLIN_RxL_1	128	136	PF00134	0.461
DOC_USP7_MATH_1	284	288	PF00917	0.643
DOC_USP7_MATH_1	313	317	PF00917	0.705
DOC_USP7_MATH_1	99	103	PF00917	0.695
DOC_USP7_UBL2_3	163	167	PF12436	0.572
DOC_WW_Pin1_4	343	348	PF00397	0.645
DOC_WW_Pin1_4	54	59	PF00397	0.551
LIG_14-3-3_CanoR_1	140	146	PF00244	0.481
LIG_14-3-3_CanoR_1	152	162	PF00244	0.708
LIG_14-3-3_CanoR_1	18	22	PF00244	0.445
LIG_14-3-3_CanoR_1	237	244	PF00244	0.617
LIG_14-3-3_CanoR_1	293	297	PF00244	0.609
LIG_14-3-3_CanoR_1	90	99	PF00244	0.730
LIG_Clathr_ClatBox_1	132	136	PF01394	0.449
LIG_CSL_BTD_1	305	308	PF09270	0.649
LIG_FHA_2	202	208	PF00498	0.537
LIG_FHA_2	230	236	PF00498	0.497
LIG_LIR_Apic_2	294	299	PF02991	0.646
LIG_LIR_Apic_2	60	66	PF02991	0.650
LIG_NRBOX	128	134	PF00104	0.423
LIG_NRBOX	251	257	PF00104	0.597
LIG_PTAP_UEV_1	307	312	PF05743	0.575
LIG_SH2_SRC	296	299	PF00017	0.613
LIG_SH2_STAT3	5	8	PF00017	0.594
LIG_SH2_STAT5	169	172	PF00017	0.680
LIG_SH2_STAT5	87	90	PF00017	0.580
LIG_SH3_3	213	219	PF00018	0.581
LIG_SH3_3	302	308	PF00018	0.701
LIG_SH3_3	55	61	PF00018	0.593
LIG_SH3_4	163	170	PF00018	0.480
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.614
LIG_SUMO_SIM_par_1	130	136	PF11976	0.449
LIG_SUMO_SIM_par_1	322	329	PF11976	0.527
LIG_UBA3_1	132	138	PF00899	0.451
MOD_CK1_1	156	162	PF00069	0.700
MOD_CK1_1	17	23	PF00069	0.452
MOD_CK1_1	171	177	PF00069	0.678
MOD_CK1_1	316	322	PF00069	0.667
MOD_CK2_1	107	113	PF00069	0.588
MOD_CK2_1	180	186	PF00069	0.753
MOD_CK2_1	201	207	PF00069	0.519
MOD_CK2_1	275	281	PF00069	0.709
MOD_GlcNHglycan	155	158	PF01048	0.660
MOD_GlcNHglycan	170	173	PF01048	0.717
MOD_GlcNHglycan	179	183	PF01048	0.684
MOD_GlcNHglycan	277	280	PF01048	0.597
MOD_GlcNHglycan	311	314	PF01048	0.632
MOD_GlcNHglycan	329	333	PF01048	0.645
MOD_GlcNHglycan	337	340	PF01048	0.638
MOD_GlcNHglycan	35	38	PF01048	0.634
MOD_GlcNHglycan	50	53	PF01048	0.507
MOD_GSK3_1	107	114	PF00069	0.667
MOD_GSK3_1	152	159	PF00069	0.688
MOD_GSK3_1	167	174	PF00069	0.655
MOD_GSK3_1	17	24	PF00069	0.332
MOD_GSK3_1	309	316	PF00069	0.694
MOD_N-GLC_1	107	112	PF02516	0.555
MOD_N-GLC_1	152	157	PF02516	0.625
MOD_N-GLC_1	21	26	PF02516	0.319
MOD_N-GLC_1	67	72	PF02516	0.512
MOD_N-GLC_1	90	95	PF02516	0.672
MOD_N-GLC_2	42	44	PF02516	0.548
MOD_N-GLC_2	45	47	PF02516	0.544
MOD_NEK2_1	14	19	PF00069	0.366
MOD_NEK2_1	178	183	PF00069	0.720
MOD_NEK2_1	26	31	PF00069	0.478
MOD_NEK2_1	285	290	PF00069	0.642
MOD_NEK2_1	33	38	PF00069	0.481
MOD_NEK2_1	72	77	PF00069	0.557
MOD_NEK2_2	107	112	PF00069	0.770
MOD_PIKK_1	138	144	PF00454	0.552
MOD_PIKK_1	26	32	PF00454	0.546
MOD_PIKK_1	313	319	PF00454	0.662
MOD_PIKK_1	99	105	PF00454	0.619
MOD_PKA_1	237	243	PF00069	0.581
MOD_PKA_2	17	23	PF00069	0.446
MOD_PKA_2	292	298	PF00069	0.659
MOD_Plk_1	67	73	PF00069	0.626
MOD_Plk_2-3	201	207	PF00069	0.462
MOD_ProDKin_1	343	349	PF00069	0.647
MOD_ProDKin_1	54	60	PF00069	0.548
MOD_SUMO_rev_2	130	139	PF00179	0.427
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.425
TRG_NES_CRM1_1	125	136	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J4	Leptomonas seymouri	58%	98%
A0A1X0P6Q1	Trypanosomatidae	37%	86%
A0A3R7RRK4	Trypanosoma rangeli	35%	92%
A4HK16	Leishmania braziliensis	77%	98%
A4I7K0	Leishmania infantum	99%	100%
D0A0A3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B2F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q5P9	Leishmania major	94%	100%