Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGQ7_LEIDO

TriTrypDb:

LdBPK_330600.1 , LdCL_330011500 , LDHU3_33.0880

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032991	protein-containing complex	1	1
GO:0034708	methyltransferase complex	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0043527	tRNA methyltransferase complex	5	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A0A3Q8IGQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGQ7

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	10
GO:0006399	tRNA metabolic process	7	10
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	10
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0032259	methylation	2	11
GO:0034470	ncRNA processing	7	10
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	10
GO:0036265	RNA (guanine-N7)-methylation	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0043414	macromolecule methylation	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:0006400	tRNA modification	6	1
GO:0030488	tRNA methylation	5	1
GO:0106004	tRNA (guanine-N7)-methylation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	419	423	PF00656	0.430
CLV_C14_Caspase3-7	73	77	PF00656	0.341
CLV_MEL_PAP_1	368	374	PF00089	0.371
CLV_NRD_NRD_1	120	122	PF00675	0.697
CLV_NRD_NRD_1	235	237	PF00675	0.349
CLV_NRD_NRD_1	535	537	PF00675	0.588
CLV_PCSK_FUR_1	532	536	PF00082	0.623
CLV_PCSK_KEX2_1	120	122	PF00082	0.697
CLV_PCSK_KEX2_1	153	155	PF00082	0.354
CLV_PCSK_KEX2_1	235	237	PF00082	0.354
CLV_PCSK_KEX2_1	440	442	PF00082	0.417
CLV_PCSK_KEX2_1	534	536	PF00082	0.603
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.354
CLV_PCSK_PC1ET2_1	440	442	PF00082	0.405
CLV_PCSK_SKI1_1	153	157	PF00082	0.351
CLV_PCSK_SKI1_1	196	200	PF00082	0.481
CLV_PCSK_SKI1_1	235	239	PF00082	0.321
CLV_PCSK_SKI1_1	383	387	PF00082	0.370
DOC_ANK_TNKS_1	344	351	PF00023	0.388
DOC_CDC14_PxL_1	5	13	PF14671	0.431
DOC_CYCLIN_RxL_1	229	241	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.469
DOC_MAPK_gen_1	440	447	PF00069	0.330
DOC_PP1_RVXF_1	177	183	PF00149	0.462
DOC_PP1_RVXF_1	55	62	PF00149	0.410
DOC_PP2B_LxvP_1	213	216	PF13499	0.428
DOC_PP2B_LxvP_1	304	307	PF13499	0.517
DOC_PP2B_LxvP_1	62	65	PF13499	0.387
DOC_PP4_FxxP_1	372	375	PF00568	0.440
DOC_PP4_FxxP_1	396	399	PF00568	0.424
DOC_USP7_MATH_1	246	250	PF00917	0.338
DOC_USP7_MATH_1	285	289	PF00917	0.579
DOC_USP7_MATH_1	330	334	PF00917	0.467
DOC_USP7_MATH_1	412	416	PF00917	0.589
DOC_USP7_MATH_1	427	431	PF00917	0.332
DOC_USP7_MATH_1	44	48	PF00917	0.529
DOC_USP7_UBL2_3	564	568	PF12436	0.663
DOC_WW_Pin1_4	180	185	PF00397	0.474
DOC_WW_Pin1_4	38	43	PF00397	0.647
LIG_14-3-3_CanoR_1	154	159	PF00244	0.431
LIG_14-3-3_CanoR_1	177	183	PF00244	0.408
LIG_14-3-3_CanoR_1	264	268	PF00244	0.482
LIG_14-3-3_CanoR_1	3	11	PF00244	0.449
LIG_14-3-3_CanoR_1	418	422	PF00244	0.457
LIG_14-3-3_CanoR_1	424	430	PF00244	0.435
LIG_14-3-3_CanoR_1	511	518	PF00244	0.433
LIG_AP2alpha_1	168	172	PF02296	0.300
LIG_BIR_III_2	422	426	PF00653	0.421
LIG_BRCT_BRCA1_1	392	396	PF00533	0.361
LIG_FHA_1	109	115	PF00498	0.635
LIG_FHA_1	150	156	PF00498	0.388
LIG_FHA_1	185	191	PF00498	0.490
LIG_FHA_1	197	203	PF00498	0.412
LIG_FHA_1	208	214	PF00498	0.365
LIG_FHA_1	252	258	PF00498	0.363
LIG_FHA_1	335	341	PF00498	0.486
LIG_FHA_1	433	439	PF00498	0.431
LIG_FHA_2	158	164	PF00498	0.423
LIG_FHA_2	417	423	PF00498	0.389
LIG_FHA_2	505	511	PF00498	0.635
LIG_LIR_Apic_2	140	144	PF02991	0.553
LIG_LIR_Apic_2	370	375	PF02991	0.433
LIG_LIR_Apic_2	393	399	PF02991	0.432
LIG_LIR_Gen_1	336	346	PF02991	0.372
LIG_LIR_Gen_1	446	455	PF02991	0.481
LIG_LIR_Gen_1	523	531	PF02991	0.521
LIG_LIR_Gen_1	76	85	PF02991	0.439
LIG_LIR_Nem_3	170	175	PF02991	0.321
LIG_LIR_Nem_3	336	341	PF02991	0.370
LIG_LIR_Nem_3	354	359	PF02991	0.419
LIG_LIR_Nem_3	394	400	PF02991	0.320
LIG_LIR_Nem_3	446	450	PF02991	0.446
LIG_LIR_Nem_3	523	529	PF02991	0.509
LIG_LIR_Nem_3	76	82	PF02991	0.436
LIG_MYND_3	482	486	PF01753	0.496
LIG_Pex14_1	142	146	PF04695	0.443
LIG_Pex14_2	168	172	PF04695	0.300
LIG_SH2_CRK	401	405	PF00017	0.545
LIG_SH2_NCK_1	401	405	PF00017	0.395
LIG_SH2_NCK_1	526	530	PF00017	0.480
LIG_SH2_SRC	146	149	PF00017	0.429
LIG_SH2_STAP1	286	290	PF00017	0.540
LIG_SH2_STAP1	308	312	PF00017	0.404
LIG_SH2_STAT5	255	258	PF00017	0.480
LIG_SH2_STAT5	279	282	PF00017	0.626
LIG_SH2_STAT5	311	314	PF00017	0.359
LIG_SH2_STAT5	484	487	PF00017	0.450
LIG_SH3_3	343	349	PF00018	0.502
LIG_SH3_3	372	378	PF00018	0.354
LIG_SH3_3	450	456	PF00018	0.390
LIG_SH3_3	477	483	PF00018	0.553
LIG_SH3_3	525	531	PF00018	0.497
LIG_SH3_3	62	68	PF00018	0.521
LIG_SH3_4	143	150	PF00018	0.512
LIG_SUMO_SIM_par_1	185	191	PF11976	0.528
LIG_TRAF2_1	225	228	PF00917	0.558
LIG_TRAF2_1	498	501	PF00917	0.604
LIG_WRC_WIRS_1	341	346	PF05994	0.486
MOD_CK1_1	157	163	PF00069	0.514
MOD_CK1_1	206	212	PF00069	0.328
MOD_CK1_1	266	272	PF00069	0.344
MOD_CK1_1	417	423	PF00069	0.515
MOD_CK1_1	547	553	PF00069	0.676
MOD_CK1_1	555	561	PF00069	0.600
MOD_CK2_1	157	163	PF00069	0.490
MOD_CK2_1	275	281	PF00069	0.410
MOD_CK2_1	330	336	PF00069	0.489
MOD_CK2_1	427	433	PF00069	0.432
MOD_CK2_1	510	516	PF00069	0.508
MOD_Cter_Amidation	566	569	PF01082	0.616
MOD_GlcNHglycan	227	232	PF01048	0.540
MOD_GlcNHglycan	268	271	PF01048	0.370
MOD_GlcNHglycan	414	417	PF01048	0.541
MOD_GlcNHglycan	549	552	PF01048	0.631
MOD_GlcNHglycan	559	562	PF01048	0.664
MOD_GlcNHglycan	72	75	PF01048	0.328
MOD_GSK3_1	149	156	PF00069	0.412
MOD_GSK3_1	178	185	PF00069	0.461
MOD_GSK3_1	192	199	PF00069	0.276
MOD_GSK3_1	203	210	PF00069	0.326
MOD_GSK3_1	223	230	PF00069	0.357
MOD_GSK3_1	3	10	PF00069	0.575
MOD_GSK3_1	306	313	PF00069	0.383
MOD_GSK3_1	330	337	PF00069	0.466
MOD_GSK3_1	360	367	PF00069	0.544
MOD_GSK3_1	40	47	PF00069	0.606
MOD_GSK3_1	412	419	PF00069	0.445
MOD_GSK3_1	459	466	PF00069	0.724
MOD_LATS_1	151	157	PF00433	0.359
MOD_N-GLC_1	3	8	PF02516	0.618
MOD_N-GLC_1	300	305	PF02516	0.567
MOD_N-GLC_1	334	339	PF02516	0.513
MOD_N-GLC_1	547	552	PF02516	0.612
MOD_N-GLC_1	83	88	PF02516	0.523
MOD_N-GLC_1	97	102	PF02516	0.611
MOD_NEK2_1	211	216	PF00069	0.340
MOD_NEK2_1	260	265	PF00069	0.509
MOD_NEK2_1	340	345	PF00069	0.438
MOD_NEK2_1	520	525	PF00069	0.517
MOD_NEK2_2	405	410	PF00069	0.343
MOD_OFUCOSY	234	240	PF10250	0.425
MOD_PKA_1	120	126	PF00069	0.694
MOD_PKA_1	153	159	PF00069	0.346
MOD_PKA_2	120	126	PF00069	0.713
MOD_PKA_2	153	159	PF00069	0.346
MOD_PKA_2	178	184	PF00069	0.430
MOD_PKA_2	246	252	PF00069	0.336
MOD_PKA_2	263	269	PF00069	0.411
MOD_PKA_2	417	423	PF00069	0.457
MOD_PKA_2	510	516	PF00069	0.461
MOD_Plk_1	275	281	PF00069	0.501
MOD_Plk_1	286	292	PF00069	0.612
MOD_Plk_1	300	306	PF00069	0.704
MOD_Plk_1	334	340	PF00069	0.452
MOD_Plk_1	432	438	PF00069	0.404
MOD_Plk_1	83	89	PF00069	0.507
MOD_Plk_2-3	510	516	PF00069	0.505
MOD_Plk_4	162	168	PF00069	0.344
MOD_Plk_4	196	202	PF00069	0.371
MOD_Plk_4	251	257	PF00069	0.431
MOD_Plk_4	306	312	PF00069	0.426
MOD_Plk_4	360	366	PF00069	0.370
MOD_Plk_4	44	50	PF00069	0.512
MOD_Plk_4	443	449	PF00069	0.451
MOD_ProDKin_1	180	186	PF00069	0.482
MOD_ProDKin_1	38	44	PF00069	0.640
MOD_SUMO_for_1	137	140	PF00179	0.583
MOD_SUMO_rev_2	73	80	PF00179	0.367
TRG_DiLeu_BaEn_1	336	341	PF01217	0.391
TRG_DiLeu_BaEn_2	432	438	PF01217	0.390
TRG_ENDOCYTIC_2	401	404	PF00928	0.429
TRG_ENDOCYTIC_2	526	529	PF00928	0.479
TRG_ER_diArg_1	176	179	PF00400	0.453
TRG_ER_diArg_1	235	237	PF00400	0.359
TRG_ER_diArg_1	344	347	PF00400	0.473
TRG_ER_diArg_1	531	534	PF00400	0.546
TRG_NES_CRM1_1	54	66	PF08389	0.402
TRG_NLS_MonoExtC_3	567	572	PF00514	0.703
TRG_NLS_MonoExtN_4	120	125	PF00514	0.580
TRG_NLS_MonoExtN_4	568	573	PF00514	0.703
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL73	Leptomonas seymouri	66%	100%
A0A1X0P0S8	Trypanosomatidae	29%	100%
A0A422N539	Trypanosoma rangeli	32%	100%
A4HL95	Leishmania braziliensis	79%	99%
A4I8S1	Leishmania infantum	99%	100%
D0A4R4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B3N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4F0	Leishmania major	94%	100%
V5D2Q1	Trypanosoma cruzi	32%	100%