KIF-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

KIF-binding protein

Gene product:

KIF-1 binding protein C terminal, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGQ4_LEIDO

TriTrypDb:

LdBPK_252200.1 , LdCL_250027800 , LDHU3_25.2670

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A0A3Q8IGQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	331	335	PF00656	0.358
CLV_NRD_NRD_1	257	259	PF00675	0.429
CLV_NRD_NRD_1	415	417	PF00675	0.235
CLV_NRD_NRD_1	464	466	PF00675	0.310
CLV_NRD_NRD_1	484	486	PF00675	0.125
CLV_NRD_NRD_1	524	526	PF00675	0.250
CLV_PCSK_FUR_1	413	417	PF00082	0.310
CLV_PCSK_KEX2_1	415	417	PF00082	0.235
CLV_PCSK_KEX2_1	524	526	PF00082	0.265
CLV_PCSK_PC7_1	520	526	PF00082	0.250
CLV_PCSK_SKI1_1	158	162	PF00082	0.317
CLV_PCSK_SKI1_1	322	326	PF00082	0.183
CLV_PCSK_SKI1_1	444	448	PF00082	0.215
CLV_PCSK_SKI1_1	473	477	PF00082	0.310
CLV_PCSK_SKI1_1	579	583	PF00082	0.339
DEG_APCC_DBOX_1	310	318	PF00400	0.472
DEG_APCC_DBOX_1	443	451	PF00400	0.415
DEG_APCC_DBOX_1	578	586	PF00400	0.425
DEG_Nend_UBRbox_2	1	3	PF02207	0.413
DOC_CKS1_1	534	539	PF01111	0.496
DOC_CYCLIN_RxL_1	441	449	PF00134	0.415
DOC_CYCLIN_RxL_1	59	70	PF00134	0.387
DOC_CYCLIN_yClb1_LxF_4	142	148	PF00134	0.386
DOC_MAPK_gen_1	524	530	PF00069	0.450
DOC_MAPK_MEF2A_6	204	212	PF00069	0.329
DOC_PP1_RVXF_1	551	558	PF00149	0.429
DOC_USP7_MATH_1	127	131	PF00917	0.427
DOC_USP7_MATH_1	236	240	PF00917	0.511
DOC_USP7_MATH_1	298	302	PF00917	0.450
DOC_USP7_MATH_1	384	388	PF00917	0.464
DOC_USP7_MATH_1	569	573	PF00917	0.510
DOC_USP7_MATH_1	98	102	PF00917	0.348
DOC_USP7_UBL2_3	370	374	PF12436	0.472
DOC_WW_Pin1_4	533	538	PF00397	0.510
LIG_14-3-3_CanoR_1	258	262	PF00244	0.441
LIG_14-3-3_CanoR_1	485	489	PF00244	0.524
LIG_14-3-3_CanoR_1	499	509	PF00244	0.544
LIG_14-3-3_CterR_2	598	601	PF00244	0.561
LIG_Actin_WH2_2	180	198	PF00022	0.350
LIG_APCC_ABBA_1	45	50	PF00400	0.447
LIG_BRCT_BRCA1_1	23	27	PF00533	0.590
LIG_BRCT_BRCA1_1	272	276	PF00533	0.446
LIG_deltaCOP1_diTrp_1	170	175	PF00928	0.400
LIG_deltaCOP1_diTrp_1	341	347	PF00928	0.399
LIG_eIF4E_1	403	409	PF01652	0.467
LIG_FHA_1	195	201	PF00498	0.458
LIG_FHA_1	217	223	PF00498	0.295
LIG_FHA_1	261	267	PF00498	0.429
LIG_FHA_1	388	394	PF00498	0.415
LIG_FHA_1	501	507	PF00498	0.497
LIG_FHA_1	94	100	PF00498	0.360
LIG_FHA_2	118	124	PF00498	0.382
LIG_FHA_2	157	163	PF00498	0.375
LIG_FHA_2	323	329	PF00498	0.510
LIG_FHA_2	359	365	PF00498	0.414
LIG_FHA_2	534	540	PF00498	0.510
LIG_FHA_2	68	74	PF00498	0.290
LIG_FXI_DFP_1	344	348	PF00024	0.264
LIG_GBD_Chelix_1	442	450	PF00786	0.215
LIG_LIR_Apic_2	496	501	PF02991	0.415
LIG_LIR_Apic_2	531	537	PF02991	0.496
LIG_LIR_Gen_1	245	256	PF02991	0.319
LIG_LIR_Gen_1	279	287	PF02991	0.467
LIG_LIR_Nem_3	245	251	PF02991	0.295
LIG_LIR_Nem_3	269	275	PF02991	0.447
LIG_LIR_Nem_3	279	285	PF02991	0.500
LIG_LIR_Nem_3	341	347	PF02991	0.413
LIG_LIR_Nem_3	435	439	PF02991	0.435
LIG_LIR_Nem_3	539	544	PF02991	0.415
LIG_LIR_Nem_3	591	596	PF02991	0.327
LIG_LIR_Nem_3	78	84	PF02991	0.513
LIG_LYPXL_SIV_4	277	285	PF13949	0.510
LIG_LYPXL_SIV_4	438	446	PF13949	0.510
LIG_LYPXL_yS_3	439	442	PF13949	0.415
LIG_MAD2	14	22	PF02301	0.398
LIG_MLH1_MIPbox_1	272	276	PF16413	0.450
LIG_MYND_1	351	355	PF01753	0.433
LIG_Pex14_2	27	31	PF04695	0.487
LIG_Pex14_2	494	498	PF04695	0.423
LIG_Pex14_2	6	10	PF04695	0.321
LIG_PTB_Apo_2	474	481	PF02174	0.375
LIG_REV1ctd_RIR_1	516	524	PF16727	0.429
LIG_SH2_CRK	138	142	PF00017	0.344
LIG_SH2_CRK	248	252	PF00017	0.284
LIG_SH2_CRK	320	324	PF00017	0.472
LIG_SH2_CRK	403	407	PF00017	0.446
LIG_SH2_CRK	534	538	PF00017	0.460
LIG_SH2_CRK	541	545	PF00017	0.416
LIG_SH2_NCK_1	278	282	PF00017	0.467
LIG_SH2_STAP1	218	222	PF00017	0.330
LIG_SH2_STAP1	272	276	PF00017	0.415
LIG_SH2_STAP1	278	282	PF00017	0.415
LIG_SH2_STAP1	454	458	PF00017	0.472
LIG_SH2_STAP1	551	555	PF00017	0.496
LIG_SH2_STAT3	454	457	PF00017	0.463
LIG_SH2_STAT5	148	151	PF00017	0.307
LIG_SH2_STAT5	218	221	PF00017	0.316
LIG_SH2_STAT5	241	244	PF00017	0.334
LIG_SH2_STAT5	275	278	PF00017	0.436
LIG_SH2_STAT5	313	316	PF00017	0.421
LIG_SH3_1	345	351	PF00018	0.467
LIG_SH3_3	345	351	PF00018	0.438
LIG_SH3_3	352	358	PF00018	0.418
LIG_SUMO_SIM_par_1	63	70	PF11976	0.241
LIG_TRAF2_1	252	255	PF00917	0.299
LIG_TRAF2_1	294	297	PF00917	0.358
LIG_TRAF2_1	537	540	PF00917	0.429
LIG_TYR_ITIM	136	141	PF00017	0.349
LIG_TYR_ITIM	246	251	PF00017	0.265
LIG_UBA3_1	336	342	PF00899	0.417
LIG_UBA3_1	581	588	PF00899	0.436
LIG_WRC_WIRS_1	359	364	PF05994	0.415
LIG_WRC_WIRS_1	385	390	PF05994	0.450
MOD_CDK_SPK_2	533	538	PF00069	0.510
MOD_CK1_1	216	222	PF00069	0.434
MOD_CK1_1	260	266	PF00069	0.467
MOD_CK1_1	387	393	PF00069	0.450
MOD_CK2_1	117	123	PF00069	0.377
MOD_CK2_1	249	255	PF00069	0.279
MOD_CK2_1	322	328	PF00069	0.510
MOD_CK2_1	358	364	PF00069	0.472
MOD_CK2_1	449	455	PF00069	0.534
MOD_CK2_1	533	539	PF00069	0.510
MOD_CK2_1	67	73	PF00069	0.284
MOD_CMANNOS	171	174	PF00535	0.314
MOD_GlcNHglycan	120	123	PF01048	0.580
MOD_GlcNHglycan	129	132	PF01048	0.540
MOD_GlcNHglycan	199	203	PF01048	0.507
MOD_GlcNHglycan	268	271	PF01048	0.215
MOD_GSK3_1	118	125	PF00069	0.579
MOD_GSK3_1	187	194	PF00069	0.488
MOD_GSK3_1	214	221	PF00069	0.293
MOD_GSK3_1	266	273	PF00069	0.415
MOD_N-GLC_1	117	122	PF02516	0.506
MOD_N-GLC_1	16	21	PF02516	0.454
MOD_NEK2_1	117	122	PF00069	0.470
MOD_NEK2_1	147	152	PF00069	0.314
MOD_NEK2_1	214	219	PF00069	0.336
MOD_NEK2_1	266	271	PF00069	0.442
MOD_NEK2_1	340	345	PF00069	0.510
MOD_NEK2_1	40	45	PF00069	0.346
MOD_NEK2_1	494	499	PF00069	0.415
MOD_NEK2_1	66	71	PF00069	0.392
MOD_NEK2_2	218	223	PF00069	0.358
MOD_NEK2_2	242	247	PF00069	0.288
MOD_PIKK_1	236	242	PF00454	0.465
MOD_PKA_2	257	263	PF00069	0.323
MOD_PKA_2	40	46	PF00069	0.350
MOD_PKA_2	484	490	PF00069	0.467
MOD_Plk_1	122	128	PF00069	0.484
MOD_Plk_1	214	220	PF00069	0.350
MOD_Plk_1	340	346	PF00069	0.488
MOD_Plk_1	511	517	PF00069	0.472
MOD_Plk_2-3	328	334	PF00069	0.417
MOD_Plk_2-3	449	455	PF00069	0.562
MOD_Plk_4	156	162	PF00069	0.375
MOD_Plk_4	218	224	PF00069	0.297
MOD_Plk_4	271	277	PF00069	0.410
MOD_Plk_4	40	46	PF00069	0.410
MOD_Plk_4	449	455	PF00069	0.494
MOD_Plk_4	67	73	PF00069	0.361
MOD_ProDKin_1	533	539	PF00069	0.510
MOD_SUMO_for_1	29	32	PF00179	0.484
MOD_SUMO_for_1	537	540	PF00179	0.429
MOD_SUMO_rev_2	24	31	PF00179	0.439
MOD_SUMO_rev_2	295	304	PF00179	0.466
TRG_DiLeu_BaEn_1	300	305	PF01217	0.496
TRG_DiLeu_BaEn_1	580	585	PF01217	0.429
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.392
TRG_ENDOCYTIC_2	138	141	PF00928	0.346
TRG_ENDOCYTIC_2	248	251	PF00928	0.282
TRG_ENDOCYTIC_2	320	323	PF00928	0.422
TRG_ENDOCYTIC_2	403	406	PF00928	0.415
TRG_ENDOCYTIC_2	439	442	PF00928	0.415
TRG_ENDOCYTIC_2	491	494	PF00928	0.429
TRG_ENDOCYTIC_2	541	544	PF00928	0.429
TRG_ENDOCYTIC_2	81	84	PF00928	0.454
TRG_ENDOCYTIC_2	88	91	PF00928	0.374
TRG_ER_diArg_1	413	416	PF00400	0.444
TRG_ER_diArg_1	458	461	PF00400	0.475
TRG_ER_diArg_1	523	525	PF00400	0.450
TRG_NES_CRM1_1	398	410	PF08389	0.467
TRG_NES_CRM1_1	566	580	PF08389	0.510
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.404
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	444	449	PF00026	0.197
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFB1	Leptomonas seymouri	72%	100%
A0A1X0NY49	Trypanosomatidae	47%	100%
A0A3R7RTL1	Trypanosoma rangeli	46%	100%
A4HEB4	Leishmania braziliensis	84%	100%
A4I1R0	Leishmania infantum	99%	100%
A8WE67	Danio rerio	28%	95%
C9ZKB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AXU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q0IIZ5	Xenopus tropicalis	26%	98%
Q3SYS9	Bos taurus	27%	97%
Q4G074	Rattus norvegicus	28%	97%
Q4Q9M7	Leishmania major	94%	100%
Q5ZIL9	Gallus gallus	28%	100%
Q6ZPU9	Mus musculus	28%	97%
Q96EK5	Homo sapiens	27%	97%
Q9VMX1	Drosophila melanogaster	24%	100%
V5ASJ5	Trypanosoma cruzi	47%	97%