CRAL/TRIO_domain_containing_protein_putative/Pfam:PF00650

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGQ2_LEIDO

TriTrypDb:

LdBPK_321320.1 , LdCL_320018900 , LDHU3_32.1680

Length:

478

Annotations

LeishMANIAdb annotations

Carries a conserved CRAL-TRIO domain. Its didtant homologs are cytoplasmic and are involved in antiviral response.

Annotations by Jardim et al.

Transporters, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	433	437	PF00656	0.524
CLV_NRD_NRD_1	149	151	PF00675	0.402
CLV_NRD_NRD_1	168	170	PF00675	0.188
CLV_NRD_NRD_1	221	223	PF00675	0.273
CLV_PCSK_KEX2_1	149	151	PF00082	0.402
CLV_PCSK_KEX2_1	221	223	PF00082	0.282
CLV_PCSK_KEX2_1	417	419	PF00082	0.571
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.604
CLV_PCSK_SKI1_1	169	173	PF00082	0.317
CLV_PCSK_SKI1_1	241	245	PF00082	0.343
CLV_PCSK_SKI1_1	279	283	PF00082	0.395
CLV_PCSK_SKI1_1	414	418	PF00082	0.669
CLV_PCSK_SKI1_1	77	81	PF00082	0.432
DEG_APCC_DBOX_1	148	156	PF00400	0.431
DOC_CKS1_1	53	58	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.337
DOC_MAPK_gen_1	169	177	PF00069	0.402
DOC_MAPK_gen_1	221	229	PF00069	0.297
DOC_MAPK_gen_1	404	412	PF00069	0.576
DOC_MAPK_MEF2A_6	169	177	PF00069	0.232
DOC_MAPK_MEF2A_6	404	412	PF00069	0.576
DOC_PP1_RVXF_1	290	296	PF00149	0.308
DOC_PP4_FxxP_1	295	298	PF00568	0.361
DOC_SPAK_OSR1_1	387	391	PF12202	0.466
DOC_USP7_MATH_1	304	308	PF00917	0.388
DOC_WW_Pin1_4	124	129	PF00397	0.561
DOC_WW_Pin1_4	134	139	PF00397	0.411
DOC_WW_Pin1_4	294	299	PF00397	0.432
DOC_WW_Pin1_4	472	477	PF00397	0.485
DOC_WW_Pin1_4	52	57	PF00397	0.491
LIG_14-3-3_CanoR_1	131	137	PF00244	0.449
LIG_14-3-3_CanoR_1	22	30	PF00244	0.483
LIG_14-3-3_CanoR_1	279	289	PF00244	0.393
LIG_14-3-3_CanoR_1	387	391	PF00244	0.408
LIG_14-3-3_CanoR_1	418	426	PF00244	0.510
LIG_14-3-3_CanoR_1	465	473	PF00244	0.492
LIG_BIR_II_1	1	5	PF00653	0.512
LIG_BRCT_BRCA1_1	388	392	PF00533	0.397
LIG_deltaCOP1_diTrp_1	372	378	PF00928	0.335
LIG_deltaCOP1_diTrp_1	97	104	PF00928	0.455
LIG_FHA_1	1	7	PF00498	0.540
LIG_FHA_1	162	168	PF00498	0.443
LIG_FHA_1	22	28	PF00498	0.439
LIG_FHA_1	224	230	PF00498	0.325
LIG_FHA_1	300	306	PF00498	0.396
LIG_FHA_1	349	355	PF00498	0.425
LIG_FHA_1	35	41	PF00498	0.375
LIG_FHA_1	48	54	PF00498	0.492
LIG_FHA_2	16	22	PF00498	0.351
LIG_FHA_2	177	183	PF00498	0.315
LIG_FHA_2	417	423	PF00498	0.596
LIG_FHA_2	92	98	PF00498	0.287
LIG_LIR_Apic_2	294	298	PF02991	0.376
LIG_LIR_Apic_2	436	441	PF02991	0.516
LIG_LIR_Apic_2	97	101	PF02991	0.305
LIG_LIR_Gen_1	182	193	PF02991	0.402
LIG_LIR_Gen_1	385	394	PF02991	0.472
LIG_LIR_Nem_3	182	188	PF02991	0.306
LIG_LIR_Nem_3	235	239	PF02991	0.370
LIG_LIR_Nem_3	36	41	PF02991	0.465
LIG_MAD2	264	272	PF02301	0.324
LIG_Pex14_2	184	188	PF04695	0.232
LIG_Pex14_2	38	42	PF04695	0.277
LIG_Pex14_2	388	392	PF04695	0.365
LIG_Pex14_2	88	92	PF04695	0.396
LIG_REV1ctd_RIR_1	86	95	PF16727	0.277
LIG_SH2_CRK	278	282	PF00017	0.361
LIG_SH2_CRK	65	69	PF00017	0.340
LIG_SH2_NCK_1	109	113	PF00017	0.298
LIG_SH2_SRC	202	205	PF00017	0.258
LIG_SH2_STAP1	65	69	PF00017	0.430
LIG_SH2_STAT3	393	396	PF00017	0.481
LIG_SH3_1	170	176	PF00018	0.212
LIG_SH3_3	170	176	PF00018	0.449
LIG_SH3_3	265	271	PF00018	0.392
LIG_SUMO_SIM_par_1	225	230	PF11976	0.375
LIG_TRAF2_1	18	21	PF00917	0.342
LIG_TRAF2_1	180	183	PF00917	0.212
LIG_TRFH_1	4	8	PF08558	0.318
LIG_TYR_ITIM	154	159	PF00017	0.417
LIG_TYR_ITIM	234	239	PF00017	0.400
LIG_WRC_WIRS_1	1	6	PF05994	0.358
MOD_CDK_SPxxK_3	124	131	PF00069	0.335
MOD_CK1_1	102	108	PF00069	0.473
MOD_CK1_1	455	461	PF00069	0.453
MOD_CK2_1	15	21	PF00069	0.357
MOD_CK2_1	176	182	PF00069	0.369
MOD_CK2_1	416	422	PF00069	0.577
MOD_CK2_1	472	478	PF00069	0.517
MOD_Cter_Amidation	358	361	PF01082	0.473
MOD_GlcNHglycan	101	104	PF01048	0.452
MOD_GlcNHglycan	282	285	PF01048	0.377
MOD_GSK3_1	294	301	PF00069	0.368
MOD_GSK3_1	333	340	PF00069	0.652
MOD_GSK3_1	377	384	PF00069	0.410
MOD_GSK3_1	412	419	PF00069	0.555
MOD_N-GLC_1	299	304	PF02516	0.386
MOD_N-GLC_2	223	225	PF02516	0.402
MOD_NEK2_1	122	127	PF00069	0.464
MOD_NEK2_1	244	249	PF00069	0.355
MOD_NEK2_1	280	285	PF00069	0.335
MOD_NEK2_1	378	383	PF00069	0.352
MOD_PIKK_1	21	27	PF00454	0.453
MOD_PKA_1	417	423	PF00069	0.551
MOD_PKA_2	21	27	PF00069	0.485
MOD_PKA_2	386	392	PF00069	0.447
MOD_PKA_2	417	423	PF00069	0.520
MOD_PKA_2	47	53	PF00069	0.406
MOD_Plk_1	412	418	PF00069	0.390
MOD_Plk_4	163	169	PF00069	0.337
MOD_Plk_4	223	229	PF00069	0.366
MOD_Plk_4	304	310	PF00069	0.398
MOD_Plk_4	434	440	PF00069	0.418
MOD_Plk_4	452	458	PF00069	0.347
MOD_ProDKin_1	124	130	PF00069	0.557
MOD_ProDKin_1	134	140	PF00069	0.409
MOD_ProDKin_1	294	300	PF00069	0.432
MOD_ProDKin_1	472	478	PF00069	0.493
MOD_ProDKin_1	52	58	PF00069	0.482
MOD_SUMO_for_1	338	341	PF00179	0.455
MOD_SUMO_for_1	426	429	PF00179	0.438
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.428
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.516
TRG_ENDOCYTIC_2	130	133	PF00928	0.430
TRG_ENDOCYTIC_2	156	159	PF00928	0.388
TRG_ENDOCYTIC_2	236	239	PF00928	0.371
TRG_ENDOCYTIC_2	278	281	PF00928	0.375
TRG_ENDOCYTIC_2	65	68	PF00928	0.344
TRG_ER_diArg_1	220	222	PF00400	0.268
TRG_ER_diArg_1	407	410	PF00400	0.572
TRG_NLS_MonoExtC_3	168	173	PF00514	0.232
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6D4	Leptomonas seymouri	27%	91%
A0A0N0P991	Leptomonas seymouri	67%	100%
A0A0N0P9K9	Leptomonas seymouri	29%	100%
A0A0N1I2J8	Leptomonas seymouri	33%	100%
A0A0N1PCS4	Leptomonas seymouri	31%	100%
A0A0S4J7N0	Bodo saltans	25%	100%
A0A0S4KJL3	Bodo saltans	32%	100%
A0A1X0NUH5	Trypanosomatidae	25%	82%
A0A1X0NUJ5	Trypanosomatidae	30%	100%
A0A3Q8ICN0	Leishmania donovani	30%	100%
A0A3R7MUL5	Trypanosoma rangeli	24%	87%
A0A3S7X4P4	Leishmania donovani	28%	92%
A0A3S7X4R1	Leishmania donovani	32%	97%
A0A422P1E3	Trypanosoma rangeli	28%	100%
A4HJI7	Leishmania braziliensis	29%	100%
A4HJI8	Leishmania braziliensis	31%	100%
A4HJI9	Leishmania braziliensis	31%	100%
A4HKB3	Leishmania braziliensis	83%	100%
A4HKB4	Leishmania braziliensis	24%	99%
A4I6Y2	Leishmania infantum	29%	100%
A4I6Y3	Leishmania infantum	32%	100%
A4I6Y4	Leishmania infantum	30%	100%
A4I7U3	Leishmania infantum	100%	100%
A8Y5H7	Mus musculus	22%	67%
E9B204	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B205	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B206	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B2Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q0V9N0	Xenopus tropicalis	25%	68%
Q16KN5	Aedes aegypti	21%	74%
Q29JQ0	Drosophila pseudoobscura pseudoobscura	24%	71%
Q4Q5F6	Leishmania major	94%	100%
Q4Q655	Leishmania major	29%	100%
Q4Q656	Leishmania major	33%	99%
Q4Q657	Leishmania major	28%	100%
Q7PWB1	Anopheles gambiae	20%	70%
Q92503	Homo sapiens	22%	67%
Q9VMD6	Drosophila melanogaster	23%	73%
V5BL84	Trypanosoma cruzi	27%	100%
V5BQT0	Trypanosoma cruzi	25%	86%