Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGP8_LEIDO

TriTrypDb:

LdBPK_366090.1 , LdCL_360068300 , LDHU3_36.8020

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IGP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGP8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.573
CLV_C14_Caspase3-7	91	95	PF00656	0.622
CLV_NRD_NRD_1	121	123	PF00675	0.504
CLV_NRD_NRD_1	127	129	PF00675	0.502
CLV_NRD_NRD_1	150	152	PF00675	0.735
CLV_NRD_NRD_1	173	175	PF00675	0.731
CLV_NRD_NRD_1	177	179	PF00675	0.737
CLV_NRD_NRD_1	40	42	PF00675	0.495
CLV_PCSK_KEX2_1	127	129	PF00082	0.512
CLV_PCSK_KEX2_1	173	175	PF00082	0.752
CLV_PCSK_KEX2_1	177	179	PF00082	0.763
CLV_PCSK_KEX2_1	202	204	PF00082	0.686
CLV_PCSK_KEX2_1	39	41	PF00082	0.490
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.720
CLV_PCSK_PC7_1	173	179	PF00082	0.572
CLV_PCSK_SKI1_1	106	110	PF00082	0.462
CLV_PCSK_SKI1_1	139	143	PF00082	0.659
CLV_PCSK_SKI1_1	241	245	PF00082	0.564
CLV_PCSK_SKI1_1	32	36	PF00082	0.630
CLV_PCSK_SKI1_1	80	84	PF00082	0.486
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DEG_SPOP_SBC_1	300	304	PF00917	0.764
DOC_ANK_TNKS_1	231	238	PF00023	0.588
DOC_CKS1_1	140	145	PF01111	0.619
DOC_CKS1_1	319	324	PF01111	0.688
DOC_MAPK_gen_1	104	113	PF00069	0.522
DOC_MAPK_MEF2A_6	139	147	PF00069	0.655
DOC_USP7_MATH_1	158	162	PF00917	0.756
DOC_USP7_MATH_1	194	198	PF00917	0.716
DOC_USP7_MATH_1	299	303	PF00917	0.741
DOC_USP7_MATH_1	339	343	PF00917	0.759
DOC_USP7_UBL2_3	164	168	PF12436	0.691
DOC_WW_Pin1_4	139	144	PF00397	0.649
DOC_WW_Pin1_4	208	213	PF00397	0.590
DOC_WW_Pin1_4	274	279	PF00397	0.735
DOC_WW_Pin1_4	288	293	PF00397	0.758
DOC_WW_Pin1_4	318	323	PF00397	0.764
DOC_WW_Pin1_4	332	337	PF00397	0.726
DOC_WW_Pin1_4	99	104	PF00397	0.577
LIG_14-3-3_CanoR_1	173	180	PF00244	0.797
LIG_14-3-3_CanoR_1	203	209	PF00244	0.518
LIG_14-3-3_CanoR_1	239	244	PF00244	0.618
LIG_14-3-3_CanoR_1	40	50	PF00244	0.490
LIG_14-3-3_CanoR_1	8	12	PF00244	0.560
LIG_BRCT_BRCA1_1	43	47	PF00533	0.586
LIG_BRCT_BRCA1_2	43	49	PF00533	0.481
LIG_DCNL_PONY_1	1	4	PF03556	0.688
LIG_FHA_1	140	146	PF00498	0.697
LIG_FHA_1	310	316	PF00498	0.757
LIG_FHA_1	82	88	PF00498	0.483
LIG_FHA_2	190	196	PF00498	0.573
LIG_FHA_2	242	248	PF00498	0.576
LIG_FHA_2	33	39	PF00498	0.622
LIG_FHA_2	81	87	PF00498	0.412
LIG_LIR_Gen_1	211	221	PF02991	0.515
LIG_LIR_Gen_1	83	89	PF02991	0.424
LIG_LIR_Nem_3	211	216	PF02991	0.497
LIG_LIR_Nem_3	238	243	PF02991	0.615
LIG_LIR_Nem_3	44	50	PF02991	0.514
LIG_LIR_Nem_3	83	88	PF02991	0.424
LIG_PDZ_Class_2	342	347	PF00595	0.669
LIG_PTAP_UEV_1	153	158	PF05743	0.569
LIG_PTB_Apo_2	92	99	PF02174	0.423
LIG_Rb_LxCxE_1	18	35	PF01857	0.538
LIG_SH2_STAP1	213	217	PF00017	0.503
LIG_SH2_STAP1	85	89	PF00017	0.396
LIG_SH2_STAT5	78	81	PF00017	0.609
LIG_SH3_1	151	157	PF00018	0.744
LIG_SH3_2	146	151	PF14604	0.723
LIG_SH3_3	137	143	PF00018	0.589
LIG_SH3_3	151	157	PF00018	0.782
LIG_SH3_3	206	212	PF00018	0.656
LIG_SH3_3	289	295	PF00018	0.753
LIG_SH3_3	317	323	PF00018	0.705
LIG_SH3_3	333	339	PF00018	0.545
LIG_TRAF2_1	244	247	PF00917	0.655
LIG_UBA3_1	55	59	PF00899	0.583
MOD_CDK_SPK_2	332	337	PF00069	0.709
MOD_CDK_SPK_2	99	104	PF00069	0.605
MOD_CDK_SPxxK_3	99	106	PF00069	0.521
MOD_CK1_1	159	165	PF00069	0.825
MOD_CK1_1	172	178	PF00069	0.586
MOD_CK1_1	277	283	PF00069	0.756
MOD_CK1_1	302	308	PF00069	0.812
MOD_CK1_1	309	315	PF00069	0.720
MOD_CK2_1	113	119	PF00069	0.407
MOD_CK2_1	241	247	PF00069	0.602
MOD_CK2_1	27	33	PF00069	0.560
MOD_CK2_1	80	86	PF00069	0.440
MOD_CK2_1	99	105	PF00069	0.499
MOD_GlcNHglycan	158	161	PF01048	0.778
MOD_GlcNHglycan	191	195	PF01048	0.725
MOD_GlcNHglycan	281	284	PF01048	0.746
MOD_GlcNHglycan	328	331	PF01048	0.758
MOD_GSK3_1	152	159	PF00069	0.751
MOD_GSK3_1	190	197	PF00069	0.687
MOD_GSK3_1	302	309	PF00069	0.779
MOD_GSK3_1	326	333	PF00069	0.797
MOD_GSK3_1	339	346	PF00069	0.754
MOD_N-GLC_1	27	32	PF02516	0.510
MOD_N-GLC_1	326	331	PF02516	0.806
MOD_NEK2_1	2	7	PF00069	0.590
MOD_PIKK_1	202	208	PF00454	0.525
MOD_PIKK_1	302	308	PF00454	0.797
MOD_PIKK_1	313	319	PF00454	0.616
MOD_PIKK_1	339	345	PF00454	0.684
MOD_PIKK_1	41	47	PF00454	0.454
MOD_PKA_1	152	158	PF00069	0.657
MOD_PKA_1	202	208	PF00069	0.699
MOD_PKA_1	48	54	PF00069	0.526
MOD_PKA_2	126	132	PF00069	0.547
MOD_PKA_2	172	178	PF00069	0.732
MOD_PKA_2	2	8	PF00069	0.628
MOD_PKA_2	202	208	PF00069	0.729
MOD_PKB_1	239	247	PF00069	0.633
MOD_PKB_1	39	47	PF00069	0.381
MOD_Plk_1	27	33	PF00069	0.512
MOD_ProDKin_1	139	145	PF00069	0.648
MOD_ProDKin_1	208	214	PF00069	0.586
MOD_ProDKin_1	274	280	PF00069	0.736
MOD_ProDKin_1	288	294	PF00069	0.756
MOD_ProDKin_1	318	324	PF00069	0.767
MOD_ProDKin_1	332	338	PF00069	0.716
MOD_ProDKin_1	99	105	PF00069	0.573
MOD_SUMO_rev_2	102	111	PF00179	0.568
MOD_SUMO_rev_2	271	278	PF00179	0.721
TRG_ENDOCYTIC_2	114	117	PF00928	0.549
TRG_ENDOCYTIC_2	213	216	PF00928	0.486
TRG_ENDOCYTIC_2	85	88	PF00928	0.418
TRG_ER_diArg_1	232	235	PF00400	0.592
TRG_ER_diArg_1	39	41	PF00400	0.401
TRG_NLS_Bipartite_1	151	170	PF00514	0.701
TRG_NLS_MonoExtC_3	165	170	PF00514	0.753
TRG_NLS_MonoExtN_4	149	155	PF00514	0.683
TRG_NLS_MonoExtN_4	164	170	PF00514	0.747
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P908	Leptomonas seymouri	47%	97%
A0A1X0NMA4	Trypanosomatidae	28%	100%
A0A3R7NVJ3	Trypanosoma rangeli	29%	100%
A4HQA0	Leishmania braziliensis	68%	99%
A4IDZ6	Leishmania infantum	100%	100%
D0A409	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AU18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q0H7	Leishmania major	88%	100%