Protein HGH1 homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGP7_LEIDO

TriTrypDb:

LdBPK_332170.1 , LdCL_330028700 , LDHU3_33.3150

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IGP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.446
CLV_C14_Caspase3-7	70	74	PF00656	0.516
CLV_NRD_NRD_1	109	111	PF00675	0.399
CLV_NRD_NRD_1	113	115	PF00675	0.348
CLV_NRD_NRD_1	40	42	PF00675	0.354
CLV_PCSK_KEX2_1	335	337	PF00082	0.292
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.292
CLV_PCSK_SKI1_1	224	228	PF00082	0.302
CLV_PCSK_SKI1_1	335	339	PF00082	0.444
CLV_PCSK_SKI1_1	84	88	PF00082	0.473
DEG_APCC_DBOX_1	223	231	PF00400	0.354
DEG_APCC_KENBOX_2	52	56	PF00400	0.412
DOC_MAPK_gen_1	110	119	PF00069	0.364
DOC_MAPK_gen_1	53	62	PF00069	0.343
DOC_MAPK_MEF2A_6	134	143	PF00069	0.333
DOC_MAPK_MEF2A_6	224	233	PF00069	0.294
DOC_MAPK_MEF2A_6	53	62	PF00069	0.554
DOC_USP7_MATH_1	16	20	PF00917	0.586
DOC_USP7_MATH_1	211	215	PF00917	0.762
DOC_USP7_MATH_1	49	53	PF00917	0.344
DOC_USP7_MATH_1	99	103	PF00917	0.430
DOC_USP7_UBL2_3	111	115	PF12436	0.383
DOC_WW_Pin1_4	256	261	PF00397	0.467
DOC_WW_Pin1_4	275	280	PF00397	0.422
DOC_WW_Pin1_4	61	66	PF00397	0.395
LIG_14-3-3_CanoR_1	250	260	PF00244	0.531
LIG_14-3-3_CanoR_1	263	268	PF00244	0.394
LIG_APCC_ABBA_1	174	179	PF00400	0.448
LIG_APCC_ABBA_1	391	396	PF00400	0.362
LIG_APCC_ABBAyCdc20_2	173	179	PF00400	0.452
LIG_deltaCOP1_diTrp_1	57	61	PF00928	0.406
LIG_FHA_1	138	144	PF00498	0.319
LIG_FHA_1	232	238	PF00498	0.460
LIG_FHA_1	372	378	PF00498	0.601
LIG_FHA_1	90	96	PF00498	0.311
LIG_FHA_2	151	157	PF00498	0.420
LIG_FHA_2	292	298	PF00498	0.377
LIG_GBD_Chelix_1	312	320	PF00786	0.367
LIG_LIR_Apic_2	400	405	PF02991	0.551
LIG_LIR_Gen_1	28	36	PF02991	0.415
LIG_LIR_Gen_1	57	67	PF02991	0.392
LIG_LIR_Nem_3	28	33	PF02991	0.381
LIG_LIR_Nem_3	57	62	PF02991	0.407
LIG_MYND_3	392	396	PF01753	0.337
LIG_NRBOX	226	232	PF00104	0.307
LIG_PCNA_yPIPBox_3	302	316	PF02747	0.470
LIG_Rb_LxCxE_1	294	314	PF01857	0.394
LIG_RPA_C_Fungi	215	227	PF08784	0.329
LIG_SH2_CRK	283	287	PF00017	0.463
LIG_SH2_PTP2	402	405	PF00017	0.594
LIG_SH2_SRC	78	81	PF00017	0.451
LIG_SH2_STAP1	178	182	PF00017	0.468
LIG_SH2_STAT5	132	135	PF00017	0.502
LIG_SH2_STAT5	170	173	PF00017	0.375
LIG_SH2_STAT5	394	397	PF00017	0.477
LIG_SH2_STAT5	402	405	PF00017	0.448
LIG_SH2_STAT5	78	81	PF00017	0.451
LIG_SUMO_SIM_anti_2	138	143	PF11976	0.313
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.338
LIG_TRAF2_1	135	138	PF00917	0.362
LIG_UBA3_1	75	84	PF00899	0.472
MOD_CDK_SPK_2	275	280	PF00069	0.473
MOD_CDK_SPxxK_3	256	263	PF00069	0.471
MOD_CK1_1	150	156	PF00069	0.357
MOD_CK1_1	19	25	PF00069	0.552
MOD_CK1_1	214	220	PF00069	0.510
MOD_CK1_1	255	261	PF00069	0.483
MOD_CK1_1	3	9	PF00069	0.664
MOD_CK2_1	132	138	PF00069	0.421
MOD_CK2_1	180	186	PF00069	0.395
MOD_CK2_1	308	314	PF00069	0.437
MOD_CK2_1	315	321	PF00069	0.485
MOD_CK2_1	356	362	PF00069	0.600
MOD_CK2_1	379	385	PF00069	0.437
MOD_CK2_1	99	105	PF00069	0.402
MOD_GlcNHglycan	18	21	PF01048	0.546
MOD_GlcNHglycan	182	185	PF01048	0.538
MOD_GlcNHglycan	205	208	PF01048	0.579
MOD_GlcNHglycan	6	9	PF01048	0.718
MOD_GlcNHglycan	97	100	PF01048	0.411
MOD_GSK3_1	146	153	PF00069	0.350
MOD_GSK3_1	2	9	PF00069	0.648
MOD_GSK3_1	210	217	PF00069	0.629
MOD_GSK3_1	249	256	PF00069	0.391
MOD_GSK3_1	315	322	PF00069	0.474
MOD_GSK3_1	371	378	PF00069	0.630
MOD_GSK3_1	67	74	PF00069	0.432
MOD_GSK3_1	95	102	PF00069	0.464
MOD_N-GLC_1	145	150	PF02516	0.310
MOD_N-GLC_1	231	236	PF02516	0.314
MOD_N-GLC_1	95	100	PF02516	0.343
MOD_NEK2_1	147	152	PF00069	0.349
MOD_NEK2_1	215	220	PF00069	0.509
MOD_NEK2_1	231	236	PF00069	0.288
MOD_NEK2_1	253	258	PF00069	0.417
MOD_NEK2_1	315	320	PF00069	0.408
MOD_NEK2_1	342	347	PF00069	0.500
MOD_NEK2_1	387	392	PF00069	0.377
MOD_OFUCOSY	97	103	PF10250	0.389
MOD_PIKK_1	342	348	PF00454	0.370
MOD_PK_1	328	334	PF00069	0.491
MOD_PKA_2	249	255	PF00069	0.551
MOD_Plk_1	137	143	PF00069	0.321
MOD_Plk_1	220	226	PF00069	0.452
MOD_Plk_4	137	143	PF00069	0.320
MOD_Plk_4	315	321	PF00069	0.479
MOD_Plk_4	379	385	PF00069	0.403
MOD_Plk_4	387	393	PF00069	0.409
MOD_Plk_4	71	77	PF00069	0.330
MOD_Plk_4	89	95	PF00069	0.312
MOD_ProDKin_1	256	262	PF00069	0.468
MOD_ProDKin_1	275	281	PF00069	0.423
MOD_ProDKin_1	61	67	PF00069	0.392
TRG_DiLeu_BaEn_2	27	33	PF01217	0.367
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.334
TRG_ENDOCYTIC_2	178	181	PF00928	0.403
TRG_ENDOCYTIC_2	283	286	PF00928	0.529
TRG_ER_diArg_1	262	265	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC4	Leptomonas seymouri	69%	94%
A0A0S4J7H7	Bodo saltans	36%	100%
A0A1X0P3N1	Trypanosomatidae	49%	100%
A0A422N467	Trypanosoma rangeli	48%	100%
A4HLR7	Leishmania braziliensis	76%	100%
A4I943	Leishmania infantum	100%	100%
D0A6A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B443	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q3Y2	Leishmania major	88%	97%
V5BTV3	Trypanosoma cruzi	48%	92%