Proteasome assembly chaperone 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGP4_LEIDO

TriTrypDb:

LdBPK_251970.1 , LdCL_250025500 , LDHU3_25.2440

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGP4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0043248	proteasome assembly	6	7
GO:0043933	protein-containing complex organization	4	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.330
CLV_PCSK_FUR_1	168	172	PF00082	0.330
CLV_PCSK_KEX2_1	170	172	PF00082	0.330
CLV_PCSK_SKI1_1	176	180	PF00082	0.330
CLV_PCSK_SKI1_1	197	201	PF00082	0.461
CLV_PCSK_SKI1_1	60	64	PF00082	0.472
CLV_PCSK_SKI1_1	93	97	PF00082	0.489
DEG_APCC_DBOX_1	175	183	PF00400	0.330
DOC_CYCLIN_RxL_1	194	202	PF00134	0.521
DOC_MAPK_FxFP_2	64	67	PF00069	0.513
DOC_MAPK_MEF2A_6	176	184	PF00069	0.330
DOC_MAPK_MEF2A_6	93	100	PF00069	0.474
DOC_MAPK_NFAT4_5	93	101	PF00069	0.478
DOC_PP1_RVXF_1	58	65	PF00149	0.529
DOC_PP4_FxxP_1	64	67	PF00568	0.541
DOC_USP7_MATH_1	26	30	PF00917	0.711
DOC_USP7_MATH_1	67	71	PF00917	0.521
DOC_WW_Pin1_4	138	143	PF00397	0.430
DOC_WW_Pin1_4	214	219	PF00397	0.640
DOC_WW_Pin1_4	42	47	PF00397	0.639
DOC_WW_Pin1_4	8	13	PF00397	0.609
LIG_14-3-3_CanoR_1	27	33	PF00244	0.656
LIG_14-3-3_CanoR_1	60	65	PF00244	0.419
LIG_BRCT_BRCA1_1	142	146	PF00533	0.330
LIG_FHA_1	139	145	PF00498	0.440
LIG_FHA_1	156	162	PF00498	0.429
LIG_FHA_1	173	179	PF00498	0.330
LIG_FHA_1	9	15	PF00498	0.602
LIG_LIR_Apic_2	61	67	PF02991	0.534
LIG_LIR_Gen_1	105	111	PF02991	0.370
LIG_LIR_Gen_1	143	152	PF02991	0.330
LIG_LIR_Nem_3	105	109	PF02991	0.373
LIG_LIR_Nem_3	143	149	PF02991	0.330
LIG_SH2_CRK	125	129	PF00017	0.439
LIG_SH2_NCK_1	125	129	PF00017	0.546
LIG_SH2_PTP2	106	109	PF00017	0.343
LIG_SH2_STAT5	106	109	PF00017	0.361
LIG_SH3_3	212	218	PF00018	0.475
LIG_SH3_3	43	49	PF00018	0.610
LIG_TYR_ITIM	104	109	PF00017	0.386
LIG_UBA3_1	1	9	PF00899	0.590
MOD_CDC14_SPxK_1	217	220	PF00782	0.630
MOD_CDK_SPxK_1	214	220	PF00069	0.606
MOD_CK1_1	42	48	PF00069	0.575
MOD_CK1_1	70	76	PF00069	0.649
MOD_GlcNHglycan	162	165	PF01048	0.389
MOD_GSK3_1	109	116	PF00069	0.523
MOD_GSK3_1	180	187	PF00069	0.330
MOD_GSK3_1	22	29	PF00069	0.643
MOD_GSK3_1	36	43	PF00069	0.582
MOD_GSK3_1	67	74	PF00069	0.528
MOD_N-GLC_1	191	196	PF02516	0.400
MOD_NEK2_1	1	6	PF00069	0.591
MOD_NEK2_1	160	165	PF00069	0.483
MOD_NEK2_1	180	185	PF00069	0.183
MOD_NEK2_1	191	196	PF00069	0.427
MOD_NEK2_1	28	33	PF00069	0.661
MOD_NEK2_1	96	101	PF00069	0.360
MOD_PKA_2	26	32	PF00069	0.609
MOD_PKB_1	58	66	PF00069	0.479
MOD_Plk_1	88	94	PF00069	0.457
MOD_Plk_2-3	140	146	PF00069	0.330
MOD_Plk_4	1	7	PF00069	0.557
MOD_Plk_4	180	186	PF00069	0.330
MOD_ProDKin_1	138	144	PF00069	0.430
MOD_ProDKin_1	214	220	PF00069	0.606
MOD_ProDKin_1	42	48	PF00069	0.640
MOD_ProDKin_1	8	14	PF00069	0.611
TRG_DiLeu_LyEn_5	174	179	PF01217	0.330
TRG_ENDOCYTIC_2	106	109	PF00928	0.361
TRG_ER_diArg_1	168	171	PF00400	0.330
TRG_ER_diArg_1	57	60	PF00400	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W5	Leptomonas seymouri	64%	100%
A4HE91	Leishmania braziliensis	76%	100%
A4I1N7	Leishmania infantum	100%	100%
E9AXS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9Q0	Leishmania major	96%	100%