Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGN7_LEIDO

TriTrypDb:

LdBPK_280890.1 , LdCL_280013500 , LDHU3_28.1060

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	146	150	PF00082	0.480
CLV_PCSK_KEX2_1	148	150	PF00082	0.721
CLV_PCSK_KEX2_1	206	208	PF00082	0.618
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.461
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.618
CLV_PCSK_SKI1_1	206	210	PF00082	0.490
CLV_PCSK_SKI1_1	79	83	PF00082	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.649
DOC_CYCLIN_yClb5_NLxxxL_5	219	228	PF00134	0.609
DOC_MAPK_gen_1	17	25	PF00069	0.538
DOC_MAPK_RevD_3	133	149	PF00069	0.521
DOC_MIT_MIM_1	201	211	PF04212	0.553
DOC_USP7_MATH_1	155	159	PF00917	0.621
DOC_USP7_MATH_1	175	179	PF00917	0.632
DOC_USP7_MATH_1	46	50	PF00917	0.585
DOC_USP7_MATH_1	75	79	PF00917	0.614
DOC_WW_Pin1_4	119	124	PF00397	0.573
DOC_WW_Pin1_4	44	49	PF00397	0.510
LIG_14-3-3_CanoR_1	11	16	PF00244	0.577
LIG_14-3-3_CanoR_1	244	252	PF00244	0.612
LIG_BRCT_BRCA1_1	238	242	PF00533	0.596
LIG_CtBP_PxDLS_1	142	146	PF00389	0.520
LIG_FHA_1	223	229	PF00498	0.542
LIG_FHA_1	235	241	PF00498	0.616
LIG_FHA_1	29	35	PF00498	0.595
LIG_FHA_2	244	250	PF00498	0.614
LIG_FHA_2	90	96	PF00498	0.721
LIG_LIR_Gen_1	169	179	PF02991	0.653
LIG_LIR_Nem_3	169	174	PF02991	0.627
LIG_PDZ_Class_1	247	252	PF00595	0.530
LIG_SH2_CRK	171	175	PF00017	0.689
LIG_SH2_STAT5	110	113	PF00017	0.599
LIG_SH2_STAT5	151	154	PF00017	0.532
LIG_SH3_3	149	155	PF00018	0.536
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.600
LIG_UBA3_1	221	226	PF00899	0.609
MOD_CK1_1	128	134	PF00069	0.650
MOD_CK1_1	89	95	PF00069	0.604
MOD_CK2_1	128	134	PF00069	0.747
MOD_CK2_1	243	249	PF00069	0.615
MOD_CK2_1	90	96	PF00069	0.581
MOD_GlcNHglycan	201	204	PF01048	0.548
MOD_GlcNHglycan	234	237	PF01048	0.645
MOD_GlcNHglycan	25	28	PF01048	0.555
MOD_GlcNHglycan	48	51	PF01048	0.711
MOD_GlcNHglycan	83	86	PF01048	0.579
MOD_GlcNHglycan	88	91	PF01048	0.533
MOD_GSK3_1	155	162	PF00069	0.525
MOD_GSK3_1	206	213	PF00069	0.485
MOD_GSK3_1	232	239	PF00069	0.723
MOD_GSK3_1	243	250	PF00069	0.568
MOD_GSK3_1	40	47	PF00069	0.630
MOD_GSK3_1	86	93	PF00069	0.583
MOD_LATS_1	9	15	PF00433	0.593
MOD_N-GLC_1	128	133	PF02516	0.625
MOD_N-GLC_1	222	227	PF02516	0.591
MOD_N-GLC_2	245	247	PF02516	0.616
MOD_NEK2_1	136	141	PF00069	0.566
MOD_NEK2_1	222	227	PF00069	0.526
MOD_NEK2_1	40	45	PF00069	0.615
MOD_NEK2_1	99	104	PF00069	0.602
MOD_PIKK_1	62	68	PF00454	0.557
MOD_PIKK_1	90	96	PF00454	0.581
MOD_PKA_1	206	212	PF00069	0.484
MOD_PKA_2	206	212	PF00069	0.505
MOD_PKA_2	243	249	PF00069	0.615
MOD_Plk_1	175	181	PF00069	0.671
MOD_Plk_4	11	17	PF00069	0.582
MOD_Plk_4	166	172	PF00069	0.579
MOD_ProDKin_1	119	125	PF00069	0.579
MOD_ProDKin_1	44	50	PF00069	0.509
TRG_DiLeu_BaEn_1	217	222	PF01217	0.602
TRG_ENDOCYTIC_2	171	174	PF00928	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HGC5	Leishmania braziliensis	72%	100%
E9ADJ9	Leishmania major	89%	100%
E9AHH8	Leishmania infantum	98%	100%
E9AZP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%