Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGM7_LEIDO

TriTrypDb:

LdBPK_331750.1 , LdCL_330024200 , LDHU3_33.2610

Length:

265

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGM7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.539
CLV_NRD_NRD_1	30	32	PF00675	0.543
CLV_NRD_NRD_1	34	36	PF00675	0.517
CLV_PCSK_KEX2_1	171	173	PF00082	0.539
CLV_PCSK_KEX2_1	203	205	PF00082	0.550
CLV_PCSK_KEX2_1	30	32	PF00082	0.542
CLV_PCSK_KEX2_1	34	36	PF00082	0.517
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.516
CLV_PCSK_PC7_1	30	36	PF00082	0.472
CLV_PCSK_SKI1_1	35	39	PF00082	0.533
DOC_MAPK_FxFP_2	3	6	PF00069	0.423
DOC_MAPK_gen_1	253	262	PF00069	0.498
DOC_MAPK_gen_1	30	40	PF00069	0.480
DOC_MAPK_MEF2A_6	230	237	PF00069	0.491
DOC_PP4_FxxP_1	3	6	PF00568	0.395
DOC_USP7_MATH_1	56	60	PF00917	0.547
DOC_USP7_UBL2_3	226	230	PF12436	0.561
LIG_14-3-3_CanoR_1	171	180	PF00244	0.494
LIG_14-3-3_CanoR_1	210	217	PF00244	0.438
LIG_14-3-3_CanoR_1	253	262	PF00244	0.514
LIG_14-3-3_CanoR_1	34	38	PF00244	0.408
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BRCT_BRCA1_1	89	93	PF00533	0.317
LIG_Clathr_ClatBox_1	18	22	PF01394	0.432
LIG_Clathr_ClatBox_1	244	248	PF01394	0.496
LIG_FHA_1	13	19	PF00498	0.488
LIG_FHA_1	182	188	PF00498	0.510
LIG_FHA_1	255	261	PF00498	0.423
LIG_FHA_1	40	46	PF00498	0.479
LIG_FHA_1	81	87	PF00498	0.480
LIG_FHA_1	94	100	PF00498	0.314
LIG_FHA_2	142	148	PF00498	0.523
LIG_FHA_2	174	180	PF00498	0.528
LIG_FHA_2	49	55	PF00498	0.447
LIG_GBD_Chelix_1	99	107	PF00786	0.516
LIG_LIR_Gen_1	10	19	PF02991	0.471
LIG_LIR_Gen_1	216	224	PF02991	0.479
LIG_LIR_Gen_1	49	56	PF02991	0.375
LIG_LIR_Nem_3	10	14	PF02991	0.467
LIG_LIR_Nem_3	216	220	PF02991	0.436
LIG_LIR_Nem_3	49	53	PF02991	0.370
LIG_LIR_Nem_3	87	92	PF02991	0.459
LIG_NRBOX	190	196	PF00104	0.520
LIG_Pex14_2	245	249	PF04695	0.350
LIG_Pex14_2	89	93	PF04695	0.317
LIG_SH2_CRK	217	221	PF00017	0.501
LIG_SH2_NCK_1	143	147	PF00017	0.535
LIG_SH2_NCK_1	50	54	PF00017	0.487
LIG_SH2_STAT3	17	20	PF00017	0.474
LIG_SH2_STAT5	143	146	PF00017	0.489
LIG_SH2_STAT5	17	20	PF00017	0.353
LIG_SH2_STAT5	50	53	PF00017	0.440
LIG_SH3_3	40	46	PF00018	0.460
LIG_SUMO_SIM_par_1	93	98	PF11976	0.451
MOD_CK1_1	185	191	PF00069	0.465
MOD_CK1_1	49	55	PF00069	0.533
MOD_CK1_1	84	90	PF00069	0.535
MOD_CK2_1	171	177	PF00069	0.444
MOD_Cter_Amidation	32	35	PF01082	0.528
MOD_GlcNHglycan	206	210	PF01048	0.479
MOD_GlcNHglycan	89	92	PF01048	0.453
MOD_GSK3_1	181	188	PF00069	0.439
MOD_GSK3_1	205	212	PF00069	0.551
MOD_GSK3_1	248	255	PF00069	0.435
MOD_GSK3_1	80	87	PF00069	0.472
MOD_NEK2_1	12	17	PF00069	0.419
MOD_NEK2_1	182	187	PF00069	0.428
MOD_NEK2_1	205	210	PF00069	0.484
MOD_NEK2_1	21	26	PF00069	0.425
MOD_NEK2_1	38	43	PF00069	0.404
MOD_NEK2_1	48	53	PF00069	0.415
MOD_NEK2_1	81	86	PF00069	0.391
MOD_PIKK_1	12	18	PF00454	0.449
MOD_PKA_1	171	177	PF00069	0.540
MOD_PKA_2	171	177	PF00069	0.566
MOD_PKA_2	209	215	PF00069	0.480
MOD_PKA_2	222	228	PF00069	0.337
MOD_PKA_2	252	258	PF00069	0.515
MOD_PKA_2	33	39	PF00069	0.423
MOD_Plk_1	101	107	PF00069	0.422
MOD_Plk_1	21	27	PF00069	0.436
MOD_Plk_1	228	234	PF00069	0.438
MOD_Plk_4	229	235	PF00069	0.456
MOD_Plk_4	81	87	PF00069	0.475
TRG_ENDOCYTIC_2	217	220	PF00928	0.505
TRG_ENDOCYTIC_2	50	53	PF00928	0.406
TRG_ER_diArg_1	170	172	PF00400	0.513
TRG_ER_diArg_1	29	31	PF00400	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K0	Leptomonas seymouri	61%	100%
A0A1X0P1S9	Trypanosomatidae	29%	100%
A0A3R7MBB6	Trypanosoma rangeli	30%	98%
A4HLM6	Leishmania braziliensis	85%	100%
A4I937	Leishmania infantum	100%	100%
C9ZIV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	98%
E9B402	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q422	Leishmania major	96%	100%
V5AXA5	Trypanosoma cruzi	29%	98%