Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IGM6_LEIDO

TriTrypDb:

LdBPK_313130.1 , LdCL_310039600 , LDHU3_31.5340

Length:

470

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	225	227	PF00675	0.731
CLV_NRD_NRD_1	443	445	PF00675	0.791
CLV_PCSK_KEX2_1	78	80	PF00082	0.724
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.724
CLV_PCSK_SKI1_1	15	19	PF00082	0.551
CLV_PCSK_SKI1_1	266	270	PF00082	0.573
CLV_PCSK_SKI1_1	428	432	PF00082	0.700
DEG_APCC_DBOX_1	14	22	PF00400	0.637
DEG_APCC_DBOX_1	263	271	PF00400	0.493
DEG_SCF_FBW7_1	194	200	PF00400	0.649
DEG_SCF_FBW7_1	359	365	PF00400	0.615
DOC_CKS1_1	194	199	PF01111	0.672
DOC_CKS1_1	218	223	PF01111	0.680
DOC_CKS1_1	359	364	PF01111	0.615
DOC_CKS1_1	406	411	PF01111	0.680
DOC_MAPK_gen_1	264	272	PF00069	0.488
DOC_MAPK_gen_1	426	435	PF00069	0.698
DOC_MAPK_MEF2A_6	264	272	PF00069	0.488
DOC_PP1_RVXF_1	429	436	PF00149	0.762
DOC_PP4_FxxP_1	411	414	PF00568	0.679
DOC_PP4_FxxP_1	435	438	PF00568	0.707
DOC_USP7_MATH_1	106	110	PF00917	0.686
DOC_USP7_MATH_1	122	126	PF00917	0.633
DOC_USP7_MATH_1	158	162	PF00917	0.681
DOC_USP7_MATH_1	197	201	PF00917	0.620
DOC_USP7_MATH_1	219	223	PF00917	0.646
DOC_USP7_MATH_1	354	358	PF00917	0.819
DOC_USP7_MATH_1	401	405	PF00917	0.625
DOC_USP7_MATH_1	72	76	PF00917	0.693
DOC_WW_Pin1_4	153	158	PF00397	0.732
DOC_WW_Pin1_4	193	198	PF00397	0.728
DOC_WW_Pin1_4	212	217	PF00397	0.501
DOC_WW_Pin1_4	335	340	PF00397	0.717
DOC_WW_Pin1_4	355	360	PF00397	0.781
DOC_WW_Pin1_4	362	367	PF00397	0.670
DOC_WW_Pin1_4	379	384	PF00397	0.514
DOC_WW_Pin1_4	393	398	PF00397	0.571
DOC_WW_Pin1_4	405	410	PF00397	0.591
DOC_WW_Pin1_4	449	454	PF00397	0.751
DOC_WW_Pin1_4	460	465	PF00397	0.573
LIG_14-3-3_CanoR_1	152	157	PF00244	0.762
LIG_14-3-3_CanoR_1	176	184	PF00244	0.585
LIG_14-3-3_CanoR_1	198	202	PF00244	0.719
LIG_14-3-3_CanoR_1	287	297	PF00244	0.556
LIG_14-3-3_CanoR_1	312	317	PF00244	0.751
LIG_14-3-3_CanoR_1	330	335	PF00244	0.513
LIG_14-3-3_CanoR_1	375	380	PF00244	0.674
LIG_14-3-3_CanoR_1	444	448	PF00244	0.677
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BIR_III_2	351	355	PF00653	0.720
LIG_BRCT_BRCA1_1	160	164	PF00533	0.691
LIG_BRCT_BRCA1_1	41	45	PF00533	0.726
LIG_BRCT_BRCA1_1	47	51	PF00533	0.679
LIG_CaM_IQ_9	270	285	PF13499	0.473
LIG_CSL_BTD_1	380	383	PF09270	0.744
LIG_deltaCOP1_diTrp_1	282	289	PF00928	0.593
LIG_FHA_1	169	175	PF00498	0.569
LIG_FHA_1	218	224	PF00498	0.789
LIG_FHA_1	299	305	PF00498	0.666
LIG_FHA_1	408	414	PF00498	0.734
LIG_FHA_1	418	424	PF00498	0.653
LIG_FHA_1	444	450	PF00498	0.740
LIG_Integrin_RGD_1	231	233	PF01839	0.580
LIG_LIR_Apic_2	404	409	PF02991	0.688
LIG_LIR_Apic_2	410	414	PF02991	0.584
LIG_LIR_Apic_2	434	438	PF02991	0.702
LIG_LIR_Gen_1	189	197	PF02991	0.764
LIG_LIR_Gen_1	233	244	PF02991	0.563
LIG_LIR_Gen_1	317	326	PF02991	0.727
LIG_LIR_Gen_1	33	43	PF02991	0.685
LIG_LIR_Gen_1	48	58	PF02991	0.505
LIG_LIR_Nem_3	142	148	PF02991	0.751
LIG_LIR_Nem_3	189	194	PF02991	0.766
LIG_LIR_Nem_3	233	239	PF02991	0.587
LIG_LIR_Nem_3	317	323	PF02991	0.793
LIG_LIR_Nem_3	33	39	PF02991	0.745
LIG_LIR_Nem_3	48	54	PF02991	0.522
LIG_MLH1_MIPbox_1	160	164	PF16413	0.691
LIG_PDZ_Class_2	465	470	PF00595	0.656
LIG_PTAP_UEV_1	169	174	PF05743	0.569
LIG_SH2_CRK	265	269	PF00017	0.585
LIG_SH2_CRK	406	410	PF00017	0.681
LIG_SH2_NCK_1	236	240	PF00017	0.535
LIG_SH2_NCK_1	36	40	PF00017	0.658
LIG_SH2_SRC	236	239	PF00017	0.539
LIG_SH2_STAP1	236	240	PF00017	0.535
LIG_SH2_STAT5	146	149	PF00017	0.704
LIG_SH2_STAT5	163	166	PF00017	0.586
LIG_SH3_1	356	362	PF00018	0.705
LIG_SH3_2	400	405	PF14604	0.694
LIG_SH3_3	167	173	PF00018	0.693
LIG_SH3_3	213	219	PF00018	0.739
LIG_SH3_3	342	348	PF00018	0.714
LIG_SH3_3	356	362	PF00018	0.594
LIG_SH3_3	394	400	PF00018	0.751
LIG_SH3_3	412	418	PF00018	0.748
LIG_SH3_3	452	458	PF00018	0.742
LIG_SH3_3	51	57	PF00018	0.658
LIG_SH3_3	92	98	PF00018	0.701
LIG_SH3_CIN85_PxpxPR_1	362	367	PF14604	0.693
LIG_SUMO_SIM_anti_2	238	243	PF11976	0.619
LIG_SUMO_SIM_par_1	457	463	PF11976	0.554
LIG_SUMO_SIM_par_1	67	73	PF11976	0.501
LIG_TYR_ITIM	234	239	PF00017	0.573
LIG_WRC_WIRS_1	188	193	PF05994	0.673
LIG_WRC_WIRS_1	323	328	PF05994	0.733
LIG_WRC_WIRS_1	389	394	PF05994	0.751
LIG_WW_3	347	351	PF00397	0.679
MOD_CDC14_SPxK_1	463	466	PF00782	0.652
MOD_CDK_SPK_2	193	198	PF00069	0.674
MOD_CDK_SPK_2	362	367	PF00069	0.731
MOD_CDK_SPxK_1	460	466	PF00069	0.657
MOD_CDK_SPxxK_3	360	367	PF00069	0.695
MOD_CK1_1	109	115	PF00069	0.721
MOD_CK1_1	11	17	PF00069	0.625
MOD_CK1_1	121	127	PF00069	0.621
MOD_CK1_1	183	189	PF00069	0.670
MOD_CK1_1	200	206	PF00069	0.533
MOD_CK1_1	217	223	PF00069	0.654
MOD_CK1_1	225	231	PF00069	0.582
MOD_CK1_1	315	321	PF00069	0.683
MOD_CK1_1	335	341	PF00069	0.756
MOD_CK1_1	358	364	PF00069	0.682
MOD_CK1_1	38	44	PF00069	0.708
MOD_CK1_1	396	402	PF00069	0.693
MOD_CK1_1	46	52	PF00069	0.672
MOD_CK2_1	122	128	PF00069	0.722
MOD_CK2_1	183	189	PF00069	0.679
MOD_Cter_Amidation	76	79	PF01082	0.641
MOD_GlcNHglycan	1	4	PF01048	0.608
MOD_GlcNHglycan	120	123	PF01048	0.718
MOD_GlcNHglycan	124	127	PF01048	0.670
MOD_GlcNHglycan	128	131	PF01048	0.642
MOD_GlcNHglycan	135	138	PF01048	0.583
MOD_GlcNHglycan	202	205	PF01048	0.693
MOD_GlcNHglycan	257	260	PF01048	0.602
MOD_GlcNHglycan	290	293	PF01048	0.577
MOD_GlcNHglycan	306	309	PF01048	0.567
MOD_GlcNHglycan	312	315	PF01048	0.608
MOD_GlcNHglycan	334	337	PF01048	0.730
MOD_GlcNHglycan	393	396	PF01048	0.743
MOD_GlcNHglycan	75	78	PF01048	0.709
MOD_GSK3_1	118	125	PF00069	0.741
MOD_GSK3_1	133	140	PF00069	0.672
MOD_GSK3_1	147	154	PF00069	0.576
MOD_GSK3_1	183	190	PF00069	0.692
MOD_GSK3_1	193	200	PF00069	0.625
MOD_GSK3_1	208	215	PF00069	0.556
MOD_GSK3_1	26	33	PF00069	0.707
MOD_GSK3_1	322	329	PF00069	0.700
MOD_GSK3_1	35	42	PF00069	0.678
MOD_GSK3_1	354	361	PF00069	0.717
MOD_GSK3_1	375	382	PF00069	0.652
MOD_GSK3_1	401	408	PF00069	0.736
MOD_GSK3_1	43	50	PF00069	0.586
MOD_GSK3_1	84	91	PF00069	0.791
MOD_N-GLC_1	84	89	PF02516	0.617
MOD_NEK2_1	120	125	PF00069	0.672
MOD_NEK2_1	147	152	PF00069	0.739
MOD_NEK2_1	253	258	PF00069	0.642
MOD_NEK2_1	298	303	PF00069	0.706
MOD_NEK2_1	326	331	PF00069	0.709
MOD_NEK2_1	43	48	PF00069	0.729
MOD_PIKK_1	109	115	PF00454	0.727
MOD_PK_1	312	318	PF00069	0.653
MOD_PK_1	35	41	PF00069	0.655
MOD_PK_1	375	381	PF00069	0.613
MOD_PKA_2	126	132	PF00069	0.654
MOD_PKA_2	151	157	PF00069	0.722
MOD_PKA_2	175	181	PF00069	0.576
MOD_PKA_2	197	203	PF00069	0.663
MOD_PKA_2	225	231	PF00069	0.571
MOD_PKA_2	443	449	PF00069	0.743
MOD_Plk_1	39	45	PF00069	0.709
MOD_Plk_2-3	187	193	PF00069	0.673
MOD_Plk_4	159	165	PF00069	0.754
MOD_Plk_4	180	186	PF00069	0.670
MOD_Plk_4	197	203	PF00069	0.581
MOD_Plk_4	50	56	PF00069	0.690
MOD_Plk_4	96	102	PF00069	0.754
MOD_ProDKin_1	153	159	PF00069	0.733
MOD_ProDKin_1	193	199	PF00069	0.728
MOD_ProDKin_1	212	218	PF00069	0.502
MOD_ProDKin_1	335	341	PF00069	0.718
MOD_ProDKin_1	355	361	PF00069	0.779
MOD_ProDKin_1	362	368	PF00069	0.672
MOD_ProDKin_1	379	385	PF00069	0.511
MOD_ProDKin_1	393	399	PF00069	0.571
MOD_ProDKin_1	405	411	PF00069	0.591
MOD_ProDKin_1	449	455	PF00069	0.749
MOD_ProDKin_1	460	466	PF00069	0.572
TRG_ENDOCYTIC_2	145	148	PF00928	0.693
TRG_ENDOCYTIC_2	236	239	PF00928	0.574
TRG_ENDOCYTIC_2	265	268	PF00928	0.587
TRG_ENDOCYTIC_2	36	39	PF00928	0.690

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJU1	Leishmania braziliensis	51%	99%
A4I7A7	Leishmania infantum	99%	100%
E9B2A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q5V6	Leishmania major	87%	100%