Phosphorylated CTD interacting factor 1 WW domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphorylated CTD interacting factor 1 WW domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGM5_LEIDO

TriTrypDb:

LdBPK_365770.1 , LdCL_360065100 , LDHU3_36.7670

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGM5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000993	RNA polymerase II complex binding	5	8
GO:0001098	basal transcription machinery binding	3	8
GO:0001099	basal RNA polymerase II transcription machinery binding	4	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0008168	methyltransferase activity	4	8
GO:0008173	RNA methyltransferase activity	4	8
GO:0008174	mRNA methyltransferase activity	5	8
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	8
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity	6	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0019899	enzyme binding	3	8
GO:0043175	RNA polymerase core enzyme binding	5	8
GO:0070063	RNA polymerase binding	4	8
GO:0099122	RNA polymerase II C-terminal domain binding	6	8
GO:0140098	catalytic activity, acting on RNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.501
CLV_NRD_NRD_1	213	215	PF00675	0.380
CLV_NRD_NRD_1	587	589	PF00675	0.716
CLV_NRD_NRD_1	82	84	PF00675	0.551
CLV_PCSK_KEX2_1	195	197	PF00082	0.497
CLV_PCSK_KEX2_1	589	591	PF00082	0.701
CLV_PCSK_KEX2_1	82	84	PF00082	0.551
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.497
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.707
CLV_PCSK_SKI1_1	12	16	PF00082	0.489
CLV_PCSK_SKI1_1	145	149	PF00082	0.612
CLV_PCSK_SKI1_1	171	175	PF00082	0.565
CLV_PCSK_SKI1_1	361	365	PF00082	0.433
CLV_PCSK_SKI1_1	38	42	PF00082	0.595
CLV_PCSK_SKI1_1	420	424	PF00082	0.501
CLV_PCSK_SKI1_1	92	96	PF00082	0.603
CLV_Separin_Metazoa	7	11	PF03568	0.409
DEG_APCC_DBOX_1	99	107	PF00400	0.588
DEG_Nend_UBRbox_3	1	3	PF02207	0.580
DEG_SPOP_SBC_1	132	136	PF00917	0.502
DEG_SPOP_SBC_1	520	524	PF00917	0.516
DOC_CKS1_1	146	151	PF01111	0.622
DOC_CYCLIN_RxL_1	167	175	PF00134	0.611
DOC_CYCLIN_RxL_1	488	496	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	324	330	PF00134	0.546
DOC_MAPK_gen_1	10	17	PF00069	0.545
DOC_MAPK_gen_1	235	243	PF00069	0.560
DOC_MAPK_gen_1	82	90	PF00069	0.603
DOC_MAPK_HePTP_8	322	334	PF00069	0.544
DOC_MAPK_JIP1_4	235	241	PF00069	0.550
DOC_MAPK_MEF2A_6	171	178	PF00069	0.581
DOC_MAPK_MEF2A_6	235	243	PF00069	0.595
DOC_MAPK_MEF2A_6	325	334	PF00069	0.545
DOC_MAPK_MEF2A_6	72	81	PF00069	0.502
DOC_MAPK_NFAT4_5	171	179	PF00069	0.586
DOC_PP2B_LxvP_1	295	298	PF13499	0.564
DOC_PP2B_LxvP_1	324	327	PF13499	0.542
DOC_PP2B_LxvP_1	559	562	PF13499	0.491
DOC_PP4_FxxP_1	412	415	PF00568	0.376
DOC_USP7_MATH_1	132	136	PF00917	0.500
DOC_USP7_MATH_1	253	257	PF00917	0.577
DOC_USP7_MATH_1	303	307	PF00917	0.659
DOC_USP7_MATH_1	31	35	PF00917	0.606
DOC_USP7_MATH_1	346	350	PF00917	0.427
DOC_USP7_MATH_1	351	355	PF00917	0.417
DOC_USP7_MATH_1	433	437	PF00917	0.478
DOC_USP7_MATH_1	473	477	PF00917	0.720
DOC_USP7_MATH_1	481	485	PF00917	0.623
DOC_USP7_MATH_1	651	655	PF00917	0.599
DOC_WW_Pin1_4	145	150	PF00397	0.496
DOC_WW_Pin1_4	29	34	PF00397	0.627
DOC_WW_Pin1_4	398	403	PF00397	0.439
DOC_WW_Pin1_4	411	416	PF00397	0.322
LIG_14-3-3_CanoR_1	137	142	PF00244	0.504
LIG_14-3-3_CanoR_1	554	560	PF00244	0.530
LIG_14-3-3_CanoR_1	613	617	PF00244	0.515
LIG_14-3-3_CanoR_1	92	101	PF00244	0.455
LIG_APCC_ABBA_1	424	429	PF00400	0.501
LIG_BIR_III_4	36	40	PF00653	0.611
LIG_BRCT_BRCA1_1	42	46	PF00533	0.502
LIG_CaM_NSCaTE_8	177	184	PF13499	0.538
LIG_Clathr_ClatBox_1	492	496	PF01394	0.538
LIG_deltaCOP1_diTrp_1	285	292	PF00928	0.522
LIG_FHA_1	134	140	PF00498	0.499
LIG_FHA_1	268	274	PF00498	0.579
LIG_FHA_1	336	342	PF00498	0.536
LIG_FHA_1	404	410	PF00498	0.440
LIG_FHA_1	480	486	PF00498	0.625
LIG_FHA_1	52	58	PF00498	0.550
LIG_FHA_1	521	527	PF00498	0.423
LIG_FHA_2	544	550	PF00498	0.398
LIG_LIR_Apic_2	410	415	PF02991	0.376
LIG_LIR_Apic_2	71	77	PF02991	0.533
LIG_LIR_Gen_1	284	293	PF02991	0.577
LIG_LIR_Gen_1	313	322	PF02991	0.583
LIG_LIR_Gen_1	602	611	PF02991	0.617
LIG_LIR_Nem_3	205	211	PF02991	0.553
LIG_LIR_Nem_3	284	289	PF02991	0.576
LIG_LIR_Nem_3	291	295	PF02991	0.486
LIG_LIR_Nem_3	313	317	PF02991	0.597
LIG_LIR_Nem_3	431	437	PF02991	0.468
LIG_LIR_Nem_3	602	606	PF02991	0.672
LIG_MYND_3	158	162	PF01753	0.592
LIG_NRBOX	358	364	PF00104	0.430
LIG_Pex14_2	412	416	PF04695	0.501
LIG_Pex14_2	423	427	PF04695	0.320
LIG_PTB_Apo_2	495	502	PF02174	0.412
LIG_SH2_CRK	366	370	PF00017	0.376
LIG_SH2_SRC	566	569	PF00017	0.469
LIG_SH2_STAT5	108	111	PF00017	0.582
LIG_SH2_STAT5	208	211	PF00017	0.553
LIG_SH2_STAT5	340	343	PF00017	0.511
LIG_SH2_STAT5	566	569	PF00017	0.469
LIG_SH3_3	113	119	PF00018	0.576
LIG_SH3_3	27	33	PF00018	0.616
LIG_SH3_3	324	330	PF00018	0.468
LIG_SH3_3	381	387	PF00018	0.408
LIG_SH3_3	399	405	PF00018	0.233
LIG_SUMO_SIM_anti_2	521	530	PF11976	0.537
LIG_SUMO_SIM_anti_2	618	627	PF11976	0.459
LIG_SUMO_SIM_par_1	405	410	PF11976	0.501
LIG_SUMO_SIM_par_1	481	487	PF11976	0.631
LIG_SUMO_SIM_par_1	527	535	PF11976	0.545
LIG_SUMO_SIM_par_1	86	91	PF11976	0.530
LIG_TRAF2_1	4	7	PF00917	0.539
LIG_TRAF2_1	466	469	PF00917	0.683
LIG_TRAF2_1	546	549	PF00917	0.503
LIG_TYR_ITIM	364	369	PF00017	0.376
LIG_UBA3_1	173	180	PF00899	0.579
MOD_CDC14_SPxK_1	401	404	PF00782	0.404
MOD_CDK_SPxK_1	398	404	PF00069	0.404
MOD_CK1_1	264	270	PF00069	0.672
MOD_CK1_1	296	302	PF00069	0.734
MOD_CK1_1	32	38	PF00069	0.528
MOD_CK1_1	484	490	PF00069	0.629
MOD_CK1_1	51	57	PF00069	0.443
MOD_CK1_1	521	527	PF00069	0.550
MOD_CK1_1	578	584	PF00069	0.746
MOD_CK1_1	596	602	PF00069	0.735
MOD_CK1_1	615	621	PF00069	0.391
MOD_CK1_1	646	652	PF00069	0.505
MOD_CK2_1	285	291	PF00069	0.481
MOD_CK2_1	296	302	PF00069	0.573
MOD_CK2_1	543	549	PF00069	0.475
MOD_Cter_Amidation	586	589	PF01082	0.732
MOD_GlcNHglycan	2	5	PF01048	0.510
MOD_GlcNHglycan	244	247	PF01048	0.539
MOD_GlcNHglycan	263	266	PF01048	0.580
MOD_GlcNHglycan	295	298	PF01048	0.632
MOD_GlcNHglycan	347	351	PF01048	0.396
MOD_GlcNHglycan	377	380	PF01048	0.417
MOD_GlcNHglycan	42	45	PF01048	0.520
MOD_GlcNHglycan	468	473	PF01048	0.728
MOD_GlcNHglycan	475	478	PF01048	0.651
MOD_GlcNHglycan	534	537	PF01048	0.474
MOD_GlcNHglycan	574	578	PF01048	0.606
MOD_GlcNHglycan	595	598	PF01048	0.612
MOD_GlcNHglycan	653	656	PF01048	0.593
MOD_GSK3_1	127	134	PF00069	0.723
MOD_GSK3_1	253	260	PF00069	0.611
MOD_GSK3_1	281	288	PF00069	0.583
MOD_GSK3_1	48	55	PF00069	0.599
MOD_GSK3_1	520	527	PF00069	0.420
MOD_GSK3_1	543	550	PF00069	0.430
MOD_GSK3_1	575	582	PF00069	0.736
MOD_GSK3_1	592	599	PF00069	0.536
MOD_GSK3_1	646	653	PF00069	0.503
MOD_GSK3_1	88	95	PF00069	0.548
MOD_N-GLC_1	416	421	PF02516	0.376
MOD_NEK2_1	176	181	PF00069	0.499
MOD_NEK2_1	188	193	PF00069	0.482
MOD_NEK2_1	293	298	PF00069	0.660
MOD_NEK2_1	416	421	PF00069	0.357
MOD_NEK2_1	422	427	PF00069	0.337
MOD_NEK2_1	52	57	PF00069	0.579
MOD_NEK2_2	579	584	PF00069	0.762
MOD_PIKK_1	484	490	PF00454	0.704
MOD_PK_1	137	143	PF00069	0.509
MOD_PKA_2	261	267	PF00069	0.519
MOD_PKA_2	403	409	PF00069	0.501
MOD_PKA_2	543	549	PF00069	0.446
MOD_PKA_2	591	597	PF00069	0.790
MOD_PKA_2	612	618	PF00069	0.505
MOD_PKA_2	646	652	PF00069	0.496
MOD_PKB_1	343	351	PF00069	0.287
MOD_PKB_1	465	473	PF00069	0.541
MOD_PKB_1	590	598	PF00069	0.574
MOD_Plk_1	188	194	PF00069	0.582
MOD_Plk_1	204	210	PF00069	0.352
MOD_Plk_1	312	318	PF00069	0.600
MOD_Plk_1	547	553	PF00069	0.442
MOD_Plk_1	579	585	PF00069	0.640
MOD_Plk_2-3	285	291	PF00069	0.503
MOD_Plk_4	204	210	PF00069	0.483
MOD_Plk_4	403	409	PF00069	0.473
MOD_Plk_4	524	530	PF00069	0.410
MOD_Plk_4	599	605	PF00069	0.615
MOD_Plk_4	607	613	PF00069	0.490
MOD_ProDKin_1	145	151	PF00069	0.501
MOD_ProDKin_1	29	35	PF00069	0.626
MOD_ProDKin_1	398	404	PF00069	0.439
MOD_ProDKin_1	411	417	PF00069	0.322
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.501
TRG_DiLeu_BaLyEn_6	488	493	PF01217	0.538
TRG_ENDOCYTIC_2	366	369	PF00928	0.376
TRG_ER_diArg_1	100	103	PF00400	0.575
TRG_ER_diArg_1	322	325	PF00400	0.545
TRG_ER_diArg_1	588	591	PF00400	0.704
TRG_ER_diArg_1	62	65	PF00400	0.577
TRG_ER_diArg_1	81	83	PF00400	0.495
TRG_NLS_MonoExtC_3	587	592	PF00514	0.762
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P0J4	Trypanosomatidae	31%	100%
A0A422NKA3	Trypanosoma rangeli	33%	100%
A4HQ69	Leishmania braziliensis	78%	100%
A4IDW7	Leishmania infantum	100%	100%
E9ATY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0K8	Leishmania major	92%	100%