PUA domain/NOL1/NOP2/sun family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUA domain/NOL1/NOP2/sun family, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGM4_LEIDO

TriTrypDb:

LdBPK_251560.1 , LdCL_250021300 , LDHU3_25.1930

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGM4

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009451	RNA modification	5	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0032259	methylation	2	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0043414	macromolecule methylation	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0008168	methyltransferase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016741	transferase activity, transferring one-carbon groups	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.474
CLV_C14_Caspase3-7	517	521	PF00656	0.342
CLV_NRD_NRD_1	159	161	PF00675	0.772
CLV_NRD_NRD_1	228	230	PF00675	0.518
CLV_NRD_NRD_1	375	377	PF00675	0.585
CLV_NRD_NRD_1	501	503	PF00675	0.529
CLV_NRD_NRD_1	557	559	PF00675	0.271
CLV_PCSK_KEX2_1	228	230	PF00082	0.518
CLV_PCSK_KEX2_1	375	377	PF00082	0.585
CLV_PCSK_KEX2_1	501	503	PF00082	0.495
CLV_PCSK_PC1ET2_1	501	503	PF00082	0.547
CLV_PCSK_SKI1_1	115	119	PF00082	0.607
CLV_PCSK_SKI1_1	312	316	PF00082	0.553
CLV_PCSK_SKI1_1	498	502	PF00082	0.480
CLV_PCSK_SKI1_1	558	562	PF00082	0.295
DEG_APCC_DBOX_1	307	315	PF00400	0.529
DEG_Nend_Nbox_1	1	3	PF02207	0.588
DEG_SPOP_SBC_1	326	330	PF00917	0.718
DOC_CKS1_1	98	103	PF01111	0.630
DOC_CYCLIN_RxL_1	160	172	PF00134	0.557
DOC_CYCLIN_RxL_1	552	563	PF00134	0.499
DOC_CYCLIN_yClb1_LxF_4	592	598	PF00134	0.529
DOC_MAPK_DCC_7	676	684	PF00069	0.529
DOC_MAPK_gen_1	112	121	PF00069	0.580
DOC_MAPK_gen_1	447	456	PF00069	0.521
DOC_MAPK_JIP1_4	165	171	PF00069	0.496
DOC_MAPK_MEF2A_6	115	123	PF00069	0.564
DOC_MAPK_MEF2A_6	161	170	PF00069	0.562
DOC_MAPK_MEF2A_6	405	412	PF00069	0.404
DOC_MAPK_NFAT4_5	405	413	PF00069	0.405
DOC_PP2B_LxvP_1	185	188	PF13499	0.529
DOC_PP2B_LxvP_1	465	468	PF13499	0.641
DOC_PP4_FxxP_1	110	113	PF00568	0.690
DOC_USP7_MATH_1	111	115	PF00917	0.594
DOC_USP7_MATH_1	265	269	PF00917	0.651
DOC_USP7_MATH_1	326	330	PF00917	0.748
DOC_USP7_MATH_1	430	434	PF00917	0.555
DOC_USP7_MATH_1	466	470	PF00917	0.645
DOC_USP7_MATH_1	507	511	PF00917	0.670
DOC_USP7_MATH_1	54	58	PF00917	0.631
DOC_USP7_MATH_1	622	626	PF00917	0.559
DOC_WW_Pin1_4	13	18	PF00397	0.624
DOC_WW_Pin1_4	146	151	PF00397	0.737
DOC_WW_Pin1_4	298	303	PF00397	0.497
DOC_WW_Pin1_4	327	332	PF00397	0.777
DOC_WW_Pin1_4	334	339	PF00397	0.790
DOC_WW_Pin1_4	37	42	PF00397	0.630
DOC_WW_Pin1_4	386	391	PF00397	0.687
DOC_WW_Pin1_4	468	473	PF00397	0.649
DOC_WW_Pin1_4	568	573	PF00397	0.529
DOC_WW_Pin1_4	90	95	PF00397	0.660
DOC_WW_Pin1_4	97	102	PF00397	0.603
LIG_14-3-3_CanoR_1	141	150	PF00244	0.557
LIG_14-3-3_CanoR_1	24	28	PF00244	0.615
LIG_14-3-3_CanoR_1	267	271	PF00244	0.617
LIG_14-3-3_CanoR_1	308	312	PF00244	0.475
LIG_14-3-3_CanoR_1	327	331	PF00244	0.793
LIG_14-3-3_CanoR_1	459	468	PF00244	0.596
LIG_14-3-3_CanoR_1	608	617	PF00244	0.495
LIG_Actin_WH2_2	359	377	PF00022	0.539
LIG_APCC_ABBA_1	682	687	PF00400	0.575
LIG_BRCT_BRCA1_1	193	197	PF00533	0.512
LIG_DCNL_PONY_1	1	4	PF03556	0.577
LIG_EVH1_1	332	336	PF00568	0.700
LIG_FHA_1	116	122	PF00498	0.564
LIG_FHA_1	129	135	PF00498	0.559
LIG_FHA_1	18	24	PF00498	0.614
LIG_FHA_1	267	273	PF00498	0.557
LIG_FHA_1	404	410	PF00498	0.393
LIG_FHA_1	484	490	PF00498	0.483
LIG_FHA_1	582	588	PF00498	0.485
LIG_FHA_1	66	72	PF00498	0.490
LIG_FHA_1	81	87	PF00498	0.657
LIG_FHA_2	16	22	PF00498	0.595
LIG_FHA_2	213	219	PF00498	0.654
LIG_FHA_2	377	383	PF00498	0.566
LIG_FHA_2	392	398	PF00498	0.390
LIG_FHA_2	583	589	PF00498	0.473
LIG_LIR_Apic_2	108	113	PF02991	0.646
LIG_LIR_Apic_2	59	65	PF02991	0.546
LIG_LIR_Gen_1	519	530	PF02991	0.496
LIG_LIR_Gen_1	683	693	PF02991	0.558
LIG_LIR_Nem_3	135	140	PF02991	0.686
LIG_LIR_Nem_3	243	248	PF02991	0.617
LIG_LIR_Nem_3	26	31	PF02991	0.578
LIG_LIR_Nem_3	282	286	PF02991	0.567
LIG_LIR_Nem_3	435	441	PF02991	0.493
LIG_LIR_Nem_3	5	10	PF02991	0.627
LIG_LIR_Nem_3	519	525	PF02991	0.472
LIG_LIR_Nem_3	600	604	PF02991	0.566
LIG_LIR_Nem_3	683	688	PF02991	0.582
LIG_LYPXL_yS_3	601	604	PF13949	0.495
LIG_MYND_1	538	542	PF01753	0.471
LIG_NRBOX	310	316	PF00104	0.545
LIG_NRBOX	408	414	PF00104	0.459
LIG_NRBOX	452	458	PF00104	0.438
LIG_NRBOX	81	87	PF00104	0.556
LIG_PCNA_PIPBox_1	454	463	PF02747	0.538
LIG_PCNA_yPIPBox_3	445	457	PF02747	0.470
LIG_PDZ_Class_1	703	708	PF00595	0.607
LIG_Pex14_2	696	700	PF04695	0.343
LIG_RPA_C_Fungi	605	617	PF08784	0.372
LIG_SH2_CRK	14	18	PF00017	0.622
LIG_SH2_CRK	62	66	PF00017	0.559
LIG_SH2_NCK_1	14	18	PF00017	0.622
LIG_SH2_NCK_1	62	66	PF00017	0.607
LIG_SH2_NCK_1	685	689	PF00017	0.590
LIG_SH2_SRC	12	15	PF00017	0.638
LIG_SH2_SRC	186	189	PF00017	0.408
LIG_SH2_SRC	685	688	PF00017	0.580
LIG_SH2_STAP1	356	360	PF00017	0.433
LIG_SH2_STAP1	7	11	PF00017	0.610
LIG_SH2_STAT3	10	13	PF00017	0.691
LIG_SH2_STAT3	626	629	PF00017	0.460
LIG_SH2_STAT5	10	13	PF00017	0.655
LIG_SH2_STAT5	208	211	PF00017	0.567
LIG_SH2_STAT5	484	487	PF00017	0.562
LIG_SH2_STAT5	705	708	PF00017	0.622
LIG_SH3_1	160	166	PF00018	0.631
LIG_SH3_1	569	575	PF00018	0.408
LIG_SH3_3	160	166	PF00018	0.683
LIG_SH3_3	24	30	PF00018	0.583
LIG_SH3_3	330	336	PF00018	0.771
LIG_SH3_3	569	575	PF00018	0.408
LIG_SH3_3	95	101	PF00018	0.565
LIG_SUMO_SIM_anti_2	670	676	PF11976	0.457
LIG_SUMO_SIM_par_1	166	172	PF11976	0.360
LIG_TRAF2_1	417	420	PF00917	0.575
LIG_TRAF2_1	448	451	PF00917	0.514
LIG_TRAF2_1	586	589	PF00917	0.360
LIG_UBA3_1	314	319	PF00899	0.677
MOD_CDK_SPK_2	37	42	PF00069	0.632
MOD_CK1_1	144	150	PF00069	0.713
MOD_CK1_1	15	21	PF00069	0.632
MOD_CK1_1	156	162	PF00069	0.669
MOD_CK1_1	288	294	PF00069	0.630
MOD_CK1_1	307	313	PF00069	0.539
MOD_CK1_1	35	41	PF00069	0.680
MOD_CK1_1	473	479	PF00069	0.705
MOD_CK1_1	511	517	PF00069	0.685
MOD_CK1_1	546	552	PF00069	0.408
MOD_CK1_1	571	577	PF00069	0.377
MOD_CK1_1	581	587	PF00069	0.269
MOD_CK1_1	635	641	PF00069	0.651
MOD_CK1_1	92	98	PF00069	0.665
MOD_CK2_1	15	21	PF00069	0.597
MOD_CK2_1	151	157	PF00069	0.745
MOD_CK2_1	212	218	PF00069	0.644
MOD_CK2_1	430	436	PF00069	0.568
MOD_CK2_1	582	588	PF00069	0.329
MOD_CK2_1	73	79	PF00069	0.510
MOD_GlcNHglycan	222	225	PF01048	0.667
MOD_GlcNHglycan	275	278	PF01048	0.520
MOD_GlcNHglycan	34	37	PF01048	0.675
MOD_GlcNHglycan	370	373	PF01048	0.278
MOD_GlcNHglycan	432	435	PF01048	0.526
MOD_GlcNHglycan	44	47	PF01048	0.659
MOD_GlcNHglycan	468	471	PF01048	0.623
MOD_GlcNHglycan	477	480	PF01048	0.589
MOD_GlcNHglycan	512	516	PF01048	0.715
MOD_GlcNHglycan	552	555	PF01048	0.318
MOD_GlcNHglycan	619	623	PF01048	0.345
MOD_GlcNHglycan	637	640	PF01048	0.510
MOD_GlcNHglycan	667	670	PF01048	0.534
MOD_GlcNHglycan	702	705	PF01048	0.445
MOD_GSK3_1	111	118	PF00069	0.646
MOD_GSK3_1	12	19	PF00069	0.620
MOD_GSK3_1	128	135	PF00069	0.610
MOD_GSK3_1	140	147	PF00069	0.623
MOD_GSK3_1	151	158	PF00069	0.769
MOD_GSK3_1	287	294	PF00069	0.611
MOD_GSK3_1	32	39	PF00069	0.543
MOD_GSK3_1	321	328	PF00069	0.685
MOD_GSK3_1	404	411	PF00069	0.423
MOD_GSK3_1	466	473	PF00069	0.646
MOD_GSK3_1	507	514	PF00069	0.567
MOD_GSK3_1	546	553	PF00069	0.389
MOD_GSK3_1	578	585	PF00069	0.360
MOD_GSK3_1	618	625	PF00069	0.356
MOD_GSK3_1	90	97	PF00069	0.664
MOD_N-GLC_1	220	225	PF02516	0.695
MOD_N-GLC_1	354	359	PF02516	0.411
MOD_N-GLC_1	474	479	PF02516	0.620
MOD_NEK2_1	139	144	PF00069	0.641
MOD_NEK2_1	23	28	PF00069	0.622
MOD_NEK2_1	287	292	PF00069	0.595
MOD_NEK2_1	408	413	PF00069	0.421
MOD_NEK2_1	474	479	PF00069	0.636
MOD_NEK2_1	560	565	PF00069	0.356
MOD_NEK2_1	597	602	PF00069	0.400
MOD_NEK2_1	700	705	PF00069	0.426
MOD_PK_1	52	58	PF00069	0.721
MOD_PKA_1	502	508	PF00069	0.568
MOD_PKA_2	111	117	PF00069	0.652
MOD_PKA_2	140	146	PF00069	0.650
MOD_PKA_2	180	186	PF00069	0.360
MOD_PKA_2	23	29	PF00069	0.611
MOD_PKA_2	266	272	PF00069	0.624
MOD_PKA_2	288	294	PF00069	0.442
MOD_PKA_2	307	313	PF00069	0.630
MOD_PKA_2	326	332	PF00069	0.716
MOD_Plk_1	354	360	PF00069	0.410
MOD_Plk_1	419	425	PF00069	0.560
MOD_Plk_1	52	58	PF00069	0.721
MOD_Plk_1	618	624	PF00069	0.351
MOD_Plk_2-3	686	692	PF00069	0.595
MOD_Plk_4	132	138	PF00069	0.636
MOD_Plk_4	23	29	PF00069	0.558
MOD_Plk_4	266	272	PF00069	0.572
MOD_Plk_4	282	288	PF00069	0.530
MOD_Plk_4	355	361	PF00069	0.403
MOD_Plk_4	391	397	PF00069	0.510
MOD_Plk_4	404	410	PF00069	0.306
MOD_ProDKin_1	13	19	PF00069	0.617
MOD_ProDKin_1	146	152	PF00069	0.740
MOD_ProDKin_1	298	304	PF00069	0.498
MOD_ProDKin_1	327	333	PF00069	0.777
MOD_ProDKin_1	334	340	PF00069	0.789
MOD_ProDKin_1	37	43	PF00069	0.629
MOD_ProDKin_1	386	392	PF00069	0.674
MOD_ProDKin_1	468	474	PF00069	0.647
MOD_ProDKin_1	568	574	PF00069	0.408
MOD_ProDKin_1	90	96	PF00069	0.657
MOD_ProDKin_1	97	103	PF00069	0.596
MOD_SUMO_rev_2	276	286	PF00179	0.541
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.490
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.371
TRG_DiLeu_BaLyEn_6	668	673	PF01217	0.505
TRG_ENDOCYTIC_2	356	359	PF00928	0.437
TRG_ENDOCYTIC_2	601	604	PF00928	0.326
TRG_ENDOCYTIC_2	685	688	PF00928	0.580
TRG_ER_diArg_1	227	229	PF00400	0.537
TRG_ER_diArg_1	374	376	PF00400	0.568
TRG_ER_diArg_1	445	448	PF00400	0.506
TRG_NLS_MonoExtC_3	500	506	PF00514	0.588
TRG_NLS_MonoExtN_4	498	505	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	558	562	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	615	619	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA86	Leptomonas seymouri	49%	99%
A0A0S4JUU1	Bodo saltans	31%	100%
A0A1X0NZU0	Trypanosomatidae	36%	100%
A4HEK2	Leishmania braziliensis	78%	100%
A4I1J6	Leishmania infantum	99%	100%
Q4Q9U1	Leishmania major	92%	100%
Q84MA1	Arabidopsis thaliana	25%	100%