Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGM3_LEIDO

TriTrypDb:

LdBPK_320830.1 , LdCL_320013900 , LDHU3_32.1030

Length:

165

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGM3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.542
CLV_PCSK_SKI1_1	161	165	PF00082	0.613
DOC_CDC14_PxL_1	66	74	PF14671	0.568
DOC_PP1_RVXF_1	159	165	PF00149	0.515
DOC_USP7_MATH_1	151	155	PF00917	0.584
DOC_USP7_MATH_1	59	63	PF00917	0.694
DOC_USP7_MATH_1	79	83	PF00917	0.607
DOC_WW_Pin1_4	36	41	PF00397	0.572
DOC_WW_Pin1_4	9	14	PF00397	0.511
LIG_14-3-3_CanoR_1	107	116	PF00244	0.679
LIG_FHA_1	110	116	PF00498	0.524
LIG_FHA_1	122	128	PF00498	0.533
LIG_FHA_1	135	141	PF00498	0.548
LIG_LIR_Gen_1	117	127	PF02991	0.592
LIG_LIR_Nem_3	117	123	PF02991	0.558
LIG_LIR_Nem_3	147	153	PF02991	0.518
LIG_LYPXL_L_2	149	158	PF13949	0.538
LIG_LYPXL_S_1	149	153	PF13949	0.538
LIG_LYPXL_yS_3	150	153	PF13949	0.612
LIG_SH2_GRB2like	157	160	PF00017	0.510
LIG_SH2_STAT3	157	160	PF00017	0.510
LIG_SH2_STAT5	157	160	PF00017	0.510
LIG_SH2_STAT5	84	87	PF00017	0.529
LIG_SUMO_SIM_par_1	4	12	PF11976	0.602
MOD_DYRK1A_RPxSP_1	36	40	PF00069	0.574
MOD_GlcNHglycan	130	133	PF01048	0.583
MOD_GlcNHglycan	41	44	PF01048	0.596
MOD_GlcNHglycan	60	64	PF01048	0.556
MOD_GlcNHglycan	72	75	PF01048	0.549
MOD_GlcNHglycan	77	80	PF01048	0.614
MOD_GSK3_1	15	22	PF00069	0.675
MOD_GSK3_1	75	82	PF00069	0.582
MOD_NEK2_1	41	46	PF00069	0.697
MOD_NEK2_2	151	156	PF00069	0.529
MOD_NEK2_2	31	36	PF00069	0.574
MOD_PKA_1	134	140	PF00069	0.647
MOD_PKA_2	25	31	PF00069	0.607
MOD_Plk_4	151	157	PF00069	0.616
MOD_ProDKin_1	36	42	PF00069	0.566
MOD_ProDKin_1	9	15	PF00069	0.519
TRG_ENDOCYTIC_2	150	153	PF00928	0.543
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.671

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEH7	Leptomonas seymouri	83%	100%
A0A0S4J9U7	Bodo saltans	63%	99%
A0A1X0NUN3	Trypanosomatidae	67%	100%
A0A422N080	Trypanosoma rangeli	70%	100%
A4HK60	Leishmania braziliensis	93%	100%
A4I7P6	Leishmania infantum	100%	100%
D0A9U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9B2K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q5K3	Leishmania major	99%	100%
V5AQT2	Trypanosoma cruzi	70%	68%