Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGM0_LEIDO

TriTrypDb:

LdBPK_331590.1 , LdCL_330022500 , LDHU3_33.2420

Length:

632

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.533
CLV_C14_Caspase3-7	506	510	PF00656	0.347
CLV_NRD_NRD_1	216	218	PF00675	0.696
CLV_NRD_NRD_1	311	313	PF00675	0.604
CLV_NRD_NRD_1	335	337	PF00675	0.641
CLV_NRD_NRD_1	394	396	PF00675	0.410
CLV_NRD_NRD_1	441	443	PF00675	0.599
CLV_NRD_NRD_1	573	575	PF00675	0.646
CLV_NRD_NRD_1	87	89	PF00675	0.508
CLV_PCSK_FUR_1	392	396	PF00082	0.449
CLV_PCSK_KEX2_1	215	217	PF00082	0.688
CLV_PCSK_KEX2_1	311	313	PF00082	0.604
CLV_PCSK_KEX2_1	335	337	PF00082	0.641
CLV_PCSK_KEX2_1	394	396	PF00082	0.410
CLV_PCSK_KEX2_1	441	443	PF00082	0.422
CLV_PCSK_KEX2_1	573	575	PF00082	0.650
CLV_PCSK_SKI1_1	178	182	PF00082	0.621
CLV_PCSK_SKI1_1	328	332	PF00082	0.566
CLV_PCSK_SKI1_1	453	457	PF00082	0.389
CLV_PCSK_SKI1_1	505	509	PF00082	0.482
CLV_Separin_Metazoa	212	216	PF03568	0.657
CLV_Separin_Metazoa	438	442	PF03568	0.531
DEG_Nend_UBRbox_1	1	4	PF02207	0.531
DEG_SPOP_SBC_1	483	487	PF00917	0.706
DOC_CDC14_PxL_1	158	166	PF14671	0.645
DOC_CYCLIN_RxL_1	341	352	PF00134	0.520
DOC_CYCLIN_RxL_1	370	380	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	180	186	PF00134	0.631
DOC_MAPK_gen_1	374	383	PF00069	0.472
DOC_MAPK_MEF2A_6	2	9	PF00069	0.494
DOC_MAPK_MEF2A_6	377	385	PF00069	0.469
DOC_PP2B_LxvP_1	184	187	PF13499	0.586
DOC_PP2B_LxvP_1	25	28	PF13499	0.661
DOC_USP7_MATH_1	109	113	PF00917	0.442
DOC_USP7_MATH_1	128	132	PF00917	0.665
DOC_USP7_MATH_1	189	193	PF00917	0.580
DOC_USP7_MATH_1	28	32	PF00917	0.634
DOC_USP7_MATH_1	294	298	PF00917	0.633
DOC_USP7_MATH_1	40	44	PF00917	0.744
DOC_USP7_MATH_1	429	433	PF00917	0.505
DOC_USP7_MATH_1	483	487	PF00917	0.704
DOC_USP7_MATH_1	598	602	PF00917	0.600
DOC_USP7_MATH_1	62	66	PF00917	0.412
DOC_USP7_MATH_1	90	94	PF00917	0.512
DOC_USP7_MATH_2	314	320	PF00917	0.500
DOC_WW_Pin1_4	167	172	PF00397	0.599
DOC_WW_Pin1_4	357	362	PF00397	0.731
DOC_WW_Pin1_4	363	368	PF00397	0.567
DOC_WW_Pin1_4	410	415	PF00397	0.430
DOC_WW_Pin1_4	558	563	PF00397	0.686
DOC_WW_Pin1_4	614	619	PF00397	0.552
LIG_14-3-3_CanoR_1	215	222	PF00244	0.693
LIG_14-3-3_CanoR_1	244	252	PF00244	0.576
LIG_14-3-3_CanoR_1	256	261	PF00244	0.662
LIG_14-3-3_CanoR_1	370	378	PF00244	0.603
LIG_14-3-3_CanoR_1	392	402	PF00244	0.534
LIG_14-3-3_CanoR_1	493	500	PF00244	0.525
LIG_14-3-3_CanoR_1	579	587	PF00244	0.654
LIG_14-3-3_CanoR_1	88	96	PF00244	0.495
LIG_Actin_WH2_2	228	246	PF00022	0.521
LIG_Actin_WH2_2	378	396	PF00022	0.495
LIG_Actin_WH2_2	454	469	PF00022	0.402
LIG_Actin_WH2_2	519	535	PF00022	0.429
LIG_APCC_ABBA_1	5	10	PF00400	0.482
LIG_BRCT_BRCA1_1	305	309	PF00533	0.557
LIG_BRCT_BRCA1_1	53	57	PF00533	0.574
LIG_deltaCOP1_diTrp_1	301	309	PF00928	0.494
LIG_deltaCOP1_diTrp_1	503	511	PF00928	0.551
LIG_FHA_1	179	185	PF00498	0.581
LIG_FHA_1	197	203	PF00498	0.576
LIG_FHA_1	288	294	PF00498	0.647
LIG_FHA_1	322	328	PF00498	0.425
LIG_FHA_1	343	349	PF00498	0.612
LIG_FHA_1	370	376	PF00498	0.482
LIG_FHA_1	4	10	PF00498	0.495
LIG_FHA_2	221	227	PF00498	0.612
LIG_FHA_2	263	269	PF00498	0.662
LIG_FHA_2	421	427	PF00498	0.572
LIG_FHA_2	468	474	PF00498	0.553
LIG_FHA_2	580	586	PF00498	0.799
LIG_LIR_Gen_1	152	162	PF02991	0.586
LIG_LIR_Nem_3	152	158	PF02991	0.574
LIG_LYPXL_yS_3	449	452	PF13949	0.441
LIG_NRBOX	288	294	PF00104	0.498
LIG_NRBOX	326	332	PF00104	0.556
LIG_PCNA_PIPBox_1	1	10	PF02747	0.626
LIG_SH2_CRK	430	434	PF00017	0.388
LIG_SH2_NCK_1	275	279	PF00017	0.636
LIG_SH2_NCK_1	91	95	PF00017	0.482
LIG_SH2_SRC	103	106	PF00017	0.585
LIG_SH2_STAP1	275	279	PF00017	0.636
LIG_SH2_STAP1	430	434	PF00017	0.388
LIG_SH2_STAP1	91	95	PF00017	0.482
LIG_SH2_STAT5	460	463	PF00017	0.388
LIG_SH2_STAT5	95	98	PF00017	0.477
LIG_SH3_3	122	128	PF00018	0.613
LIG_SH3_3	263	269	PF00018	0.699
LIG_Sin3_3	72	79	PF02671	0.601
LIG_SUMO_SIM_anti_2	345	350	PF11976	0.508
LIG_TRAF2_1	171	174	PF00917	0.735
LIG_TYR_ITIM	447	452	PF00017	0.563
MOD_CDK_SPxxK_3	363	370	PF00069	0.656
MOD_CK1_1	112	118	PF00069	0.615
MOD_CK1_1	192	198	PF00069	0.625
MOD_CK1_1	31	37	PF00069	0.632
MOD_CK1_1	352	358	PF00069	0.717
MOD_CK1_1	369	375	PF00069	0.439
MOD_CK1_1	39	45	PF00069	0.619
MOD_CK1_1	558	564	PF00069	0.700
MOD_CK1_1	61	67	PF00069	0.531
MOD_CK2_1	167	173	PF00069	0.723
MOD_CK2_1	188	194	PF00069	0.738
MOD_CK2_1	220	226	PF00069	0.609
MOD_CK2_1	467	473	PF00069	0.481
MOD_CK2_1	579	585	PF00069	0.788
MOD_CK2_1	62	68	PF00069	0.453
MOD_Cter_Amidation	571	574	PF01082	0.593
MOD_Cter_Amidation	86	89	PF01082	0.516
MOD_GlcNHglycan	111	114	PF01048	0.374
MOD_GlcNHglycan	130	133	PF01048	0.775
MOD_GlcNHglycan	159	162	PF01048	0.650
MOD_GlcNHglycan	22	25	PF01048	0.507
MOD_GlcNHglycan	318	321	PF01048	0.499
MOD_GlcNHglycan	351	354	PF01048	0.697
MOD_GlcNHglycan	38	41	PF01048	0.551
MOD_GlcNHglycan	414	417	PF01048	0.422
MOD_GlcNHglycan	42	45	PF01048	0.422
MOD_GlcNHglycan	443	447	PF01048	0.404
MOD_GlcNHglycan	486	489	PF01048	0.609
MOD_GlcNHglycan	495	498	PF01048	0.495
MOD_GlcNHglycan	505	508	PF01048	0.380
MOD_GlcNHglycan	596	599	PF01048	0.620
MOD_GlcNHglycan	60	63	PF01048	0.321
MOD_GlcNHglycan	600	603	PF01048	0.545
MOD_GlcNHglycan	92	95	PF01048	0.503
MOD_GSK3_1	105	112	PF00069	0.581
MOD_GSK3_1	136	143	PF00069	0.741
MOD_GSK3_1	188	195	PF00069	0.653
MOD_GSK3_1	217	224	PF00069	0.661
MOD_GSK3_1	251	258	PF00069	0.609
MOD_GSK3_1	28	35	PF00069	0.643
MOD_GSK3_1	357	364	PF00069	0.701
MOD_GSK3_1	36	43	PF00069	0.684
MOD_GSK3_1	456	463	PF00069	0.397
MOD_GSK3_1	489	496	PF00069	0.518
MOD_GSK3_1	57	64	PF00069	0.468
MOD_GSK3_1	594	601	PF00069	0.496
MOD_LATS_1	454	460	PF00433	0.397
MOD_N-GLC_1	262	267	PF02516	0.784
MOD_N-GLC_1	467	472	PF02516	0.527
MOD_NEK2_1	292	297	PF00069	0.448
MOD_NEK2_1	342	347	PF00069	0.425
MOD_NEK2_1	420	425	PF00069	0.517
MOD_NEK2_1	466	471	PF00069	0.427
MOD_NEK2_1	548	553	PF00069	0.571
MOD_NEK2_1	555	560	PF00069	0.635
MOD_NEK2_1	57	62	PF00069	0.581
MOD_PIKK_1	28	34	PF00454	0.726
MOD_PIKK_1	294	300	PF00454	0.557
MOD_PIKK_1	604	610	PF00454	0.562
MOD_PK_1	377	383	PF00069	0.542
MOD_PKA_1	215	221	PF00069	0.697
MOD_PKA_2	126	132	PF00069	0.767
MOD_PKA_2	215	221	PF00069	0.697
MOD_PKA_2	255	261	PF00069	0.593
MOD_PKA_2	28	34	PF00069	0.667
MOD_PKA_2	369	375	PF00069	0.625
MOD_PKA_2	393	399	PF00069	0.503
MOD_PKA_2	466	472	PF00069	0.464
MOD_PKA_2	57	63	PF00069	0.567
MOD_PKA_2	594	600	PF00069	0.558
MOD_PKB_1	215	223	PF00069	0.697
MOD_Plk_1	140	146	PF00069	0.682
MOD_Plk_1	262	268	PF00069	0.621
MOD_Plk_1	442	448	PF00069	0.529
MOD_Plk_1	9	15	PF00069	0.479
MOD_Plk_2-3	140	146	PF00069	0.668
MOD_Plk_4	270	276	PF00069	0.565
MOD_Plk_4	3	9	PF00069	0.490
MOD_Plk_4	305	311	PF00069	0.483
MOD_Plk_4	377	383	PF00069	0.516
MOD_Plk_4	429	435	PF00069	0.394
MOD_Plk_4	456	462	PF00069	0.388
MOD_ProDKin_1	167	173	PF00069	0.602
MOD_ProDKin_1	357	363	PF00069	0.715
MOD_ProDKin_1	410	416	PF00069	0.426
MOD_ProDKin_1	558	564	PF00069	0.690
MOD_ProDKin_1	614	620	PF00069	0.545
MOD_SUMO_for_1	14	17	PF00179	0.504
TRG_DiLeu_BaEn_1	338	343	PF01217	0.543
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.439
TRG_DiLeu_BaLyEn_6	527	532	PF01217	0.399
TRG_ENDOCYTIC_2	103	106	PF00928	0.473
TRG_ENDOCYTIC_2	430	433	PF00928	0.392
TRG_ENDOCYTIC_2	449	452	PF00928	0.441
TRG_ER_diArg_1	214	217	PF00400	0.682
TRG_ER_diArg_1	310	312	PF00400	0.599
TRG_ER_diArg_1	392	395	PF00400	0.396
TRG_ER_diArg_1	440	442	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	311	316	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	530	534	PF00026	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P490	Leptomonas seymouri	36%	100%
A4HLL1	Leishmania braziliensis	71%	98%
A4I923	Leishmania infantum	100%	100%
E9B3Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q437	Leishmania major	88%	100%