WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGL8_LEIDO

TriTrypDb:

LdBPK_365600.1 , LdCL_360063300 , LDHU3_36.7430

Length:

545

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGL8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGL8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.340
CLV_C14_Caspase3-7	394	398	PF00656	0.502
CLV_C14_Caspase3-7	466	470	PF00656	0.601
CLV_NRD_NRD_1	14	16	PF00675	0.533
CLV_NRD_NRD_1	297	299	PF00675	0.576
CLV_NRD_NRD_1	33	35	PF00675	0.612
CLV_NRD_NRD_1	333	335	PF00675	0.413
CLV_NRD_NRD_1	399	401	PF00675	0.519
CLV_NRD_NRD_1	75	77	PF00675	0.572
CLV_PCSK_KEX2_1	14	16	PF00082	0.578
CLV_PCSK_KEX2_1	297	299	PF00082	0.570
CLV_PCSK_KEX2_1	31	33	PF00082	0.615
CLV_PCSK_KEX2_1	335	337	PF00082	0.543
CLV_PCSK_KEX2_1	399	401	PF00082	0.519
CLV_PCSK_KEX2_1	453	455	PF00082	0.569
CLV_PCSK_KEX2_1	75	77	PF00082	0.572
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.615
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.543
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.552
CLV_PCSK_SKI1_1	161	165	PF00082	0.558
CLV_PCSK_SKI1_1	167	171	PF00082	0.564
CLV_PCSK_SKI1_1	454	458	PF00082	0.557
CLV_PCSK_SKI1_1	475	479	PF00082	0.578
CLV_Separin_Metazoa	221	225	PF03568	0.388
DEG_Nend_UBRbox_3	1	3	PF02207	0.592
DOC_ANK_TNKS_1	101	108	PF00023	0.521
DOC_CYCLIN_RxL_1	472	482	PF00134	0.546
DOC_CYCLIN_yClb1_LxF_4	428	434	PF00134	0.382
DOC_MAPK_gen_1	334	342	PF00069	0.415
DOC_MAPK_MEF2A_6	362	370	PF00069	0.401
DOC_MAPK_MEF2A_6	496	505	PF00069	0.484
DOC_PP1_RVXF_1	178	184	PF00149	0.463
DOC_PP1_RVXF_1	227	234	PF00149	0.492
DOC_PP2B_LxvP_1	407	410	PF13499	0.409
DOC_PP4_FxxP_1	505	508	PF00568	0.400
DOC_USP7_MATH_1	101	105	PF00917	0.617
DOC_USP7_MATH_1	136	140	PF00917	0.345
DOC_USP7_MATH_1	238	242	PF00917	0.496
DOC_USP7_MATH_1	311	315	PF00917	0.484
DOC_USP7_MATH_1	341	345	PF00917	0.462
DOC_USP7_MATH_1	357	361	PF00917	0.387
DOC_USP7_MATH_1	424	428	PF00917	0.370
DOC_USP7_MATH_1	43	47	PF00917	0.534
DOC_USP7_MATH_1	442	446	PF00917	0.631
DOC_USP7_UBL2_3	27	31	PF12436	0.638
DOC_WW_Pin1_4	109	114	PF00397	0.604
DOC_WW_Pin1_4	234	239	PF00397	0.567
DOC_WW_Pin1_4	272	277	PF00397	0.479
DOC_WW_Pin1_4	405	410	PF00397	0.497
DOC_WW_Pin1_4	497	502	PF00397	0.412
LIG_14-3-3_CanoR_1	180	184	PF00244	0.448
LIG_14-3-3_CanoR_1	399	407	PF00244	0.488
LIG_14-3-3_CanoR_1	47	53	PF00244	0.615
LIG_14-3-3_CanoR_1	92	100	PF00244	0.492
LIG_AP2alpha_1	467	471	PF02296	0.527
LIG_BRCT_BRCA1_1	429	433	PF00533	0.361
LIG_BRCT_BRCA1_1	501	505	PF00533	0.403
LIG_BRCT_BRCA1_1	64	68	PF00533	0.616
LIG_CSL_BTD_1	498	501	PF09270	0.440
LIG_FHA_1	186	192	PF00498	0.436
LIG_FHA_1	223	229	PF00498	0.572
LIG_FHA_1	244	250	PF00498	0.369
LIG_FHA_1	264	270	PF00498	0.303
LIG_FHA_1	294	300	PF00498	0.737
LIG_FHA_1	446	452	PF00498	0.607
LIG_FHA_2	122	128	PF00498	0.418
LIG_FHA_2	18	24	PF00498	0.588
LIG_FHA_2	249	255	PF00498	0.372
LIG_FHA_2	304	310	PF00498	0.361
LIG_LIR_Apic_2	502	508	PF02991	0.531
LIG_LIR_Gen_1	116	125	PF02991	0.341
LIG_LIR_Gen_1	139	146	PF02991	0.339
LIG_LIR_Gen_1	385	393	PF02991	0.464
LIG_LIR_Nem_3	116	122	PF02991	0.357
LIG_LIR_Nem_3	139	144	PF02991	0.340
LIG_LIR_Nem_3	182	186	PF02991	0.456
LIG_LIR_Nem_3	385	390	PF02991	0.466
LIG_LIR_Nem_3	430	436	PF02991	0.386
LIG_LYPXL_S_1	422	426	PF13949	0.326
LIG_LYPXL_yS_3	423	426	PF13949	0.327
LIG_MLH1_MIPbox_1	64	68	PF16413	0.616
LIG_PCNA_yPIPBox_3	2	15	PF02747	0.711
LIG_Pex14_2	467	471	PF04695	0.597
LIG_Pex14_2	505	509	PF04695	0.394
LIG_SH2_CRK	119	123	PF00017	0.330
LIG_SH2_GRB2like	38	41	PF00017	0.524
LIG_SH2_SRC	132	135	PF00017	0.402
LIG_SH2_SRC	38	41	PF00017	0.594
LIG_SH2_SRC	434	437	PF00017	0.435
LIG_SH2_STAP1	38	42	PF00017	0.573
LIG_SH2_STAT5	132	135	PF00017	0.409
LIG_SH3_3	13	19	PF00018	0.611
LIG_SH3_3	280	286	PF00018	0.511
LIG_SH3_3	351	357	PF00018	0.402
LIG_SH3_3	473	479	PF00018	0.595
LIG_SUMO_SIM_par_1	162	168	PF11976	0.532
LIG_SUMO_SIM_par_1	246	254	PF11976	0.368
LIG_SUMO_SIM_par_1	266	273	PF11976	0.249
LIG_SUMO_SIM_par_1	325	332	PF11976	0.360
LIG_SUMO_SIM_par_1	338	344	PF11976	0.394
LIG_TRAF2_1	386	389	PF00917	0.404
LIG_TYR_ITIM	421	426	PF00017	0.326
LIG_UBA3_1	327	335	PF00899	0.432
LIG_WRC_WIRS_1	114	119	PF05994	0.450
MOD_CDC14_SPxK_1	408	411	PF00782	0.458
MOD_CDK_SPxK_1	405	411	PF00069	0.490
MOD_CK1_1	120	126	PF00069	0.388
MOD_CK1_1	194	200	PF00069	0.485
MOD_CK1_1	241	247	PF00069	0.385
MOD_CK1_1	398	404	PF00069	0.524
MOD_CK1_1	427	433	PF00069	0.329
MOD_CK1_1	445	451	PF00069	0.564
MOD_CK1_1	497	503	PF00069	0.543
MOD_CK1_1	510	516	PF00069	0.433
MOD_CK2_1	17	23	PF00069	0.583
MOD_CK2_1	303	309	PF00069	0.430
MOD_CK2_1	382	388	PF00069	0.433
MOD_Cter_Amidation	73	76	PF01082	0.568
MOD_GlcNHglycan	10	13	PF01048	0.605
MOD_GlcNHglycan	103	106	PF01048	0.523
MOD_GlcNHglycan	138	141	PF01048	0.525
MOD_GlcNHglycan	167	170	PF01048	0.467
MOD_GlcNHglycan	201	204	PF01048	0.401
MOD_GlcNHglycan	243	246	PF01048	0.507
MOD_GlcNHglycan	289	292	PF01048	0.544
MOD_GlcNHglycan	373	376	PF01048	0.444
MOD_GlcNHglycan	403	406	PF01048	0.485
MOD_GlcNHglycan	5	8	PF01048	0.552
MOD_GlcNHglycan	519	522	PF01048	0.356
MOD_GlcNHglycan	525	528	PF01048	0.381
MOD_GlcNHglycan	542	545	PF01048	0.425
MOD_GlcNHglycan	64	67	PF01048	0.690
MOD_GSK3_1	109	116	PF00069	0.514
MOD_GSK3_1	117	124	PF00069	0.384
MOD_GSK3_1	17	24	PF00069	0.661
MOD_GSK3_1	190	197	PF00069	0.451
MOD_GSK3_1	234	241	PF00069	0.524
MOD_GSK3_1	244	251	PF00069	0.376
MOD_GSK3_1	259	266	PF00069	0.347
MOD_GSK3_1	378	385	PF00069	0.433
MOD_GSK3_1	388	395	PF00069	0.364
MOD_GSK3_1	401	408	PF00069	0.482
MOD_GSK3_1	440	447	PF00069	0.599
MOD_GSK3_1	452	459	PF00069	0.638
MOD_GSK3_1	495	502	PF00069	0.505
MOD_GSK3_1	503	510	PF00069	0.376
MOD_GSK3_1	515	522	PF00069	0.394
MOD_GSK3_1	538	545	PF00069	0.446
MOD_GSK3_1	90	97	PF00069	0.545
MOD_N-GLC_1	405	410	PF02516	0.507
MOD_N-GLC_2	263	265	PF02516	0.355
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	117	122	PF00069	0.424
MOD_NEK2_1	144	149	PF00069	0.431
MOD_NEK2_1	185	190	PF00069	0.380
MOD_NEK2_1	191	196	PF00069	0.440
MOD_NEK2_1	239	244	PF00069	0.496
MOD_NEK2_1	452	457	PF00069	0.588
MOD_NEK2_1	494	499	PF00069	0.629
MOD_NEK2_1	503	508	PF00069	0.352
MOD_NEK2_1	540	545	PF00069	0.470
MOD_NEK2_1	68	73	PF00069	0.653
MOD_NEK2_1	8	13	PF00069	0.576
MOD_NEK2_2	113	118	PF00069	0.524
MOD_NEK2_2	357	362	PF00069	0.537
MOD_PIKK_1	185	191	PF00454	0.408
MOD_PIKK_1	398	404	PF00454	0.493
MOD_PIKK_1	442	448	PF00454	0.522
MOD_PIKK_1	456	462	PF00454	0.616
MOD_PIKK_1	51	57	PF00454	0.541
MOD_PKA_1	495	501	PF00069	0.484
MOD_PKA_2	101	107	PF00069	0.589
MOD_PKA_2	117	123	PF00069	0.489
MOD_PKA_2	179	185	PF00069	0.440
MOD_PKA_2	391	397	PF00069	0.438
MOD_PKA_2	398	404	PF00069	0.465
MOD_Plk_1	388	394	PF00069	0.417
MOD_Plk_2-3	480	486	PF00069	0.725
MOD_Plk_4	117	123	PF00069	0.413
MOD_Plk_4	145	151	PF00069	0.528
MOD_Plk_4	410	416	PF00069	0.495
MOD_Plk_4	427	433	PF00069	0.284
MOD_Plk_4	463	469	PF00069	0.750
MOD_Plk_4	499	505	PF00069	0.556
MOD_ProDKin_1	109	115	PF00069	0.595
MOD_ProDKin_1	234	240	PF00069	0.564
MOD_ProDKin_1	272	278	PF00069	0.474
MOD_ProDKin_1	405	411	PF00069	0.490
MOD_ProDKin_1	497	503	PF00069	0.410
MOD_SUMO_rev_2	147	156	PF00179	0.450
MOD_SUMO_rev_2	160	169	PF00179	0.426
MOD_SUMO_rev_2	23	29	PF00179	0.581
MOD_SUMO_rev_2	492	497	PF00179	0.558
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.388
TRG_ENDOCYTIC_2	119	122	PF00928	0.400
TRG_ENDOCYTIC_2	423	426	PF00928	0.327
TRG_ER_diArg_1	14	16	PF00400	0.533
TRG_ER_diArg_1	297	299	PF00400	0.626
TRG_ER_diArg_1	32	34	PF00400	0.601
TRG_ER_diArg_1	333	336	PF00400	0.471
TRG_ER_diArg_1	75	77	PF00400	0.545
TRG_Pf-PMV_PEXEL_1	229	234	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC59	Leptomonas seymouri	43%	84%
A4HQ51	Leishmania braziliensis	75%	100%
A4IC79	Leishmania infantum	100%	100%
E9ATX1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q0M5	Leishmania major	90%	100%