WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGL7_LEIDO

TriTrypDb:

LdBPK_280290.1 , LdCL_280009600 , LDHU3_28.0580

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGL7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006356	regulation of transcription by RNA polymerase I	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045943	positive regulation of transcription by RNA polymerase I	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2000232	regulation of rRNA processing	6	1
GO:2000234	positive regulation of rRNA processing	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	739	743	PF00656	0.609
CLV_NRD_NRD_1	105	107	PF00675	0.584
CLV_NRD_NRD_1	249	251	PF00675	0.425
CLV_NRD_NRD_1	28	30	PF00675	0.521
CLV_NRD_NRD_1	479	481	PF00675	0.417
CLV_NRD_NRD_1	572	574	PF00675	0.408
CLV_NRD_NRD_1	654	656	PF00675	0.510
CLV_NRD_NRD_1	793	795	PF00675	0.621
CLV_PCSK_FUR_1	477	481	PF00082	0.406
CLV_PCSK_KEX2_1	105	107	PF00082	0.607
CLV_PCSK_KEX2_1	249	251	PF00082	0.425
CLV_PCSK_KEX2_1	476	478	PF00082	0.479
CLV_PCSK_KEX2_1	479	481	PF00082	0.392
CLV_PCSK_KEX2_1	572	574	PF00082	0.408
CLV_PCSK_KEX2_1	588	590	PF00082	0.406
CLV_PCSK_KEX2_1	654	656	PF00082	0.514
CLV_PCSK_KEX2_1	793	795	PF00082	0.528
CLV_PCSK_PC1ET2_1	476	478	PF00082	0.509
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.374
CLV_PCSK_SKI1_1	199	203	PF00082	0.374
CLV_PCSK_SKI1_1	306	310	PF00082	0.477
CLV_PCSK_SKI1_1	479	483	PF00082	0.339
CLV_PCSK_SKI1_1	53	57	PF00082	0.381
CLV_PCSK_SKI1_1	589	593	PF00082	0.414
CLV_PCSK_SKI1_1	735	739	PF00082	0.554
CLV_Separin_Metazoa	651	655	PF03568	0.409
DEG_APCC_DBOX_1	554	562	PF00400	0.391
DEG_APCC_DBOX_1	660	668	PF00400	0.503
DEG_Nend_UBRbox_3	1	3	PF02207	0.536
DEG_SPOP_SBC_1	239	243	PF00917	0.365
DEG_SPOP_SBC_1	91	95	PF00917	0.640
DOC_CKS1_1	503	508	PF01111	0.540
DOC_CKS1_1	516	521	PF01111	0.348
DOC_MAPK_gen_1	249	257	PF00069	0.395
DOC_MAPK_gen_1	306	312	PF00069	0.434
DOC_MAPK_MEF2A_6	249	257	PF00069	0.463
DOC_MAPK_MEF2A_6	371	378	PF00069	0.457
DOC_MAPK_MEF2A_6	40	48	PF00069	0.383
DOC_MAPK_MEF2A_6	466	474	PF00069	0.441
DOC_PP1_RVXF_1	587	594	PF00149	0.320
DOC_PP2B_LxvP_1	689	692	PF13499	0.506
DOC_PP4_FxxP_1	22	25	PF00568	0.319
DOC_USP7_MATH_1	121	125	PF00917	0.571
DOC_USP7_MATH_1	152	156	PF00917	0.567
DOC_USP7_MATH_1	464	468	PF00917	0.409
DOC_USP7_MATH_1	517	521	PF00917	0.420
DOC_USP7_MATH_1	530	534	PF00917	0.363
DOC_USP7_MATH_1	6	10	PF00917	0.449
DOC_USP7_MATH_1	640	644	PF00917	0.658
DOC_USP7_MATH_1	657	661	PF00917	0.474
DOC_USP7_MATH_1	699	703	PF00917	0.707
DOC_USP7_MATH_1	707	711	PF00917	0.490
DOC_USP7_MATH_1	86	90	PF00917	0.534
DOC_USP7_MATH_1	92	96	PF00917	0.594
DOC_USP7_UBL2_3	26	30	PF12436	0.364
DOC_WW_Pin1_4	154	159	PF00397	0.718
DOC_WW_Pin1_4	235	240	PF00397	0.424
DOC_WW_Pin1_4	269	274	PF00397	0.331
DOC_WW_Pin1_4	370	375	PF00397	0.559
DOC_WW_Pin1_4	407	412	PF00397	0.568
DOC_WW_Pin1_4	460	465	PF00397	0.360
DOC_WW_Pin1_4	502	507	PF00397	0.650
DOC_WW_Pin1_4	515	520	PF00397	0.341
DOC_WW_Pin1_4	574	579	PF00397	0.501
LIG_14-3-3_CanoR_1	209	215	PF00244	0.487
LIG_14-3-3_CanoR_1	346	356	PF00244	0.499
LIG_14-3-3_CanoR_1	426	432	PF00244	0.343
LIG_14-3-3_CanoR_1	479	485	PF00244	0.334
LIG_14-3-3_CanoR_1	598	606	PF00244	0.361
LIG_14-3-3_CanoR_1	87	91	PF00244	0.533
LIG_Actin_WH2_2	649	667	PF00022	0.516
LIG_APCC_ABBA_1	253	258	PF00400	0.423
LIG_BRCT_BRCA1_1	532	536	PF00533	0.325
LIG_Clathr_ClatBox_1	254	258	PF01394	0.452
LIG_FHA_1	120	126	PF00498	0.562
LIG_FHA_1	165	171	PF00498	0.352
LIG_FHA_1	186	192	PF00498	0.339
LIG_FHA_1	205	211	PF00498	0.241
LIG_FHA_1	332	338	PF00498	0.362
LIG_FHA_1	361	367	PF00498	0.431
LIG_FHA_1	456	462	PF00498	0.475
LIG_FHA_1	523	529	PF00498	0.401
LIG_FHA_1	566	572	PF00498	0.459
LIG_FHA_1	620	626	PF00498	0.381
LIG_FHA_1	629	635	PF00498	0.350
LIG_FHA_1	723	729	PF00498	0.561
LIG_FHA_1	78	84	PF00498	0.514
LIG_FHA_2	170	176	PF00498	0.416
LIG_FHA_2	347	353	PF00498	0.422
LIG_FHA_2	496	502	PF00498	0.610
LIG_FHA_2	62	68	PF00498	0.384
LIG_FHA_2	707	713	PF00498	0.681
LIG_FHA_2	92	98	PF00498	0.518
LIG_LIR_Apic_2	447	451	PF02991	0.392
LIG_LIR_Apic_2	501	506	PF02991	0.539
LIG_LIR_Apic_2	775	781	PF02991	0.497
LIG_LIR_Gen_1	200	210	PF02991	0.471
LIG_LIR_Gen_1	430	439	PF02991	0.407
LIG_LIR_LC3C_4	188	192	PF02991	0.437
LIG_LIR_LC3C_4	363	367	PF02991	0.335
LIG_LIR_Nem_3	200	206	PF02991	0.412
LIG_LIR_Nem_3	430	434	PF02991	0.345
LIG_LIR_Nem_3	554	559	PF02991	0.433
LIG_LIR_Nem_3	684	689	PF02991	0.370
LIG_LIR_Nem_3	732	737	PF02991	0.490
LIG_MYND_1	221	225	PF01753	0.468
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.396
LIG_Pex14_2	202	206	PF04695	0.384
LIG_Pex14_2	265	269	PF04695	0.350
LIG_REV1ctd_RIR_1	731	739	PF16727	0.658
LIG_SH2_CRK	448	452	PF00017	0.402
LIG_SH2_CRK	503	507	PF00017	0.584
LIG_SH2_CRK	778	782	PF00017	0.502
LIG_SH2_NCK_1	778	782	PF00017	0.482
LIG_SH2_PTP2	256	259	PF00017	0.339
LIG_SH2_PTP2	45	48	PF00017	0.318
LIG_SH2_SRC	256	259	PF00017	0.339
LIG_SH2_STAP1	149	153	PF00017	0.346
LIG_SH2_STAP1	397	401	PF00017	0.388
LIG_SH2_STAT3	391	394	PF00017	0.494
LIG_SH2_STAT3	545	548	PF00017	0.483
LIG_SH2_STAT5	181	184	PF00017	0.514
LIG_SH2_STAT5	256	259	PF00017	0.339
LIG_SH2_STAT5	287	290	PF00017	0.371
LIG_SH2_STAT5	391	394	PF00017	0.494
LIG_SH2_STAT5	45	48	PF00017	0.407
LIG_SH2_STAT5	565	568	PF00017	0.533
LIG_SH2_STAT5	778	781	PF00017	0.502
LIG_SH2_STAT5	790	793	PF00017	0.504
LIG_SH3_3	190	196	PF00018	0.417
LIG_SH3_3	212	218	PF00018	0.590
LIG_SH3_3	219	225	PF00018	0.396
LIG_SH3_3	384	390	PF00018	0.327
LIG_SH3_3	406	412	PF00018	0.514
LIG_SH3_3	435	441	PF00018	0.480
LIG_SH3_3	458	464	PF00018	0.521
LIG_SH3_3	572	578	PF00018	0.511
LIG_SH3_3	695	701	PF00018	0.554
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.345
LIG_SUMO_SIM_anti_2	292	299	PF11976	0.355
LIG_SUMO_SIM_par_1	166	172	PF11976	0.331
LIG_SUMO_SIM_par_1	292	299	PF11976	0.351
LIG_SUMO_SIM_par_1	334	341	PF11976	0.399
LIG_SUMO_SIM_par_1	467	473	PF11976	0.327
LIG_TRAF2_1	750	753	PF00917	0.547
LIG_TRAF2_1	95	98	PF00917	0.525
LIG_TYR_ITIM	254	259	PF00017	0.306
LIG_UBA3_1	138	145	PF00899	0.372
LIG_WRC_WIRS_1	170	175	PF05994	0.446
LIG_WRC_WIRS_1	431	436	PF05994	0.509
LIG_WRC_WIRS_1	730	735	PF05994	0.656
LIG_WW_3	410	414	PF00397	0.483
MOD_CDC14_SPxK_1	410	413	PF00782	0.558
MOD_CDC14_SPxK_1	463	466	PF00782	0.410
MOD_CDK_SPxK_1	407	413	PF00069	0.571
MOD_CDK_SPxK_1	460	466	PF00069	0.412
MOD_CDK_SPxxK_3	574	581	PF00069	0.446
MOD_CK1_1	163	169	PF00069	0.540
MOD_CK1_1	204	210	PF00069	0.501
MOD_CK1_1	238	244	PF00069	0.480
MOD_CK1_1	331	337	PF00069	0.363
MOD_CK1_1	395	401	PF00069	0.471
MOD_CK1_1	427	433	PF00069	0.421
MOD_CK1_1	577	583	PF00069	0.434
MOD_CK1_1	617	623	PF00069	0.354
MOD_CK1_1	93	99	PF00069	0.627
MOD_CK2_1	169	175	PF00069	0.413
MOD_CK2_1	346	352	PF00069	0.443
MOD_CK2_1	400	406	PF00069	0.444
MOD_CK2_1	604	610	PF00069	0.435
MOD_CK2_1	61	67	PF00069	0.432
MOD_CK2_1	629	635	PF00069	0.386
MOD_CK2_1	699	705	PF00069	0.703
MOD_CK2_1	706	712	PF00069	0.729
MOD_CK2_1	91	97	PF00069	0.668
MOD_Cter_Amidation	247	250	PF01082	0.410
MOD_Cter_Amidation	477	480	PF01082	0.423
MOD_Cter_Amidation	586	589	PF01082	0.355
MOD_GlcNHglycan	154	157	PF01048	0.602
MOD_GlcNHglycan	162	165	PF01048	0.545
MOD_GlcNHglycan	210	213	PF01048	0.515
MOD_GlcNHglycan	282	286	PF01048	0.386
MOD_GlcNHglycan	349	352	PF01048	0.399
MOD_GlcNHglycan	466	469	PF01048	0.507
MOD_GlcNHglycan	49	52	PF01048	0.417
MOD_GlcNHglycan	513	516	PF01048	0.424
MOD_GlcNHglycan	528	531	PF01048	0.388
MOD_GlcNHglycan	616	619	PF01048	0.350
MOD_GlcNHglycan	711	716	PF01048	0.725
MOD_GlcNHglycan	783	786	PF01048	0.515
MOD_GSK3_1	159	166	PF00069	0.549
MOD_GSK3_1	204	211	PF00069	0.508
MOD_GSK3_1	231	238	PF00069	0.449
MOD_GSK3_1	281	288	PF00069	0.474
MOD_GSK3_1	316	323	PF00069	0.424
MOD_GSK3_1	328	335	PF00069	0.280
MOD_GSK3_1	395	402	PF00069	0.394
MOD_GSK3_1	430	437	PF00069	0.497
MOD_GSK3_1	460	467	PF00069	0.383
MOD_GSK3_1	495	502	PF00069	0.543
MOD_GSK3_1	511	518	PF00069	0.376
MOD_GSK3_1	522	529	PF00069	0.421
MOD_GSK3_1	597	604	PF00069	0.499
MOD_GSK3_1	707	714	PF00069	0.775
MOD_GSK3_1	73	80	PF00069	0.432
MOD_GSK3_1	736	743	PF00069	0.669
MOD_GSK3_1	755	762	PF00069	0.637
MOD_GSK3_1	781	788	PF00069	0.497
MOD_GSK3_1	86	93	PF00069	0.466
MOD_N-GLC_1	36	41	PF02516	0.421
MOD_N-GLC_1	422	427	PF02516	0.378
MOD_N-GLC_1	511	516	PF02516	0.410
MOD_N-GLC_1	657	662	PF02516	0.461
MOD_NEK2_1	201	206	PF00069	0.390
MOD_NEK2_1	281	286	PF00069	0.475
MOD_NEK2_1	328	333	PF00069	0.449
MOD_NEK2_1	345	350	PF00069	0.480
MOD_NEK2_1	36	41	PF00069	0.529
MOD_NEK2_1	399	404	PF00069	0.439
MOD_NEK2_1	422	427	PF00069	0.446
MOD_NEK2_1	434	439	PF00069	0.390
MOD_NEK2_1	619	624	PF00069	0.477
MOD_NEK2_1	628	633	PF00069	0.462
MOD_NEK2_1	77	82	PF00069	0.420
MOD_NEK2_2	61	66	PF00069	0.533
MOD_PIKK_1	389	395	PF00454	0.350
MOD_PIKK_1	400	406	PF00454	0.444
MOD_PIKK_1	455	461	PF00454	0.401
MOD_PIKK_1	517	523	PF00454	0.526
MOD_PIKK_1	565	571	PF00454	0.426
MOD_PIKK_1	6	12	PF00454	0.390
MOD_PIKK_1	740	746	PF00454	0.622
MOD_PK_1	79	85	PF00069	0.440
MOD_PKA_2	208	214	PF00069	0.491
MOD_PKA_2	216	222	PF00069	0.575
MOD_PKA_2	290	296	PF00069	0.416
MOD_PKA_2	345	351	PF00069	0.487
MOD_PKA_2	597	603	PF00069	0.358
MOD_PKA_2	86	92	PF00069	0.528
MOD_Plk_1	15	21	PF00069	0.380
MOD_Plk_1	511	517	PF00069	0.508
MOD_Plk_1	61	67	PF00069	0.386
MOD_Plk_1	620	626	PF00069	0.467
MOD_Plk_1	628	634	PF00069	0.459
MOD_Plk_1	657	663	PF00069	0.460
MOD_Plk_1	735	741	PF00069	0.655
MOD_Plk_2-3	597	603	PF00069	0.358
MOD_Plk_2-3	629	635	PF00069	0.441
MOD_Plk_2-3	736	742	PF00069	0.668
MOD_Plk_4	121	127	PF00069	0.479
MOD_Plk_4	164	170	PF00069	0.383
MOD_Plk_4	201	207	PF00069	0.388
MOD_Plk_4	290	296	PF00069	0.418
MOD_Plk_4	392	398	PF00069	0.439
MOD_Plk_4	434	440	PF00069	0.485
MOD_Plk_4	457	463	PF00069	0.491
MOD_Plk_4	601	607	PF00069	0.424
MOD_Plk_4	61	67	PF00069	0.443
MOD_Plk_4	620	626	PF00069	0.346
MOD_Plk_4	629	635	PF00069	0.343
MOD_Plk_4	699	705	PF00069	0.627
MOD_Plk_4	729	735	PF00069	0.656
MOD_Plk_4	73	79	PF00069	0.494
MOD_Plk_4	786	792	PF00069	0.497
MOD_Plk_4	86	92	PF00069	0.616
MOD_ProDKin_1	154	160	PF00069	0.721
MOD_ProDKin_1	235	241	PF00069	0.429
MOD_ProDKin_1	269	275	PF00069	0.330
MOD_ProDKin_1	370	376	PF00069	0.553
MOD_ProDKin_1	407	413	PF00069	0.570
MOD_ProDKin_1	460	466	PF00069	0.369
MOD_ProDKin_1	502	508	PF00069	0.643
MOD_ProDKin_1	515	521	PF00069	0.346
MOD_ProDKin_1	574	580	PF00069	0.500
TRG_AP2beta_CARGO_1	200	209	PF09066	0.400
TRG_DiLeu_BaEn_1	292	297	PF01217	0.329
TRG_DiLeu_BaEn_1	324	329	PF01217	0.295
TRG_DiLeu_BaEn_1	629	634	PF01217	0.353
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.440
TRG_DiLeu_BaLyEn_6	438	443	PF01217	0.398
TRG_DiLeu_LyEn_5	554	559	PF01217	0.477
TRG_ENDOCYTIC_2	181	184	PF00928	0.385
TRG_ENDOCYTIC_2	203	206	PF00928	0.435
TRG_ENDOCYTIC_2	256	259	PF00928	0.317
TRG_ENDOCYTIC_2	431	434	PF00928	0.380
TRG_ENDOCYTIC_2	45	48	PF00928	0.318
TRG_ER_diArg_1	477	480	PF00400	0.455
TRG_ER_diArg_1	571	573	PF00400	0.402
TRG_ER_diArg_1	653	655	PF00400	0.523
TRG_ER_diArg_1	793	795	PF00400	0.531
TRG_NES_CRM1_1	137	150	PF08389	0.252
TRG_NLS_MonoExtC_3	28	34	PF00514	0.365
TRG_NLS_MonoExtN_4	26	33	PF00514	0.375
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K6	Leptomonas seymouri	70%	97%
A0A0S4J855	Bodo saltans	35%	100%
A0A1X0NYJ9	Trypanosomatidae	41%	100%
A0A422P1N8	Trypanosoma rangeli	42%	100%
A4HG86	Leishmania braziliensis	84%	100%
A4I3A1	Leishmania infantum	100%	100%
D0A824	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	95%
E9AZK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q8M4	Leishmania major	94%	100%