Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGL6_LEIDO

TriTrypDb:

LdBPK_324090.1 , LdCL_320046900 , LDHU3_32.5260

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.360
CLV_NRD_NRD_1	100	102	PF00675	0.473
CLV_NRD_NRD_1	148	150	PF00675	0.486
CLV_NRD_NRD_1	294	296	PF00675	0.555
CLV_NRD_NRD_1	418	420	PF00675	0.431
CLV_NRD_NRD_1	516	518	PF00675	0.326
CLV_NRD_NRD_1	88	90	PF00675	0.456
CLV_PCSK_KEX2_1	100	102	PF00082	0.371
CLV_PCSK_KEX2_1	148	150	PF00082	0.433
CLV_PCSK_KEX2_1	516	518	PF00082	0.326
CLV_PCSK_KEX2_1	537	539	PF00082	0.376
CLV_PCSK_KEX2_1	88	90	PF00082	0.389
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.378
CLV_PCSK_SKI1_1	118	122	PF00082	0.395
CLV_PCSK_SKI1_1	149	153	PF00082	0.475
CLV_PCSK_SKI1_1	162	166	PF00082	0.488
CLV_PCSK_SKI1_1	419	423	PF00082	0.349
CLV_PCSK_SKI1_1	488	492	PF00082	0.453
CLV_PCSK_SKI1_1	529	533	PF00082	0.381
DEG_APCC_DBOX_1	148	156	PF00400	0.463
DEG_APCC_DBOX_1	161	169	PF00400	0.481
DEG_APCC_DBOX_1	528	536	PF00400	0.436
DEG_SCF_FBW7_1	75	81	PF00400	0.470
DOC_CDC14_PxL_1	449	457	PF14671	0.393
DOC_CKS1_1	75	80	PF01111	0.477
DOC_CYCLIN_RxL_1	364	372	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.368
DOC_MAPK_DCC_7	173	181	PF00069	0.423
DOC_MAPK_gen_1	300	310	PF00069	0.495
DOC_MAPK_gen_1	537	548	PF00069	0.458
DOC_MAPK_MEF2A_6	228	235	PF00069	0.293
DOC_MAPK_MEF2A_6	541	550	PF00069	0.451
DOC_MAPK_NFAT4_5	228	236	PF00069	0.288
DOC_MAPK_RevD_3	405	420	PF00069	0.396
DOC_PP1_RVXF_1	417	424	PF00149	0.375
DOC_USP7_MATH_1	120	124	PF00917	0.520
DOC_USP7_MATH_1	207	211	PF00917	0.530
DOC_USP7_MATH_1	445	449	PF00917	0.388
DOC_USP7_MATH_1	78	82	PF00917	0.521
DOC_USP7_UBL2_3	296	300	PF12436	0.562
DOC_WW_Pin1_4	210	215	PF00397	0.375
DOC_WW_Pin1_4	303	308	PF00397	0.539
DOC_WW_Pin1_4	74	79	PF00397	0.546
DOC_WW_Pin1_4	8	13	PF00397	0.532
LIG_14-3-3_CanoR_1	19	24	PF00244	0.491
LIG_14-3-3_CanoR_1	199	205	PF00244	0.528
LIG_14-3-3_CanoR_1	425	430	PF00244	0.387
LIG_14-3-3_CanoR_1	475	480	PF00244	0.320
LIG_14-3-3_CanoR_1	517	523	PF00244	0.417
LIG_Actin_WH2_2	184	201	PF00022	0.480
LIG_Actin_WH2_2	472	490	PF00022	0.353
LIG_BIR_II_1	1	5	PF00653	0.465
LIG_BRCT_BRCA1_1	1	5	PF00533	0.610
LIG_BRCT_BRCA1_1	212	216	PF00533	0.281
LIG_Clathr_ClatBox_1	353	357	PF01394	0.322
LIG_FHA_1	122	128	PF00498	0.434
LIG_FHA_1	349	355	PF00498	0.319
LIG_FHA_1	356	362	PF00498	0.292
LIG_FHA_1	390	396	PF00498	0.452
LIG_FHA_1	487	493	PF00498	0.420
LIG_FHA_2	220	226	PF00498	0.402
LIG_FHA_2	243	249	PF00498	0.456
LIG_FHA_2	397	403	PF00498	0.342
LIG_FHA_2	42	48	PF00498	0.405
LIG_FHA_2	498	504	PF00498	0.416
LIG_HCF-1_HBM_1	372	375	PF13415	0.485
LIG_LIR_Gen_1	213	223	PF02991	0.397
LIG_LIR_Gen_1	22	30	PF02991	0.383
LIG_LIR_Gen_1	254	264	PF02991	0.389
LIG_LIR_Gen_1	267	277	PF02991	0.416
LIG_LIR_Gen_1	309	319	PF02991	0.432
LIG_LIR_Gen_1	372	383	PF02991	0.441
LIG_LIR_Nem_3	213	219	PF02991	0.285
LIG_LIR_Nem_3	22	26	PF02991	0.387
LIG_LIR_Nem_3	254	259	PF02991	0.382
LIG_LIR_Nem_3	267	272	PF02991	0.367
LIG_LIR_Nem_3	309	314	PF02991	0.396
LIG_LIR_Nem_3	372	377	PF02991	0.398
LIG_LIR_Nem_3	62	68	PF02991	0.388
LIG_LYPXL_yS_3	382	385	PF13949	0.342
LIG_MYND_1	552	556	PF01753	0.468
LIG_NRBOX	131	137	PF00104	0.556
LIG_NRBOX	506	512	PF00104	0.458
LIG_OCRL_FandH_1	187	199	PF00620	0.286
LIG_PCNA_PIPBox_1	368	377	PF02747	0.429
LIG_PCNA_yPIPBox_3	250	264	PF02747	0.416
LIG_PCNA_yPIPBox_3	366	375	PF02747	0.384
LIG_SH2_CRK	256	260	PF00017	0.366
LIG_SH2_CRK	66	70	PF00017	0.379
LIG_SH2_STAP1	264	268	PF00017	0.449
LIG_SH2_STAP1	325	329	PF00017	0.417
LIG_SH2_STAP1	335	339	PF00017	0.448
LIG_SH2_STAT3	377	380	PF00017	0.427
LIG_SH2_STAT5	36	39	PF00017	0.573
LIG_SH2_STAT5	436	439	PF00017	0.377
LIG_SH2_STAT5	486	489	PF00017	0.365
LIG_SH2_STAT5	518	521	PF00017	0.498
LIG_SH3_2	75	80	PF14604	0.442
LIG_SH3_3	37	43	PF00018	0.455
LIG_SH3_3	390	396	PF00018	0.403
LIG_SH3_3	519	525	PF00018	0.307
LIG_SH3_3	69	75	PF00018	0.414
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.459
LIG_SUMO_SIM_anti_2	351	358	PF11976	0.292
LIG_SUMO_SIM_par_1	351	358	PF11976	0.292
LIG_TRAF2_1	222	225	PF00917	0.437
LIG_TYR_ITIM	63	68	PF00017	0.353
LIG_UBA3_1	219	228	PF00899	0.452
LIG_UBA3_1	361	367	PF00899	0.461
LIG_UBA3_1	507	512	PF00899	0.330
LIG_UBA3_1	531	537	PF00899	0.353
MOD_CDK_SPxK_1	74	80	PF00069	0.494
MOD_CK1_1	210	216	PF00069	0.368
MOD_CK1_1	338	344	PF00069	0.528
MOD_CK1_1	58	64	PF00069	0.417
MOD_CK2_1	219	225	PF00069	0.425
MOD_CK2_1	242	248	PF00069	0.428
MOD_CK2_1	396	402	PF00069	0.339
MOD_CK2_1	41	47	PF00069	0.419
MOD_CK2_1	497	503	PF00069	0.423
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.448
MOD_GlcNHglycan	1	4	PF01048	0.485
MOD_GlcNHglycan	108	111	PF01048	0.549
MOD_GlcNHglycan	195	198	PF01048	0.475
MOD_GlcNHglycan	216	219	PF01048	0.337
MOD_GlcNHglycan	242	245	PF01048	0.534
MOD_GlcNHglycan	344	347	PF01048	0.403
MOD_GSK3_1	15	22	PF00069	0.414
MOD_GSK3_1	151	158	PF00069	0.440
MOD_GSK3_1	210	217	PF00069	0.389
MOD_GSK3_1	219	226	PF00069	0.404
MOD_GSK3_1	319	326	PF00069	0.386
MOD_GSK3_1	338	345	PF00069	0.200
MOD_GSK3_1	4	11	PF00069	0.505
MOD_GSK3_1	421	428	PF00069	0.345
MOD_GSK3_1	475	482	PF00069	0.428
MOD_GSK3_1	486	493	PF00069	0.357
MOD_GSK3_1	55	62	PF00069	0.386
MOD_GSK3_1	74	81	PF00069	0.479
MOD_N-GLC_1	251	256	PF02516	0.557
MOD_NEK2_1	121	126	PF00069	0.445
MOD_NEK2_1	141	146	PF00069	0.232
MOD_NEK2_1	15	20	PF00069	0.393
MOD_NEK2_1	155	160	PF00069	0.335
MOD_NEK2_1	198	203	PF00069	0.441
MOD_NEK2_1	223	228	PF00069	0.433
MOD_NEK2_1	242	247	PF00069	0.245
MOD_NEK2_1	319	324	PF00069	0.396
MOD_NEK2_1	421	426	PF00069	0.321
MOD_NEK2_1	496	501	PF00069	0.508
MOD_NEK2_2	320	325	PF00069	0.386
MOD_NEK2_2	518	523	PF00069	0.500
MOD_PIKK_1	55	61	PF00454	0.369
MOD_PK_1	475	481	PF00069	0.364
MOD_PKA_1	537	543	PF00069	0.343
MOD_PKA_2	198	204	PF00069	0.433
MOD_PKA_2	294	300	PF00069	0.623
MOD_PKA_2	537	543	PF00069	0.363
MOD_Plk_1	142	148	PF00069	0.488
MOD_Plk_1	251	257	PF00069	0.551
MOD_Plk_1	78	84	PF00069	0.524
MOD_Plk_4	131	137	PF00069	0.468
MOD_Plk_4	19	25	PF00069	0.440
MOD_Plk_4	251	257	PF00069	0.501
MOD_Plk_4	313	319	PF00069	0.467
MOD_Plk_4	320	326	PF00069	0.377
MOD_Plk_4	338	344	PF00069	0.297
MOD_Plk_4	389	395	PF00069	0.465
MOD_Plk_4	425	431	PF00069	0.343
MOD_Plk_4	50	56	PF00069	0.465
MOD_Plk_4	59	65	PF00069	0.288
MOD_Plk_4	78	84	PF00069	0.397
MOD_ProDKin_1	210	216	PF00069	0.370
MOD_ProDKin_1	303	309	PF00069	0.541
MOD_ProDKin_1	74	80	PF00069	0.550
MOD_ProDKin_1	8	14	PF00069	0.532
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.381
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.433
TRG_ENDOCYTIC_2	256	259	PF00928	0.362
TRG_ENDOCYTIC_2	269	272	PF00928	0.338
TRG_ENDOCYTIC_2	375	378	PF00928	0.347
TRG_ENDOCYTIC_2	382	385	PF00928	0.330
TRG_ENDOCYTIC_2	457	460	PF00928	0.355
TRG_ENDOCYTIC_2	65	68	PF00928	0.369
TRG_ER_diArg_1	148	150	PF00400	0.489
TRG_ER_diArg_1	284	287	PF00400	0.554
TRG_ER_diArg_1	515	517	PF00400	0.313
TRG_ER_diArg_1	87	89	PF00400	0.497
TRG_ER_diArg_1	99	101	PF00400	0.547
TRG_NLS_MonoExtN_4	293	299	PF00514	0.451
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II47	Leptomonas seymouri	57%	100%
A0A0S4JG92	Bodo saltans	22%	77%
A0A1X0NRZ6	Trypanosomatidae	40%	99%
A0A422NHU1	Trypanosoma rangeli	42%	98%
A4HL31	Leishmania braziliensis	82%	100%
A4I8L2	Leishmania infantum	100%	100%
D0AAK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	92%
E9B3H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q4M8	Leishmania major	95%	100%
V5BI03	Trypanosoma cruzi	42%	98%