Kinetoplast-associated_protein_p18-2_putative/Gen eDB:LmjF.32.3770

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein p18-2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGK7_LEIDO

TriTrypDb:

LdBPK_323920.1 , LdCL_320045200 , LDHU3_32.5050

Length:

132

Annotations

Annotations by Jardim et al.

Kinetoplastid proteins, kinetoplast-associated p18-2

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IGK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGK7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	7	13	PF00089	0.377
CLV_NRD_NRD_1	119	121	PF00675	0.505
CLV_NRD_NRD_1	130	132	PF00675	0.500
CLV_NRD_NRD_1	3	5	PF00675	0.574
CLV_NRD_NRD_1	54	56	PF00675	0.388
CLV_NRD_NRD_1	72	74	PF00675	0.326
CLV_NRD_NRD_1	76	78	PF00675	0.413
CLV_PCSK_KEX2_1	3	5	PF00082	0.574
CLV_PCSK_KEX2_1	54	56	PF00082	0.423
CLV_PCSK_KEX2_1	72	74	PF00082	0.326
CLV_PCSK_KEX2_1	76	78	PF00082	0.446
CLV_PCSK_KEX2_1	85	87	PF00082	0.373
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.463
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.463
CLV_PCSK_SKI1_1	125	129	PF00082	0.582
CLV_PCSK_SKI1_1	28	32	PF00082	0.451
CLV_PCSK_SKI1_1	49	53	PF00082	0.434
CLV_PCSK_SKI1_1	54	58	PF00082	0.439
CLV_PCSK_SKI1_1	69	73	PF00082	0.272
DEG_COP1_1	103	112	PF00400	0.469
DEG_Nend_Nbox_1	1	3	PF02207	0.620
DOC_MAPK_gen_1	3	11	PF00069	0.471
DOC_MAPK_gen_1	72	83	PF00069	0.477
DOC_MAPK_MEF2A_6	3	11	PF00069	0.425
DOC_USP7_MATH_1	47	51	PF00917	0.405
DOC_USP7_UBL2_3	113	117	PF12436	0.593
DOC_USP7_UBL2_3	121	125	PF12436	0.524
DOC_USP7_UBL2_3	128	132	PF12436	0.458
DOC_USP7_UBL2_3	39	43	PF12436	0.378
DOC_WW_Pin1_4	42	47	PF00397	0.591
DOC_WW_Pin1_4	9	14	PF00397	0.459
LIG_14-3-3_CanoR_1	3	11	PF00244	0.405
LIG_Actin_WH2_2	14	30	PF00022	0.395
LIG_CaM_IQ_9	15	30	PF13499	0.397
LIG_FHA_1	104	110	PF00498	0.552
LIG_FHA_1	22	28	PF00498	0.453
LIG_FHA_1	58	64	PF00498	0.480
LIG_LIR_Gen_1	12	21	PF02991	0.362
LIG_LIR_Gen_1	65	75	PF02991	0.386
LIG_LIR_Nem_3	12	17	PF02991	0.402
LIG_TRAF2_1	62	65	PF00917	0.423
MOD_CDK_SPxxK_3	42	49	PF00069	0.447
MOD_CK1_1	100	106	PF00069	0.548
MOD_CK1_1	50	56	PF00069	0.330
MOD_CK2_1	42	48	PF00069	0.449
MOD_Cter_Amidation	122	125	PF01082	0.555
MOD_GlcNHglycan	110	113	PF01048	0.661
MOD_GlcNHglycan	48	52	PF01048	0.396
MOD_GSK3_1	93	100	PF00069	0.490
MOD_N-GLC_2	32	34	PF02516	0.417
MOD_NEK2_1	2	7	PF00069	0.469
MOD_NEK2_1	97	102	PF00069	0.569
MOD_PIKK_1	97	103	PF00454	0.411
MOD_PKA_1	57	63	PF00069	0.371
MOD_PKA_2	2	8	PF00069	0.498
MOD_PKA_2	97	103	PF00069	0.488
MOD_Plk_1	47	53	PF00069	0.529
MOD_ProDKin_1	42	48	PF00069	0.591
MOD_ProDKin_1	9	15	PF00069	0.460
TRG_ENDOCYTIC_2	41	44	PF00928	0.436
TRG_ENDOCYTIC_2	67	70	PF00928	0.445
TRG_ER_diArg_1	2	4	PF00400	0.595
TRG_ER_diArg_1	75	77	PF00400	0.449
TRG_NLS_Bipartite_1	54	76	PF00514	0.361
TRG_NLS_MonoExtC_3	71	76	PF00514	0.338
TRG_NLS_MonoExtN_4	54	61	PF00514	0.356
TRG_NLS_MonoExtN_4	69	76	PF00514	0.285
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NSD7	Trypanosomatidae	35%	73%
A0A3Q8ITR1	Leishmania donovani	38%	97%
A0A422P329	Trypanosoma rangeli	33%	69%
A4HL14	Leishmania braziliensis	57%	100%
A4HL15	Leishmania braziliensis	40%	100%
A4I8J5	Leishmania infantum	100%	100%
A4I8J6	Leishmania infantum	38%	100%
E9B3F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9B3F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
Q4Q4P4	Leishmania major	42%	100%
Q4Q4P5	Leishmania major	87%	100%
Q8IS98	Crithidia fasciculata	41%	99%
Q9TY83	Crithidia fasciculata	41%	100%
Q9TY84	Crithidia fasciculata	42%	100%