LMBR1-like membrane protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LMBR1-like membrane protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGK4_LEIDO

TriTrypDb:

LdBPK_251200.1 , LdCL_250017600 , LDHU3_25.1530

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0020016	ciliary pocket	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IGK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	465	467	PF00675	0.407
CLV_PCSK_KEX2_1	465	467	PF00082	0.405
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.454
CLV_PCSK_SKI1_1	304	308	PF00082	0.362
CLV_PCSK_SKI1_1	374	378	PF00082	0.394
DEG_Nend_Nbox_1	1	3	PF02207	0.396
DEG_SPOP_SBC_1	164	168	PF00917	0.322
DOC_ANK_TNKS_1	223	230	PF00023	0.467
DOC_ANK_TNKS_1	433	440	PF00023	0.369
DOC_CYCLIN_yCln2_LP_2	56	62	PF00134	0.286
DOC_MAPK_gen_1	264	272	PF00069	0.552
DOC_MAPK_gen_1	434	442	PF00069	0.268
DOC_MAPK_gen_1	465	476	PF00069	0.647
DOC_MAPK_HePTP_8	240	252	PF00069	0.491
DOC_MAPK_MEF2A_6	177	186	PF00069	0.271
DOC_MAPK_MEF2A_6	232	241	PF00069	0.498
DOC_MAPK_MEF2A_6	243	252	PF00069	0.454
DOC_MAPK_MEF2A_6	41	50	PF00069	0.324
DOC_MAPK_MEF2A_6	434	442	PF00069	0.268
DOC_MAPK_RevD_3	452	466	PF00069	0.314
DOC_PP1_RVXF_1	372	379	PF00149	0.577
DOC_PP2B_LxvP_1	56	59	PF13499	0.286
DOC_USP7_MATH_1	164	168	PF00917	0.284
DOC_USP7_MATH_1	51	55	PF00917	0.445
DOC_USP7_UBL2_3	222	226	PF12436	0.535
DOC_WW_Pin1_4	294	299	PF00397	0.547
DOC_WW_Pin1_4	62	67	PF00397	0.314
LIG_Actin_WH2_2	420	438	PF00022	0.313
LIG_AP2alpha_2	331	333	PF02296	0.379
LIG_BIR_III_2	329	333	PF00653	0.341
LIG_CaM_IQ_9	251	266	PF13499	0.619
LIG_EH1_1	394	402	PF00400	0.391
LIG_FHA_1	125	131	PF00498	0.326
LIG_FHA_1	177	183	PF00498	0.277
LIG_FHA_1	186	192	PF00498	0.228
LIG_FHA_1	334	340	PF00498	0.329
LIG_GBD_Chelix_1	312	320	PF00786	0.336
LIG_LIR_Gen_1	21	28	PF02991	0.388
LIG_LIR_Gen_1	33	44	PF02991	0.512
LIG_LIR_Gen_1	361	370	PF02991	0.437
LIG_LIR_Gen_1	403	412	PF02991	0.363
LIG_LIR_Gen_1	417	424	PF02991	0.388
LIG_LIR_Gen_1	456	464	PF02991	0.310
LIG_LIR_Nem_3	149	155	PF02991	0.289
LIG_LIR_Nem_3	21	26	PF02991	0.388
LIG_LIR_Nem_3	297	302	PF02991	0.532
LIG_LIR_Nem_3	33	39	PF02991	0.512
LIG_LIR_Nem_3	361	365	PF02991	0.398
LIG_LIR_Nem_3	403	408	PF02991	0.351
LIG_LIR_Nem_3	414	418	PF02991	0.297
LIG_LIR_Nem_3	456	462	PF02991	0.303
LIG_NRBOX	333	339	PF00104	0.369
LIG_Pex14_1	199	203	PF04695	0.296
LIG_Pex14_2	101	105	PF04695	0.364
LIG_Pex14_2	197	201	PF04695	0.445
LIG_Pex14_2	358	362	PF04695	0.296
LIG_PTB_Apo_2	272	279	PF02174	0.560
LIG_PTB_Phospho_1	272	278	PF10480	0.559
LIG_SH2_CRK	23	27	PF00017	0.367
LIG_SH2_CRK	302	306	PF00017	0.460
LIG_SH2_CRK	353	357	PF00017	0.412
LIG_SH2_CRK	405	409	PF00017	0.364
LIG_SH2_NCK_1	291	295	PF00017	0.577
LIG_SH2_NCK_1	405	409	PF00017	0.423
LIG_SH2_NCK_1	60	64	PF00017	0.279
LIG_SH2_STAP1	187	191	PF00017	0.327
LIG_SH2_STAP1	23	27	PF00017	0.367
LIG_SH2_STAP1	405	409	PF00017	0.423
LIG_SH2_STAT3	142	145	PF00017	0.367
LIG_SH2_STAT5	171	174	PF00017	0.314
LIG_SH2_STAT5	187	190	PF00017	0.173
LIG_SH2_STAT5	23	26	PF00017	0.309
LIG_SH2_STAT5	27	30	PF00017	0.453
LIG_SH2_STAT5	278	281	PF00017	0.555
LIG_SH2_STAT5	291	294	PF00017	0.563
LIG_SH2_STAT5	359	362	PF00017	0.296
LIG_SH2_STAT5	38	41	PF00017	0.453
LIG_SH2_STAT5	409	412	PF00017	0.367
LIG_SH2_STAT5	74	77	PF00017	0.322
LIG_SH3_3	108	114	PF00018	0.441
LIG_SH3_3	208	214	PF00018	0.321
LIG_SH3_3	94	100	PF00018	0.337
LIG_SUMO_SIM_anti_2	398	404	PF11976	0.356
LIG_SUMO_SIM_anti_2	453	459	PF11976	0.324
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.377
LIG_SUMO_SIM_par_1	178	185	PF11976	0.361
LIG_SUMO_SIM_par_1	398	404	PF11976	0.343
LIG_TYR_ITIM	300	305	PF00017	0.536
LIG_TYR_ITIM	407	412	PF00017	0.421
LIG_TYR_ITSM	19	26	PF00017	0.423
LIG_TYR_ITSM	401	408	PF00017	0.423
LIG_UBA3_1	457	465	PF00899	0.402
LIG_WRC_WIRS_1	22	27	PF05994	0.270
LIG_WRC_WIRS_1	325	330	PF05994	0.369
LIG_WRC_WIRS_1	412	417	PF05994	0.350
MOD_CK1_1	115	121	PF00069	0.495
MOD_CK1_1	167	173	PF00069	0.276
MOD_CK1_1	175	181	PF00069	0.246
MOD_CK1_1	185	191	PF00069	0.176
MOD_CK1_1	258	264	PF00069	0.632
MOD_CK1_1	453	459	PF00069	0.374
MOD_GSK3_1	163	170	PF00069	0.282
MOD_GSK3_1	172	179	PF00069	0.232
MOD_GSK3_1	258	265	PF00069	0.582
MOD_GSK3_1	27	34	PF00069	0.550
MOD_GSK3_1	465	472	PF00069	0.646
MOD_GSK3_1	62	69	PF00069	0.335
MOD_N-GLC_1	395	400	PF02516	0.372
MOD_NEK2_1	333	338	PF00069	0.331
MOD_NEK2_1	358	363	PF00069	0.386
MOD_NEK2_1	395	400	PF00069	0.331
MOD_NEK2_1	401	406	PF00069	0.303
MOD_NEK2_1	450	455	PF00069	0.364
MOD_PIKK_1	115	121	PF00454	0.532
MOD_PIKK_1	77	83	PF00454	0.327
MOD_PKA_1	465	471	PF00069	0.645
MOD_PKA_2	258	264	PF00069	0.595
MOD_PKA_2	465	471	PF00069	0.680
MOD_Plk_1	164	170	PF00069	0.276
MOD_Plk_1	395	401	PF00069	0.368
MOD_Plk_4	124	130	PF00069	0.355
MOD_Plk_4	18	24	PF00069	0.397
MOD_Plk_4	182	188	PF00069	0.264
MOD_Plk_4	213	219	PF00069	0.385
MOD_Plk_4	333	339	PF00069	0.315
MOD_Plk_4	385	391	PF00069	0.499
MOD_Plk_4	395	401	PF00069	0.257
MOD_Plk_4	450	456	PF00069	0.310
MOD_Plk_4	51	57	PF00069	0.418
MOD_ProDKin_1	294	300	PF00069	0.546
MOD_ProDKin_1	62	68	PF00069	0.314
TRG_DiLeu_BaEn_3	235	241	PF01217	0.495
TRG_ENDOCYTIC_2	23	26	PF00928	0.324
TRG_ENDOCYTIC_2	302	305	PF00928	0.531
TRG_ENDOCYTIC_2	325	328	PF00928	0.317
TRG_ENDOCYTIC_2	353	356	PF00928	0.296
TRG_ENDOCYTIC_2	405	408	PF00928	0.364
TRG_ENDOCYTIC_2	409	412	PF00928	0.364
TRG_ENDOCYTIC_2	418	421	PF00928	0.383
TRG_NLS_MonoExtC_3	464	469	PF00514	0.674
TRG_NLS_MonoExtN_4	464	469	PF00514	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRR8	Leptomonas seymouri	74%	100%
A0A0N1I533	Leptomonas seymouri	24%	100%
A0A0S4IQ17	Bodo saltans	48%	100%
A0A0S4JTI8	Bodo saltans	34%	94%
A0A1X0NKT2	Trypanosomatidae	35%	100%
A0A1X0NM00	Trypanosomatidae	56%	100%
A0A3S5H7Y2	Leishmania donovani	24%	100%
A0A422P212	Trypanosoma rangeli	56%	100%
A4HE60	Leishmania braziliensis	80%	100%
A4HM51	Leishmania braziliensis	24%	98%
A4I1F8	Leishmania infantum	99%	100%
A4IAR3	Leishmania infantum	22%	96%
C9ZK11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
D0A2E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D8TFA8	Selaginella moellendorffii	27%	100%
E9AEI9	Leishmania major	23%	96%
E9AXJ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B5Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	96%
Q4Q9X7	Leishmania major	97%	100%
Q54BI3	Dictyostelium discoideum	33%	95%
Q54QP7	Dictyostelium discoideum	33%	95%
Q658I5	Oryza sativa subsp. japonica	31%	94%
Q9M028	Arabidopsis thaliana	29%	94%
Q9SR93	Arabidopsis thaliana	30%	94%