Sperm-tail_PG-rich_repeat_putative/Pfam:PF07004

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGK1_LEIDO

TriTrypDb:

LdBPK_353970.1 , LdCL_350044800 , LDHU3_35.5140

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.530
CLV_NRD_NRD_1	111	113	PF00675	0.310
CLV_NRD_NRD_1	150	152	PF00675	0.238
CLV_NRD_NRD_1	163	165	PF00675	0.542
CLV_NRD_NRD_1	267	269	PF00675	0.533
CLV_NRD_NRD_1	304	306	PF00675	0.296
CLV_NRD_NRD_1	307	309	PF00675	0.608
CLV_NRD_NRD_1	352	354	PF00675	0.545
CLV_NRD_NRD_1	425	427	PF00675	0.667
CLV_PCSK_FUR_1	305	309	PF00082	0.265
CLV_PCSK_KEX2_1	150	152	PF00082	0.224
CLV_PCSK_KEX2_1	201	203	PF00082	0.594
CLV_PCSK_KEX2_1	267	269	PF00082	0.531
CLV_PCSK_KEX2_1	304	306	PF00082	0.267
CLV_PCSK_KEX2_1	307	309	PF00082	0.556
CLV_PCSK_KEX2_1	31	33	PF00082	0.358
CLV_PCSK_KEX2_1	352	354	PF00082	0.545
CLV_PCSK_KEX2_1	425	427	PF00082	0.605
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.594
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.358
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.654
CLV_PCSK_PC7_1	348	354	PF00082	0.593
DEG_APCC_KENBOX_2	9	13	PF00400	0.494
DEG_Nend_UBRbox_2	1	3	PF02207	0.600
DEG_SCF_TRCP1_1	129	135	PF00400	0.532
DEG_SPOP_SBC_1	273	277	PF00917	0.493
DOC_CDC14_PxL_1	1	9	PF14671	0.601
DOC_PP1_RVXF_1	432	439	PF00149	0.644
DOC_PP2B_LxvP_1	67	70	PF13499	0.431
DOC_PP4_FxxP_1	120	123	PF00568	0.513
DOC_PP4_FxxP_1	312	315	PF00568	0.716
DOC_PP4_FxxP_1	58	61	PF00568	0.275
DOC_PP4_MxPP_1	167	170	PF00568	0.443
DOC_USP7_MATH_1	123	127	PF00917	0.569
DOC_USP7_MATH_1	238	242	PF00917	0.503
DOC_USP7_MATH_1	273	277	PF00917	0.645
DOC_USP7_MATH_1	279	283	PF00917	0.583
DOC_USP7_MATH_1	317	321	PF00917	0.497
DOC_USP7_MATH_1	384	388	PF00917	0.398
DOC_USP7_MATH_1	41	45	PF00917	0.435
DOC_USP7_MATH_1	81	85	PF00917	0.483
DOC_USP7_MATH_2	232	238	PF00917	0.566
DOC_WW_Pin1_4	210	215	PF00397	0.541
DOC_WW_Pin1_4	292	297	PF00397	0.659
DOC_WW_Pin1_4	323	328	PF00397	0.514
DOC_WW_Pin1_4	346	351	PF00397	0.568
DOC_WW_Pin1_4	94	99	PF00397	0.495
LIG_14-3-3_CanoR_1	116	121	PF00244	0.443
LIG_14-3-3_CanoR_1	353	359	PF00244	0.494
LIG_14-3-3_CanoR_1	437	444	PF00244	0.566
LIG_14-3-3_CanoR_1	455	460	PF00244	0.549
LIG_BIR_III_4	253	257	PF00653	0.510
LIG_BRCT_BRCA1_1	116	120	PF00533	0.465
LIG_BRCT_BRCA1_1	192	196	PF00533	0.531
LIG_BRCT_BRCA1_1	242	246	PF00533	0.611
LIG_BRCT_BRCA1_1	276	280	PF00533	0.577
LIG_BRCT_BRCA1_1	71	75	PF00533	0.500
LIG_BRCT_BRCA1_1	78	82	PF00533	0.561
LIG_BRCT_BRCA1_1	85	89	PF00533	0.513
LIG_FHA_1	259	265	PF00498	0.511
LIG_FHA_1	403	409	PF00498	0.580
LIG_FHA_1	470	476	PF00498	0.623
LIG_FHA_1	72	78	PF00498	0.460
LIG_LIR_Apic_2	117	123	PF02991	0.513
LIG_LIR_Apic_2	378	384	PF02991	0.496
LIG_LIR_Apic_2	55	61	PF02991	0.531
LIG_LIR_Gen_1	282	292	PF02991	0.623
LIG_LIR_Gen_1	413	422	PF02991	0.567
LIG_LIR_Gen_1	435	444	PF02991	0.570
LIG_LIR_Nem_3	157	161	PF02991	0.594
LIG_LIR_Nem_3	177	181	PF02991	0.435
LIG_LIR_Nem_3	234	239	PF02991	0.576
LIG_LIR_Nem_3	282	287	PF02991	0.616
LIG_LIR_Nem_3	413	417	PF02991	0.624
LIG_LIR_Nem_3	435	441	PF02991	0.637
LIG_MLH1_MIPbox_1	243	247	PF16413	0.491
LIG_MYND_1	180	184	PF01753	0.511
LIG_Pex14_2	325	329	PF04695	0.643
LIG_PTB_Apo_2	139	146	PF02174	0.478
LIG_PTB_Phospho_1	139	145	PF10480	0.478
LIG_REV1ctd_RIR_1	244	254	PF16727	0.501
LIG_SH2_CRK	178	182	PF00017	0.452
LIG_SH2_CRK	64	68	PF00017	0.478
LIG_SH2_NCK_1	145	149	PF00017	0.513
LIG_SH2_SRC	219	222	PF00017	0.546
LIG_SH2_STAP1	124	128	PF00017	0.706
LIG_SH2_STAP1	377	381	PF00017	0.572
LIG_SH2_STAT5	118	121	PF00017	0.431
LIG_SH2_STAT5	235	238	PF00017	0.643
LIG_SH2_STAT5	260	263	PF00017	0.514
LIG_SH2_STAT5	311	314	PF00017	0.462
LIG_SH2_STAT5	414	417	PF00017	0.594
LIG_SH3_3	163	169	PF00018	0.617
LIG_SH3_3	405	411	PF00018	0.598
LIG_WRC_WIRS_1	355	360	PF05994	0.487
MOD_CDC14_SPxK_1	349	352	PF00782	0.419
MOD_CDK_SPxK_1	346	352	PF00069	0.421
MOD_CDK_SPxxK_3	346	353	PF00069	0.584
MOD_CK1_1	241	247	PF00069	0.549
MOD_CK1_1	272	278	PF00069	0.535
MOD_CK1_1	346	352	PF00069	0.421
MOD_CK1_1	84	90	PF00069	0.480
MOD_CK2_1	410	416	PF00069	0.650
MOD_Cter_Amidation	162	165	PF01082	0.580
MOD_GlcNHglycan	120	123	PF01048	0.313
MOD_GlcNHglycan	125	128	PF01048	0.639
MOD_GlcNHglycan	129	132	PF01048	0.381
MOD_GlcNHglycan	161	164	PF01048	0.517
MOD_GlcNHglycan	236	239	PF01048	0.504
MOD_GlcNHglycan	271	274	PF01048	0.565
MOD_GlcNHglycan	276	279	PF01048	0.517
MOD_GlcNHglycan	281	284	PF01048	0.486
MOD_GlcNHglycan	340	343	PF01048	0.660
MOD_GlcNHglycan	345	348	PF01048	0.586
MOD_GlcNHglycan	366	369	PF01048	0.672
MOD_GlcNHglycan	444	447	PF01048	0.588
MOD_GlcNHglycan	52	55	PF01048	0.708
MOD_GSK3_1	114	121	PF00069	0.513
MOD_GSK3_1	123	130	PF00069	0.375
MOD_GSK3_1	14	21	PF00069	0.545
MOD_GSK3_1	191	198	PF00069	0.495
MOD_GSK3_1	234	241	PF00069	0.582
MOD_GSK3_1	269	276	PF00069	0.582
MOD_GSK3_1	323	330	PF00069	0.517
MOD_GSK3_1	332	339	PF00069	0.535
MOD_GSK3_1	385	392	PF00069	0.549
MOD_GSK3_1	417	424	PF00069	0.542
MOD_GSK3_1	460	467	PF00069	0.500
MOD_GSK3_1	99	106	PF00069	0.506
MOD_N-GLC_1	35	40	PF02516	0.270
MOD_N-GLC_1	390	395	PF02516	0.720
MOD_N-GLC_1	42	47	PF02516	0.440
MOD_N-GLC_1	464	469	PF02516	0.480
MOD_N-GLC_1	94	99	PF02516	0.495
MOD_NEK2_1	132	137	PF00069	0.517
MOD_NEK2_1	239	244	PF00069	0.478
MOD_NEK2_1	269	274	PF00069	0.447
MOD_NEK2_1	318	323	PF00069	0.581
MOD_NEK2_1	402	407	PF00069	0.624
MOD_NEK2_1	417	422	PF00069	0.517
MOD_NEK2_1	42	47	PF00069	0.610
MOD_NEK2_1	460	465	PF00069	0.504
MOD_PIKK_1	76	82	PF00454	0.693
MOD_PK_1	191	197	PF00069	0.496
MOD_PKA_2	14	20	PF00069	0.590
MOD_PKA_2	436	442	PF00069	0.643
MOD_PKA_2	454	460	PF00069	0.632
MOD_Plk_1	373	379	PF00069	0.687
MOD_Plk_1	390	396	PF00069	0.564
MOD_Plk_1	42	48	PF00069	0.707
MOD_Plk_1	464	470	PF00069	0.510
MOD_Plk_1	84	90	PF00069	0.547
MOD_Plk_4	191	197	PF00069	0.582
MOD_Plk_4	455	461	PF00069	0.515
MOD_Plk_4	469	475	PF00069	0.504
MOD_ProDKin_1	210	216	PF00069	0.547
MOD_ProDKin_1	292	298	PF00069	0.418
MOD_ProDKin_1	323	329	PF00069	0.519
MOD_ProDKin_1	346	352	PF00069	0.569
MOD_ProDKin_1	94	100	PF00069	0.275
TRG_DiLeu_BaEn_2	84	90	PF01217	0.545
TRG_DiLeu_BaEn_4	2	8	PF01217	0.600
TRG_DiLeu_BaLyEn_6	177	182	PF01217	0.413
TRG_DiLeu_LyEn_5	2	7	PF01217	0.664
TRG_ENDOCYTIC_2	178	181	PF00928	0.492
TRG_ENDOCYTIC_2	284	287	PF00928	0.614
TRG_ENDOCYTIC_2	414	417	PF00928	0.661
TRG_ENDOCYTIC_2	64	67	PF00928	0.462
TRG_ER_diArg_1	150	152	PF00400	0.513
TRG_ER_diArg_1	266	268	PF00400	0.531
TRG_ER_diArg_1	304	307	PF00400	0.555
TRG_ER_diArg_1	425	427	PF00400	0.659
TRG_NLS_MonoExtC_3	351	356	PF00514	0.540
TRG_NLS_MonoExtN_4	350	357	PF00514	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAQ4	Leptomonas seymouri	60%	99%
A0A0S4IX55	Bodo saltans	31%	89%
A0A1X0P6L3	Trypanosomatidae	39%	100%
A0A3R7LN85	Trypanosoma rangeli	35%	100%
A4HN63	Leishmania braziliensis	76%	100%
A4IBT0	Leishmania infantum	99%	100%
C9ZYT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AFL7	Leishmania major	93%	100%
E9B6S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q08BC4	Danio rerio	29%	85%
Q8C8J0	Mus musculus	26%	85%
V5C2R9	Trypanosoma cruzi	36%	100%