Cilia- and flagella-associated protein 58

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGJ9_LEIDO

TriTrypDb:

LdBPK_365250.1 , LdCL_360059700 , LDHU3_36.7030

Length:

845

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005856	cytoskeleton	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3Q8IGJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.498
CLV_C14_Caspase3-7	287	291	PF00656	0.630
CLV_NRD_NRD_1	196	198	PF00675	0.526
CLV_NRD_NRD_1	266	268	PF00675	0.511
CLV_NRD_NRD_1	347	349	PF00675	0.530
CLV_NRD_NRD_1	361	363	PF00675	0.469
CLV_NRD_NRD_1	429	431	PF00675	0.550
CLV_NRD_NRD_1	474	476	PF00675	0.551
CLV_NRD_NRD_1	482	484	PF00675	0.576
CLV_NRD_NRD_1	537	539	PF00675	0.640
CLV_NRD_NRD_1	619	621	PF00675	0.417
CLV_NRD_NRD_1	714	716	PF00675	0.655
CLV_NRD_NRD_1	816	818	PF00675	0.387
CLV_PCSK_FUR_1	712	716	PF00082	0.670
CLV_PCSK_FUR_1	814	818	PF00082	0.389
CLV_PCSK_KEX2_1	156	158	PF00082	0.504
CLV_PCSK_KEX2_1	265	267	PF00082	0.513
CLV_PCSK_KEX2_1	363	365	PF00082	0.506
CLV_PCSK_KEX2_1	429	431	PF00082	0.526
CLV_PCSK_KEX2_1	482	484	PF00082	0.576
CLV_PCSK_KEX2_1	503	505	PF00082	0.568
CLV_PCSK_KEX2_1	619	621	PF00082	0.417
CLV_PCSK_KEX2_1	681	683	PF00082	0.557
CLV_PCSK_KEX2_1	714	716	PF00082	0.679
CLV_PCSK_KEX2_1	816	818	PF00082	0.377
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.504
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.496
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.556
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.557
CLV_PCSK_SKI1_1	121	125	PF00082	0.531
CLV_PCSK_SKI1_1	156	160	PF00082	0.564
CLV_PCSK_SKI1_1	179	183	PF00082	0.562
CLV_PCSK_SKI1_1	197	201	PF00082	0.337
CLV_PCSK_SKI1_1	267	271	PF00082	0.506
CLV_PCSK_SKI1_1	314	318	PF00082	0.608
CLV_PCSK_SKI1_1	48	52	PF00082	0.462
CLV_PCSK_SKI1_1	482	486	PF00082	0.611
CLV_PCSK_SKI1_1	553	557	PF00082	0.571
CLV_PCSK_SKI1_1	583	587	PF00082	0.533
CLV_PCSK_SKI1_1	688	692	PF00082	0.531
CLV_PCSK_SKI1_1	735	739	PF00082	0.506
CLV_Separin_Metazoa	205	209	PF03568	0.560
DEG_APCC_DBOX_1	431	439	PF00400	0.591
DEG_APCC_DBOX_1	645	653	PF00400	0.491
DOC_CYCLIN_RxL_1	194	202	PF00134	0.552
DOC_MAPK_gen_1	619	626	PF00069	0.405
DOC_MAPK_gen_1	646	654	PF00069	0.420
DOC_MAPK_gen_1	684	692	PF00069	0.552
DOC_MAPK_gen_1	823	831	PF00069	0.571
DOC_USP7_MATH_1	7	11	PF00917	0.673
DOC_USP7_UBL2_3	152	156	PF12436	0.513
DOC_USP7_UBL2_3	233	237	PF12436	0.539
DOC_USP7_UBL2_3	544	548	PF12436	0.649
DOC_USP7_UBL2_3	583	587	PF12436	0.421
DOC_USP7_UBL2_3	782	786	PF12436	0.589
DOC_USP7_UBL2_3	97	101	PF12436	0.442
LIG_14-3-3_CanoR_1	157	165	PF00244	0.561
LIG_14-3-3_CanoR_1	179	184	PF00244	0.620
LIG_14-3-3_CanoR_1	245	249	PF00244	0.568
LIG_14-3-3_CanoR_1	482	491	PF00244	0.580
LIG_14-3-3_CanoR_1	538	547	PF00244	0.642
LIG_Actin_WH2_2	645	662	PF00022	0.528
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_CaM_IQ_9	586	602	PF13499	0.558
LIG_DLG_GKlike_1	395	403	PF00625	0.517
LIG_eIF4E_1	223	229	PF01652	0.551
LIG_eIF4E_1	628	634	PF01652	0.527
LIG_FHA_1	143	149	PF00498	0.552
LIG_FHA_1	178	184	PF00498	0.465
LIG_FHA_1	293	299	PF00498	0.561
LIG_FHA_1	370	376	PF00498	0.405
LIG_FHA_1	401	407	PF00498	0.553
LIG_FHA_1	66	72	PF00498	0.452
LIG_FHA_2	158	164	PF00498	0.578
LIG_FHA_2	186	192	PF00498	0.517
LIG_FHA_2	292	298	PF00498	0.659
LIG_FHA_2	313	319	PF00498	0.587
LIG_FHA_2	325	331	PF00498	0.621
LIG_FHA_2	569	575	PF00498	0.606
LIG_FHA_2	737	743	PF00498	0.573
LIG_LIR_Gen_1	336	344	PF02991	0.608
LIG_LIR_Gen_1	42	50	PF02991	0.430
LIG_LIR_Gen_1	602	609	PF02991	0.590
LIG_LIR_Nem_3	100	106	PF02991	0.449
LIG_LIR_Nem_3	13	19	PF02991	0.553
LIG_LIR_Nem_3	331	337	PF02991	0.506
LIG_LIR_Nem_3	42	46	PF02991	0.427
LIG_LIR_Nem_3	710	716	PF02991	0.583
LIG_LYPXL_yS_3	720	723	PF13949	0.657
LIG_PTB_Apo_2	830	837	PF02174	0.559
LIG_SH2_CRK	43	47	PF00017	0.456
LIG_SH2_CRK	628	632	PF00017	0.501
LIG_SH2_STAP1	172	176	PF00017	0.523
LIG_SH2_STAP1	43	47	PF00017	0.465
LIG_SH2_STAP1	827	831	PF00017	0.469
LIG_SH2_STAT5	172	175	PF00017	0.542
LIG_SH3_3	1	7	PF00018	0.741
LIG_SUMO_SIM_anti_2	202	208	PF11976	0.591
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.603
LIG_SUMO_SIM_anti_2	377	383	PF11976	0.501
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.393
LIG_SUMO_SIM_par_1	227	234	PF11976	0.546
LIG_SUMO_SIM_par_1	293	300	PF11976	0.647
LIG_TRAF2_1	189	192	PF00917	0.573
LIG_TRAF2_1	193	196	PF00917	0.572
LIG_TRAF2_1	238	241	PF00917	0.578
LIG_TRAF2_1	355	358	PF00917	0.596
LIG_TRAF2_1	374	377	PF00917	0.621
LIG_TRAF2_1	394	397	PF00917	0.313
LIG_TRAF2_1	459	462	PF00917	0.477
LIG_TRAF2_1	571	574	PF00917	0.585
LIG_TRAF2_1	750	753	PF00917	0.562
LIG_TYR_ITIM	41	46	PF00017	0.446
LIG_TYR_ITIM	626	631	PF00017	0.405
LIG_UBA3_1	228	237	PF00899	0.551
LIG_UBA3_1	654	658	PF00899	0.409
MOD_CDC14_SPxK_1	3	6	PF00782	0.660
MOD_CK1_1	129	135	PF00069	0.605
MOD_CK1_1	139	145	PF00069	0.583
MOD_CK1_1	291	297	PF00069	0.637
MOD_CK1_1	398	404	PF00069	0.550
MOD_CK1_1	422	428	PF00069	0.511
MOD_CK1_1	450	456	PF00069	0.467
MOD_CK1_1	53	59	PF00069	0.437
MOD_CK1_1	542	548	PF00069	0.606
MOD_CK1_1	564	570	PF00069	0.583
MOD_CK2_1	143	149	PF00069	0.616
MOD_CK2_1	157	163	PF00069	0.481
MOD_CK2_1	185	191	PF00069	0.540
MOD_CK2_1	199	205	PF00069	0.397
MOD_CK2_1	291	297	PF00069	0.650
MOD_CK2_1	312	318	PF00069	0.570
MOD_CK2_1	324	330	PF00069	0.576
MOD_CK2_1	371	377	PF00069	0.575
MOD_CK2_1	384	390	PF00069	0.493
MOD_CK2_1	455	461	PF00069	0.593
MOD_CK2_1	53	59	PF00069	0.545
MOD_CK2_1	568	574	PF00069	0.597
MOD_CK2_1	719	725	PF00069	0.517
MOD_CK2_1	736	742	PF00069	0.443
MOD_CK2_1	834	840	PF00069	0.567
MOD_CK2_1	87	93	PF00069	0.459
MOD_Cter_Amidation	427	430	PF01082	0.541
MOD_GlcNHglycan	385	389	PF01048	0.621
MOD_GlcNHglycan	452	455	PF01048	0.576
MOD_GlcNHglycan	457	460	PF01048	0.564
MOD_GlcNHglycan	836	839	PF01048	0.452
MOD_GlcNHglycan	9	12	PF01048	0.600
MOD_GSK3_1	135	142	PF00069	0.608
MOD_GSK3_1	159	166	PF00069	0.637
MOD_GSK3_1	284	291	PF00069	0.609
MOD_GSK3_1	312	319	PF00069	0.678
MOD_GSK3_1	453	460	PF00069	0.410
MOD_GSK3_1	5	12	PF00069	0.655
MOD_GSK3_1	564	571	PF00069	0.610
MOD_GSK3_1	87	94	PF00069	0.559
MOD_N-GLC_1	288	293	PF02516	0.632
MOD_N-GLC_1	561	566	PF02516	0.576
MOD_N-GLC_1	708	713	PF02516	0.593
MOD_N-GLC_1	798	803	PF02516	0.469
MOD_N-GLC_1	832	837	PF02516	0.602
MOD_NEK2_1	119	124	PF00069	0.559
MOD_NEK2_1	199	204	PF00069	0.548
MOD_NEK2_1	228	233	PF00069	0.547
MOD_NEK2_1	281	286	PF00069	0.501
MOD_NEK2_1	417	422	PF00069	0.497
MOD_NEK2_1	431	436	PF00069	0.330
MOD_NEK2_1	50	55	PF00069	0.551
MOD_NEK2_1	798	803	PF00069	0.473
MOD_PIKK_1	400	406	PF00454	0.563
MOD_PIKK_1	419	425	PF00454	0.318
MOD_PIKK_1	447	453	PF00454	0.496
MOD_PIKK_1	482	488	PF00454	0.526
MOD_PIKK_1	542	548	PF00454	0.645
MOD_PIKK_1	59	65	PF00454	0.504
MOD_PKA_1	482	488	PF00069	0.579
MOD_PKA_2	244	250	PF00069	0.528
MOD_PKA_2	324	330	PF00069	0.619
MOD_PKA_2	431	437	PF00069	0.451
MOD_PKA_2	482	488	PF00069	0.571
MOD_PKA_2	609	615	PF00069	0.550
MOD_Plk_1	288	294	PF00069	0.632
MOD_Plk_1	32	38	PF00069	0.587
MOD_Plk_1	357	363	PF00069	0.589
MOD_Plk_1	384	390	PF00069	0.627
MOD_Plk_1	395	401	PF00069	0.499
MOD_Plk_1	417	423	PF00069	0.553
MOD_Plk_1	447	453	PF00069	0.477
MOD_Plk_1	542	548	PF00069	0.625
MOD_Plk_1	568	574	PF00069	0.487
MOD_Plk_1	708	714	PF00069	0.617
MOD_Plk_1	87	93	PF00069	0.445
MOD_Plk_2-3	371	377	PF00069	0.591
MOD_Plk_2-3	88	94	PF00069	0.445
MOD_Plk_4	129	135	PF00069	0.641
MOD_Plk_4	244	250	PF00069	0.615
MOD_Plk_4	312	318	PF00069	0.492
MOD_Plk_4	663	669	PF00069	0.478
MOD_SUMO_for_1	123	126	PF00179	0.504
MOD_SUMO_for_1	368	371	PF00179	0.596
MOD_SUMO_for_1	489	492	PF00179	0.583
MOD_SUMO_for_1	529	532	PF00179	0.481
MOD_SUMO_for_1	745	748	PF00179	0.581
MOD_SUMO_for_1	95	98	PF00179	0.444
MOD_SUMO_rev_2	149	158	PF00179	0.500
MOD_SUMO_rev_2	191	200	PF00179	0.540
MOD_SUMO_rev_2	385	394	PF00179	0.580
MOD_SUMO_rev_2	456	466	PF00179	0.458
MOD_SUMO_rev_2	576	585	PF00179	0.512
MOD_SUMO_rev_2	722	730	PF00179	0.540
TRG_DiLeu_BaEn_1	244	249	PF01217	0.596
TRG_DiLeu_BaEn_1	377	382	PF01217	0.566
TRG_DiLeu_BaEn_1	581	586	PF01217	0.543
TRG_DiLeu_BaEn_1	753	758	PF01217	0.459
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.607
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.524
TRG_ENDOCYTIC_2	43	46	PF00928	0.410
TRG_ENDOCYTIC_2	47	50	PF00928	0.412
TRG_ENDOCYTIC_2	491	494	PF00928	0.473
TRG_ENDOCYTIC_2	628	631	PF00928	0.397
TRG_ENDOCYTIC_2	720	723	PF00928	0.657
TRG_ENDOCYTIC_2	826	829	PF00928	0.478
TRG_ER_diArg_1	265	267	PF00400	0.589
TRG_ER_diArg_1	361	364	PF00400	0.551
TRG_ER_diArg_1	429	432	PF00400	0.556
TRG_ER_diArg_1	482	484	PF00400	0.576
TRG_ER_diArg_1	515	518	PF00400	0.546
TRG_ER_diArg_1	713	715	PF00400	0.672
TRG_ER_diArg_1	814	817	PF00400	0.394
TRG_NES_CRM1_1	622	636	PF08389	0.486
TRG_NES_CRM1_1	647	661	PF08389	0.491
TRG_NLS_Bipartite_1	348	366	PF00514	0.626
TRG_NLS_MonoExtC_3	679	684	PF00514	0.383
TRG_NLS_MonoExtN_4	680	685	PF00514	0.380
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.590
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	373	377	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	558	563	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J7	Leptomonas seymouri	74%	99%
A0A0S4JDB4	Bodo saltans	39%	99%
A0A0S4JNC8	Bodo saltans	22%	86%
A0A1X0NE93	Trypanosomatidae	48%	99%
A0A3R7L4Y2	Trypanosoma rangeli	25%	88%
A0A3R7NDH9	Trypanosoma rangeli	47%	99%
A4HQ18	Leishmania braziliensis	84%	100%
A4IDS5	Leishmania infantum	100%	100%
A8HUA1	Chlamydomonas reinhardtii	31%	98%
B2RW38	Mus musculus	33%	97%
D0A8V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ATT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B537	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	79%
Q4Q0R0	Leishmania major	96%	100%
Q4Q2U9	Leishmania major	23%	79%
V5A873	Trypanosoma cruzi	46%	99%
V5DGR4	Trypanosoma cruzi	22%	85%