Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGJ4_LEIDO

TriTrypDb:

LdBPK_323800.1 , LdCL_320044000 , LDHU3_32.4800

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.370
CLV_C14_Caspase3-7	220	224	PF00656	0.535
CLV_C14_Caspase3-7	235	239	PF00656	0.405
CLV_NRD_NRD_1	12	14	PF00675	0.382
CLV_NRD_NRD_1	199	201	PF00675	0.426
CLV_NRD_NRD_1	246	248	PF00675	0.364
CLV_NRD_NRD_1	383	385	PF00675	0.656
CLV_PCSK_KEX2_1	12	14	PF00082	0.389
CLV_PCSK_KEX2_1	163	165	PF00082	0.504
CLV_PCSK_KEX2_1	201	203	PF00082	0.436
CLV_PCSK_KEX2_1	212	214	PF00082	0.305
CLV_PCSK_KEX2_1	383	385	PF00082	0.597
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.428
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.436
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.305
DEG_APCC_DBOX_1	249	257	PF00400	0.398
DEG_COP1_1	27	36	PF00400	0.418
DEG_SPOP_SBC_1	18	22	PF00917	0.435
DOC_MAPK_gen_1	353	361	PF00069	0.548
DOC_MAPK_MEF2A_6	355	363	PF00069	0.553
DOC_PP2B_LxvP_1	359	362	PF13499	0.557
DOC_PP4_FxxP_1	122	125	PF00568	0.409
DOC_USP7_MATH_1	151	155	PF00917	0.504
DOC_USP7_MATH_1	185	189	PF00917	0.267
DOC_USP7_MATH_1	232	236	PF00917	0.402
DOC_USP7_MATH_1	276	280	PF00917	0.606
DOC_USP7_MATH_1	84	88	PF00917	0.337
DOC_WW_Pin1_4	384	389	PF00397	0.698
LIG_14-3-3_CanoR_1	101	105	PF00244	0.328
LIG_14-3-3_CanoR_1	12	18	PF00244	0.497
LIG_14-3-3_CanoR_1	355	360	PF00244	0.715
LIG_14-3-3_CterR_2	421	423	PF00244	0.470
LIG_Actin_WH2_2	88	103	PF00022	0.373
LIG_deltaCOP1_diTrp_1	66	72	PF00928	0.292
LIG_FHA_1	178	184	PF00498	0.540
LIG_FHA_1	19	25	PF00498	0.535
LIG_FHA_1	260	266	PF00498	0.445
LIG_FHA_1	323	329	PF00498	0.335
LIG_FHA_1	333	339	PF00498	0.364
LIG_FHA_1	342	348	PF00498	0.581
LIG_FHA_1	356	362	PF00498	0.505
LIG_FHA_2	404	410	PF00498	0.723
LIG_LIR_Apic_2	188	192	PF02991	0.350
LIG_LIR_Nem_3	225	231	PF02991	0.369
LIG_LIR_Nem_3	66	72	PF02991	0.311
LIG_SH2_CRK	189	193	PF00017	0.398
LIG_SH2_NCK_1	15	19	PF00017	0.417
LIG_SH2_NCK_1	189	193	PF00017	0.398
LIG_SH2_SRC	32	35	PF00017	0.331
LIG_SH2_STAT5	104	107	PF00017	0.317
LIG_SH2_STAT5	228	231	PF00017	0.355
LIG_SH2_STAT5	32	35	PF00017	0.432
LIG_SH3_3	243	249	PF00018	0.479
LIG_SH3_3	327	333	PF00018	0.376
LIG_SH3_3	346	352	PF00018	0.477
LIG_SH3_3	374	380	PF00018	0.708
LIG_SH3_3	55	61	PF00018	0.396
LIG_SUMO_SIM_anti_2	180	185	PF11976	0.348
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.412
LIG_SUMO_SIM_anti_2	393	409	PF11976	0.507
LIG_SUMO_SIM_anti_2	411	417	PF11976	0.499
LIG_SUMO_SIM_par_1	182	188	PF11976	0.317
LIG_SUMO_SIM_par_1	334	340	PF11976	0.354
LIG_SUMO_SIM_par_1	414	419	PF11976	0.400
LIG_TRAF2_1	393	396	PF00917	0.667
LIG_TRAF2_2	89	94	PF00917	0.295
LIG_WRC_WIRS_1	1	6	PF05994	0.526
MOD_CK1_1	279	285	PF00069	0.615
MOD_CK1_1	292	298	PF00069	0.251
MOD_CK1_1	311	317	PF00069	0.556
MOD_CK1_1	339	345	PF00069	0.528
MOD_CK1_1	41	47	PF00069	0.488
MOD_CK2_1	17	23	PF00069	0.476
MOD_CK2_1	390	396	PF00069	0.604
MOD_CK2_1	403	409	PF00069	0.718
MOD_GlcNHglycan	15	18	PF01048	0.455
MOD_GlcNHglycan	169	172	PF01048	0.323
MOD_GlcNHglycan	219	222	PF01048	0.351
MOD_GlcNHglycan	280	284	PF01048	0.566
MOD_GlcNHglycan	294	297	PF01048	0.293
MOD_GlcNHglycan	325	328	PF01048	0.433
MOD_GlcNHglycan	43	46	PF01048	0.513
MOD_GSK3_1	100	107	PF00069	0.205
MOD_GSK3_1	13	20	PF00069	0.464
MOD_GSK3_1	232	239	PF00069	0.492
MOD_GSK3_1	318	325	PF00069	0.393
MOD_GSK3_1	332	339	PF00069	0.311
MOD_GSK3_1	390	397	PF00069	0.665
MOD_GSK3_1	404	411	PF00069	0.537
MOD_GSK3_1	416	423	PF00069	0.366
MOD_GSK3_1	80	87	PF00069	0.319
MOD_N-GLC_1	107	112	PF02516	0.508
MOD_NEK2_1	100	105	PF00069	0.385
MOD_NEK2_1	254	259	PF00069	0.409
MOD_NEK2_1	290	295	PF00069	0.419
MOD_NEK2_1	416	421	PF00069	0.372
MOD_PIKK_1	139	145	PF00454	0.441
MOD_PIKK_1	151	157	PF00454	0.399
MOD_PIKK_1	232	238	PF00454	0.436
MOD_PIKK_1	416	422	PF00454	0.384
MOD_PIKK_1	84	90	PF00454	0.394
MOD_PKA_1	73	79	PF00069	0.424
MOD_PKA_2	100	106	PF00069	0.325
MOD_Plk_1	139	145	PF00069	0.378
MOD_Plk_1	371	377	PF00069	0.712
MOD_Plk_4	179	185	PF00069	0.354
MOD_Plk_4	332	338	PF00069	0.364
MOD_ProDKin_1	384	390	PF00069	0.699
TRG_DiLeu_BaEn_1	400	405	PF01217	0.514
TRG_ENDOCYTIC_2	135	138	PF00928	0.342
TRG_ER_diArg_1	11	13	PF00400	0.389
TRG_ER_diArg_1	383	386	PF00400	0.671
TRG_NLS_MonoCore_2	246	251	PF00514	0.418
TRG_NLS_MonoExtC_3	199	204	PF00514	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I9	Leptomonas seymouri	55%	100%
A0A1X0NRZ3	Trypanosomatidae	33%	100%
A0A422P320	Trypanosoma rangeli	39%	100%
A4HL03	Leishmania braziliensis	78%	100%
A4I8I3	Leishmania infantum	100%	100%
D0AAN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B3E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q3SWZ7	Bos taurus	29%	78%
Q4Q4Q8	Leishmania major	95%	100%
Q6NL34	Drosophila melanogaster	27%	78%
V5DMD9	Trypanosoma cruzi	35%	100%