Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGJ2_LEIDO

TriTrypDb:

LdBPK_320390.1 , LdCL_320008800 , LDHU3_32.0480

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.619
CLV_C14_Caspase3-7	664	668	PF00656	0.704
CLV_NRD_NRD_1	102	104	PF00675	0.353
CLV_NRD_NRD_1	164	166	PF00675	0.597
CLV_NRD_NRD_1	233	235	PF00675	0.543
CLV_NRD_NRD_1	265	267	PF00675	0.463
CLV_NRD_NRD_1	297	299	PF00675	0.636
CLV_NRD_NRD_1	30	32	PF00675	0.478
CLV_NRD_NRD_1	316	318	PF00675	0.477
CLV_NRD_NRD_1	354	356	PF00675	0.616
CLV_NRD_NRD_1	384	386	PF00675	0.679
CLV_NRD_NRD_1	613	615	PF00675	0.600
CLV_NRD_NRD_1	626	628	PF00675	0.473
CLV_PCSK_FUR_1	162	166	PF00082	0.552
CLV_PCSK_KEX2_1	101	103	PF00082	0.357
CLV_PCSK_KEX2_1	162	164	PF00082	0.595
CLV_PCSK_KEX2_1	233	235	PF00082	0.543
CLV_PCSK_KEX2_1	265	267	PF00082	0.464
CLV_PCSK_KEX2_1	29	31	PF00082	0.484
CLV_PCSK_KEX2_1	297	299	PF00082	0.686
CLV_PCSK_KEX2_1	315	317	PF00082	0.471
CLV_PCSK_KEX2_1	353	355	PF00082	0.601
CLV_PCSK_KEX2_1	422	424	PF00082	0.660
CLV_PCSK_KEX2_1	626	628	PF00082	0.473
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.660
CLV_PCSK_PC7_1	159	165	PF00082	0.653
CLV_PCSK_PC7_1	261	267	PF00082	0.515
CLV_PCSK_PC7_1	350	356	PF00082	0.573
CLV_PCSK_SKI1_1	268	272	PF00082	0.472
CLV_PCSK_SKI1_1	316	320	PF00082	0.642
CLV_PCSK_SKI1_1	614	618	PF00082	0.572
CLV_Separin_Metazoa	294	298	PF03568	0.516
DEG_Nend_UBRbox_3	1	3	PF02207	0.457
DEG_SPOP_SBC_1	200	204	PF00917	0.655
DEG_SPOP_SBC_1	643	647	PF00917	0.557
DOC_CKS1_1	378	383	PF01111	0.751
DOC_CYCLIN_RxL_1	37	48	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.374
DOC_MAPK_DCC_7	81	91	PF00069	0.412
DOC_MAPK_gen_1	128	136	PF00069	0.460
DOC_MAPK_gen_1	233	239	PF00069	0.647
DOC_MAPK_gen_1	37	46	PF00069	0.429
DOC_MAPK_RevD_3	87	103	PF00069	0.356
DOC_PP2B_LxvP_1	607	610	PF13499	0.660
DOC_PP2B_LxvP_1	87	90	PF13499	0.383
DOC_PP4_FxxP_1	146	149	PF00568	0.447
DOC_PP4_FxxP_1	378	381	PF00568	0.583
DOC_PP4_FxxP_1	74	77	PF00568	0.412
DOC_USP7_MATH_1	10	14	PF00917	0.452
DOC_USP7_MATH_1	147	151	PF00917	0.438
DOC_USP7_MATH_1	168	172	PF00917	0.611
DOC_USP7_MATH_1	194	198	PF00917	0.718
DOC_USP7_MATH_1	199	203	PF00917	0.715
DOC_USP7_MATH_1	207	211	PF00917	0.619
DOC_USP7_MATH_1	393	397	PF00917	0.753
DOC_USP7_MATH_1	49	53	PF00917	0.407
DOC_USP7_MATH_1	515	519	PF00917	0.690
DOC_USP7_MATH_1	543	547	PF00917	0.661
DOC_USP7_MATH_1	563	567	PF00917	0.832
DOC_USP7_MATH_1	644	648	PF00917	0.711
DOC_WW_Pin1_4	140	145	PF00397	0.475
DOC_WW_Pin1_4	209	214	PF00397	0.643
DOC_WW_Pin1_4	377	382	PF00397	0.750
DOC_WW_Pin1_4	442	447	PF00397	0.643
DOC_WW_Pin1_4	495	500	PF00397	0.619
DOC_WW_Pin1_4	505	510	PF00397	0.621
DOC_WW_Pin1_4	522	527	PF00397	0.638
DOC_WW_Pin1_4	646	651	PF00397	0.612
DOC_WW_Pin1_4	655	660	PF00397	0.579
LIG_14-3-3_CanoR_1	128	136	PF00244	0.460
LIG_14-3-3_CanoR_1	180	186	PF00244	0.486
LIG_14-3-3_CanoR_1	265	275	PF00244	0.613
LIG_14-3-3_CanoR_1	285	289	PF00244	0.695
LIG_14-3-3_CanoR_1	298	304	PF00244	0.532
LIG_14-3-3_CanoR_1	360	365	PF00244	0.671
LIG_14-3-3_CanoR_1	377	381	PF00244	0.572
LIG_14-3-3_CanoR_1	453	462	PF00244	0.669
LIG_14-3-3_CanoR_1	598	607	PF00244	0.734
LIG_14-3-3_CanoR_1	642	650	PF00244	0.697
LIG_BRCT_BRCA1_1	110	114	PF00533	0.363
LIG_BRCT_BRCA1_1	142	146	PF00533	0.474
LIG_BRCT_BRCA1_1	194	198	PF00533	0.596
LIG_BRCT_BRCA1_1	51	55	PF00533	0.417
LIG_BRCT_BRCA1_1	593	597	PF00533	0.703
LIG_BRCT_BRCA1_1	65	69	PF00533	0.423
LIG_EVH1_1	506	510	PF00568	0.581
LIG_FHA_1	129	135	PF00498	0.460
LIG_FHA_1	222	228	PF00498	0.621
LIG_FHA_1	617	623	PF00498	0.520
LIG_FHA_2	436	442	PF00498	0.627
LIG_FHA_2	529	535	PF00498	0.770
LIG_FHA_2	570	576	PF00498	0.562
LIG_FHA_2	662	668	PF00498	0.724
LIG_LIR_Apic_2	143	149	PF02991	0.462
LIG_LIR_Nem_3	412	416	PF02991	0.589
LIG_LIR_Nem_3	61	65	PF02991	0.500
LIG_LYPXL_yS_3	413	416	PF13949	0.593
LIG_MYND_1	414	418	PF01753	0.567
LIG_MYND_1	433	437	PF01753	0.588
LIG_Pex14_2	110	114	PF04695	0.363
LIG_Pex14_2	55	59	PF04695	0.429
LIG_Pex14_2	65	69	PF04695	0.427
LIG_PROFILIN_1	424	430	PF00235	0.560
LIG_PTAP_UEV_1	190	195	PF05743	0.650
LIG_PTAP_UEV_1	649	654	PF05743	0.614
LIG_Rb_LxCxE_1	544	560	PF01857	0.674
LIG_SH2_CRK	104	108	PF00017	0.339
LIG_SH2_NCK_1	104	108	PF00017	0.339
LIG_SH2_STAP1	104	108	PF00017	0.399
LIG_SH2_STAT3	129	132	PF00017	0.454
LIG_SH2_STAT3	630	633	PF00017	0.411
LIG_SH2_STAT5	623	626	PF00017	0.516
LIG_SH3_1	422	428	PF00018	0.671
LIG_SH3_1	504	510	PF00018	0.622
LIG_SH3_3	164	170	PF00018	0.676
LIG_SH3_3	188	194	PF00018	0.705
LIG_SH3_3	234	240	PF00018	0.641
LIG_SH3_3	387	393	PF00018	0.767
LIG_SH3_3	421	427	PF00018	0.703
LIG_SH3_3	428	434	PF00018	0.737
LIG_SH3_3	504	510	PF00018	0.686
LIG_SH3_3	520	526	PF00018	0.681
LIG_SH3_3	556	562	PF00018	0.716
LIG_SH3_3	647	653	PF00018	0.633
LIG_SH3_CIN85_PxpxPR_1	140	145	PF14604	0.475
LIG_TYR_ITIM	411	416	PF00017	0.587
LIG_WW_2	433	436	PF00397	0.583
MOD_CDC14_SPxK_1	445	448	PF00782	0.644
MOD_CDK_SPK_2	140	145	PF00069	0.475
MOD_CDK_SPK_2	495	500	PF00069	0.687
MOD_CDK_SPK_2	655	660	PF00069	0.579
MOD_CDK_SPxK_1	442	448	PF00069	0.645
MOD_CDK_SPxxK_3	655	662	PF00069	0.560
MOD_CK1_1	112	118	PF00069	0.369
MOD_CK1_1	150	156	PF00069	0.676
MOD_CK1_1	18	24	PF00069	0.529
MOD_CK1_1	189	195	PF00069	0.732
MOD_CK1_1	269	275	PF00069	0.570
MOD_CK1_1	287	293	PF00069	0.567
MOD_CK1_1	391	397	PF00069	0.823
MOD_CK1_1	525	531	PF00069	0.797
MOD_CK1_1	53	59	PF00069	0.423
MOD_CK1_1	567	573	PF00069	0.772
MOD_CK1_1	601	607	PF00069	0.646
MOD_CK1_1	61	67	PF00069	0.429
MOD_CK1_1	646	652	PF00069	0.609
MOD_CK2_1	528	534	PF00069	0.613
MOD_Cter_Amidation	612	615	PF01082	0.595
MOD_GlcNHglycan	140	143	PF01048	0.590
MOD_GlcNHglycan	149	152	PF01048	0.532
MOD_GlcNHglycan	188	191	PF01048	0.648
MOD_GlcNHglycan	20	23	PF01048	0.486
MOD_GlcNHglycan	209	212	PF01048	0.643
MOD_GlcNHglycan	268	271	PF01048	0.665
MOD_GlcNHglycan	3	6	PF01048	0.434
MOD_GlcNHglycan	368	371	PF01048	0.663
MOD_GlcNHglycan	472	475	PF01048	0.647
MOD_GlcNHglycan	566	569	PF01048	0.710
MOD_GlcNHglycan	600	603	PF01048	0.663
MOD_GlcNHglycan	635	639	PF01048	0.598
MOD_GlcNHglycan	65	68	PF01048	0.432
MOD_GlcNHglycan	650	653	PF01048	0.615
MOD_GSK3_1	108	115	PF00069	0.360
MOD_GSK3_1	116	123	PF00069	0.387
MOD_GSK3_1	49	56	PF00069	0.413
MOD_GSK3_1	521	528	PF00069	0.671
MOD_GSK3_1	563	570	PF00069	0.735
MOD_GSK3_1	592	599	PF00069	0.706
MOD_GSK3_1	601	608	PF00069	0.584
MOD_GSK3_1	63	70	PF00069	0.422
MOD_GSK3_1	642	649	PF00069	0.584
MOD_N-GLC_1	1	6	PF02516	0.445
MOD_N-GLC_1	470	475	PF02516	0.638
MOD_NEK2_1	1	6	PF00069	0.502
MOD_NEK2_1	114	119	PF00069	0.378
MOD_NEK2_1	469	474	PF00069	0.625
MOD_NEK2_1	54	59	PF00069	0.427
MOD_NEK2_2	336	341	PF00069	0.608
MOD_OFUCOSY	176	183	PF10250	0.510
MOD_PIKK_1	114	120	PF00454	0.444
MOD_PIKK_1	128	134	PF00454	0.470
MOD_PIKK_1	192	198	PF00454	0.692
MOD_PIKK_1	201	207	PF00454	0.686
MOD_PIKK_1	330	336	PF00454	0.497
MOD_PIKK_1	404	410	PF00454	0.750
MOD_PIKK_1	493	499	PF00454	0.701
MOD_PIKK_1	592	598	PF00454	0.584
MOD_PK_1	586	592	PF00069	0.584
MOD_PKA_2	158	164	PF00069	0.607
MOD_PKA_2	179	185	PF00069	0.505
MOD_PKA_2	18	24	PF00069	0.489
MOD_PKA_2	207	213	PF00069	0.769
MOD_PKA_2	216	222	PF00069	0.712
MOD_PKA_2	284	290	PF00069	0.672
MOD_PKA_2	299	305	PF00069	0.476
MOD_PKA_2	336	342	PF00069	0.608
MOD_PKA_2	376	382	PF00069	0.755
MOD_PKA_2	441	447	PF00069	0.675
MOD_PKA_2	661	667	PF00069	0.549
MOD_PKB_1	126	134	PF00069	0.453
MOD_PKB_1	451	459	PF00069	0.651
MOD_Plk_1	543	549	PF00069	0.691
MOD_Plk_4	10	16	PF00069	0.504
MOD_Plk_4	109	115	PF00069	0.363
MOD_Plk_4	299	305	PF00069	0.636
MOD_Plk_4	50	56	PF00069	0.415
MOD_Plk_4	58	64	PF00069	0.427
MOD_ProDKin_1	140	146	PF00069	0.474
MOD_ProDKin_1	209	215	PF00069	0.644
MOD_ProDKin_1	377	383	PF00069	0.750
MOD_ProDKin_1	442	448	PF00069	0.645
MOD_ProDKin_1	495	501	PF00069	0.621
MOD_ProDKin_1	505	511	PF00069	0.622
MOD_ProDKin_1	522	528	PF00069	0.641
MOD_ProDKin_1	646	652	PF00069	0.609
MOD_ProDKin_1	655	661	PF00069	0.566
MOD_SUMO_for_1	409	412	PF00179	0.745
MOD_SUMO_for_1	418	421	PF00179	0.624
MOD_SUMO_for_1	541	544	PF00179	0.669
MOD_SUMO_rev_2	518	524	PF00179	0.638
TRG_DiLeu_BaEn_1	412	417	PF01217	0.590
TRG_DiLeu_BaLyEn_6	39	44	PF01217	0.427
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.605
TRG_ENDOCYTIC_2	104	107	PF00928	0.338
TRG_ENDOCYTIC_2	413	416	PF00928	0.593
TRG_ER_diArg_1	101	103	PF00400	0.370
TRG_ER_diArg_1	126	129	PF00400	0.446
TRG_ER_diArg_1	162	165	PF00400	0.650
TRG_ER_diArg_1	232	234	PF00400	0.678
TRG_ER_diArg_1	265	267	PF00400	0.459
TRG_ER_diArg_1	29	31	PF00400	0.484
TRG_ER_diArg_1	296	298	PF00400	0.512
TRG_ER_diArg_1	315	317	PF00400	0.470
TRG_ER_diArg_1	353	355	PF00400	0.601
TRG_ER_diArg_1	36	39	PF00400	0.443
TRG_ER_diArg_1	626	629	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM69	Leptomonas seymouri	36%	100%
A4HK18	Leishmania braziliensis	63%	98%
A4I7K2	Leishmania infantum	99%	100%
E9B2F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%