Ribosomal protein L18e/L15 family protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L27A/L29, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGI9_LEIDO

TriTrypDb:

LdBPK_353810.1 , LdCL_350043100 , LdCL_350043300 , LDHU3_35.4970 , LDHU3_35.4990

Length:

145

Annotations

Annotations by Jardim et al.

Ribosomal Protein, 60S ribosomal L27A/L29

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	10
GO:0032991	protein-containing complex	1	10
GO:0044391	ribosomal subunit	3	10
GO:1990904	ribonucleoprotein complex	2	10
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGI9

PDB structure(s): 6az3_L

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	10
GO:0006518	peptide metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009059	macromolecule biosynthetic process	4	10
GO:0009987	cellular process	1	10
GO:0019538	protein metabolic process	3	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	10
GO:0043043	peptide biosynthetic process	5	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0043604	amide biosynthetic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	10
GO:0005198	structural molecule activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.383
CLV_NRD_NRD_1	25	27	PF00675	0.568
CLV_NRD_NRD_1	62	64	PF00675	0.545
DOC_MAPK_DCC_7	92	101	PF00069	0.386
DOC_MAPK_gen_1	132	143	PF00069	0.383
DOC_MAPK_gen_1	89	98	PF00069	0.385
DOC_MAPK_MEF2A_6	92	101	PF00069	0.383
DOC_PP1_RVXF_1	40	46	PF00149	0.383
DOC_USP7_UBL2_3	128	132	PF12436	0.383
LIG_14-3-3_CanoR_1	12	17	PF00244	0.519
LIG_FHA_1	70	76	PF00498	0.384
LIG_FHA_1	93	99	PF00498	0.445
LIG_LIR_Gen_1	103	110	PF02991	0.500
LIG_LIR_Nem_3	103	109	PF02991	0.500
LIG_LIR_Nem_3	14	19	PF02991	0.518
LIG_PDZ_Class_2	140	145	PF00595	0.488
LIG_SH2_CRK	106	110	PF00017	0.383
LIG_SH2_CRK	19	23	PF00017	0.533
LIG_SH2_STAP1	106	110	PF00017	0.383
LIG_SH2_STAT5	125	128	PF00017	0.515
LIG_SH2_STAT5	52	55	PF00017	0.383
LIG_SUMO_SIM_par_1	97	104	PF11976	0.501
LIG_TRAF2_1	83	86	PF00917	0.525
MOD_GlcNHglycan	103	106	PF01048	0.515
MOD_GlcNHglycan	29	32	PF01048	0.383
MOD_GSK3_1	88	95	PF00069	0.496
MOD_LATS_1	10	16	PF00433	0.516
MOD_LATS_1	25	31	PF00433	0.383
MOD_N-GLC_1	76	81	PF02516	0.414
MOD_NEK2_1	101	106	PF00069	0.515
MOD_PKA_2	11	17	PF00069	0.522
MOD_Plk_1	76	82	PF00069	0.491
MOD_SUMO_rev_2	127	134	PF00179	0.383
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.515
TRG_ENDOCYTIC_2	106	109	PF00928	0.383
TRG_ENDOCYTIC_2	19	22	PF00928	0.535
TRG_NLS_MonoExtC_3	62	67	PF00514	0.445
TRG_NLS_MonoExtN_4	4	10	PF00514	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J103	Bodo saltans	81%	100%
A0A1D8PSC5	Candida albicans (strain SC5314 / ATCC MYA-2876)	54%	97%
A0A1X0NDQ3	Trypanosomatidae	82%	100%
A0A3R7KFD5	Trypanosoma rangeli	83%	100%
A1RT57	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	40%	93%
A1RWR4	Thermofilum pendens (strain DSM 2475 / Hrk 5)	37%	96%
A2BME1	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	41%	96%
A3DNC9	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	32%	95%
A3MUZ1	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	37%	93%
A4FVT7	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	37%	100%
A4HN47	Leishmania braziliensis	97%	100%
A4IBR5	Leishmania infantum	100%	100%
A4WM07	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	37%	94%
A5UL66	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	34%	100%
A6UQ66	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	37%	100%
A6UWW0	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	35%	100%
A6VH07	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	38%	100%
A9A9P2	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	37%	100%
B1Y901	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	33%	93%
B8D5U8	Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)	37%	94%
C9ZYV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
E9AFK0	Leishmania major	99%	100%
E9B6Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O01358	Oscheius tipulae	50%	100%
O05643	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	31%	100%
O15883	Trypanosoma brucei brucei	81%	100%
O26133	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	35%	99%
O62581	Encephalitozoon cuniculi (strain GB-M1)	41%	99%
P02406	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	56%	97%
P08978	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	57%	97%
P14032	Methanococcus vannielii	37%	100%
P14115	Mus musculus	55%	98%
P18445	Rattus norvegicus	55%	98%
P36585	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	98%
P41092	Drosophila melanogaster	57%	97%
P46776	Homo sapiens	54%	98%
P47830	Xenopus laevis	54%	98%
P48160	Dictyostelium discoideum	56%	98%
P48161	Euplotes crassus	48%	98%
P49637	Arabidopsis thaliana	55%	99%
P54047	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	39%	100%
P57728	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	51%	98%
P78987	Blumeria hordei	54%	97%
Q00454	Tetrahymena thermophila	45%	97%
Q27021	Tenebrio molitor	51%	98%
Q2NFX9	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	37%	100%
Q4R723	Macaca fascicularis	54%	98%
Q56K03	Bos taurus	55%	98%
Q5JJH0	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	37%	98%
Q5R1X0	Pan troglodytes	54%	98%
Q5REY2	Pongo abelii	54%	98%
Q6LXD1	Methanococcus maripaludis (strain S2 / LL)	36%	100%
Q8ZT50	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	36%	93%
Q9BH80	Entamoeba histolytica	46%	97%
Q9BI06	Entamoeba histolytica	46%	97%
Q9BI14	Entamoeba histolytica	46%	97%
Q9LPV3	Arabidopsis thaliana	30%	100%
Q9LR33	Arabidopsis thaliana	53%	99%
Q9UX85	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	36%	100%
Q9YF98	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	39%	92%