Peptidase_S9 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGI7_LEIDO

TriTrypDb:

LdBPK_331110.1 , LdCL_330017200 , LDHU3_33.1710

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGI7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.672
CLV_NRD_NRD_1	233	235	PF00675	0.397
CLV_NRD_NRD_1	379	381	PF00675	0.564
CLV_NRD_NRD_1	74	76	PF00675	0.448
CLV_NRD_NRD_1	77	79	PF00675	0.609
CLV_NRD_NRD_1	84	86	PF00675	0.519
CLV_PCSK_FUR_1	377	381	PF00082	0.478
CLV_PCSK_FUR_1	75	79	PF00082	0.436
CLV_PCSK_KEX2_1	122	124	PF00082	0.672
CLV_PCSK_KEX2_1	233	235	PF00082	0.406
CLV_PCSK_KEX2_1	364	366	PF00082	0.441
CLV_PCSK_KEX2_1	379	381	PF00082	0.442
CLV_PCSK_KEX2_1	74	76	PF00082	0.527
CLV_PCSK_KEX2_1	77	79	PF00082	0.482
CLV_PCSK_KEX2_1	84	86	PF00082	0.492
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.550
CLV_PCSK_SKI1_1	194	198	PF00082	0.348
CLV_PCSK_SKI1_1	237	241	PF00082	0.505
CLV_PCSK_SKI1_1	276	280	PF00082	0.309
CLV_PCSK_SKI1_1	30	34	PF00082	0.354
CLV_PCSK_SKI1_1	77	81	PF00082	0.504
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.319
DOC_MAPK_gen_1	233	241	PF00069	0.401
DOC_MAPK_gen_1	263	272	PF00069	0.387
DOC_MAPK_gen_1	64	72	PF00069	0.471
DOC_MAPK_MEF2A_6	107	116	PF00069	0.582
DOC_MAPK_MEF2A_6	15	23	PF00069	0.463
DOC_MAPK_RevD_3	349	365	PF00069	0.395
DOC_USP7_MATH_1	117	121	PF00917	0.610
DOC_USP7_MATH_1	256	260	PF00917	0.631
DOC_USP7_MATH_1	404	408	PF00917	0.464
DOC_WW_Pin1_4	108	113	PF00397	0.627
DOC_WW_Pin1_4	166	171	PF00397	0.382
DOC_WW_Pin1_4	286	291	PF00397	0.359
DOC_WW_Pin1_4	8	13	PF00397	0.424
LIG_14-3-3_CanoR_1	107	112	PF00244	0.768
LIG_14-3-3_CanoR_1	132	138	PF00244	0.566
LIG_14-3-3_CanoR_1	153	160	PF00244	0.488
LIG_14-3-3_CanoR_1	276	286	PF00244	0.310
LIG_Actin_WH2_2	63	79	PF00022	0.462
LIG_Clathr_ClatBox_1	298	302	PF01394	0.316
LIG_FHA_1	108	114	PF00498	0.525
LIG_FHA_1	153	159	PF00498	0.365
LIG_FHA_1	227	233	PF00498	0.464
LIG_FHA_1	369	375	PF00498	0.352
LIG_FHA_1	400	406	PF00498	0.438
LIG_FHA_1	52	58	PF00498	0.551
LIG_FHA_2	124	130	PF00498	0.613
LIG_FHA_2	241	247	PF00498	0.597
LIG_FHA_2	333	339	PF00498	0.406
LIG_FHA_2	35	41	PF00498	0.358
LIG_GBD_Chelix_1	72	80	PF00786	0.497
LIG_Integrin_RGD_1	127	129	PF01839	0.532
LIG_LIR_Gen_1	280	290	PF02991	0.330
LIG_LIR_Gen_1	302	312	PF02991	0.353
LIG_LIR_Nem_3	302	308	PF02991	0.348
LIG_LIR_Nem_3	419	425	PF02991	0.364
LIG_Pex14_2	325	329	PF04695	0.415
LIG_Rb_pABgroove_1	416	424	PF01858	0.347
LIG_SH2_CRK	181	185	PF00017	0.534
LIG_SH2_NCK_1	211	215	PF00017	0.369
LIG_SH2_SRC	8	11	PF00017	0.419
LIG_SH2_STAT5	36	39	PF00017	0.349
LIG_SH2_STAT5	414	417	PF00017	0.328
LIG_SH2_STAT5	425	428	PF00017	0.368
LIG_SH2_STAT5	58	61	PF00017	0.425
LIG_SH3_3	18	24	PF00018	0.394
LIG_SH3_3	298	304	PF00018	0.408
LIG_SH3_3	50	56	PF00018	0.517
LIG_SUMO_SIM_anti_2	110	117	PF11976	0.469
LIG_SUMO_SIM_anti_2	297	302	PF11976	0.329
LIG_SUMO_SIM_anti_2	391	396	PF11976	0.448
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.332
LIG_SUMO_SIM_par_1	297	302	PF11976	0.334
LIG_TRAF2_1	289	292	PF00917	0.438
LIG_TRAF2_1	335	338	PF00917	0.438
LIG_WRC_WIRS_1	326	331	PF05994	0.363
LIG_WW_3	12	16	PF00397	0.458
MOD_CDK_SPxxK_3	8	15	PF00069	0.406
MOD_CK1_1	261	267	PF00069	0.618
MOD_CK1_1	28	34	PF00069	0.385
MOD_CK1_1	89	95	PF00069	0.619
MOD_CK2_1	240	246	PF00069	0.459
MOD_CK2_1	286	292	PF00069	0.421
MOD_CK2_1	332	338	PF00069	0.422
MOD_CK2_1	46	52	PF00069	0.424
MOD_GlcNHglycan	283	286	PF01048	0.438
MOD_GlcNHglycan	397	400	PF01048	0.381
MOD_GlcNHglycan	88	91	PF01048	0.595
MOD_GSK3_1	130	137	PF00069	0.544
MOD_GSK3_1	24	31	PF00069	0.418
MOD_GSK3_1	240	247	PF00069	0.604
MOD_GSK3_1	257	264	PF00069	0.602
MOD_GSK3_1	272	279	PF00069	0.314
MOD_GSK3_1	395	402	PF00069	0.472
MOD_GSK3_1	421	428	PF00069	0.379
MOD_LATS_1	238	244	PF00433	0.428
MOD_N-GLC_1	46	51	PF02516	0.562
MOD_N-GLC_2	368	370	PF02516	0.436
MOD_NEK2_1	272	277	PF00069	0.298
MOD_NEK2_1	325	330	PF00069	0.391
MOD_NEK2_1	357	362	PF00069	0.336
MOD_NEK2_1	395	400	PF00069	0.354
MOD_NEK2_1	421	426	PF00069	0.424
MOD_NEK2_2	152	157	PF00069	0.374
MOD_NEK2_2	200	205	PF00069	0.430
MOD_NEK2_2	25	30	PF00069	0.385
MOD_NEK2_2	277	282	PF00069	0.342
MOD_PIKK_1	368	374	PF00454	0.392
MOD_PKA_2	131	137	PF00069	0.448
MOD_PKA_2	152	158	PF00069	0.332
MOD_PKA_2	256	262	PF00069	0.551
MOD_PKA_2	332	338	PF00069	0.461
MOD_PKA_2	34	40	PF00069	0.349
MOD_PKA_2	65	71	PF00069	0.502
MOD_Plk_1	257	263	PF00069	0.623
MOD_Plk_1	312	318	PF00069	0.428
MOD_Plk_4	17	23	PF00069	0.414
MOD_Plk_4	294	300	PF00069	0.404
MOD_Plk_4	40	46	PF00069	0.447
MOD_ProDKin_1	108	114	PF00069	0.628
MOD_ProDKin_1	166	172	PF00069	0.381
MOD_ProDKin_1	286	292	PF00069	0.355
MOD_ProDKin_1	8	14	PF00069	0.425
MOD_SUMO_rev_2	289	296	PF00179	0.401
MOD_SUMO_rev_2	331	341	PF00179	0.393
MOD_SUMO_rev_2	343	349	PF00179	0.291
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.336
TRG_ENDOCYTIC_2	181	184	PF00928	0.544
TRG_ENDOCYTIC_2	283	286	PF00928	0.321
TRG_ENDOCYTIC_2	414	417	PF00928	0.328
TRG_ER_diArg_1	122	125	PF00400	0.654
TRG_ER_diArg_1	175	178	PF00400	0.415
TRG_ER_diArg_1	232	234	PF00400	0.395
TRG_ER_diArg_1	377	380	PF00400	0.510
TRG_ER_diArg_1	74	77	PF00400	0.496
TRG_ER_diArg_1	83	85	PF00400	0.561
TRG_Pf-PMV_PEXEL_1	78	82	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5H7	Leptomonas seymouri	58%	94%
A0A1X0P162	Trypanosomatidae	42%	100%
A4HLF9	Leishmania braziliensis	78%	100%
A4I8X0	Leishmania infantum	99%	100%
D0A4W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B3T9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q485	Leishmania major	95%	100%