Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IGI6_LEIDO

TriTrypDb:

LdBPK_312460.1 , LdCL_310032600 , LDHU3_31.4440

Length:

818

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.575
CLV_C14_Caspase3-7	167	171	PF00656	0.807
CLV_C14_Caspase3-7	778	782	PF00656	0.760
CLV_NRD_NRD_1	167	169	PF00675	0.635
CLV_NRD_NRD_1	197	199	PF00675	0.653
CLV_NRD_NRD_1	283	285	PF00675	0.719
CLV_NRD_NRD_1	320	322	PF00675	0.729
CLV_NRD_NRD_1	402	404	PF00675	0.825
CLV_NRD_NRD_1	408	410	PF00675	0.789
CLV_NRD_NRD_1	474	476	PF00675	0.869
CLV_NRD_NRD_1	478	480	PF00675	0.791
CLV_NRD_NRD_1	482	484	PF00675	0.710
CLV_NRD_NRD_1	523	525	PF00675	0.655
CLV_NRD_NRD_1	594	596	PF00675	0.820
CLV_NRD_NRD_1	619	621	PF00675	0.782
CLV_NRD_NRD_1	789	791	PF00675	0.853
CLV_PCSK_FUR_1	790	794	PF00082	0.845
CLV_PCSK_KEX2_1	197	199	PF00082	0.653
CLV_PCSK_KEX2_1	283	285	PF00082	0.719
CLV_PCSK_KEX2_1	322	324	PF00082	0.733
CLV_PCSK_KEX2_1	379	381	PF00082	0.762
CLV_PCSK_KEX2_1	401	403	PF00082	0.823
CLV_PCSK_KEX2_1	408	410	PF00082	0.784
CLV_PCSK_KEX2_1	478	480	PF00082	0.857
CLV_PCSK_KEX2_1	523	525	PF00082	0.655
CLV_PCSK_KEX2_1	593	595	PF00082	0.819
CLV_PCSK_KEX2_1	619	621	PF00082	0.782
CLV_PCSK_KEX2_1	792	794	PF00082	0.837
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.733
CLV_PCSK_PC1ET2_1	379	381	PF00082	0.762
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.837
CLV_PCSK_PC7_1	589	595	PF00082	0.705
CLV_PCSK_SKI1_1	408	412	PF00082	0.702
CLV_PCSK_SKI1_1	524	528	PF00082	0.570
CLV_PCSK_SKI1_1	589	593	PF00082	0.783
CLV_PCSK_SKI1_1	679	683	PF00082	0.815
DEG_Nend_Nbox_1	1	3	PF02207	0.694
DEG_SPOP_SBC_1	11	15	PF00917	0.625
DEG_SPOP_SBC_1	384	388	PF00917	0.750
DEG_SPOP_SBC_1	423	427	PF00917	0.659
DEG_SPOP_SBC_1	503	507	PF00917	0.765
DEG_SPOP_SBC_1	667	671	PF00917	0.695
DEG_SPOP_SBC_1	776	780	PF00917	0.740
DOC_PP2B_LxvP_1	204	207	PF13499	0.745
DOC_PP2B_LxvP_1	298	301	PF13499	0.684
DOC_PP2B_LxvP_1	734	737	PF13499	0.725
DOC_PP4_FxxP_1	140	143	PF00568	0.630
DOC_USP7_MATH_1	207	211	PF00917	0.748
DOC_USP7_MATH_1	27	31	PF00917	0.717
DOC_USP7_MATH_1	341	345	PF00917	0.736
DOC_USP7_MATH_1	364	368	PF00917	0.770
DOC_USP7_MATH_1	370	374	PF00917	0.733
DOC_USP7_MATH_1	418	422	PF00917	0.846
DOC_USP7_MATH_1	512	516	PF00917	0.846
DOC_USP7_MATH_1	61	65	PF00917	0.748
DOC_USP7_MATH_1	624	628	PF00917	0.738
DOC_USP7_MATH_1	667	671	PF00917	0.727
DOC_USP7_MATH_1	737	741	PF00917	0.759
DOC_USP7_MATH_1	814	818	PF00917	0.755
DOC_USP7_UBL2_3	476	480	PF12436	0.858
DOC_WW_Pin1_4	172	177	PF00397	0.736
DOC_WW_Pin1_4	23	28	PF00397	0.681
DOC_WW_Pin1_4	316	321	PF00397	0.770
DOC_WW_Pin1_4	336	341	PF00397	0.502
DOC_WW_Pin1_4	352	357	PF00397	0.563
DOC_WW_Pin1_4	460	465	PF00397	0.630
DOC_WW_Pin1_4	576	581	PF00397	0.833
DOC_WW_Pin1_4	614	619	PF00397	0.838
DOC_WW_Pin1_4	659	664	PF00397	0.776
DOC_WW_Pin1_4	673	678	PF00397	0.584
LIG_14-3-3_CanoR_1	116	120	PF00244	0.721
LIG_14-3-3_CanoR_1	150	155	PF00244	0.730
LIG_14-3-3_CanoR_1	197	201	PF00244	0.811
LIG_14-3-3_CanoR_1	256	263	PF00244	0.684
LIG_14-3-3_CanoR_1	290	298	PF00244	0.711
LIG_14-3-3_CanoR_1	402	412	PF00244	0.754
LIG_14-3-3_CanoR_1	489	496	PF00244	0.749
LIG_14-3-3_CanoR_1	523	531	PF00244	0.670
LIG_14-3-3_CanoR_1	567	576	PF00244	0.778
LIG_14-3-3_CanoR_1	626	632	PF00244	0.747
LIG_14-3-3_CanoR_1	767	772	PF00244	0.819
LIG_14-3-3_CanoR_1	777	786	PF00244	0.675
LIG_14-3-3_CanoR_1	78	83	PF00244	0.764
LIG_14-3-3_CanoR_1	87	96	PF00244	0.767
LIG_BRCT_BRCA1_1	341	345	PF00533	0.697
LIG_BRCT_BRCA1_1	62	66	PF00533	0.669
LIG_BRCT_BRCA1_1	669	673	PF00533	0.827
LIG_CSL_BTD_1	660	663	PF09270	0.841
LIG_EH_1	760	764	PF12763	0.727
LIG_FHA_1	12	18	PF00498	0.776
LIG_FHA_1	280	286	PF00498	0.653
LIG_FHA_1	293	299	PF00498	0.779
LIG_FHA_1	360	366	PF00498	0.750
LIG_FHA_1	386	392	PF00498	0.665
LIG_FHA_2	291	297	PF00498	0.757
LIG_FHA_2	323	329	PF00498	0.763
LIG_FHA_2	34	40	PF00498	0.746
LIG_FHA_2	385	391	PF00498	0.759
LIG_FHA_2	538	544	PF00498	0.764
LIG_Integrin_RGD_1	231	233	PF01839	0.670
LIG_LIR_Apic_2	118	123	PF02991	0.715
LIG_LIR_Gen_1	355	365	PF02991	0.608
LIG_LIR_Gen_1	678	684	PF02991	0.775
LIG_LIR_Nem_3	221	226	PF02991	0.566
LIG_LIR_Nem_3	355	360	PF02991	0.742
LIG_LIR_Nem_3	678	683	PF02991	0.774
LIG_MYND_1	435	439	PF01753	0.668
LIG_Pex14_2	62	66	PF04695	0.772
LIG_RPA_C_Fungi	390	402	PF08784	0.637
LIG_SH2_CRK	114	118	PF00017	0.767
LIG_SH2_CRK	120	124	PF00017	0.730
LIG_SH2_CRK	649	653	PF00017	0.610
LIG_SH2_NCK_1	114	118	PF00017	0.686
LIG_SH2_NCK_1	332	336	PF00017	0.631
LIG_SH2_NCK_1	649	653	PF00017	0.610
LIG_SH2_SRC	103	106	PF00017	0.734
LIG_SH2_SRC	225	228	PF00017	0.513
LIG_SH2_SRC	596	599	PF00017	0.733
LIG_SH2_STAT5	225	228	PF00017	0.661
LIG_SH2_STAT5	35	38	PF00017	0.806
LIG_SH2_STAT5	596	599	PF00017	0.811
LIG_SH3_2	615	620	PF14604	0.766
LIG_SH3_3	429	435	PF00018	0.767
LIG_SH3_3	552	558	PF00018	0.774
LIG_SH3_3	575	581	PF00018	0.737
LIG_SH3_3	612	618	PF00018	0.828
LIG_SH3_3	634	640	PF00018	0.796
LIG_SH3_3	649	655	PF00018	0.627
LIG_SH3_4	476	483	PF00018	0.850
LIG_TYR_ITIM	647	652	PF00017	0.611
LIG_WW_1	580	583	PF00397	0.737
MOD_CDC14_SPxK_1	319	322	PF00782	0.731
MOD_CDC14_SPxK_1	617	620	PF00782	0.771
MOD_CDK_SPK_2	316	321	PF00069	0.766
MOD_CDK_SPK_2	614	619	PF00069	0.761
MOD_CDK_SPxK_1	316	322	PF00069	0.729
MOD_CDK_SPxK_1	614	620	PF00069	0.763
MOD_CDK_SPxK_1	673	679	PF00069	0.814
MOD_CDK_SPxxK_3	316	323	PF00069	0.769
MOD_CK1_1	115	121	PF00069	0.720
MOD_CK1_1	153	159	PF00069	0.814
MOD_CK1_1	178	184	PF00069	0.815
MOD_CK1_1	185	191	PF00069	0.701
MOD_CK1_1	193	199	PF00069	0.580
MOD_CK1_1	209	215	PF00069	0.555
MOD_CK1_1	218	224	PF00069	0.654
MOD_CK1_1	258	264	PF00069	0.670
MOD_CK1_1	271	277	PF00069	0.693
MOD_CK1_1	307	313	PF00069	0.681
MOD_CK1_1	334	340	PF00069	0.815
MOD_CK1_1	394	400	PF00069	0.636
MOD_CK1_1	419	425	PF00069	0.837
MOD_CK1_1	455	461	PF00069	0.744
MOD_CK1_1	488	494	PF00069	0.848
MOD_CK1_1	505	511	PF00069	0.577
MOD_CK1_1	515	521	PF00069	0.702
MOD_CK1_1	550	556	PF00069	0.752
MOD_CK1_1	571	577	PF00069	0.840
MOD_CK1_1	579	585	PF00069	0.674
MOD_CK1_1	60	66	PF00069	0.746
MOD_CK1_1	625	631	PF00069	0.862
MOD_CK1_1	668	674	PF00069	0.821
MOD_CK1_1	722	728	PF00069	0.842
MOD_CK1_1	748	754	PF00069	0.825
MOD_CK1_1	772	778	PF00069	0.819
MOD_CK1_1	88	94	PF00069	0.792
MOD_CK1_1	9	15	PF00069	0.800
MOD_CK2_1	290	296	PF00069	0.810
MOD_CK2_1	384	390	PF00069	0.758
MOD_CK2_1	579	585	PF00069	0.814
MOD_CK2_1	602	608	PF00069	0.682
MOD_CK2_1	714	720	PF00069	0.785
MOD_CK2_1	727	733	PF00069	0.676
MOD_CK2_1	752	758	PF00069	0.815
MOD_CK2_1	78	84	PF00069	0.849
MOD_GlcNHglycan	146	149	PF01048	0.769
MOD_GlcNHglycan	156	159	PF01048	0.638
MOD_GlcNHglycan	177	180	PF01048	0.815
MOD_GlcNHglycan	2	5	PF01048	0.690
MOD_GlcNHglycan	220	223	PF01048	0.745
MOD_GlcNHglycan	250	253	PF01048	0.772
MOD_GlcNHglycan	306	309	PF01048	0.677
MOD_GlcNHglycan	333	336	PF01048	0.820
MOD_GlcNHglycan	341	344	PF01048	0.725
MOD_GlcNHglycan	374	377	PF01048	0.773
MOD_GlcNHglycan	397	400	PF01048	0.597
MOD_GlcNHglycan	415	419	PF01048	0.755
MOD_GlcNHglycan	421	424	PF01048	0.699
MOD_GlcNHglycan	428	431	PF01048	0.621
MOD_GlcNHglycan	471	474	PF01048	0.831
MOD_GlcNHglycan	50	53	PF01048	0.651
MOD_GlcNHglycan	541	547	PF01048	0.763
MOD_GlcNHglycan	570	573	PF01048	0.642
MOD_GlcNHglycan	59	62	PF01048	0.688
MOD_GlcNHglycan	604	607	PF01048	0.677
MOD_GlcNHglycan	629	632	PF01048	0.772
MOD_GlcNHglycan	63	66	PF01048	0.739
MOD_GlcNHglycan	663	666	PF01048	0.838
MOD_GlcNHglycan	684	687	PF01048	0.721
MOD_GlcNHglycan	729	732	PF01048	0.841
MOD_GlcNHglycan	767	770	PF01048	0.761
MOD_GlcNHglycan	774	777	PF01048	0.749
MOD_GlcNHglycan	781	784	PF01048	0.642
MOD_GlcNHglycan	97	100	PF01048	0.691
MOD_GSK3_1	144	151	PF00069	0.794
MOD_GSK3_1	178	185	PF00069	0.815
MOD_GSK3_1	196	203	PF00069	0.530
MOD_GSK3_1	207	214	PF00069	0.640
MOD_GSK3_1	23	30	PF00069	0.502
MOD_GSK3_1	257	264	PF00069	0.791
MOD_GSK3_1	267	274	PF00069	0.706
MOD_GSK3_1	290	297	PF00069	0.803
MOD_GSK3_1	304	311	PF00069	0.576
MOD_GSK3_1	327	334	PF00069	0.763
MOD_GSK3_1	391	398	PF00069	0.769
MOD_GSK3_1	414	421	PF00069	0.827
MOD_GSK3_1	422	429	PF00069	0.737
MOD_GSK3_1	455	462	PF00069	0.691
MOD_GSK3_1	485	492	PF00069	0.848
MOD_GSK3_1	5	12	PF00069	0.804
MOD_GSK3_1	502	509	PF00069	0.576
MOD_GSK3_1	512	519	PF00069	0.690
MOD_GSK3_1	542	549	PF00069	0.735
MOD_GSK3_1	57	64	PF00069	0.784
MOD_GSK3_1	570	577	PF00069	0.828
MOD_GSK3_1	622	629	PF00069	0.776
MOD_GSK3_1	650	657	PF00069	0.824
MOD_GSK3_1	659	666	PF00069	0.689
MOD_GSK3_1	667	674	PF00069	0.548
MOD_GSK3_1	711	718	PF00069	0.749
MOD_GSK3_1	748	755	PF00069	0.823
MOD_GSK3_1	765	772	PF00069	0.536
MOD_GSK3_1	775	782	PF00069	0.672
MOD_GSK3_1	85	92	PF00069	0.707
MOD_LATS_1	522	528	PF00433	0.572
MOD_N-GLC_1	238	243	PF02516	0.626
MOD_N-GLC_1	391	396	PF02516	0.633
MOD_N-GLC_1	485	490	PF02516	0.827
MOD_NEK2_1	154	159	PF00069	0.749
MOD_NEK2_1	200	205	PF00069	0.800
MOD_NEK2_1	21	26	PF00069	0.548
MOD_NEK2_1	211	216	PF00069	0.657
MOD_NEK2_1	257	262	PF00069	0.832
MOD_NEK2_1	279	284	PF00069	0.775
MOD_NEK2_1	304	309	PF00069	0.806
MOD_NEK2_1	48	53	PF00069	0.752
MOD_NEK2_1	5	10	PF00069	0.760
MOD_NEK2_1	57	62	PF00069	0.650
MOD_NEK2_1	702	707	PF00069	0.807
MOD_NEK2_1	745	750	PF00069	0.798
MOD_NEK2_2	769	774	PF00069	0.745
MOD_PIKK_1	327	333	PF00454	0.648
MOD_PIKK_1	550	556	PF00454	0.760
MOD_PIKK_1	6	12	PF00454	0.690
MOD_PIKK_1	631	637	PF00454	0.796
MOD_PIKK_1	689	695	PF00454	0.741
MOD_PK_1	489	495	PF00069	0.850
MOD_PKA_1	322	328	PF00069	0.726
MOD_PKA_1	408	414	PF00069	0.723
MOD_PKA_1	524	530	PF00069	0.572
MOD_PKA_2	115	121	PF00069	0.720
MOD_PKA_2	196	202	PF00069	0.755
MOD_PKA_2	215	221	PF00069	0.558
MOD_PKA_2	255	261	PF00069	0.764
MOD_PKA_2	271	277	PF00069	0.555
MOD_PKA_2	289	295	PF00069	0.602
MOD_PKA_2	322	328	PF00069	0.728
MOD_PKA_2	394	400	PF00069	0.659
MOD_PKA_2	408	414	PF00069	0.641
MOD_PKA_2	488	494	PF00069	0.848
MOD_PKA_2	515	521	PF00069	0.750
MOD_PKA_2	625	631	PF00069	0.745
MOD_PKA_2	776	782	PF00069	0.702
MOD_PKA_2	88	94	PF00069	0.742
MOD_PKB_1	401	409	PF00069	0.700
MOD_PKB_1	87	95	PF00069	0.666
MOD_Plk_1	185	191	PF00069	0.739
MOD_Plk_1	226	232	PF00069	0.813
MOD_Plk_1	258	264	PF00069	0.763
MOD_Plk_1	327	333	PF00069	0.627
MOD_Plk_1	719	725	PF00069	0.737
MOD_Plk_1	752	758	PF00069	0.738
MOD_Plk_4	115	121	PF00069	0.720
MOD_Plk_4	178	184	PF00069	0.602
MOD_Plk_4	27	33	PF00069	0.718
MOD_Plk_4	433	439	PF00069	0.769
MOD_ProDKin_1	172	178	PF00069	0.736
MOD_ProDKin_1	23	29	PF00069	0.680
MOD_ProDKin_1	316	322	PF00069	0.772
MOD_ProDKin_1	336	342	PF00069	0.503
MOD_ProDKin_1	352	358	PF00069	0.565
MOD_ProDKin_1	460	466	PF00069	0.633
MOD_ProDKin_1	576	582	PF00069	0.828
MOD_ProDKin_1	614	620	PF00069	0.841
MOD_ProDKin_1	659	665	PF00069	0.775
MOD_ProDKin_1	673	679	PF00069	0.582
MOD_SUMO_rev_2	446	452	PF00179	0.801
TRG_DiLeu_BaEn_3	806	812	PF01217	0.618
TRG_ENDOCYTIC_2	114	117	PF00928	0.726
TRG_ENDOCYTIC_2	223	226	PF00928	0.567
TRG_ENDOCYTIC_2	649	652	PF00928	0.610
TRG_ER_diArg_1	283	285	PF00400	0.719
TRG_ER_diArg_1	320	323	PF00400	0.732
TRG_ER_diArg_1	400	403	PF00400	0.845
TRG_ER_diArg_1	477	479	PF00400	0.859
TRG_ER_diArg_1	592	595	PF00400	0.817
TRG_ER_diArg_1	618	620	PF00400	0.778
TRG_ER_diArg_1	86	89	PF00400	0.631
TRG_NLS_MonoCore_2	474	479	PF00514	0.864
TRG_NLS_MonoCore_2	789	794	PF00514	0.845
TRG_NLS_MonoExtC_3	474	479	PF00514	0.864
TRG_NLS_MonoExtC_3	790	796	PF00514	0.840
TRG_NLS_MonoExtN_4	320	325	PF00514	0.729
TRG_NLS_MonoExtN_4	790	795	PF00514	0.842
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	595	600	PF00026	0.733

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HJM2	Leishmania braziliensis	61%	100%
A4I744	Leishmania infantum	98%	99%
E9B238	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q623	Leishmania major	85%	100%