39S ribosomal protein L23, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGI5_LEIDO

TriTrypDb:

LdBPK_250920.1 , LdCL_250014500 , LDHU3_25.1190

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005737	cytoplasm	2	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A0A3Q8IGI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGI5

PDB structure(s): 7aih_N , 7am2_N , 7ane_N

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0032543	mitochondrial translation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.562
CLV_NRD_NRD_1	117	119	PF00675	0.432
CLV_NRD_NRD_1	136	138	PF00675	0.286
CLV_NRD_NRD_1	207	209	PF00675	0.448
CLV_PCSK_FUR_1	205	209	PF00082	0.422
CLV_PCSK_KEX2_1	136	138	PF00082	0.473
CLV_PCSK_KEX2_1	2	4	PF00082	0.554
CLV_PCSK_KEX2_1	207	209	PF00082	0.442
CLV_PCSK_KEX2_1	48	50	PF00082	0.621
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.663
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.640
CLV_PCSK_SKI1_1	156	160	PF00082	0.416
CLV_PCSK_SKI1_1	169	173	PF00082	0.426
CLV_PCSK_SKI1_1	207	211	PF00082	0.541
CLV_PCSK_SKI1_1	238	242	PF00082	0.508
DEG_APCC_DBOX_1	155	163	PF00400	0.399
DEG_Nend_UBRbox_1	1	4	PF02207	0.684
DOC_CYCLIN_yCln2_LP_2	229	235	PF00134	0.379
DOC_MAPK_MEF2A_6	148	157	PF00069	0.508
DOC_PP4_FxxP_1	172	175	PF00568	0.398
DOC_PP4_FxxP_1	52	55	PF00568	0.521
DOC_PP4_FxxP_1	91	94	PF00568	0.477
DOC_USP7_MATH_1	22	26	PF00917	0.718
DOC_WW_Pin1_4	135	140	PF00397	0.478
DOC_WW_Pin1_4	228	233	PF00397	0.427
DOC_WW_Pin1_4	243	248	PF00397	0.559
DOC_WW_Pin1_4	39	44	PF00397	0.601
LIG_14-3-3_CanoR_1	198	202	PF00244	0.475
LIG_BRCT_BRCA1_1	146	150	PF00533	0.478
LIG_BRCT_BRCA1_1	233	237	PF00533	0.486
LIG_deltaCOP1_diTrp_1	121	125	PF00928	0.430
LIG_FHA_1	166	172	PF00498	0.472
LIG_FHA_1	39	45	PF00498	0.657
LIG_FHA_2	74	80	PF00498	0.497
LIG_LIR_Apic_2	121	126	PF02991	0.416
LIG_LIR_Nem_3	103	109	PF02991	0.426
LIG_LIR_Nem_3	138	144	PF02991	0.380
LIG_LIR_Nem_3	147	153	PF02991	0.408
LIG_LIR_Nem_3	234	240	PF02991	0.497
LIG_MLH1_MIPbox_1	146	150	PF16413	0.511
LIG_Pex14_2	142	146	PF04695	0.396
LIG_REV1ctd_RIR_1	142	150	PF16727	0.383
LIG_SH2_CRK	53	57	PF00017	0.506
LIG_SH2_STAT5	141	144	PF00017	0.388
LIG_SH2_STAT5	149	152	PF00017	0.369
LIG_SH2_STAT5	186	189	PF00017	0.383
LIG_SH2_STAT5	99	102	PF00017	0.417
LIG_SUMO_SIM_anti_2	230	237	PF11976	0.524
LIG_SUMO_SIM_par_1	225	231	PF11976	0.352
LIG_TRAF2_1	179	182	PF00917	0.478
MOD_CDK_SPxxK_3	243	250	PF00069	0.568
MOD_CK1_1	231	237	PF00069	0.479
MOD_CK1_1	25	31	PF00069	0.676
MOD_CK1_1	36	42	PF00069	0.674
MOD_CK2_1	176	182	PF00069	0.402
MOD_CK2_1	73	79	PF00069	0.553
MOD_CMANNOS	75	78	PF00535	0.455
MOD_Cter_Amidation	205	208	PF01082	0.415
MOD_GlcNHglycan	15	18	PF01048	0.673
MOD_GlcNHglycan	24	27	PF01048	0.549
MOD_GSK3_1	34	41	PF00069	0.640
MOD_N-GLC_1	164	169	PF02516	0.409
MOD_NEK2_1	100	105	PF00069	0.423
MOD_NEK2_1	144	149	PF00069	0.523
MOD_NEK2_1	63	68	PF00069	0.605
MOD_PKA_1	2	8	PF00069	0.607
MOD_PKA_2	197	203	PF00069	0.418
MOD_PKA_2	2	8	PF00069	0.607
MOD_Plk_2-3	215	221	PF00069	0.521
MOD_Plk_4	158	164	PF00069	0.393
MOD_Plk_4	231	237	PF00069	0.531
MOD_ProDKin_1	135	141	PF00069	0.468
MOD_ProDKin_1	228	234	PF00069	0.429
MOD_ProDKin_1	243	249	PF00069	0.563
MOD_ProDKin_1	39	45	PF00069	0.600
MOD_SUMO_for_1	209	212	PF00179	0.546
MOD_SUMO_rev_2	212	219	PF00179	0.438
MOD_SUMO_rev_2	244	252	PF00179	0.597
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.500
TRG_ENDOCYTIC_2	141	144	PF00928	0.426
TRG_ENDOCYTIC_2	53	56	PF00928	0.523
TRG_ER_diArg_1	102	105	PF00400	0.432
TRG_ER_diArg_1	135	137	PF00400	0.483
TRG_ER_diArg_1	204	207	PF00400	0.461
TRG_ER_diArg_1	49	52	PF00400	0.525
TRG_ER_diArg_1	64	67	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Z4	Leptomonas seymouri	80%	100%
A0A0S4J3V0	Bodo saltans	58%	100%
A0A1X0P4M1	Trypanosomatidae	75%	100%
A0A422NTM0	Trypanosoma rangeli	71%	100%
A4HE24	Leishmania braziliensis	88%	100%
A4I1D0	Leishmania infantum	99%	100%
D0A5M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AXG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	98%
Q4QA05	Leishmania major	94%	98%