Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGI2_LEIDO

TriTrypDb:

LdBPK_323640.1 , LdCL_320042300 , LDHU3_32.4590

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.615
CLV_C14_Caspase3-7	574	578	PF00656	0.598
CLV_NRD_NRD_1	14	16	PF00675	0.620
CLV_NRD_NRD_1	28	30	PF00675	0.552
CLV_NRD_NRD_1	459	461	PF00675	0.619
CLV_NRD_NRD_1	622	624	PF00675	0.640
CLV_PCSK_KEX2_1	13	15	PF00082	0.711
CLV_PCSK_KEX2_1	262	264	PF00082	0.516
CLV_PCSK_KEX2_1	27	29	PF00082	0.589
CLV_PCSK_KEX2_1	458	460	PF00082	0.733
CLV_PCSK_KEX2_1	622	624	PF00082	0.640
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.516
CLV_PCSK_SKI1_1	270	274	PF00082	0.473
CLV_PCSK_SKI1_1	386	390	PF00082	0.547
CLV_PCSK_SKI1_1	622	626	PF00082	0.639
CLV_PCSK_SKI1_1	644	648	PF00082	0.576
DEG_APCC_DBOX_1	621	629	PF00400	0.603
DEG_Nend_UBRbox_2	1	3	PF02207	0.556
DOC_CYCLIN_yClb1_LxF_4	654	659	PF00134	0.492
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.595
DOC_CYCLIN_yCln2_LP_2	215	221	PF00134	0.593
DOC_MAPK_gen_1	13	22	PF00069	0.597
DOC_MAPK_gen_1	622	628	PF00069	0.596
DOC_MAPK_HePTP_8	10	22	PF00069	0.586
DOC_MAPK_MEF2A_6	13	22	PF00069	0.597
DOC_MAPK_MEF2A_6	166	174	PF00069	0.609
DOC_MAPK_MEF2A_6	470	479	PF00069	0.606
DOC_PP1_RVXF_1	654	660	PF00149	0.602
DOC_PP2B_LxvP_1	20	23	PF13499	0.609
DOC_PP4_FxxP_1	154	157	PF00568	0.510
DOC_PP4_FxxP_1	173	176	PF00568	0.554
DOC_USP7_MATH_1	183	187	PF00917	0.631
DOC_USP7_MATH_1	234	238	PF00917	0.682
DOC_USP7_MATH_1	489	493	PF00917	0.605
DOC_USP7_MATH_1	513	517	PF00917	0.545
DOC_USP7_MATH_1	529	533	PF00917	0.653
DOC_USP7_MATH_1	700	704	PF00917	0.562
DOC_USP7_MATH_1	709	713	PF00917	0.483
DOC_WW_Pin1_4	160	165	PF00397	0.601
DOC_WW_Pin1_4	179	184	PF00397	0.452
DOC_WW_Pin1_4	197	202	PF00397	0.587
DOC_WW_Pin1_4	22	27	PF00397	0.703
DOC_WW_Pin1_4	229	234	PF00397	0.611
DOC_WW_Pin1_4	241	246	PF00397	0.681
DOC_WW_Pin1_4	318	323	PF00397	0.522
DOC_WW_Pin1_4	471	476	PF00397	0.705
DOC_WW_Pin1_4	538	543	PF00397	0.690
DOC_WW_Pin1_4	615	620	PF00397	0.629
LIG_14-3-3_CanoR_1	118	122	PF00244	0.678
LIG_14-3-3_CanoR_1	150	155	PF00244	0.537
LIG_14-3-3_CanoR_1	217	222	PF00244	0.626
LIG_14-3-3_CanoR_1	312	319	PF00244	0.603
LIG_14-3-3_CanoR_1	416	426	PF00244	0.580
LIG_14-3-3_CanoR_1	42	48	PF00244	0.499
LIG_14-3-3_CanoR_1	470	475	PF00244	0.655
LIG_14-3-3_CanoR_1	488	498	PF00244	0.615
LIG_14-3-3_CanoR_1	554	560	PF00244	0.591
LIG_14-3-3_CanoR_1	623	629	PF00244	0.597
LIG_14-3-3_CanoR_1	684	690	PF00244	0.493
LIG_BIR_III_2	387	391	PF00653	0.530
LIG_BRCT_BRCA1_1	288	292	PF00533	0.538
LIG_CaM_NSCaTE_8	117	124	PF13499	0.537
LIG_CSL_BTD_1	499	502	PF09270	0.618
LIG_deltaCOP1_diTrp_1	396	402	PF00928	0.501
LIG_EH1_1	351	359	PF00400	0.429
LIG_eIF4E_1	352	358	PF01652	0.353
LIG_EVH1_2	611	615	PF00568	0.606
LIG_FHA_1	203	209	PF00498	0.626
LIG_FHA_1	299	305	PF00498	0.550
LIG_FHA_1	312	318	PF00498	0.479
LIG_FHA_1	418	424	PF00498	0.575
LIG_FHA_1	531	537	PF00498	0.647
LIG_FHA_1	638	644	PF00498	0.633
LIG_FHA_1	691	697	PF00498	0.576
LIG_FHA_2	117	123	PF00498	0.618
LIG_FHA_2	142	148	PF00498	0.518
LIG_FHA_2	361	367	PF00498	0.594
LIG_FHA_2	535	541	PF00498	0.667
LIG_FHA_2	572	578	PF00498	0.595
LIG_LIR_Apic_2	153	157	PF02991	0.502
LIG_LIR_Apic_2	503	508	PF02991	0.578
LIG_LIR_Gen_1	60	67	PF02991	0.543
LIG_LIR_Nem_3	60	66	PF02991	0.538
LIG_LIR_Nem_3	703	708	PF02991	0.518
LIG_LYPXL_S_1	380	384	PF13949	0.520
LIG_LYPXL_yS_3	381	384	PF13949	0.521
LIG_MAD2	29	37	PF02301	0.515
LIG_MYND_1	461	465	PF01753	0.538
LIG_NRBOX	518	524	PF00104	0.524
LIG_PDZ_Class_2	710	715	PF00595	0.492
LIG_Pex14_1	398	402	PF04695	0.509
LIG_Pex14_1	500	504	PF04695	0.605
LIG_Pex14_2	154	158	PF04695	0.574
LIG_SH2_CRK	63	67	PF00017	0.493
LIG_SH2_CRK	708	712	PF00017	0.504
LIG_SH2_NCK_1	708	712	PF00017	0.487
LIG_SH2_STAP1	352	356	PF00017	0.357
LIG_SH2_STAP1	494	498	PF00017	0.511
LIG_SH2_STAP1	63	67	PF00017	0.493
LIG_SH2_STAT5	63	66	PF00017	0.523
LIG_SH3_2	23	28	PF14604	0.621
LIG_SH3_3	20	26	PF00018	0.644
LIG_SH3_3	227	233	PF00018	0.622
LIG_SH3_3	27	33	PF00018	0.548
LIG_SH3_3	323	329	PF00018	0.483
LIG_SH3_3	433	439	PF00018	0.614
LIG_SH3_3	445	451	PF00018	0.504
LIG_SH3_3	496	502	PF00018	0.659
LIG_SH3_3	539	545	PF00018	0.695
LIG_SH3_3	547	553	PF00018	0.511
LIG_SH3_3	606	612	PF00018	0.630
LIG_SUMO_SIM_anti_2	353	358	PF11976	0.478
LIG_SUMO_SIM_par_1	305	311	PF11976	0.489
LIG_SUMO_SIM_par_1	339	345	PF11976	0.585
LIG_SUMO_SIM_par_1	624	630	PF11976	0.594
LIG_SUMO_SIM_par_1	692	699	PF11976	0.522
LIG_TRAF2_1	334	337	PF00917	0.439
LIG_TYR_ITIM	706	711	PF00017	0.493
LIG_UBA3_1	255	262	PF00899	0.563
LIG_UBA3_1	430	437	PF00899	0.489
LIG_WRC_WIRS_1	501	506	PF05994	0.595
MOD_CDC14_SPxK_1	25	28	PF00782	0.605
MOD_CDK_SPK_2	22	27	PF00069	0.636
MOD_CDK_SPxK_1	160	166	PF00069	0.604
MOD_CDK_SPxK_1	22	28	PF00069	0.628
MOD_CDK_SPxK_1	538	544	PF00069	0.697
MOD_CDK_SPxxK_3	22	29	PF00069	0.625
MOD_CDK_SPxxK_3	615	622	PF00069	0.510
MOD_CK1_1	106	112	PF00069	0.613
MOD_CK1_1	120	126	PF00069	0.485
MOD_CK1_1	131	137	PF00069	0.610
MOD_CK1_1	182	188	PF00069	0.697
MOD_CK1_1	298	304	PF00069	0.668
MOD_CK1_1	362	368	PF00069	0.511
MOD_CK1_1	492	498	PF00069	0.626
MOD_CK1_1	534	540	PF00069	0.663
MOD_CK1_1	690	696	PF00069	0.587
MOD_CK2_1	116	122	PF00069	0.622
MOD_CK2_1	150	156	PF00069	0.547
MOD_CK2_1	331	337	PF00069	0.468
MOD_CK2_1	360	366	PF00069	0.527
MOD_CK2_1	43	49	PF00069	0.502
MOD_CK2_1	624	630	PF00069	0.617
MOD_Cter_Amidation	11	14	PF01082	0.681
MOD_GlcNHglycan	105	108	PF01048	0.578
MOD_GlcNHglycan	122	125	PF01048	0.595
MOD_GlcNHglycan	131	134	PF01048	0.575
MOD_GlcNHglycan	192	195	PF01048	0.673
MOD_GlcNHglycan	2	6	PF01048	0.630
MOD_GlcNHglycan	236	239	PF01048	0.720
MOD_GlcNHglycan	491	494	PF01048	0.698
MOD_GlcNHglycan	533	536	PF01048	0.654
MOD_GlcNHglycan	555	558	PF01048	0.708
MOD_GlcNHglycan	615	618	PF01048	0.613
MOD_GlcNHglycan	68	71	PF01048	0.619
MOD_GSK3_1	112	119	PF00069	0.559
MOD_GSK3_1	137	144	PF00069	0.654
MOD_GSK3_1	179	186	PF00069	0.742
MOD_GSK3_1	18	25	PF00069	0.686
MOD_GSK3_1	213	220	PF00069	0.705
MOD_GSK3_1	270	277	PF00069	0.499
MOD_GSK3_1	286	293	PF00069	0.558
MOD_GSK3_1	295	302	PF00069	0.635
MOD_GSK3_1	318	325	PF00069	0.568
MOD_GSK3_1	36	43	PF00069	0.634
MOD_GSK3_1	464	471	PF00069	0.773
MOD_GSK3_1	513	520	PF00069	0.485
MOD_GSK3_1	523	530	PF00069	0.538
MOD_GSK3_1	534	541	PF00069	0.588
MOD_GSK3_1	57	64	PF00069	0.561
MOD_GSK3_1	611	618	PF00069	0.691
MOD_GSK3_1	633	640	PF00069	0.542
MOD_N-GLC_2	93	95	PF02516	0.538
MOD_NEK2_1	128	133	PF00069	0.515
MOD_NEK2_1	190	195	PF00069	0.670
MOD_NEK2_1	523	528	PF00069	0.602
MOD_NEK2_1	66	71	PF00069	0.593
MOD_NEK2_1	701	706	PF00069	0.615
MOD_NEK2_2	709	714	PF00069	0.457
MOD_PIKK_1	270	276	PF00454	0.500
MOD_PIKK_1	286	292	PF00454	0.591
MOD_PIKK_1	417	423	PF00454	0.581
MOD_PIKK_1	492	498	PF00454	0.642
MOD_PIKK_1	649	655	PF00454	0.521
MOD_PK_1	217	223	PF00069	0.603
MOD_PK_1	544	550	PF00069	0.659
MOD_PKA_2	117	123	PF00069	0.590
MOD_PKA_2	311	317	PF00069	0.532
MOD_PKA_2	367	373	PF00069	0.637
MOD_PKA_2	43	49	PF00069	0.602
MOD_PKA_2	463	469	PF00069	0.678
MOD_PKA_2	530	536	PF00069	0.657
MOD_PKA_2	553	559	PF00069	0.620
MOD_Plk_1	432	438	PF00069	0.623
MOD_Plk_1	61	67	PF00069	0.517
MOD_Plk_4	137	143	PF00069	0.463
MOD_Plk_4	150	156	PF00069	0.550
MOD_Plk_4	36	42	PF00069	0.514
MOD_Plk_4	43	49	PF00069	0.508
MOD_Plk_4	500	506	PF00069	0.570
MOD_Plk_4	513	519	PF00069	0.436
MOD_Plk_4	523	529	PF00069	0.534
MOD_Plk_4	571	577	PF00069	0.559
MOD_Plk_4	61	67	PF00069	0.530
MOD_Plk_4	701	707	PF00069	0.535
MOD_ProDKin_1	160	166	PF00069	0.605
MOD_ProDKin_1	179	185	PF00069	0.455
MOD_ProDKin_1	197	203	PF00069	0.588
MOD_ProDKin_1	22	28	PF00069	0.695
MOD_ProDKin_1	229	235	PF00069	0.613
MOD_ProDKin_1	241	247	PF00069	0.675
MOD_ProDKin_1	318	324	PF00069	0.516
MOD_ProDKin_1	471	477	PF00069	0.705
MOD_ProDKin_1	538	544	PF00069	0.690
MOD_ProDKin_1	615	621	PF00069	0.629
MOD_SUMO_rev_2	257	264	PF00179	0.522
TRG_DiLeu_BaEn_1	260	265	PF01217	0.452
TRG_DiLeu_BaEn_1	336	341	PF01217	0.487
TRG_DiLeu_BaEn_1	62	67	PF01217	0.512
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.624
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.623
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.532
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.607
TRG_ENDOCYTIC_2	381	384	PF00928	0.521
TRG_ENDOCYTIC_2	63	66	PF00928	0.523
TRG_ENDOCYTIC_2	708	711	PF00928	0.434
TRG_ER_diArg_1	13	15	PF00400	0.636
TRG_ER_diArg_1	187	190	PF00400	0.591
TRG_ER_diArg_1	26	29	PF00400	0.535
TRG_ER_diArg_1	41	44	PF00400	0.416
TRG_ER_diArg_1	458	460	PF00400	0.727
TRG_ER_diArg_1	621	623	PF00400	0.660
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC97	Leptomonas seymouri	38%	92%
A4HKY7	Leishmania braziliensis	73%	100%
A4I8G8	Leishmania infantum	99%	100%
D0AAQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B3C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q4S8	Leishmania major	93%	100%