Membrane transporter protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGH9_LEIDO

TriTrypDb:

LdBPK_353630.1 , LdCL_350041300 , LDHU3_35.4770

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

A0A3Q8IGH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGH9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0009987	cellular process	1	9
GO:0042908	xenobiotic transport	4	9
GO:0046618	xenobiotic export from cell	3	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0140115	export across plasma membrane	3	9
GO:0140352	export from cell	2	9
GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	4	9

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	18
GO:0015291	secondary active transmembrane transporter activity	4	18
GO:0015297	antiporter activity	5	18
GO:0022804	active transmembrane transporter activity	3	18
GO:0022857	transmembrane transporter activity	2	18
GO:0042910	xenobiotic transmembrane transporter activity	3	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.218
CLV_NRD_NRD_1	334	336	PF00675	0.302
CLV_NRD_NRD_1	341	343	PF00675	0.283
CLV_NRD_NRD_1	383	385	PF00675	0.333
CLV_NRD_NRD_1	576	578	PF00675	0.419
CLV_NRD_NRD_1	692	694	PF00675	0.401
CLV_PCSK_FUR_1	690	694	PF00082	0.403
CLV_PCSK_KEX2_1	185	187	PF00082	0.218
CLV_PCSK_KEX2_1	341	343	PF00082	0.267
CLV_PCSK_KEX2_1	576	578	PF00082	0.419
CLV_PCSK_KEX2_1	692	694	PF00082	0.401
CLV_PCSK_PC7_1	688	694	PF00082	0.402
CLV_PCSK_SKI1_1	269	273	PF00082	0.426
CLV_PCSK_SKI1_1	336	340	PF00082	0.270
CLV_PCSK_SKI1_1	342	346	PF00082	0.277
CLV_PCSK_SKI1_1	384	388	PF00082	0.295
CLV_PCSK_SKI1_1	494	498	PF00082	0.440
CLV_PCSK_SKI1_1	639	643	PF00082	0.591
CLV_PCSK_SKI1_1	673	677	PF00082	0.391
CLV_Separin_Metazoa	182	186	PF03568	0.251
DEG_APCC_DBOX_1	127	135	PF00400	0.418
DEG_APCC_DBOX_1	168	176	PF00400	0.384
DEG_APCC_DBOX_1	341	349	PF00400	0.424
DEG_APCC_DBOX_1	506	514	PF00400	0.634
DEG_Nend_UBRbox_3	1	3	PF02207	0.769
DEG_SPOP_SBC_1	496	500	PF00917	0.689
DEG_SPOP_SBC_1	680	684	PF00917	0.722
DOC_CYCLIN_yClb5_NLxxxL_5	354	363	PF00134	0.259
DOC_CYCLIN_yCln2_LP_2	49	55	PF00134	0.407
DOC_MAPK_gen_1	341	348	PF00069	0.489
DOC_MAPK_HePTP_8	338	350	PF00069	0.535
DOC_MAPK_MEF2A_6	128	136	PF00069	0.439
DOC_MAPK_MEF2A_6	341	350	PF00069	0.544
DOC_MAPK_MEF2A_6	48	55	PF00069	0.435
DOC_MAPK_NFAT4_5	128	136	PF00069	0.439
DOC_MAPK_NFAT4_5	48	56	PF00069	0.480
DOC_PP1_RVXF_1	215	222	PF00149	0.375
DOC_PP1_RVXF_1	267	273	PF00149	0.268
DOC_PP1_RVXF_1	383	390	PF00149	0.212
DOC_PP2B_LxvP_1	49	52	PF13499	0.259
DOC_PP4_FxxP_1	139	142	PF00568	0.314
DOC_SPAK_OSR1_1	388	392	PF12202	0.193
DOC_USP7_MATH_1	271	275	PF00917	0.327
DOC_USP7_MATH_1	496	500	PF00917	0.766
DOC_USP7_MATH_1	589	593	PF00917	0.716
DOC_USP7_MATH_1	59	63	PF00917	0.384
DOC_USP7_MATH_1	634	638	PF00917	0.707
DOC_USP7_MATH_1	641	645	PF00917	0.724
DOC_USP7_MATH_1	681	685	PF00917	0.733
DOC_WW_Pin1_4	3	8	PF00397	0.613
DOC_WW_Pin1_4	34	39	PF00397	0.603
DOC_WW_Pin1_4	497	502	PF00397	0.678
DOC_WW_Pin1_4	534	539	PF00397	0.716
DOC_WW_Pin1_4	547	552	PF00397	0.693
DOC_WW_Pin1_4	618	623	PF00397	0.753
DOC_WW_Pin1_4	647	652	PF00397	0.631
LIG_14-3-3_CanoR_1	128	132	PF00244	0.426
LIG_14-3-3_CanoR_1	169	173	PF00244	0.389
LIG_14-3-3_CanoR_1	494	503	PF00244	0.607
LIG_14-3-3_CanoR_1	576	582	PF00244	0.718
LIG_14-3-3_CanoR_1	667	672	PF00244	0.737
LIG_14-3-3_CanoR_1	673	680	PF00244	0.699
LIG_14-3-3_CanoR_1	690	696	PF00244	0.598
LIG_Actin_WH2_2	35	50	PF00022	0.580
LIG_APCC_ABBA_1	475	480	PF00400	0.626
LIG_BRCT_BRCA1_1	206	210	PF00533	0.321
LIG_BRCT_BRCA1_1	317	321	PF00533	0.269
LIG_Clathr_ClatBox_1	178	182	PF01394	0.259
LIG_eIF4E_1	390	396	PF01652	0.259
LIG_FHA_1	116	122	PF00498	0.526
LIG_FHA_1	360	366	PF00498	0.356
LIG_FHA_1	372	378	PF00498	0.299
LIG_FHA_1	39	45	PF00498	0.561
LIG_FHA_1	465	471	PF00498	0.286
LIG_FHA_1	498	504	PF00498	0.723
LIG_FHA_1	524	530	PF00498	0.654
LIG_FHA_1	535	541	PF00498	0.715
LIG_FHA_1	599	605	PF00498	0.593
LIG_FHA_1	674	680	PF00498	0.707
LIG_FHA_1	681	687	PF00498	0.779
LIG_FHA_2	504	510	PF00498	0.781
LIG_IRF3_LxIS_1	146	153	PF10401	0.259
LIG_LIR_Apic_2	444	450	PF02991	0.274
LIG_LIR_Gen_1	164	175	PF02991	0.229
LIG_LIR_Gen_1	238	245	PF02991	0.429
LIG_LIR_Gen_1	301	309	PF02991	0.344
LIG_LIR_Gen_1	351	361	PF02991	0.374
LIG_LIR_Gen_1	471	479	PF02991	0.620
LIG_LIR_Gen_1	565	573	PF02991	0.720
LIG_LIR_Nem_3	164	170	PF02991	0.229
LIG_LIR_Nem_3	171	176	PF02991	0.270
LIG_LIR_Nem_3	207	211	PF02991	0.295
LIG_LIR_Nem_3	238	243	PF02991	0.421
LIG_LIR_Nem_3	301	306	PF02991	0.344
LIG_LIR_Nem_3	351	357	PF02991	0.374
LIG_LIR_Nem_3	471	475	PF02991	0.618
LIG_LIR_Nem_3	565	569	PF02991	0.719
LIG_PCNA_yPIPBox_3	376	388	PF02747	0.376
LIG_PCNA_yPIPBox_3	400	408	PF02747	0.431
LIG_Pex14_2	163	167	PF04695	0.286
LIG_SH2_CRK	294	298	PF00017	0.313
LIG_SH2_CRK	424	428	PF00017	0.251
LIG_SH2_CRK	462	466	PF00017	0.329
LIG_SH2_NCK_1	294	298	PF00017	0.224
LIG_SH2_NCK_1	424	428	PF00017	0.251
LIG_SH2_SRC	294	297	PF00017	0.224
LIG_SH2_STAP1	176	180	PF00017	0.259
LIG_SH2_STAP1	95	99	PF00017	0.240
LIG_SH2_STAT5	187	190	PF00017	0.431
LIG_SH2_STAT5	242	245	PF00017	0.312
LIG_SH2_STAT5	390	393	PF00017	0.294
LIG_SH2_STAT5	464	467	PF00017	0.299
LIG_SH2_STAT5	469	472	PF00017	0.495
LIG_SH3_3	1	7	PF00018	0.632
LIG_SH3_3	424	430	PF00018	0.298
LIG_SH3_3	454	460	PF00018	0.370
LIG_SUMO_SIM_anti_2	130	136	PF11976	0.361
LIG_SUMO_SIM_anti_2	177	182	PF11976	0.259
LIG_SUMO_SIM_anti_2	360	365	PF11976	0.351
LIG_SUMO_SIM_anti_2	419	425	PF11976	0.212
LIG_SUMO_SIM_anti_2	43	48	PF11976	0.488
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.221
LIG_SUMO_SIM_par_1	40	45	PF11976	0.528
LIG_TYR_ITIM	391	396	PF00017	0.314
LIG_TYR_ITIM	422	427	PF00017	0.293
LIG_UBA3_1	239	248	PF00899	0.293
LIG_WRC_WIRS_1	396	401	PF05994	0.335
LIG_WRC_WIRS_1	566	571	PF05994	0.682
MOD_CK1_1	13	19	PF00069	0.635
MOD_CK1_1	315	321	PF00069	0.358
MOD_CK1_1	398	404	PF00069	0.259
MOD_CK1_1	499	505	PF00069	0.558
MOD_CK1_1	565	571	PF00069	0.641
MOD_CK1_1	580	586	PF00069	0.606
MOD_CK1_1	6	12	PF00069	0.689
MOD_CK1_1	657	663	PF00069	0.772
MOD_CK2_1	485	491	PF00069	0.523
MOD_CK2_1	512	518	PF00069	0.687
MOD_CK2_1	539	545	PF00069	0.751
MOD_CK2_1	600	606	PF00069	0.542
MOD_CK2_1	656	662	PF00069	0.573
MOD_CMANNOS	253	256	PF00535	0.411
MOD_GlcNHglycan	19	22	PF01048	0.748
MOD_GlcNHglycan	317	320	PF01048	0.315
MOD_GlcNHglycan	552	555	PF01048	0.691
MOD_GlcNHglycan	643	646	PF01048	0.779
MOD_GlcNHglycan	651	654	PF01048	0.701
MOD_GlcNHglycan	673	676	PF01048	0.718
MOD_GlcNHglycan	683	686	PF01048	0.493
MOD_GlcNHglycan	97	100	PF01048	0.260
MOD_GSK3_1	146	153	PF00069	0.259
MOD_GSK3_1	226	233	PF00069	0.259
MOD_GSK3_1	277	284	PF00069	0.275
MOD_GSK3_1	308	315	PF00069	0.311
MOD_GSK3_1	34	41	PF00069	0.484
MOD_GSK3_1	481	488	PF00069	0.593
MOD_GSK3_1	495	502	PF00069	0.652
MOD_GSK3_1	519	526	PF00069	0.633
MOD_GSK3_1	530	537	PF00069	0.545
MOD_GSK3_1	539	546	PF00069	0.524
MOD_GSK3_1	598	605	PF00069	0.627
MOD_GSK3_1	6	13	PF00069	0.695
MOD_GSK3_1	641	648	PF00069	0.721
MOD_GSK3_1	667	674	PF00069	0.739
MOD_GSK3_1	691	698	PF00069	0.717
MOD_N-GLC_1	357	362	PF02516	0.259
MOD_N-GLC_1	485	490	PF02516	0.608
MOD_N-GLC_1	562	567	PF02516	0.646
MOD_N-GLC_1	589	594	PF02516	0.560
MOD_N-GLC_1	618	623	PF02516	0.555
MOD_N-GLC_1	90	95	PF02516	0.298
MOD_N-GLC_2	570	572	PF02516	0.525
MOD_NEK2_1	10	15	PF00069	0.615
MOD_NEK2_1	109	114	PF00069	0.242
MOD_NEK2_1	146	151	PF00069	0.419
MOD_NEK2_1	230	235	PF00069	0.300
MOD_NEK2_1	243	248	PF00069	0.380
MOD_NEK2_1	348	353	PF00069	0.307
MOD_NEK2_1	359	364	PF00069	0.329
MOD_NEK2_1	395	400	PF00069	0.397
MOD_NEK2_1	422	427	PF00069	0.251
MOD_NEK2_1	436	441	PF00069	0.325
MOD_NEK2_1	452	457	PF00069	0.264
MOD_NEK2_1	47	52	PF00069	0.387
MOD_NEK2_1	485	490	PF00069	0.546
MOD_NEK2_1	503	508	PF00069	0.538
MOD_NEK2_1	543	548	PF00069	0.751
MOD_NEK2_1	600	605	PF00069	0.757
MOD_NEK2_1	671	676	PF00069	0.672
MOD_NEK2_1	80	85	PF00069	0.427
MOD_NEK2_1	90	95	PF00069	0.359
MOD_NEK2_2	168	173	PF00069	0.259
MOD_PIKK_1	107	113	PF00454	0.259
MOD_PIKK_1	192	198	PF00454	0.504
MOD_PIKK_1	281	287	PF00454	0.282
MOD_PIKK_1	571	577	PF00454	0.521
MOD_PIKK_1	673	679	PF00454	0.650
MOD_PK_1	577	583	PF00069	0.488
MOD_PKA_2	127	133	PF00069	0.361
MOD_PKA_2	168	174	PF00069	0.304
MOD_PKA_2	530	536	PF00069	0.631
MOD_PKA_2	635	641	PF00069	0.714
MOD_PKA_2	666	672	PF00069	0.701
MOD_PKA_2	691	697	PF00069	0.538
MOD_Plk_1	357	363	PF00069	0.472
MOD_Plk_1	485	491	PF00069	0.669
MOD_Plk_1	562	568	PF00069	0.668
MOD_Plk_1	90	96	PF00069	0.237
MOD_Plk_4	104	110	PF00069	0.315
MOD_Plk_4	127	133	PF00069	0.341
MOD_Plk_4	146	152	PF00069	0.406
MOD_Plk_4	174	180	PF00069	0.355
MOD_Plk_4	235	241	PF00069	0.303
MOD_Plk_4	308	314	PF00069	0.341
MOD_Plk_4	348	354	PF00069	0.304
MOD_Plk_4	359	365	PF00069	0.338
MOD_Plk_4	368	374	PF00069	0.364
MOD_Plk_4	422	428	PF00069	0.307
MOD_Plk_4	452	458	PF00069	0.288
MOD_Plk_4	667	673	PF00069	0.489
MOD_Plk_4	80	86	PF00069	0.394
MOD_ProDKin_1	3	9	PF00069	0.529
MOD_ProDKin_1	34	40	PF00069	0.509
MOD_ProDKin_1	497	503	PF00069	0.615
MOD_ProDKin_1	534	540	PF00069	0.673
MOD_ProDKin_1	547	553	PF00069	0.636
MOD_ProDKin_1	618	624	PF00069	0.723
MOD_ProDKin_1	647	653	PF00069	0.551
TRG_DiLeu_BaEn_1	257	262	PF01217	0.332
TRG_DiLeu_BaEn_1	323	328	PF01217	0.384
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.310
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.546
TRG_ENDOCYTIC_2	176	179	PF00928	0.342
TRG_ENDOCYTIC_2	242	245	PF00928	0.251
TRG_ENDOCYTIC_2	294	297	PF00928	0.259
TRG_ENDOCYTIC_2	393	396	PF00928	0.302
TRG_ENDOCYTIC_2	424	427	PF00928	0.266
TRG_ENDOCYTIC_2	462	465	PF00928	0.298
TRG_ER_diArg_1	184	186	PF00400	0.251
TRG_ER_diArg_1	27	30	PF00400	0.504
TRG_ER_diArg_1	576	579	PF00400	0.488
TRG_ER_diArg_1	690	693	PF00400	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I213	Leptomonas seymouri	38%	100%
A0A0N1IJ56	Leptomonas seymouri	55%	99%
A0A0S4JTQ3	Bodo saltans	25%	100%
A0A0S4JV08	Bodo saltans	23%	100%
A0A0S4JZ61	Bodo saltans	24%	100%
A0A1X0NM81	Trypanosomatidae	25%	100%
A0A1X0NU76	Trypanosomatidae	47%	100%
A0A3Q8II95	Leishmania donovani	38%	100%
A0A3R7M3E2	Trypanosoma rangeli	48%	100%
A0A3R7NUJ8	Trypanosoma rangeli	44%	100%
A1L1P9	Danio rerio	27%	100%
A4HN33	Leishmania braziliensis	38%	100%
A4HN34	Leishmania braziliensis	38%	100%
A4IBQ2	Leishmania infantum	38%	100%
C9ZP80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AFI2	Leishmania major	89%	100%
E9AFI7	Leishmania major	41%	100%
E9AHW7	Leishmania infantum	99%	100%
E9B6N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
E9B6P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q38956	Arabidopsis thaliana	22%	100%
Q3V050	Mus musculus	28%	100%
Q5R7E4	Pongo abelii	28%	100%
Q5RFD2	Pongo abelii	30%	100%
Q86VL8	Homo sapiens	27%	100%
Q8K0H1	Mus musculus	29%	100%
Q96FL8	Homo sapiens	30%	100%
Q9FH21	Arabidopsis thaliana	24%	100%
Q9FKQ1	Arabidopsis thaliana	24%	100%
Q9LUH2	Arabidopsis thaliana	26%	100%
Q9SIA4	Arabidopsis thaliana	24%	100%
V5BJE3	Trypanosoma cruzi	47%	100%