Tubulin/FtsZ family, GTPase domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tubulin/FtsZ family, GTPase domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGH8_LEIDO

TriTrypDb:

LdCL_330014500

Length:

142

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	2
GO:0099080	supramolecular complex	2	2
GO:0099081	supramolecular polymer	3	2
GO:0099512	supramolecular fiber	4	2
GO:0099513	polymeric cytoskeletal fiber	5	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A0A3Q8IGH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGH8

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0003924	GTPase activity	7	2
GO:0005198	structural molecule activity	1	2
GO:0005200	structural constituent of cytoskeleton	2	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0016462	pyrophosphatase activity	5	2
GO:0016787	hydrolase activity	2	2
GO:0016817	hydrolase activity, acting on acid anhydrides	3	2
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.305
CLV_PCSK_SKI1_1	67	71	PF00082	0.301
DOC_CKS1_1	71	76	PF01111	0.308
DOC_CYCLIN_RxL_1	64	75	PF00134	0.469
DOC_MAPK_gen_1	105	111	PF00069	0.298
DOC_PP1_RVXF_1	114	120	PF00149	0.284
DOC_USP7_MATH_1	126	130	PF00917	0.330
DOC_USP7_MATH_1	137	141	PF00917	0.450
DOC_USP7_MATH_1	85	89	PF00917	0.267
DOC_WW_Pin1_4	23	28	PF00397	0.400
DOC_WW_Pin1_4	32	37	PF00397	0.400
DOC_WW_Pin1_4	70	75	PF00397	0.311
LIG_14-3-3_CanoR_1	16	22	PF00244	0.400
LIG_Actin_WH2_2	57	72	PF00022	0.400
LIG_CSL_BTD_1	33	36	PF09270	0.400
LIG_FHA_1	1	7	PF00498	0.199
LIG_FHA_1	18	24	PF00498	0.400
LIG_FHA_1	38	44	PF00498	0.400
LIG_FHA_1	66	72	PF00498	0.308
LIG_FHA_1	89	95	PF00498	0.286
LIG_FHA_2	73	79	PF00498	0.292
LIG_LIR_Gen_1	20	28	PF02991	0.400
LIG_LIR_Nem_3	20	24	PF02991	0.400
LIG_LIR_Nem_3	63	69	PF02991	0.459
LIG_LIR_Nem_3	73	79	PF02991	0.292
LIG_Pex14_2	120	124	PF04695	0.294
LIG_SH2_STAP1	62	66	PF00017	0.400
LIG_SH3_3	109	115	PF00018	0.303
LIG_SUMO_SIM_par_1	2	7	PF11976	0.400
LIG_SxIP_EBH_1	16	30	PF03271	0.400
LIG_WRC_WIRS_1	18	23	PF05994	0.400
MOD_CDK_SPxxK_3	23	30	PF00069	0.400
MOD_CK1_1	129	135	PF00069	0.390
MOD_CK1_1	50	56	PF00069	0.400
MOD_CK1_1	88	94	PF00069	0.282
MOD_GlcNHglycan	87	90	PF01048	0.275
MOD_GSK3_1	125	132	PF00069	0.342
MOD_GSK3_1	19	26	PF00069	0.400
MOD_GSK3_1	32	39	PF00069	0.400
MOD_GSK3_1	65	72	PF00069	0.299
MOD_N-GLC_1	37	42	PF02516	0.199
MOD_NEK2_1	19	24	PF00069	0.400
MOD_NEK2_1	4	9	PF00069	0.400
MOD_NEK2_1	69	74	PF00069	0.305
MOD_NEK2_2	65	70	PF00069	0.293
MOD_PIKK_1	129	135	PF00454	0.390
MOD_PKA_2	129	135	PF00069	0.390
MOD_Plk_1	37	43	PF00069	0.400
MOD_Plk_1	50	56	PF00069	0.400
MOD_ProDKin_1	23	29	PF00069	0.400
MOD_ProDKin_1	32	38	PF00069	0.400
MOD_ProDKin_1	70	76	PF00069	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0AAL4	DICPU	44%	43%
A2AQ07	MOUSE	72%	31%
A5A6J1	PANTR	41%	31%
A6NHL2	HUMAN	44%	32%
A6NNZ2	HUMAN	79%	32%
B9DGT7	ARATH	44%	32%
B9DHQ0	ARATH	40%	32%
O04386	CHLIN	81%	32%
O17449	MANSE	80%	32%
O22347	ELEIN	43%	31%
O22348	ELEIN	41%	32%
O22349	ELEIN	40%	32%
O42786	DOTSE	78%	32%
O44388	TRITR	82%	32%
O49068	ORYSJ	40%	30%
O59837	PHYCI	78%	32%
O94128	ZYMTR	41%	32%
P02550	PIG	41%	31%
P02552	CHICK	40%	34%
P02554	PIG	83%	32%
P02557	YEAST	74%	31%
P04105	PHYPO	42%	32%
P04106	TRYBR	41%	31%
P04107	TRYBR	91%	32%
P04350	HUMAN	82%	32%
P04688	SCHPO	43%	31%
P04689	SCHPO	41%	32%
P04690	CHLRE	81%	32%
P05213	MOUSE	41%	31%
P05214	MOUSE	40%	32%
P05219	SCHPO	67%	32%
P05220	NEUCR	76%	32%
P05304	GIAIN	78%	32%
P06603	DROME	40%	32%
P06604	DROME	41%	32%
P06605	DROME	41%	32%
P06606	DROME	41%	31%
P07304	STYLE	42%	32%
P07436	PHYPO	82%	30%
P07437	HUMAN	83%	32%
P08070	CHICK	42%	32%
P08537	XENLA	40%	32%
P08562	TRYCR	91%	32%
P08841	DROME	77%	31%
P09203	CHICK	82%	32%
P09204	CHLRE	43%	31%
P09205	CHLRE	43%	31%
P09206	CHICK	83%	32%
P09207	CHICK	77%	32%
P09243	STYLE	43%	32%
P09244	CHICK	83%	32%
P09642	CHICK	43%	44%
P09643	CHICK	40%	44%
P09644	CHICK	41%	32%
P09645	CHICK	40%	44%
P09652	CHICK	80%	32%
P09653	CHICK	81%	32%
P09733	YEAST	43%	32%
P09734	YEAST	44%	32%
P0DPH7	HUMAN	40%	32%
P0DPH8	HUMAN	40%	32%
P10653	EMENI	77%	32%
P10872	TETPY	42%	32%
P10873	TOXGO	42%	31%
P10874	EMENI	76%	32%
P10875	CANAX	71%	32%
P10876	TETPY	83%	32%
P10878	TOXGO	83%	32%
P11139	ARATH	39%	32%
P11237	NAEGR	43%	31%
P11480	PHYPO	43%	32%
P11481	VOLCA	43%	31%
P11482	VOLCA	81%	32%
P11833	PARLI	83%	32%
P11857	STYLE	84%	32%
P12411	ARATH	81%	32%
P12456	CAEEL	80%	32%
P12457	EUGGR	82%	32%
P12458	PHYPO	75%	31%
P12459	SOYBN	79%	32%
P12460	SOYBN	82%	32%
P12543	PLAYO	41%	31%
P13602	XENLA	83%	32%
P14140	PLAFA	83%	32%
P14640	MAIZE	43%	31%
P14641	MAIZE	43%	31%
P14642	PLAFK	42%	31%
P14643	PLAFK	83%	32%
P16040	BLUHO	78%	32%
P17938	EPITY	77%	32%
P18025	MAIZE	82%	32%
P18026	MAIZE	83%	32%
P18241	BRUPA	75%	32%
P18258	PARLI	41%	31%
P18288	ONCMY	40%	32%
P18695	EMENI	33%	31%
P18700	STRPU	83%	49%
P20364	DAUCA	80%	45%
P20365	EUPCR	83%	32%
P20802	ACHKL	79%	32%
P21148	LEIME	92%	32%
P22012	ASPFL	76%	32%
P22013	COLGR	71%	32%
P22014	COLGR	78%	32%
P22275	MAIZE	44%	32%
P22852	POLAG	81%	32%
P23258	HUMAN	38%	31%
P23330	XENLA	38%	31%
P24633	EMENI	40%	32%
P24634	EMENI	46%	31%
P24635	OCTVU	45%	59%
P24636	ARATH	82%	32%
P24637	PNECA	77%	32%
P25295	SCHPO	36%	32%
P25862	AVESA	82%	37%
P28268	EUPVA	42%	32%
P28287	OXYGR	43%	32%
P28551	SOYBN	82%	35%
P28752	ORYSJ	40%	32%
P29500	PEA	80%	32%
P29501	PEA	82%	32%
P29502	PEA	82%	32%
P29511	ARATH	44%	32%
P29513	ARATH	81%	32%
P29514	ARATH	82%	32%
P29515	ARATH	82%	32%
P29516	ARATH	82%	32%
P29517	ARATH	82%	32%
P30156	ECTVR	78%	32%
P30157	ECTVR	78%	32%
P30436	ONCKE	40%	32%
P30668	SCHCO	81%	32%
P30883	XENLA	83%	32%
P31017	ENTHI	38%	31%
P31863	HYPRU	74%	32%
P31864	HYPRU	73%	32%
P32255	DICDI	47%	31%
P32256	DICDI	75%	31%
P32348	USTVI	35%	30%
P32882	CHICK	83%	32%
P32924	GEOCN	73%	32%
P32925	GEOCN	62%	31%
P32928	COLGL	71%	32%
P33127	EPICN	77%	32%
P33188	PARTE	84%	32%
P33623	ANEPH	44%	31%
P33624	ANEPH	41%	39%
P33625	EUGGR	43%	31%
P33627	MAIZE	40%	32%
P33629	PRUDU	43%	32%
P33630	ANEPH	80%	32%
P33631	ANEPH	82%	35%
P33632	ANEPH	91%	59%
P34108	NAEPR	85%	31%
P34475	CAEEL	35%	32%
P34690	CAEEL	39%	32%
P34785	ANEPH	39%	30%
P34786	EUPOC	39%	31%
P34787	PLAFO	35%	31%
P35394	ENTDO	79%	32%
P36220	TORMA	41%	31%
P36221	NOTNE	82%	32%
P37392	LUPAL	82%	32%
P37832	ORYSJ	82%	32%
P38668	NEUCR	42%	31%
P38669	NEUCR	41%	32%
P40633	COCH5	34%	31%
P40904	COLGL	78%	32%
P40905	ERYPI	77%	32%
P41351	TETTH	42%	32%
P41352	TETTH	84%	32%
P41383	PATVU	40%	31%
P41385	BOMMO	71%	32%
P41386	HALDI	83%	42%
P41387	ONCGI	81%	32%
P41388	VENIN	77%	32%
P41741	ACRCH	76%	32%
P41742	AJECA	77%	32%
P41799	PHANO	77%	32%
P41937	CAEEL	83%	32%
P42271	DROME	37%	31%
P45960	ORYSJ	82%	32%
P46259	PEA	43%	31%
P46263	SOLTU	82%	31%
P46264	SOLTU	82%	31%
P46265	ORYSJ	82%	32%
P49741	SCHCO	43%	32%
P49742	SCHCO	43%	32%
P50258	PHYPO	44%	32%
P50259	PORPU	67%	31%
P50260	OOMCK	82%	34%
P50261	OOMCK	79%	32%
P50262	OOMCK	80%	31%
P50719	HAECO	42%	32%
P52273	BOMMO	40%	32%
P52274	CAEEL	42%	31%
P52275	CAEEL	76%	32%
P53371	AJECA	36%	34%
P53372	PNECA	43%	32%
P53373	BOTFU	78%	32%
P53374	GIBFU	77%	32%
P53375	PENDI	77%	32%
P53376	RHYSE	78%	32%
P53377	NEUCR	35%	31%
P53378	YEAST	33%	30%
P54401	ENTHI	31%	31%
P54402	EUPAE	39%	31%
P54403	EUPCR	41%	31%
P54404	EUPCR	41%	31%
P61857	DROME	83%	32%
P61858	DROHY	83%	32%
P68360	MERUN	41%	31%
P68361	CRIGR	41%	31%
P68362	CRIGR	41%	31%
P68363	HUMAN	41%	31%
P68365	CRIGR	41%	32%
P68366	HUMAN	41%	32%
P68367	MACFA	41%	32%
P68368	MOUSE	41%	32%
P68369	MOUSE	41%	31%
P68370	RAT	41%	31%
P68371	HUMAN	83%	32%
P68372	MOUSE	83%	32%
P68373	MOUSE	41%	32%
P69893	CRIGR	83%	32%
P69895	MACMU	83%	32%
P69897	RAT	83%	32%
P79008	COPC7	79%	32%
P81947	BOVIN	41%	31%
P81948	BOVIN	41%	32%
P83130	DROER	83%	32%
P83887	MOUSE	38%	31%
P83888	RAT	38%	31%
P85108	RAT	82%	32%
P86221	MESAU	87%	49%
P86234	MESAU	42%	72%
P87066	CANAX	40%	32%
P90548	EUPOC	39%	31%
P91910	CAEEL	41%	32%
P92120	ENCHE	40%	37%
P93176	HORVU	82%	32%
P99024	MOUSE	83%	32%
Q00264	ASPPA	77%	32%
Q02245	MAIZE	40%	32%
Q04709	BABBO	82%	32%
Q06331	ENTDO	41%	31%
Q07972	PNECA	46%	67%
Q08114	EUPOC	43%	32%
Q08115	EUPOC	83%	32%
Q0VCD2	BOVIN	38%	31%
Q0WV25	ARATH	44%	32%
Q13509	HUMAN	80%	32%
Q13885	HUMAN	82%	32%
Q17299	CAEBR	81%	32%
Q24560	DROME	81%	32%
Q24829	ENCHE	69%	32%
Q25008	HOMAM	40%	31%
Q25009	HOMAM	77%	31%
Q25563	NAEPR	43%	31%
Q27352	TRYCR	40%	31%
Q27380	EIMTE	83%	32%
Q27U48	GLOMM	81%	32%
Q28IX8	XENTR	41%	32%
Q2HJ81	BOVIN	81%	32%
Q2HJ86	BOVIN	41%	31%
Q2HJB8	BOVIN	40%	32%
Q2KJD0	BOVIN	83%	32%
Q2T9S0	BOVIN	80%	32%
Q2U2U3	ASPOR	77%	32%
Q2XVP4	PIG	41%	31%
Q32KM1	BOVIN	38%	31%
Q32KN8	BOVIN	40%	32%
Q38771	AVESA	40%	32%
Q39445	CICAR	80%	32%
Q39582	CHLRE	35%	30%
Q39697	DAUCA	80%	32%
Q3KRE8	RAT	83%	32%
Q3KVN1	CERBT	77%	32%
Q3MHM5	BOVIN	83%	32%
Q3UX10	MOUSE	44%	32%
Q3ZBU7	BOVIN	82%	32%
Q3ZCJ7	BOVIN	41%	32%
Q3ZCM7	HUMAN	77%	32%
Q40106	LUPAL	82%	32%
Q40665	ORYSJ	82%	32%
Q40831	PELFA	43%	31%
Q40832	PELFA	43%	31%
Q41782	MAIZE	81%	32%
Q41783	MAIZE	82%	32%
Q41784	MAIZE	82%	32%
Q41785	MAIZE	82%	32%
Q41807	MAIZE	40%	30%
Q41808	MAIZE	40%	30%
Q41874	MAIZE	40%	34%
Q42480	CHOCR	63%	31%
Q43473	HORVU	40%	32%
Q43594	ORYSJ	82%	32%
Q43695	MAIZE	81%	32%
Q43697	MAIZE	82%	32%
Q4HZS8	GIBZE	77%	32%
Q4P235	USTMA	78%	32%
Q4QRB4	RAT	80%	32%
Q4R4X8	MACFA	82%	32%
Q4R538	MACFA	41%	31%
Q4R5B3	MACFA	82%	32%
Q4R9N3	COCHE	76%	32%
Q4WA70	ASPFU	74%	32%
Q52NY7	METAN	77%	32%
Q52PV9	TYRPU	40%	32%
Q53M52	ORYSJ	43%	31%
Q55AR3	DICDI	35%	31%
Q56WH1	ARATH	40%	32%
Q56YW9	ARATH	82%	32%
Q5I2J3	GIBZE	41%	32%
Q5R1W4	PANTR	41%	31%
Q5R943	PONAB	83%	32%
Q5UBX3	TRIRU	72%	32%
Q5XIF6	RAT	41%	32%
Q60HC2	MACFA	80%	32%
Q68FR8	RAT	40%	32%
Q6AY56	RAT	40%	32%
Q6AYZ1	RAT	41%	32%
Q6B856	BOVIN	83%	32%
Q6EVK8	SUIBO	80%	32%
Q6FNU9	CANGA	32%	31%
Q6GLE7	XENTR	83%	32%
Q6P9T8	RAT	83%	32%
Q6P9V9	RAT	41%	31%
Q6PEY2	HUMAN	40%	32%
Q6QDC9	ZYMTR	77%	32%
Q6VAF4	GOSHI	82%	32%
Q6VAF5	GOSHI	77%	32%
Q6VAF6	GOSHI	82%	32%
Q6VAF7	GOSHI	82%	32%
Q6VAF8	GOSHI	82%	33%
Q6VAF9	GOSHI	43%	32%
Q6VAG0	GOSHI	43%	32%
Q6VAG1	GOSHI	44%	31%
Q71G51	NEOCA	42%	31%
Q71U36	HUMAN	41%	31%
Q752Y2	ASHGO	38%	32%
Q75A43	ASHGO	39%	30%
Q767L7	PIG	83%	32%
Q76FS2	ORYSJ	81%	32%
Q76FS3	ORYSJ	82%	32%
Q7JJU6	PANTR	83%	32%
Q7KQL5	PLAF7	83%	32%
Q7TMM9	MOUSE	82%	32%
Q7Z9Z2	COPC7	36%	31%
Q84TG9	NEOYE	67%	31%
Q86ZP5	UNCNE	77%	32%
Q875L2	HYPVI	75%	32%
Q875L3	HYPVI	74%	32%
Q8H7U1	ORYSJ	82%	32%
Q8J1R4	SUIBO	63%	32%
Q8SRD2	ENCCU	34%	33%
Q8SRI6	ENCCU	40%	32%
Q8SS99	ENCCU	70%	32%
Q8T6A5	APLCA	41%	31%
Q8VCK3	MOUSE	38%	31%
Q8WP13	PAPHA	78%	32%
Q8WP14	PANTR	77%	32%
Q8WQ47	LEPDS	41%	32%
Q8WZE0	USTVI	76%	32%
Q91060	NOTVI	40%	32%
Q91240	PSEAM	83%	32%
Q91575	XENLA	83%	32%
Q92268	PLESA	79%	32%
Q922F4	MOUSE	81%	32%
Q92335	SORMK	41%	32%
Q94570	HOMAM	38%	31%
Q94571	HOMAM	77%	31%
Q94572	HOMAM	40%	31%
Q962P8	NAEPR	40%	31%
Q96460	HORVU	44%	31%
Q96TU8	UROFA	81%	32%
Q9ASR0	ARATH	82%	32%
Q9BQE3	HUMAN	41%	32%
Q9BUF5	HUMAN	81%	32%
Q9BVA1	HUMAN	83%	32%
Q9C413	COLOR	44%	31%
Q9CWF2	MOUSE	83%	32%
Q9D6F9	MOUSE	82%	32%
Q9ERD7	MOUSE	80%	32%
Q9FT36	DAUCA	44%	31%
Q9GKK5	CANLF	38%	31%
Q9GSR5	ENCIN	70%	32%
Q9H4B7	HUMAN	74%	31%
Q9H853	HUMAN	36%	59%
Q9HFQ3	MELLI	80%	32%
Q9JJZ2	MOUSE	40%	32%
Q9LKI8	THAWE	78%	32%
Q9N2N6	EUPFO	83%	32%
Q9NFZ5	ECHMU	73%	32%
Q9NFZ6	ECHMU	80%	32%
Q9NFZ7	ECHMU	81%	32%
Q9NRH3	HUMAN	38%	31%
Q9NY65	HUMAN	40%	32%
Q9SCC8	GUITH	41%	32%
Q9SEV2	GUITH	79%	32%
Q9UV72	PESMI	78%	32%
Q9VRX3	DROME	51%	31%
Q9Y882	SCHJP	37%	32%
Q9YHC3	GADMO	82%	32%
Q9ZPN7	ELEIN	82%	32%
Q9ZPN8	ELEIN	82%	32%
Q9ZPN9	ELEIN	82%	32%
Q9ZPP0	ELEIN	82%	32%
Q9ZRA8	WHEAT	82%	32%
Q9ZRA9	WHEAT	80%	32%
Q9ZRB0	WHEAT	82%	32%
Q9ZRB1	WHEAT	82%	32%
Q9ZRB2	WHEAT	82%	32%
Q9ZRB7	WHEAT	44%	31%
Q9ZRJ4	CHLVU	43%	31%
Q9ZRR5	HORVU	43%	31%
Q9ZSW1	CYAPA	81%	32%