Thioredoxin/Thioredoxin-like_putative/Pfam:PF0008 5/Pfam:PF13905

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Thioredoxin/Thioredoxin-like, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGH5_LEIDO

TriTrypDb:

LdCL_250012500 , LDHU3_25.0900

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGH5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0015035	protein-disulfide reductase activity	3	1
GO:0015036	disulfide oxidoreductase activity	4	1
GO:0016491	oxidoreductase activity	2	1
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.345
CLV_NRD_NRD_1	46	48	PF00675	0.302
CLV_PCSK_SKI1_1	123	127	PF00082	0.298
DEG_APCC_DBOX_1	122	130	PF00400	0.344
DOC_MAPK_gen_1	121	128	PF00069	0.346
DOC_MAPK_gen_1	17	26	PF00069	0.233
DOC_MAPK_gen_1	47	53	PF00069	0.298
DOC_USP7_MATH_1	110	114	PF00917	0.320
DOC_WW_Pin1_4	58	63	PF00397	0.207
LIG_14-3-3_CanoR_1	4	10	PF00244	0.245
LIG_BIR_II_1	1	5	PF00653	0.241
LIG_FHA_1	134	140	PF00498	0.440
LIG_FHA_1	59	65	PF00498	0.358
LIG_FHA_1	95	101	PF00498	0.282
LIG_FHA_2	20	26	PF00498	0.131
LIG_FHA_2	6	12	PF00498	0.329
LIG_LIR_Apic_2	29	33	PF02991	0.233
LIG_LIR_Nem_3	75	79	PF02991	0.265
LIG_NRP_CendR_1	151	154	PF00754	0.336
LIG_Pex14_2	26	30	PF04695	0.220
LIG_REV1ctd_RIR_1	76	84	PF16727	0.330
LIG_SH2_STAT5	77	80	PF00017	0.207
LIG_SH3_3	102	108	PF00018	0.369
LIG_SH3_3	33	39	PF00018	0.198
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.335
LIG_UBA3_1	145	151	PF00899	0.271
LIG_UBA3_1	40	48	PF00899	0.207
LIG_WRC_WIRS_1	73	78	PF05994	0.183
LIG_WRC_WIRS_1	85	90	PF05994	0.183
MOD_CK2_1	110	116	PF00069	0.375
MOD_CK2_1	5	11	PF00069	0.244
MOD_NEK2_1	26	31	PF00069	0.233
MOD_PIKK_1	94	100	PF00454	0.293
MOD_Plk_4	124	130	PF00069	0.335
MOD_Plk_4	19	25	PF00069	0.198
MOD_Plk_4	72	78	PF00069	0.183
MOD_ProDKin_1	58	64	PF00069	0.207
TRG_DiLeu_BaEn_1	141	146	PF01217	0.286
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.207
TRG_ER_diArg_1	152	154	PF00400	0.329
TRG_NLS_MonoExtC_3	149	154	PF00514	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL85	Leptomonas seymouri	75%	100%
A0A0S4ISI9	Bodo saltans	51%	100%
A0A0S4JC51	Bodo saltans	32%	87%
A0A3S5H4U0	Leishmania donovani	36%	100%
A4H351	Leishmania braziliensis	39%	100%
A4HRE8	Leishmania infantum	36%	100%
E9AC16	Leishmania major	37%	100%
E9AJB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
G4NFB7	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	38%	90%
O83889	Treponema pallidum (strain Nichols)	33%	100%
P29448	Arabidopsis thaliana	38%	100%
P42115	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	100%
Q1RQI9	Malassezia sympodialis	39%	100%
Q69AB1	Rattus norvegicus	30%	100%
Q98TX1	Ophiophagus hannah	34%	100%
Q9UW02	Coprinus comatus	41%	100%